Determination of Berberine in Xianglian Wan and Zuojin Wan Using First Derivative Spectrometry Establishment of animal model with gastric hot syndrome Establishment of animal model with gastric cold syndrome Exploration on scientific connotation of compatibility of Zuojin Wan based on "disease-syndromes-formulas-medicines" binding mode Comparative study on pharmacokinetics of six major alkaloids in Zuojin Wan microemulsion based gel and hydrogel