免费文献传递   相关文献

Study on action mechanism of Danhong injection based on computational system biology approach

丹红注射液作用机制的计算机系统生物学研究



全 文 :)$5
s
)
t ô
&$
õô
4
w
P-Kc&$$ ;-+4 ?GQMOLM6$ )$5
þ189:¢†™š Ê˙.Ì͈
ÙÐ,

!
œþ*

!
A-
)
!
c
Xã\Å ÙV@A{_ aŒ
!
yZ Xã
44$$&#%
)c
9WyZXÜ{_ aŒj
!
yZ Xã
44$$$#

mn
#!
þ189:÷WÌ$,þ¢Ô1¦ …†šÔ
$
€·,’l/êSë

ߤŽàëV
$
î%!{
$
%/Adûf
j~
(
$
¿š¢† ŒŽ
$
«@÷.Ì͈$
$
‰þ189:¢/[\/¾Èx͈‘´ ¢
†™šOPeÜ
(
(
C<9SG0GX:C
=5Ë.̹
2FHKG0I@HIGMLIOMG8GLM,J!2@8
.Ì$
$
#¼þ¢
$
1¦r‚¢† 
¡»?=5
$
)Ïþ¢



þ189:Œ$¯
3
¡»‘´
$
Ú
SG0G,LMNU$D:;X$DH-S>:X$:0I2,I$9:;C
V=5Ë$#¼¡»D
QÒ
$
Ïâ¡»H†¢†‘´
(
ÏOg$þ¢$
$
\$¯Ô¡»B¨j
$
1¦$
&
\$¯Ô¡»B¨j
$
#B 
)&
\$
¯Ô

\¡»BH†¢†
$
)$?âϚ 
#$
\Ϛ ¡»H†¢†‘´
(
’†
ŒUÊ¡»H†¢†‘´ì
ЯÄ
$
­<ÇæŽwÖ
@x$c$5
 °‘´

$
°‘´$PBQM¡»
)4
$
ä
bWSS
p<@Nk9
$

;-N
~¾p<
œ#@N
$
ƒ[deá7âã±ÓA p<œ#@N
$C-K
~¾p<œ#@N
$>:S3:
~¾p<œ#@N
$
–äABž°p
<œ#@N#
5
>p<@N
$
QÒ#l

ÓAŽ¥ë

s1¥ë

S]¥ëV
(
Í†Ê˙.Ì͈†S
$
LTí1þ
189:·¸_”ˆïð¥ë ¯°™š
$
/$,…† .̏­2¢è
(

opq
#!
Ê˙.Ì͈
)
þ189:
)
¢†™š
)
p<@N
)
‘´

rs)(
#!)$&3$%3$

wxAy
#!
!
A-
!
‰ÇGa¿
!
ÇÈÉÊ<=aÅfx
!CGK$$%(##(&)#!W3.LHK$4$5)#$)&)1aac,-.

Ayz{
#!
ÙÐ,
!
Ç~a¿
!
ÇÈÉÊaÅfx=adYoZÅ[\fx
!CGK$5$55(%(!W3.LHK$Kd6L00H1)#c,-.
>0=/? 13,G0-13+6G5,3-9+17J,3513P -3X6G0-13;,96/13
G1+:=0,0-13,.9?906+;-1.1P? ,::21,G5
@PTL030H

