全 文 ：·Original Papers·
Chemical Constituents of Evodia fargesii Dode
LIU Quan-Wen1 , 2 , TAN Chang-Heng1 , QU Shi-Jin1 , FAN Xiao2 , ZHU Da-Yuan1＊
1StateKey Laboratory of Drug Research , Shanghai Institute of Materia Medica , Shanghai Institutes for Biological Sciences , Chinese Acade-
my of Sciences , Shanghai 201203;
2 Institute of Oceanology , Chinese Academy of Sciences , Qingdao 266071 , China
【ABSTRACT】　AIM:To study the chemical constituents of Evodia fargesii Dode.METHODS:Silica gel column chro-
matography was used for the isolation of compounds , and spectroscopic techniques(NMR , IR, UV andMS)were used for the
structural identification.RESULTS:Thirteen compounds , including six alkaloids:2-methyl-6-hydroxy-1 , 2 , 3 , 4-tetrahydro-
β-carboline(1), N , N-dimethyltryptamine(2), N-p-coumaroyltyramine (3), dictamnine(4), robustine (5), and hap-
lophine(6), three limonoids:limonin(7), rutaevine(8), and evodol(9), two flavanoids:quercetin(10)and(+)-dihy-
droquercetin(11), as well as β-sitosterol(12)and daucosterol(13)were obtained from the titled plant.CONCLUSION:
Compound 1 is new , the others are isolated from the plant for the first time.
【KEY WORDS】　Evodia fargesii;Alkaloid;Flavone;Limonoid
【CLCNumber】　R284.1　　【Document code】　A　　【Ariticle ID】　1672-3651(2006)01-0025-05
【Received on】　2005-03-20
【Foundation Item】　This project was supported by the National “ 863”
Project(No.2004AA625030 and 2001AA620503);Key Innovative Pro-
ject of the Academy(KZCX3-SW-215)
【＊Corresponding author】　Zhu Da-Yuan , Professor of phytochemistry
and medicinal chemistry , Tel:(86)-21-50806728 , Fax:(86) 21-
50807088 , E-mail:dyzhu@mail.shcnc.ac.cn
　　Evodia fargesii , belonging to the family Rutaceae ,
is a Chinese folk medicine used for the treatment of
hepatitis in Jiangxi province.Zhang et al had analyzed
33 essential oils from the seeds of this plant by means of
GC-MS-DS [ 1] .In the course of chemical constituents
investigation on the plant , 13 compounds were isolated
and identified as:2-methyl-6-hydroxy-1 ,2 ,3 ,4-tetrahy-
dro-β-carboline (1), N , N-dimethyltryptamine (2),
N-p-coumaroyltyramine (3), dictamnine (4), robus-
tine (5), haplophine (6), limonin (7), rutaevine
(8), and evodol(9), quercetin(10), (+)-dihydro-
quercetin (11), β-sitosterol (12) and daucosterol
(13), from the root bark.1 was structurally identified
to be a new compound , and the others were obtained
from E .fargesii for the first time.
Fig 1　The key HMBC correlations(H to C)of 1
1　Results and Discussion
Compound 1　obtained as yellowish needles , mp
248.5 ～ 250.5 ℃, showed a positive Dragendorff reac-
tion.Its molecular formula C12H14N2O was determined
by the HREI-MS(foundM+at m/z 202.1111 , calcd.
for C12H14N2O , 202.1106).The UV spectrum exhibit-
ed characteristic absorptions of indole alkaloids (λmax :
226 and 279.0 nm)[ 2] .Its IR absorptions suggested the
existence of hydroxyl (3236 cm-1)and aromatic rings
(1625 , 1596 , and 1465 cm-1).The 1H NMR spec-
trum showed proton signals for a N-methyl(δ2.39 , s ,
3H), a NH group (δ10.32 , br s , 1H), a phenolic
hydroxyl(δ8.48 , br s , 1H), and one 1 , 2 ,4-trisub-
stituted benzene ring (δ7.04 , d , J =8.5Hz;6.51 ,
dd , J = 8.5 , 1.9 Hz;6.66 , d , J = 1.9 Hz).Its
中国天然药物　2006年 1月　第 4卷　第 1期 Chin J Nat Med　Jan.2006　Vol.4　No.1　25　
13
CNMR(DEPT)spectrum (Table 1)displayed 12
carbon signals [ 1×CH3 , 3×CH2 , 3×CH , 5×C] .
