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期 刊 ：中国中药杂志 1992年 17卷 03期 页码：172.

关键词：人参皂甙类；钙通道阻滞剂；培养心肌细胞；动作电位；

Keywords:Jiang Yan, Zhong Guogan, Shao Chunjie and Yue Gang,

摘 要 ：PDS与PTS使培养的心肌细胞动作电位各参数呈剂量依赖性减小。PDS 1000肛g/ml、PTS200μg/ml与钙通道阻滞剂Mn²⁺ 0.05μg/ml的作用相当。洗脱、肾上腺素10μg/ml、Ca²⁺80μg/ml使动作电位的抑制逆转。表明PDS与PTS有钙通道阻滞作用。

Abstract:It was found that PDS and PTS decreased the action potential parameters of the cultured myocardiocytes in a dosage-dependent way. The effects of PDS 1000μg/ml, PTS 200μg/ml were in correspondence with the known Ca²⁺ channel blocker Mn²⁺ 0.05μg/ml. Washing out, administration of epinephrine 10μg/ml or Ca²⁺ 80μg/ml were able to reverse the action potential from inhibition. The above results indicate that both PDS and PTS have Ca²⁺ channel blockade action.

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