Abstract:The Seed oil of Hippophae rhamnoides markedly inhibits the rise of MDA in liver of mice and rats induced byCCl,AAP and ethyl alcohol,decreases significantly the activity of SGPT and SGOT,and markedly checks the de-pletion of GSH in liver of mice induced by AAP。 The microscopic and electron-microscopic examination has;hownthat the seed oil can lighten liver injuty。