Above-mentioned evidences indicated an indole [ c]
pyridine skeleton containing a phenolic hydroxyl and N-
methyl.
Referring to the carbon resonance data of 6-
methoxy-2-methyl-1 , 2 , 3 , 4-tetrahydro-β-carboline[ 3] ,
the quaternary carbon signals ofδ105.2 and 127.4 of 1
were attributed to C-4a and C-4b , respectively .The
proton signal atδH 6.66 was assigned to H-5 based on
its HMBC correlations with C-4a and C-4b.Conse-
quently , H-7 (δ6.51)and H-8 (δ7.04)were posi-
tioned , proving the phenolic hydroxyl to be attached on
C-6.Taking account into the low chemical shift of the
NH signal , the N-methyl was ascribed to the tetrahy-
dropyran ring.The HMBC cross-peak of N-Me/C-9b
disclosed the N-atom to be at β-position of the carbo-
line alkaloid.Therefore , 1 was unambiguously formulat-
ed to be 2-methyl-6-hydroxy-1 ,2 ,3 ,4-tetrahydro-β-car-
boline.
Table 1　NMR data of compound 1(400 MHz for 1H and 100 MHz for 13C , δ, (J , Hz), DMSO-d6)
Position δC(mult) δH(mult) HMBC(H※C)
1 52.2(t) 3.47(s , 2H) N-CH3 , C-3 , C-4a , C-4b , C-9a
3 52.7(t) 2.64(d , J = 4.8 Hz , 2H) C-1 , N-CH3 , C-4 , C-4a
4 21.3(t) 2.60(d , J = 4.8 Hz , 2H) C-3 , C-4a , C-9a
4a 105.2(s) 　　　　-
4b 127.4(s) 　　　　-
5 101.8(d) 6.66(d , J = 1.9 Hz , 1H) C-4a , C-6 , C-7 , C-8a
6 150.2(s) 　　　　-
7 110.0(d) 6.51(dd , J = 8.5 , 1.9 Hz , 1H) C-5 , C-6, C-8a
8 111.0(d) 7.04(d , J = 8.5 Hz , 1H) C-4b , C-5 , C-6 , C-8a
8a 130.3(s) 　　　　-
9a 133.3(s) 　　　　-
NH 　　　　- 10.32(s , 1H) C-4a , C-4b, C-8a , C-9a
N-CH3 45.4(q) 2.39(s , 3H) C-1 , C-3, C-9b
OH 　　　　- 8.48(s , 1H) C-5 , C-6, C-7
2　Experimental
2.1　General
All melting points were determined on a Bǜchi 510
melting point apparatus and are uncorrected.Optical ro-
tations were measured using a Perkin-Elmer polarimeter
341.IR spectra were recorded on a Nicolet Magna 750
FTIR(KBr)spectrometer.EIMS data were obtained
with a MAT-95 mass spectrometer.NMR spectra were
recorded on a Bruker AV500 or DRX400 instruments ,
the chemical shift values were reported in δand cou-
pling constants(J)were given in Hz.Silica gel(200-
300 , 400 mesh , Silica gel H)and precoated plates of
silica gel(HSGF254)(Qingdao Haiyang Chemical Group
Co., Qingdao)were used for column chromatography
(CC)and TLC , respectively.
2.2　Plant material
The root bark of E.fargesii was collected in
Jiangxi province , China , in April 2004 , and identified
by Prof.Zhu Da-Yuan.A voucher (No.0405)speci-
menwas deposited in our laboratory.
