Abstract:Matrix metalloproteinases (MMPs) are important enzymes， which can degrade extracellular matrix. MMPs participate in the formation of new blood vessels and the healing of wound under the normal physiological condition， and participate in the tissue reconstruction， malignant tumor metastasis and other pathological process. Researchers can understand the nature and the pathogenic mechanism deeply by means of MMPs detection， and get further known about the deteriorated condition， so as to detect and treat diseases in time. According to the functions and features of MMPs， the detecting technology from the two aspects of the MMPs activity and expression were summarized in this article. It will provide the reference for the researchers to choose the appropriate matrix metalloproteinases detecting technology.