Abstract:In the extraction technology of Efferveseent Granules for Arresting Cold Pain tHantongding PaotengChongji) . the drug combinative modes,solvent PH and drug granularity were optimized by orthogonal tests, with thetotal alkaloid ,paeoniflorin and glycyrrhetinic acid as indexes. The experimental resuhs show that it is better to decocttogether all the recipe ingredients,with water of PHZ for the first decoction,then water of PHS for the second decor-tion.and to make its granularities ranging from the original herbal pieces to particles which can pass through a No. 2sieve.