2.3　Extraction and isolation
The root bark of E.fargesii Dode (20 kg)was
extracted with 95%EtOH (50 L×3)at room tempera-
ture.The concentrated extract was suspended in H2O
(3L)and partitioned successively with petroleum ether
(PE), CHCl3 , EtOAc , and n-BuOH (each 3 L×3).
The CHCl3 fraction(58.4 g)was chromatographed over
silica gel columns eluted with PE-Me2CO , PE-EtOAC ,
and CHCl3-Me2CO solution system to give compounds 4
～ 9 , 12 , respectively.The EtOAc-soluble fraction(32
g)was subjected repeatedly to CC on silica gel eluted
with solution system of PE-EtOAc , CHCl3-Me2CO , and
CHCl3-MeOH , to yield compounds 1 ～ 3 , 10 , 11 , and
13 , respectively.
26　　Chin J Nat Med　Jan.2006　Vol.4　No.1 中国天然药物　2006年 1月　第 4卷　第 1期
3　Identification
3.1　2-methyl-6-Hydroxy-1 , 2 , 3 , 4-tetrahydro-β-car-
boline (1)
C12H14 N2 O , yellowish powder , mp 248.5 ～
249.4 ℃;UVmax(MeOH):226.0 , 279.0 nm;IR
(KBr):3236 , 2950 , 1625 , 1596 , 1465 , 1400 ,
1251 , 1149 , 970 , 916 , 794 cm-1;1H NMR and
13CNMR(DMSO-d6)see Table 1.EI-MS m/z (rel.
int.):202([M] + , 25), 159([M-N(CH2)CH3] + ,
100).
3.2　N , N-Dimethyltryptamine (2)
C12H16N2 , 1HNMR(CDCl3 , 400 MHz)δ:8.11
(br s , NH), 7.61(1H , d , J =7.9Hz), 7.35(1H ,
d , J =8.2 Hz), 7.19 (1H , t , J =7.3 Hz), 7.12
(1H , t , J =7.3 Hz), 7.03(1H , d , J =1.9 Hz),
2.99(2H , t , J =7.6 Hz), 2.70(2H , t , J =7.6
Hz), 2.35(6H , s);13CNMR(DEPT)(CDCl3 , 100
MHz)δ:136.3 s , 127.4 s , 121.8 d , 121.5 d , 119.1
d , 118.7 d , 113.9 s , 111.1 d , 60.2 t , 45.2 q , 45.2
q , 23.5 t[ 4] .
3.3　N-p-coumaroyltyramine (3)
C17H17NO3 , 1H NMR(DMSO-d6 , 400 MHz)δ:
7.44(1H , d , J =15.9Hz), 7.39(2H , d , J =8.3
Hz), 7.05 (2H , d , J = 8.3 Hz), 6.78 (2H , d ,
J =8.3 Hz), 6.71 (2H , d , J = 8.3 Hz), 6.39
(1H , d , J =15.9 Hz), 3.45(2H , t , J =7.5Hz),
2.14(2H , t , J =7.5 Hz);13C NMR(DEPT)(DM-
SO-d6 , 100 MHz)δ:165.4 s , 158.8 s , 155.7 s ,
155.7s , 138.6 d , 129.5 d , 129.5 d , 129.2 d , 129.2
d , 125.9 s , 118.7 d , 115.8 d , 115.8 d , 115.1 d ,
115.1 d , 40.7 t , 34.5 t[ 5] .
3.4　Dictamnine (4)
C12H9NO2 , mp 132 ～ 133 ℃.1H NMR(CDCl3 ,
400 MHz)δ:8.28(1H , dd , J =8.5Hz , 1.3 Hz),
8.05(1H , d , J =8.5 Hz), 7.70 (1H , t , J =7.6
Hz), 7.64(1H , d , J =2.8Hz), 7.46(1H , t , J =
7.6 Hz), 7.10(1H , d , J =2.8Hz), 4.46(3H , s ,
OCH3);13CNMR (DEPT)(CDCl3 , 100 MHz)δ:
163.8 s , 156.8 s , 145.5 s , 143.5 d , 129.6 d , 127.7
d , 123.7 d , 122.4 d , 118.6 s , 104.7 d , 103.4 s ,
58.9 s[ 6] .
