Abstract:Our study reveals that the earliest historical records of Sheng Mai Powder are found in 《Yixue qiyuan》, (《Origins of Medicine》), a medical book written by Zhang Yuansu and published in the beginning of 1186, 45 years earlier than the latestedition of 《Neiwai shangbian huolun》(《Treaties on the identification of Internal Diseases and External Damages》), written by Li Gao in 1231. The study also suggests that the assertion of Sheng Mai Powder to be inaugur ated by Sun Simiao is groundless.