$ RW:` HL-3JOL

$ :`2\AH0
)
!
!c7;5J&1+$6*,+5. 041D+,*46:,-(;,-% 8-95&1+3$ :,-(;,-% 44$$&#$ !;-,)
)cA,-%I@&49-(,*!4&D1041D+,*46!;-515@54D*51$&/5. @4*(5J4&(51$ :,-(;,-% 44$$$$ !;-,
*A;902,G0+!XL0J-0FH0/G,IH-0 HUL,-.[-O0N [MG[LMLIH-0 -VIMLNHIH-0LK)1$ L0N JLUQGG0 *HNGK6L[[KHGN H0 IMGLIH0F,-M-0LM6JGLMINHUGLUGUL0N HU,JG.H,G0,G[JLK-[LIJ6H0 ,KH0H,+XGU[HIGIJG,-.[KG7HI6-VHIU
,JG.H,LK,-.[-O0NUL0N IJGNHdGMUHI6-VILMFGIU$ GU[G,HLK6H0 U6UIG.QH-K-F6$ IJGMGJLdG0-ILMG[-MIV-MHIUL,IH-0 .G,JL0HU.LUL
*J-KGMGFOKLI-M6QH-K-FH,LK0GI*-MZ+:0 IJHUUION6$ [M-IGH0 NLIL-V=#/*+4&;P, L0N !#+-(+4&)1*GMGUGLM,JGN H0 C<9SG0GX:CNLIL3
QLUGL0N LFHKG0IKHIGMLIOMGUGLM,J !2@8 U6UIG.I-GUILQKHUJ IJG.OKIH3,-.[-0G0I[M-IGH0 0GI*-MZ -V=#/*+4&;P,$ !#+-(+4&)1L0N
XL0J-0FH0/G,IH-0+DGUHNGU$ IJG[M-IGH0 H0IGML,IH-0 0GI*-MZ *LUQOHKIQLUGN -0 IJG[M-IGH03[M-IGH0 H0IGML,IH-0 H0 SG0G,LMNU$ D:;X$
DH-S>:X$:0I2,I$9:;CL0N -IJGMNLILQLUGU+2,,-MNH0FI-IJGVH0NH0FU$ $ ,-.[-O0NU-V=#/*+4&;P, L0N & ,-.[-O0NU-V!#+-(<
+4&)1*GMG,-MGKLIGN *HIJ [M-IGH0U+CJG)& ,-..-0 ,-.[-O0NUJLN H0IGML,IH-0U*HIJ [M-IGH0U$L0N V-M.GN L[M-IGH0 H0IGML,IH-0 0GI3
*-MZ *HIJ #$ 0-0G3HU-KLIGN 0-NGU+CJG*-MZ L0N G7IML,I-0GUOQ30GI*-MZ *HIJ UHF0HVH,L0INHVGMG0,G@x$+$5+CJGUOQ30GI*-MZ ,-0ILH0U)4 ZG6[M-IGH0U$ *JH,J H0d-KdGN VHdG
UHF0LKH0F[LIJ*L6U$ 0L.GK6;-N3KHZGMG,G[I-MUHF0LKH0F[LIJ*L6$ G[HIJGKHLK,GKUHF0LKH0FH0 JGKH,-QL,IGM[6K-MHH0VG,IH-0$ C-K3KHZGMG3
,G[I-MUHF0LKH0F[LIJ*L6$ >:S3:3KHZGMG,G[I-MUHF0LKH0F[LIJ*L6L0N 0GOM-IM-[JH0 UHF0LKH0F[LIJ*L6IJM-OFJ bWSSUHF0LKH0F[LIJ*L6
.L[[H0F+:0 IJHUUION6$ IJG,-.[OILIH-0LKU6UIG.QH-K-F6L[[M-L,J *LULN-[IGN I-[MGKH.H0LMHK6G7[KLH0 IJG.-KG,OKLM.G,JL0HU.-V
,45,
¡`áV
#
þ189:¢†™š Ê˙.Ì͈
.LH0 ,-.[-O0NU-VXL0J-0FH0/G,IH-0 H0 [MGdG0IH0FL0N IMGLIH0FNHUGLUGUL0N [M-dHNGMGVGMG0,GV-MU6UIG.LIH,UIONHGU-0 IMLNHIH-0LK0GUG.GNH,H0G,-.[-O0NU+
*_6? T12/9+!,-.[OILIH-0LKU6UIG.QH-K-F6) XL0J-0FH0/G,IH-0) L,IH-0 .G,JL0HU.) UHF0LKH0F[LIJ*L6) 0GI*-MZ
/1-#!& %`(]aEGXG++(&!#&!
!!
þ189:/WÌ$,þ¢Ô1¦ …†š
Ô
$
.B˜¤_ï
$
@ú‚´VK%
$
‹€·,’
l/h±hž