3.5　Robustine (5)
C12H9NO3 , crystal , mp 147 ～ 148 ℃.1H NMR
(CDCl3 , 400 MHz)δ:7.74(1H , dd , J =8.6 Hz ,
1.4 Hz), 7.64(1H , d , J = 2.8 Hz), 7.34(1H ,
dd , J =8.6 Hz , 7.6 Hz), 7.18(1H , dd , J =7.6
Hz , 1.4 Hz), 7.12 (1H , d , J = 2.8 Hz), 4.46
(3H , s , OCH3), 7.74 (1H , br s , OH);13C NMR
(DEPT)(CDCl3 , 100 MHz)δ:162.5 s , 157.6 s ,
151.0 s , 143.4 d , 135.8 s , 124.3 d , 118.8 s , 112.9
d , 110.3 d , 105.0 d , 103.9 s , 59.1 q[ 6] .
3.6　Haplophine (6)
C13H11NO3 , yellowish prisms , mp 142 ～ 144 ℃.
1HNMR(CDCl3 , 400 MHz)δ:7.85(1H , dd , J =
8.5 Hz , 1.2Hz), 7.65(1H , d , J =2.8 Hz), 7.36
(1H , dd , J =8.5 Hz , 7.6Hz), 7.08(1H , d , J =
2.8 Hz), 7.06 (1H , dd , J = 7.6 Hz , 1.2 Hz),
4.45 (3H , s , OCH3), 4.08 (3H , s , OCH3);
13C NMR(DEPT)(CDCl3 , 100 MHz)δ:163.2 s ,
156.8 s , 154.5 s , 143.9 d , 137.5 s , 123.4 d , 119.6
s , 114.1 d , 107.7 d , 104.5 d , 103.8 s , 59.0 q ,
55.9 q[ 6] .
3.7　Limonin (7)
C26H30O8 , colorless crystals , mp 271 ～ 273 ℃,
[α] 20D-127.3°(c 1.21 , acetone);1H NMR (CDCl3 ,
400 MHz)δ:4.03(1H , m , 1-H), 2.68(1H , dd ,
J =17 , 2 Hz , 2-Hβ), 2.98 (1H , dd , J = 17 , 4
Hz , 2-Hα), 2.23 (1H , dd , J =16 , 3 Hz , 5-H),
2.47 (1H , dd , J = 14.5 , 3.5 Hz , 6-Hα), 2.86
(1H , dd , J = 15.5 , 14.5 Hz , 6-Hβ), 2.55 (1H ,
dd , J =12 , 2.5 Hz , 9-H), 1.83(1H , m , 11-Hα),
1.90(1H , m , 11-Hβ), 1.52(1H , m , 12-Hα), 1.78
(1H , m , 12-Hβ), 4.03(1H , s , 15-H), 5.47 (1H ,
s , 17-H), 4.47(1H , d , J =13 Hz , 19-Hα), 4.77
(1H , br d , J =13 Hz , 19-Hβ), 7.42(1H , dd , J =
1.5 Hz , 1 Hz , 21-H), 6.34(1H , ddd , J =2Hz , 1
Hz , 1 Hz , 22-H), 7.40 (1H , dd , J = 2 Hz , 1.5
Hz , 23-H), 1.30 , 1.18 , 1.07 , 1.18 (each 3H , s ,
CH3(4);13C NMR(DEPT)(CDCl3 , 100 MHz)δ:
79.1(d , C-1), 35.7 (t , C-2), 169.1 (t , C-3),
80.3(s , C-4), 60.5 (d , C-5), 36.4 (t , C-6),
206.2(s , C-7), 51.3 (s , C-8), 48.1 (d , C-9),
45.9(s , C-10), 18.9(t , C-11), 30.8(t , C-12),
中国天然药物　2006年 1月　第 4卷　第 1期 Chin J Nat Med　Jan.2006　Vol.4　No.1　27　
37.9(s , C-13), 65.7(s , C-14), 53.9(d , C-15),
166.6(s , C-16), 77.8(d , C-17), 65.4(t , C-19),
120.0 (s , C-20), 141.1 (d , C-21), 109.7 (d ,
C-22), 143.2(d , C-23), 17.6 , 20.7 , 21.4 , 30.2
(q , CH3(4)[ 7] .
