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期 刊 ：中国中药杂志 1998年 23卷 09期 页码：551.

关键词：西洋参；水溶性成分；丙二酸单酰基人参皂甙；

Keywords:American Ginseng, water-soluble components, malonyl ginsenosides,

摘 要 ：目的：研究西洋参水溶性部分的化学成分。方法：西洋参根８０％甲醇提取物的水悬浮液，乙醚、水饱和正丁醇萃取，水溶液部分大孔树脂柱脱糖，硅胶柱反复层析，光谱分析鉴定结构。结果：分得１种单体化合物，确定为丙二酸单酰基人参皂甙-Ｒｂ_１。另外还分得人参皂甙Ｒｂ_１和人参皂甙Ｒｅ。结论：首次发现并鉴定了西洋参中存在的水溶性皂甙。

Abstract:Objective:To have further comprehension of American Ginseng on the basis of its water soluble components.Method:The water suspension of 80%methanol extract of American Ginseng was sequentially extracted with ethyl ether and n-butyl alcohol.The saccharides in the water soluble portion were removed by macro reticular resin column,and three compounds were obtained by silica gel column chromatography.Their structures were confirmed on the basis of spectral analysis(IR,NMR,MALDI MS)melting points and optical degrees.Result:Three compounds were identified as malonyl ginsenosides Rb₁, ginsenoside Rb₁ and Re respectively.Among them Rb₁and Re are known,while malonyl ginsenoside Rb1 was isolated from American Ginseng for the first time.Its structure was elucidated as (3β,12β)-20-[(-6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl-O-[6-O-(carboxyacetyl)-β-D-glucopyranosyl)]-β-D-glucopyranoside.Conclusion:Water soluble ginsenosides were isolated from the water soluble extract of American Ginseng suggesting that malonyl ginsenosides exist both in American Ginseng and Ginseng.

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