h¾íl

êSë

S¼»¶

ߤŽàëV
$
î%!{
$
%/Adûfj~
*+
(
‹
)
¶·,$
$
þ¢È@÷„…¤À8[de
$
•m
?÷Æ_¹Vׂ<š
$
„…S¼¹•€úûü
_
$
1¦È{š¤:a¢Ð
$
¢C¤@×ð¹?@
$
7.a:MVŸ!¢C¤²
$
Èx¤m
$
7.Sà
öa:Mèõ î%
(
þ189:Ú/¾€ˆ

de
Œ˜Š€’†$‚B
$
Ûڌ‡ì^äo€ú
ÏÇ

Œà$€ú@¶Œ˜ƒ
$
È¢CŒàö
92˜¾¹
9X2
P@
$
­´
8\X
˜Ž
*)+
$
î›àߤª
–äKÉý…
$
@÷©
@XB
§Ç@
$
¢C
>\8
,
›
$
„…ßÆ÷ø–äxde
*4+
(
‹ÊR´ÄŃ
Y
$
Ԏà2¤á
$
§smSë’Y
$
êSë’Y
$
ԎåæŽs#’Y
$
ë6ŽS¼#V’Y‚B[²
 eÜ
*&+
$
+0sç‹€’†òá¼fŒ
(
Ď
$
$
¿š¢
† ŒŽ
$
n e܌÷ÀÊæ\¿W
$
æ
\Œ˜
$
æ¥ë’Y›hv8
$
ÊRnp<@N 
å_Gk͈Ü+ ©PeÜ
$
«@÷.ÌÍ
ˆ
*53%+
$
$
nþ189:¢/[\/¾Èx͈
‘´ ¢†™šOPeÜ
(
RÍ†^R#
¼
$
¡»H†¢†‘´)Ï
$
ÇæŽwÖ°‘´ ­
<Šp<@NÔ¥ëQÒýÖV.Ì͈†J
$
#
¼þ189:$·¸_”ˆ ¢†¡»Ô‹p<@
NŠ¥ë QÒ
$
©o¡»Ôp<@NQÒv m
Ñ
$
º‰þ189:(/¾†SÚ¡»
3
p<@N
3
¥
ë pðí1‹ïð¥ë HQ¯°¢†™š
(
R
/…-$¯…-¿š $,…†¢†™š í
1­2‚N¹V@
$
/ª1uv­2G…
(
!M
†J
!b!M
^R#¼
!
^R#¼Í†
C<9SG0GX:C
=5Ë

$
<%â­ÍŒ-g
*+
$
(
9GNKH0G
=5Ë$
$
’†‚€^R#¼†Sˆí$,

šž¹¥ëDH
†QÒ pÅ
$
%$K’†Rí1þ¢¹LÙ-Ú*
â ¯°™š
*(+
(
nþ189:$
)
¶·,
$
r
‚ oòåþ¢
=,*9, /*+4&;P,$

!,&+;,/)1
+-(+4&)1@c
/S…t
$
S…>?/W(
(5k
/
C
 
ŸK
$
Ú
C<9SG0GX:C
=5Ë$‚€S…í_”ˆŠ
‹¢† ¡»pÅ
!
nšžå/t>
( 2FHKG0I@HIGM3
LIOMG8GLM,J!2@8
ÿ?<•ÖluvÎ.Ì͈
-gÇ S….Ì
$
Յ.Ì(^  °$©Ä
Ç¡»?8šžåú
$
*LTÏâ¡»8šžQÒ
$
ÏâÈR_ ¡»8šž‘´ÏO
$
Œ†R#¼_”
ˆÔ¡»DQÒ
$
Û#¼Íúî¤$¤h$¯¯°
¿WV
*$+
(
Ú
2@8
ÿ?$¯@nþ¢¹1¦H^å
/t>›hS…¢†¡»pÅ
$
Ê
C<9SG0GX:C
=5
Ë$ ¢†¡»pśhÑÒ
$
X&íþ189:·
¸_”ˆ¹H†¢†¡»Ì
(
!b(M
þ189:Œ$¯
3
¡»‘´¹¡»H†¢†
‘´ )Ï
!
‰_”ˆnS…t>ÂS
$