3.8　Rutaevine (8)
C26H30O9 , colorless powder , mp 274 ～ 276 ℃,
[α] 20D-145.1°(c 0.76 , acetone);1H NMR(CDCl3 ,
400 MHz)δ:4.37(1H , br t , J =3 Hz , 1-H), 2.64
(1H , dd , J =15Hz , 3 Hz , 2-Hα), 2.92(1H , dd ,
J =15 Hz , 3Hz , 2-Hβ), 3.12(1H , s , 5-H), 4.35
(1H , br d , J =3 Hz , 7-H), 2.79 (1H , br d , J =
12 Hz , 9-H), 1.73(1H , dd , J =13 Hz , 8 Hz , 11-
Hα), 1.85(1H , m , 11-Hβ), 1.60(1H , m , 12-Hα),
1.95(1H , m , 12-Hβ), 4.16 (1H , s , 15-H), 5.48
(1H , br s , 17-H), 4.15(1H , d , J =12.5 Hz , 19-
Hα), 4.28(1H , br d , J =12.5 Hz , 19-Hβ), 7.44
(1H , m , 21-H), 6.35(1H , m , 22-H), 7.43(1H ,
m , 23-H), 3.89 (1H , d , J = 3 Hz , OH), 1.36 ,
1.21 , 1.44 , 0.65 (each 3H , s , CH3(4);13C NMR
(DEPT)(CDCl3 , 100MHz)δ:81.9(d , C-1), 35.9
(t , C-2), 170.9(s ,C-3), 81.3(s , C-4), 64.5(d ,
C-5), 207.3(s , C-6), 81.9(d , C-7), 48.5(s , C-
8), 45.6 (d , C-9), 45.3 (s , C-10), 19.3 (t , C-
11), 31.0(t , C-12), 37.2(s , C-13), 65.9(s , C-
14), 50.8 (s , C-15), 166.9(s , C-16), 77.5 (d ,
C-17), 69.7 (t , C-19), 120.0 (s , C-20), 141.7
(d , C-21), 110.3 (d , C-22), 143.4 (d , C-23),
28.7 , 14.7 , 20.5 , 23.8(each q , CH3(4)[ 7] .
3.9　Evodol(9)
C26H28O9 , colorless powder , mp 271 ～ 275 ℃,
[α] 20D-138.4°(c 2.28 , acetone);1H NMR(CDCl3 ,
400 MHz)δ:4.07(1H , br t , J =3 Hz , 1-H), 2.84
(1H , dd , J =17 Hz , 5 Hz , 2-Hα), 2.91(1H , dd ,
J =17 Hz , 3 Hz , 2-Hβ), 2.64 (1H , dd , J = 13
Hz , 3 Hz , 9-H), 4.12(1H , s , 15-H), 5.43(1H ,
s , 17-H), 4.62(1H , d , J =13 Hz , 19-Hα), 4.66
(1H , d , J =13Hz , 19-Hβ), 7.41(1H , m , 21-H),
6.38(1H , m , 22-H), 7.40 (1H , m , 23-H), 6.23
(1H , s , 6-OH), 1.49 , 1.54 , 1.16 , 1.04(each 3H ,
CH3(4);13C NMR (DEPT)(CDCl3 , 100 MHz)δ:
79.1 (d , C-1), 34.7 (t , C-2), 169.1 (s , C-3),
81.8(s , C-4), 139.4(s , C-5), 140.0 (s , C-6),
195.1(s , C-7), 46.8 (s , C-8), 46.3 (d , C-9),
48.3(s , C-10), 20.3(t , C-11), 31.6 (t , C-12),
37.2(s , C-13), 65.2(s , C-14), 52.0(s , C-15),
166.7(s , C-16), 77.6(d , C-17), 68.5(t , C-19),
119.6(s , C-20), 141.0(d , C-21), 109.6(d , C-
22), 143.3 (d , C-23), 18.0 , 20.3 , 25.2 , 25.6
(each q , CH3(4)[ 7] .
