Abstract:Aptamers have high affinity to target molecules, which are selected by an in vitro process known as cell systematic evolution of ligands by exponential enrichment(Cell-SELEX). SELEX is carried out using purified target molecules, but whole live cells could be used as selection targets in Cell-SELEX progress. The advantage of this technology is that aptamers could be functional with a native conformation of the target molecule on live cells. Cell surface transmembrane proteins would also be the targets. In addition, cell-specific aptamers can be obtained without any knowledge about cell surface molecules on the target cells. In this paper, the progress of Cell-SELEX technology was reviewed.