AOQ9GN
=5ËÔH†¢†¡»Ì$ %B¡»›
hQÒ
$
ÏâQÒt>
$
Ú
<6I-U,L[G
ÿ?
*+
$Ïâ
þ189:Œ$¯
3
¡»‘´
(
nH†¢†¡»Ì
$ ¡»å/Յt
$
(
SG0G,LMNU$D:;X$DH-3
S>:X$:0I2,I$9:;C
V¡»H†¢†=5Ë$
$
Îd
‹H†¢†¡»?
$
ÏâQÒt>
$
Ú
<6I-U,L[G
ÿ
?$ÏâÈR_¡»H†¢†‘´
(
!bM
¡»H†¢†‘´ ìÐ

p<@N k9¹
¥ë QÒ
!
͆
,KOUIGM\;W
†JÊ¡»H†¢
†‘´›hìÐ
$
­<‹$.BÇæŽwÖ
@x
$c$5
 °‘´
(
‰ÇæŽwÖ °‘´$ Q
M¡»›h
bWSS
p<@N k9
$
íHQ
bWSS
p<@N
$
*‰QM¡»¹p<@NÔ
\9:9
¡“Yã‹*W=5Ë
*)+
¹
bWSS
=5
Ë$ ¥ë›hQÒ
(
(M
ÏO
(b!M
þ189:Œ$¯
3
¡»‘´ ¯Ä
!
þ18
9:·¸_”ˆÔ¡»Ú‘´$H†\X¯º
$
/
_”ˆÈâO¢†R¥ë‘´$ Œ\Ϛ
$
þ¢
·¸_”ˆ#B

\$¯
$
¯@/þ¢’!

þ¢
’
2

þ¢’
D

Tþ¢’

þ¢]’

ÖTþ¢
’

Öþ¢’
:
«qþ¢’!

þ¢’

þ¢âæ’
,(45,
)$5
s
)
t ô
&$
õô
4
w
P-Kc&$$ ;-+4 ?GQMOLM6$ )$5


þšþ¢’

þ¢]’

èšþ¢I

Mh.
ÿ

‡¸»ÿ

F»!

þ¢ç

Fȍ
$
‹$Tþ¢
’

þ¢’!

þ¢’
D

‡¸»ÿ

«qþ¢’
:
þ¢]’

þ¢ç

þ¢’

Mh.ÿ
2

Fȍ
$
\$¯#¢†R
55
\¡»
!
k
2(
1¦·¸_”
ˆB
)$
\$¯
$
¯@/1¦Ÿ

;1¦Ÿ

1¦‘I
ç
2
1¦‘Iç
D
1¦ÆŸ

]1¦Ÿ

1¦I
Ÿ

–µ!

ZV!

†¨ÿ

⎆¨ÿ

Œa

¹·
!

â+!

R+«¹·!¬

tå!

iE¡!

³
ۍ

³Ÿ

1¦ç
$
‹$ZV!

R+«¹·!
¬

â+!

³Ÿ

tå!

iE¡!

¹·!


‘Iç
2
–µ!

³Û

⎆¨ÿ

1¦‘Iç
D
Œa

1¦ç
&
\$¯#¢†R
&&
\¡»
!
k
D$
þ¢¹1¦ ·¸_”ˆ#¢†R

\¡»
!
k
<(
Ò5
<6I-U,L[G
$
;GI*-MZ 20LK6UHU
$
XG3
FMGG
¯ÄÏO
$
þ¢Œ$¯
3
¡»‘´›‚
XGFMGG
/
4c$$
‹$Tþ¢’

þ¢’!