3.10　Quercetin (10)
C15H10O7 , mp 312 ～ 314 ℃.1H NMR (DMSO-
d6 , 400 MHz)δ:12.23(br s), 7.80 (1H , d , J =
2.3 Hz), 7.71 (1H , dd , J = 8.5 Hz , 2.3 Hz),
7.00(1H , d , J =8.5 Hz), 6.54(1H , d , J =2.0
Hz), 6.28(1H ,d , J =2.0 Hz)[ 8] .
3.11　(+)-Dihydroquercetin (11)
C15H12O7 , [ α] 20D +72°(c 1.20 , acetone);
1HNMR(DMSO-d6 , 400 MHz)δ:7.06 (1H , d ,
J = 1.6 Hz), 6.90 (1H , dd , J = 8.4 Hz , 1.6
Hz), 6.86 (1H , d , J = 8.4 Hz), 5.99 (1H , d ,
J =2.2 Hz), 5.94 (1H , d , J = 2.0 Hz), 5.00
(1H , d , J = 11.6 Hz), 4.60 (1H , d , J = 11.6
Hz);13C NMR (DEPT)(DMSO-d6 , 100 MHz)δ:
197.4 s , 167.5 s , 164.2 s , 163.4 s , 145.9 s , 145.2
s , 129.0 s , 120.3 d , 115.3 d , 115.3 d , 100.8 s ,
96.6 d , 95.6 d , 83.9 d , 72.5 d[ 9] .
3.12　β-sitosterol(12)
Crystals(acetone), mp 137 ～ 138 ℃, 1H NMR
(400 MHz , CDCl3)δ:0.62 , 0.81 , 0.82 , 0.84 ,
0.90 , 1.01(each 3H , s , 6×CH3), 3.52(1H , m ,
3-H), 5.35(1H , br.s , 6-H)[ 10] .
3.13　Daucosterol (13)
mp 256 ～ 259 ℃, positive Liebermann-Burchard
and Molish reaction , EI-MS m/z:414 [ M+-Glc] ,
396 [M+-Glc-18] , 273 , 255 , 231 , 213 , 161 , 147.
1HNMR(DMSO-d6 , 400 MHz)δ:0.64 ～ 0.99(6×
CH3 , s), 4.11(1H , m , H-3), 4.11(1H , m , Glc-
H-5), 4.20(1H , t , J =7.6 Hz , Glc-H-2), 4.34
(2H , m , Glc-H-3 , Glc-H-4), 4.48 (1H , dd , J =
5.3 Hz , J = 11.6 Hz , Glc-H-6), 4.65 (1H , d ,
J =11.8 Hz , Glc-H-6), 5.11 (1H , d , J = 7.5
Hz , Glc-H-1), 5.38(1H , m , H-6)[ 11] .
