Abstract:Autophagy plays critical roles in regulation of physiological functions of eukaryotes by removing denatured proteins and abnormal organelles in cytoplasm and maintaining survival. Hematopoietic stem cells are special blood cells, which possess abilities of self-renewal and differentiation of multilineages. Accumulating evidence showed that autophagy plays a significant role in sustaining and regulating features of hematopoietic stem cells. Here we summarized advances in studying in regulation of hematopoietic stem cell fetures by autophagy.