þ¢’
D
‡¸»
ÿ
$
«qþ¢’!
5
\$¯‹¨jðŸ!
$

$
#ƋM©Ô
$
\¡»¢†
$
é1¦Œ$¯
-
¡»
‘´›‚
XGFMGG
/
c4$
‹$µV!

R+«¹·


â+!

³Ÿ
&
\$¯¨jðŸ!
5

$
#ƋM©Ô
5
\¡»BH†¢†
(
2c
þ¢Œ$¯
3
¡»‘´
)Dc
1¦Œ$¯
3
¡»‘´
)þ189:Œ$¯
3
¡»‘´
(
‘´$¡»nšžå/t>
(
k
!
þ¢



þ189:Œ$¯
3
¡»‘´
?HFc!8LKdHLG9HKIH-MJHYLG>LNH7GI>JHY-.L$ (b(M
þ189:¡»H†¢†‘´ ¯Ä
!

ÉqH†¢†¡»
$
g$‹$ 
#&
\¡».BH†
¢†
!
k
)2$
‹$
&
\¡»¯@²²H†¢†
$
‹
8
#$
\Ϛ)$?âϚ ¡»H†¢†‘´
(

Ê
#$
\?âϚ ¡»H†¢
†‘´›hìÐ
$
­<Ç

@x$c$5
.BÇæŽ
wÖ °‘´
!
k
)D(
“

\‘´P#þ18
9:¡»H†¢†‘´$ ´¨jJ1¯
$
ð­<
 °‘´÷@÷f
3
Š«‰
]
Õv›h¯
$
‰‘´
ԋ21 ‘´›hçB
$@
bC#A8‘´ç2
‘´gÚwÖ
(
ÊBÇæŽwÖ °‘´›h¯
Ä
$
‰°‘´$ ¡»¢/QM¡»
$
*k9Ú
bWSS
p<@Nƒ
(
QM¡»LŠ p<@NB
;-N
~¾p<œ#@N
$
ƒ[deá7âã±Ó
A p<œ#@N
$C-K
~¾p<œ#@N
$>:S3
:
~¾p<œ#@N
$
–äABž°p<œ#@
N#
5
>p<@N
(
(bM
þ189:QM¡»¹p<@NÔ¥ë 

!
‰k
)D
$ QM¡»¹
5
>p<@N¯@
Ô
\9:9
=5˹
bWSS
=5˛hQÒ
$
g$¡
»¹p<@N‚ÔŒ\¥ëH†QÒ
!
k
4$
Û
C-K
~¾¹
;\X
~¾
)
>ÆÇÚ#l¹yz
÷ø$ôθ¢†
$
Ô#l¹ÓAŽ¥ëBQ
$
å
ԃ[deÚá7âã±ÓAÆÇ$BQ
$
#Æþ
189:ÈÉÚs1¥ë
$
skV¥ë$L.Bð

$
•ë6ÆÇÔ
>:S3:
~¾¢†™šHQ
$
é–äABž°p<œ#@NÔÈx–äABž°
¹–ä¹? KɂBQ
(
M
ò§
n.Ì͈/P# pņJ
$
Í<‘´
)Ï †J‰$,…†¢/[\/¾
$
‹¢†
¡»¹p<@NŠ‹Ô¥ë QÒ
(
͆
C<93
SG0GX:C
¹
2@8
Hϔ †J#¼$,…†$ _
”ˆpÅ
( 2@8
†Jð#¼ pŌç‚R
9GN3
,$&5,
¡`áV
#
þ189:¢†™š Ê˙.Ì͈
!!
2c
þ189:¡»H†¢†‘´
) Dc(k
)2
$­< .BÇæŽwÖ ¡»H†¢†°‘´
(
‘´$¡»nšžå/t>
(
k
)!
þ189:¡»H†¢†‘´Šp<@N
?HFc)!XL0J-0FH0/G,IH-0 [M-IGH0 H0IGML,IH-0 0GI*-MZ L0N MGKLIGN UHF0LKH0F[LIJ*L6U
k
4!
þ189:
3
¡»
3
p<@N
3
¥ë‘´k
?HFc4!XL0J-0FH0/G,IH-03[M-IGH0U3UHF0LKH0F[LIJ*L6U3NHUGLUGU
0GI*-MZ
KH0G
=5Ë
$
BŒ÷Ò5%eÜ ^pÅ
$
‹ŒÍ
†
BA@<
V$P¯ÄV@ðí _$¯
$
ÊÂ[
“$¯¯Ä=5BÚd
(
é
C<9SG0GX:C
^$_
”ˆË“WÔBq,
$
ÛÊ1¦$ ·¸“$¯Û