28　　Chin J Nat Med　Jan.2006　Vol.4　No.1 中国天然药物　2006年 1月　第 4卷　第 1期
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臭辣树化学成分
柳全文1 , 2 ,谭昌恒1 ,曲世津1 ,范　晓2 ,朱大元1＊
1中国科学院上海生命科学研究院药物研究所新药研究国家重点实验室 , 上海 201203;
2中国科学院海洋研究所 ,青岛 266071
【摘　要】　目的:研究臭辣树的化学成分。方法:采用硅胶柱层析的方法分离和纯化化合物 , 根据理化性质和波谱方
法鉴定化合物结构。结果:从臭辣树中分离得到 13 个化合物 , 包括 6 个生物碱:2-methyl-6-hydroxy-1 , 2 , 3 , 4-tetrahydro-β-car-
boline(1), N , N-dimethyltryptamine(2), N-p-coumaroyltyramine(3), dictamnine(4), robustine(5), haplophine(6);3 个柠檬苦
素类化合物:limonin(7), rutaevine(8), 和 evodol(9);2 个黄酮类化合物:quercetin (10)和(+)-dihydroquercetin(11);以及
β-sitosterol(12)和 daucosterol(13)。结论:化合物 1 为新化合物 ,其它化合物均为首次从本植物中分离得到。
【关键词】　臭辣树;生物碱;黄酮;柠檬苦素
【基金项目】　国家 863计划(2004AA625030 和 2001AA620503);中国科学院重大创新项目(KZCX3-SW-215)
中国天然药物　2006年 1月　第 4卷　第 1期 Chin J Nat Med　Jan.2006　Vol.4　No.1　29　
CHINESE JOURNAL OF NATURAL MEDICINES　　GRAPHIC ABSTRACT　　　Jan.2006 Vol.4 No.1
Chin J Nat Med , 2006, 4(1):25-29
Chemical Constituents of Evodia fargesii Dode
LIU Quan-Wen1 , 2 , TAN Chang-Heng1 , QU Shi-Jin1 , FAN Xiao2 , ZHU Da-Yuan1＊
1StateKey Laboratory of Drug Research , Shanghai Institute of Materia Medica , Shanghai Institutes
for Biological Sciences , Chinese Academy of Sciences , Shanghai 201203 ;
2Institute of Oceanology , Chinese Academy of Sciences , Qingdao 266071 , China
Thirteen compounds were isolated from Evodia fargesii for the first time.Among of these , 2-
methyl-6-hydroxy-1 , 2 , 3 , 4-tetrahydro-β-carboline is a novel compound.
【Foundation Item】　 This project was supported by the National “ 863” project (No.
2004AA625030 and 2001AA620503);Key Innovative Project of the Academy(KZCX3-SW-215)
Chin J Nat Med , 2006, 4(1):30-31
A New Isoflavone from Abrus mollis
SHI Hai-Ming1 , HUANG Zhi-Qin2 , WEN Jing1 , TU Peng-Fei1＊
　1School of Pharmaceutical Sciences , Peking University , Beijing 100083 ;
2Department of Pharmacy , Gannan Medical University , Ganzhou 341000 , China
A new isflavone was isolated from Abrus mollis and identified as 7 , 4′-dihydroxy-8-methoxy
isoflavone.
【Foundation Item】　This project was supported by the National High Technology Research and
Development Program of China(863 Program)(No.2004AA2Z3730)
Chin J Nat Med , 2006, 4(1):32-35
Chemical Constituents from Monascus anka
LI Li-Li , CHEN Jie-Peng , KONG Ling-Yi＊
Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing 210038 , China
A novel natural compound——— ankadilactone was isolated from Monascus anka with other five
known compounds.
Chin J Nat Med , 2006, 4(1):36-39
Chemical Studies on Iridoids from Picrorhiza scrophulariiflora
WANG Hao1 , WU Jia-Jun1 , LIU Ge1 , YE Wen-Cai1 , 2＊, ZHAO Shou-Xun1
1Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing
210009 ;
2 Institute of Traditional Chinese Medicine and Natural Products , Jinan University ,
Guangzhou 510632 , China
A new natural compound 3-methoyspecionin with other three known iridoids—
rehmaglutin A , rehmaglutin D and pikuroside were firstly isolated from Picrorhyza scro-
phulariifora.