Abstract:When Rhodiola sachalinensis polysaccharides A and B (RSP A and RSP B)were intraperitoneally injected to mice at dosages of 50mg/kg and 100mg/kg,the result showed that RSP B was the effective hypoglycemic ingredient of Rhodiola sachalinensis .When mice were administrated in different ways,it was shown that RSP B did not possess significant hypoglycemic effect through absorption in the instestines.However,RSP B does possess significant hypoglycemic effect if administrated subcutaneously,intramuscularly,intraperitoneally and intravenously.