$
ÿ“
$
mB+
$
Ÿ“,©ª7ˆ‚BÂÔ
$
éþ
¢“·¸ÂÔm¶Ž¹,¶ŽI

’˜Ï)
$
Ê
)

, ·¸$¯“@WÔBq,
(
͆
2@8
†JD
ES…
$
É@ëì¹ÑÒv“$¯$ pÅ
(

´ð†J#¼
$
Ò5_”ˆð¢† ¡»=›hÊ
Ë
$
þ¢Œ$¯
3
¡»‘´›‚
XGFMGG
/
4c$$

Œ$¯
3
¡»‘´›‚
XGFMGG
/
c4$
þ189:
Œ$¯
3
¡»‘´›‚
XGFMGG
/
)c(4$
áˆ#Æ$
,Œ$¯

Œ¿š«š
$
âOL#Æþ189:·¸
_”ˆÊ‘´ ò{ðùúBŒ
(
‹$Tþ¢’

þ¢’!V
5
\$¯
$
µV!

R+«¹·!¬V
&
\$¯÷Q‘´$¨jðBŒ ÷\$¯
$
Ö‹
/gó,% ·¸˜Ž$¯
(
Úþ189:¡»H†¢†‘´$
$
­< .
BÇæŽwÖ °‘´Ô~ëµ|¡»
$C-K


&$
!˜¤1çƔ|
$
–—=֞°
$

B¢†
$
‹¢Ô•#
$
de¯_Ôvw
$
S¤À¥ë
$
•–—V¢†
(
¡»H†¢†‘´$¡»‘÷ç‚
R
C<9SG0GX:C
¹
2@8
ÊR^pÅË #¼
$
R
ØêÚr“^$eÜÔþ189: ,¡¢
†HQ
$
éÊR.BÇæŽwÖ °‘´ ­<
$
É
(¢Œ ¡»H†¢†‘´$¯ÄÇ.BQM¢†
 
$
ʑ´ò{ðB̌ùú
$
J@R‹‘´ °
‘´
$
ÊR“2QM¡» ÈA¹õg
$
É@6jù
ú‘´
$
*+É@÷6j8jÆÇùúHQ¡»
gó¢†
(
þ189:É·¸@÷
5
>p<@Ng
ó¢†
$;-N
~¾p<œ#@N
;-N
¡»
*4+
Úr
Ëëµ¾ ÓA¹ÅByz÷ø$‘ôθ ¢
†
(
ÔX± ÓALY{HQ
$
B^%8u‹Ô
¾˜ŽÔ€úûü_ ëåÇæHQ
*&+
$
Ô€
ë¡#$Hø
$
nM‹
;@>A4
 #ŸÔ¡à¹?—
 XŽøð«bHQ
$
ÕÖ
;@>A4
 #ŸBER¹
?—¯_øð V¼
*5+
(
ʕg–äë6„…$
¶–ä.ÌÓA
*#+
(
Ô
;-N
~¾p<œ#@N
H ÷
C-K
p<@N
$
‹L¢Ô#lG’ p
,&5,
)$5
s
)
t ô
&$
õô
4
w
P-Kc&$$ ;-+4 ?GQMOLM6$ )$5
<@N
$
‹Ô
;-N
~¾Ú#lG’$¯=¹QÖ
tWáâ
*%+
$
X]å­A‹ÈÉÔÈx˜
èëBQ
*+
( ;-N
~¾¡»
$C-K
~¾
$
R‘!
u#šž
>:S3:
~¾nŠ
<
˜¡Ðç~¾#â
$ÅByz ŒSV@~¾
*(+
$
‹áˆÔƒ¤Ð
Üë6ÓAŽ¥ëHQ
*)$+
$
X]#Ƌïð$
¶–ä.Ì ÓAŽ¥ëåÈÉÔÈx‹ÅByz
V@~¾BQ
*)+
(
@÷Èxƒ[deá7âã±
ÓA p<œ#@NÊs1¥ë›hÈA
$
–äA
Bž°p<œ#@NÈÈxڕÍ×
$
„…¤À›
®¼
(
HÊRþ189: €,’l
$
ðîêS
ë

