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期 刊 ：中国中药杂志 1998年 23卷 06期 页码：371.

关键词：脑缺血；伊文思蓝；脑含水量；黄芪；红芪；

Keywords:middle cerebral artery, cerebral ischemia, evens blue, water content in brain, Astragalus membranaceus, Hedysarum polybotrys,

摘 要 ：用尼龙线插入法造成大鼠大脑中动脉栓塞模型，黄芪水煎剂（４．２６，７．１ｇ／ｋｇ）与红芪水煎剂（７．１ｇ／ｋｇ）均可明显改善大鼠大脑中动脉栓塞所致的运动障碍和脑毛细血管通透性增加。黄芪水煎醇沉剂（１２．５ｇ／ｋｇ）可明显改善双侧结扎颈总动脉大鼠脑含水量的增加，红芪水煎醇沉剂有改善趋势。提示黄芪保护脑缺血的作用强于红芪。

Abstract:The experimental model of middle cerebral artery embolism in rats was made by inserting nylon thread. It was discovered that Astragalus membranaceus decoction(both 4,26 g·kg ^-1 and 7.1g·kg ^-1 )could reduce the capillary hyperpermeability and alleviate the dyskinesia caused by cerebral ischemia in rats. Purified Hedysarum polybotrys decoction (waste substances removed with alcohol after decocting with water)(12.5g·kg ^-1 )could reduce the water content in brain caused by occlusion of bilateral carotids in rats.Purified Hedysarum polybotrys decoction showed a tendency to reduce the water content in brain, but without statistical significance.

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