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作 者 ：仇晴川;杨代常

期 刊 ：武汉植物学研究 2009年 27卷 1期 页码：83-89

关键词：分子医药农业；植物生物反应器；植物源医药产品；

Keywords:Molecular pharming, Plant bioreactor, Plant-made pharmaceuticals,

摘 要 ：分子医药农业是利用转基因植物为载体,以农业生产的方式规模化生产各种有治疗用途的重组蛋白质及多肽。近20年来,随着植物生物反应器技术的多元化发展以及日趋成熟,植物分子医药农业产业悄然而生。近几年,一些分子医药农业生产的植物源医药产品已实现规模化生产,并进入市场。文中结合国内外最新的研究进展,重点对几种主要植物生物反应器的研究、产品的规模化生产以及产业化进程进行了阐述,以期为我国分子医药农业领域的研究与应用提供参考。

Abstract:Molecular pharming is to use plant cells as bioreactors to produce various valuable proteins or peptides at large scales for pharmaceutical and nutritional uses.Since the last two decades,the molecular pharming industry is expanding at an accelerating pace in the developed countries due to the advantages of low cost,easily scale up and pathogen-free over other exogenous protein expression systems.In this review,we describe the progress of molecular pharming on expression systems,recombinant protein processing,and marketing.Also,the advantages and disadvantages of each system are discussed.In addition,we provide valuable information about the plant-made pharmaceuticals(PMP) products having reached or close to the market.It would be helpful for scientists who are working on this field.

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