S±

S¼»¶

ߤŽàëV
$
‹¥ë™š‚
Ô#l

yz

–äABž° ÈxY{HQ
$
ÈA
š#l ›ø
$
ïð#lž°Ê¤À¹S¼›h÷
:
(
é×QD2
$
ȍÖþ189:åÈÉ4ÚÔ
˜èë

s1¥ë

–—ðîV¥ëHQ
(
$,…†÷nŒ$¯âO¢†RŒ\¡»¹p
<@Ngóïð¥ë ¢†
$
@÷Ê¡»¹p<@N
‘´ ÈA(égó¢†
(
@÷Ê˙.Ì͈
†J#¼$,…†·¸_”ˆ

¡»

p<@NÔ¥
덠pÅ
$
Èng¼‹ïð¥ë QM¡»¹p<
@N
$
Š‹Ô] 4Ú¥ë QÒ
$
/›[Tuvv
8¹€’†­2š
(
™;$,…†·¸Í
<-Ú¯ÄJ
$
˜Ž1+¹$¯­<¯Ä¹yzV†
J›h
$
“2†JáÉP#$,…†/\_
”ˆÌ K%
(
͆Ê˙.Ì͈†J
$
áˆÈ
nPyx£
$
…- uv
$
åÈn/›[T 
­2pÅýÖ¹QÒ
$
©uv½ø
$
­2†
Š
(
R#¼þ189:·¸_”ˆ¢† QM
¡»Šp<@N
$
LT‚A‹ïð¥ë ¯°™š
$
/›[Tuvv8­2š
$
L/$¯º/…-
 $,…†¢†™š­2‚N†J¹-±
(

|h?}
#
* +!
R¸
$
0Ù°
$
Áú
$
V
c
þ189:ðîSà¤Àë 
€’†›œ
*E+c
$%A,t9
$)$)$$!(#()c
* ) +!

$
Êðÿ
$

$
V
c
þ¢ _$¯Ô,¡¢†
*E+c
%
2A,
#
‡ˆ,¯¾
$)$$%$))!7c
* 4 +!
!N
$
žÛ/
$
܆`
$
V
+
šRĞ×Ê þ189:˜Ž
ˆ?-ڕ–äx÷ø \†¢†
*E++
$%uv†Ô-
.
$)$&$)$!%#)(c
* & +!
s_
$
¤
c
þ189: €’†›œ
*E+c
u†Sà
m¤Àë-.
$)$$(!#44c
* 5 +!_JL0F2B$ 8O0 B$ RL0FA$ GILKc?OIOMG[GMU[G,IHdGU-V[GM3
U-0LKHYGN .GNH,H0GH0 IMLNHIH-0LK-K-F6L[[M-L,J MGdHG*LMIH,KG*E+c<-.[KG.G0ICJGM9GN$ )$)$
)$!=)# (4c
* # +!
Š¥
$
!q;
$

$
V
c
šR‘´Íˆ†J $,,¡¢
†™š‚èÔñ…
*E+c
$%$,-.
$)$)$4%!)#
&#c
* % +!
$F
c
‘´¿W
#
$,†Ô‘´,¡ [\{*š
*E+c
$%$,-.
$)$$4#!5#)$%c
* +!?L0FT<$ BOL0FB<$ ILQLUGV-MLUU-,HLIGN IMLNHIH-0LKGLUGH0V-M.LIH-0 OUH0FIG7I.H0H0F*E+cD9<<-.[KG.G0I2KIGM0
9GN$ )$$$ # 5c
* ( +!

