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期 刊 ：中国中药杂志 1998年 23卷 08期 页码：491.

关键词：川芎嗪；动作电位；乳头状肌；冠状动脉；

Keywords:ligustrazine, action potential, papillary muscles, coronary artery,

摘 要 ：目的：观察川芎嗪对豚鼠乳头状肌机械电话动和猪冠状动脉收缩的影响。方法：标准玻璃微电极技术、电生理方法、血管灌流方法。结果：①川芎嗪（3.0μmol/L～100μmol/L）对豚鼠乳头状肌快反应电位（FAP）的时程（APD）、收缩力（FC）和慢反应电位（SAP）的幅度（APA），APD，FC及最大去极速度（V_max）均呈剂量依赖性抑制；②川芎嗪（3.0m mol/L）可以在高钾去极、钠通道失活的豚鼠乳头状肌标本上诱发产生SAP及FC，这一现象可被β受体阻断剂所阻断。［Ca²⁺］ｏ增加，川芎嗪诱发SAP的APA随之增加；③川芎嗪（10^-5mol/L～5×10^-3mol/L）对高钾去极化收缩的猪冠状动脉环呈舒张作用，且不被β受体阻断剂所阻断和［Ca²⁺］ｏ增加的影响。结论：提示川芎嗪可能通过β受体影响心肌细胞慢内向电流。川芎嗪对冠状动脉有舒张作用，此作用可能不是通过兴奋β受体而实现的。

Abstract:Objective:To study the effects of ligustrazine on mechanical electricity in guinea pig ventricular papillary muscles and on contraction of pig coronary artery.Method:Standard glass microelectrode technology;electrophysiological method;and blood vessel perfusion were used.Result:①ligustrazine(3～100μmol/L)suppressed the action potential duration (APD)and the force of contraction (FC) of the fast action potentials (FAP),as well as the action potential amplitude (APA),APD,FC and the maximal upstroke velocity(V_max)of the slow action potentials (SAP).② ligustrazine (3.0 mmol/L)induced SAP and contraction, but failed in beta adrenoreceptor blocked muscles.Elevation of[Ca²⁺]o increased the action potential amplitude (APA).③ligustrazine(10^-5～5×10^-3mol/L)decreased the contractile response to high KCl in pig coronary artery. Conclusion: Ligustrazine might affect the inward current of myocardial cells through beta adrenoreceptor,and the diastolizing effect of ligustrazine on coronary artery might have nothing to do with the exciting beta adrenoreceptor.

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