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Research progress on salvianolic acids of Salvia miltiorrhiza

丹参酚酸类成分研究进展



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ResearchprogressonsalvianolicacidsofSalviamiltiorrhiza
LIANGWenyi,CHENWenjing,YANGGuanghui,ZHUDan,MAOXin,SHAOYanyan,
WULingfang,ZHANGXiaoxue,ZHANGLanzhen
(SchoolofChineseMateriaMedica,BeijingUniversityofChineseMedicine,Beijing100102,China)
[Abstract] SalviamiltiorhizaisoneofthemostcommontraditionalChinesemedicinesIthasrichresourcesinChinaAccordingto
modernstudies,phenolicacidsarethemainefectivecomponentsinSmiltiorhizaThesecomponentshavecardiovascularandcere
brovascularprotectiveefect,andantitumor,antioxidant,antiinflammatory,andantifibroticactivities,etcIthasbeenwidelyused
forthetreatmentofcardiovascularandcerebrovasculardiseasesandothersInthispaper,thechemicalsandpharmacologicalefectsof
phenolicacidsfromSmiltiorhizaweresummarizedinthelastdecadeItsresearchesanddevelopmentprospectswerealsoanalyzedfor
furtherstudyingandcomprehensiveutilizationofthesephenolicacids
[Keywords] Salviamiltiorhiza;salvianolicacids;cardiovasculardiseases;antitumor;antioxidant
doi:10.4268/cjcmm20160508
  
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Table1 HydrophilicphenolicacidsisolatedfromSalviamiltior
rhiza
No
_ñ.-³ ‡<› ^•
1 danshensu C9H10O5 [11]
2 cafeicacid C9H8O4 [12]
3 salvianolicacidD C20H18O10 [12]
4 salvianolicacidE C36H30O16 [12]
5 ferulicacid C10H10O4 [12]
6 isoferulicacid C10H10O4 [12]
7 protocatechuicaldehyde C7H6O3 [12]
8 protocatechuicacid C7H6O4 [12]
9 ethyllithospermate C29H26O12 [12]
10 salvianicacidC C18H18O9 [13]
11 salvianolicacidA C26H22O10 [14]
12 salvianolicacidB C36H30O16 [15]
13 salvianolicacidC C26H20O10 [15]
14 salvianolicacidF C17H14O6 [16]
15 salvianolicacidG C18H12O7 [17]
16 salvianolicacidI C27H22O12 [18]
17 salvianolicacidJ C27H22O12 [19]
18 salvianolicacidL C37H34O16 [20]
19 salvianolicacidT C27H22O12 [21]
20 salvianolicacidU C27H22O12 [21]
21 rosmarinicacid C18H16O8 [22]
22 methylrosmarinate C19H18O8 [22]
23 prolithospermicacid/przewalskinicacidC18H14O8 [22]
24 lithospermicacid C27H22O12 [22]
25 salviaflaside C24H26O13 [23]
26 salvinal C20H20O6 [24]
27 3(3,4dihydroxyphenyl)lactamide C9H11NO4 [25]
28 1hydroxypinoresinol1OβDglucosideC26H32O12 [26]
29 lithospermicacidmonomethylester C28H24O12 [27]
30 lithospermicaciddimethylester C29H26O12 [28]
31 methylsalvianolicacidC C27H22O10 [29]
32 dimethyllithospermate C29H24O12 [30]
33 9′′methyllithospermate C28H24O12 [30]
34 isosalvianolicacidC C26H20O9 [31]
35 ethyllithospermateB C38H34O16 [31]
36 magnesiumlithospermateB C36H28MgO16 [32]
37 ammoniumpotassiumlithospermateB C36H28O162
(NH4++K+)
[33]
38   2(3methoxy4hydroxyphenyl)5
(3hydroxypropyl)7methoxybenzofu
ran3carbaldehyde
C20H20O6 [34]
39 ailanthoidol C19H18O5 [34]
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Fig1 StructuresofhydrophilicphenolicacidsisolatedfromSalviamiltiorhiza
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[58]。
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