$

$
ä§
$
V
c
þ¢ÔLÙ-Ú*⯰™š .̯Ä
*E+c
cd&()
---
$A,$P_
$)$$$)!##c
*$+!
“„Æ
$
“Û
c
Íúî¤$¤h$¯¯°¿W Ê˙.Ì
͈ýÖ
*E+c
$%uv†Ô-.
$)$)$!&#)%c
*+!0GI*-MZUL0N FG0GG7[MGUUH-0 NLILOUH0F,6I-U,L[G*E+c;LIAM-3
I-,$ )$$%$ )# )4##c
*)+!
$:
$
R¿‡
$
Ix7
$
V
c
…†þ¢†·¸˜Ž$¯‘´,
¡
*E+c
$%$,-.
$)$$4# !)#)(c
*4+!H00LIGH..O0HI6L0N H0VKL..LI-M6NHUGLUG*E+c200O >GdALIJ-$
)$$($ &# 4#5c
*&+!

$
ðÜ
$
$y7
c;-N
~¾¡»
4
#l:¾Ô€úû
ü_Q. $ªÔ›œ
*E+c
$%€úü_-.
$)$&$
))!#%(c
*5+!
¶Æã
$
Ü>
$
Á„É
$
V
c;-N
~¾5¡»Ï)HHQ¡
»
4
Ú¡à¹?—$ #Ÿ
*E+c
p5Œe
#
AP
$
)$4$5!c
*#+!_JL0F_$ O` $` 9LE$ GILKcSG0GNGKGIH-0 -VFLQLML[ G0JL0,GU
;KM[4 H0VKL..LU-.G3NG[G0NG0IH0VKL..LI-M6MGU[-0UGU*E+ c
E:..O0-K$ )$4$ ($!%# 45%c
*%+!;LZL.OML;$ @HKE>$ AJO0F^ $ GILKcW0N-U-.GULMGU[G,HLK3
HYGN [KLIV-M.UV-MQL,IGMHLKUG0UH0FL0N ;-N) UHF0LKH0F*E+c;L3
IOMG$ )$&$ 5$(!%&((# )&$c
*+!AML/L[LIHD$EG0LAb$>L/[OIA$GILKc]0NGMUIL0NH0FL0N .-N3
OKLIH0FIJGC-KKHZGMG,G[I-MU!C@>U L0N ;-N KHZGMG,G[I-MU
!;@>U ,M-UUILKZ H0 I6[G) NHLQGIGU*E+cGd$
)$&$ $!4# ($c
*(+!
”^û
$
!yò
c;\X
~¾¡»#l¾â€£›œ
*E+c
deÔ¯°yz-.
$)$4$)(!5#5&(c
*)$+!\[HIYD$ WHIGKE$ 9GH7G0QGMFGMb$ GILKc>-KG-VC-K3KHZGMG,G[3
I-MU$ ;-N3KHZGMG,G[I-MUL0N >:S3:3KHZGMG,G[I-MUH0 G0N-IJGKHLK
,GKUL0N U6UIG.H,H0VG,IH-0U*E+cCJM-.Q BLG.-UI$ )$$($ $)
!## $4c
*)+!GH0GMI@$ ALKONL0 8 >$ GILKc:00LIGL0IHdHMLKUHF0LK3
KH0FH0 IJG,G0IMLK0GMd-OUU6UIG.*E+cCMG0NU:..O0-K$ )$&$
45!)# %(c

~-0
!
ƒ“
#
,)&5,