免费文献传递   相关文献

Effect of Jiaotai pill on pancreatic fat accumulation and islet cell apoptosis in rats with type 2 diabetes

交泰丸对2型糖尿病大鼠胰腺脂肪沉积和胰岛细胞凋亡的影响



全 文 :“”•Î
*
÷V|}”a–—‹˜™ÉÑ
–š01›œ‡ÔÕ
Jb

!
KDš
!*
!
KLM

!
Dv

!
MtS

!
!
NOP

!
+QR

O
ā“„I Ö6‚IŽ ¦§Ö6‚Ž  ‚7ˆ‰°
!
& «8
&)$$)$%
*O
ãԁ‚ƒ„I 9:./‚IŽ
!
9:»‚Ž
!
ã2 9:
($))#

bc
#!
9‰:ÍÐÃahů
!8@a
Bgx«¬ÑˋB2
(
¤¼î”a
@*Z9

$
ºà“”•ÔÌ
$

ÔÕV|Ð,{
! Q^@@%
‡n–š¯
!M:;8%
¥´‹˜>
!MM3%
Š‹
$
xy–š¯@°I?
!\^ 935:>$
–—­€}Ý^
x
$
‹Óç(¤^ñ–—­€LàN?
!@Q
ðÐ
$
B‚Z[ÙÀTVTA>\§Xˆ
VA@B
Jc¤
!@A;IC
¤^ñ–š0
1›œOP
&
Þù[1
$
÷­
Q^@@
Üæ
$M:;8$\^ 935:>$MM3

$
Š‹st
$
–—­€r([‹˜™É
$
–—­€
@Q
ð
Ð([TË
$
–š01›œž’

C÷­«Ê
$
“”•­
Q^@@
_`
$M:;8$\^ 935:>$MM3

$
Š‹stÇ$
–—­€‹
˜™ÉÊË
$
–—­€
@Q
ðÐ([FÎ
$
–š01›œÊË
&
¯MEÛ
$
“”•ÍDPÔ̔a
@*Z9$
‘z3ÍÅCÊ˖
—‹˜™Éіš01›œD*
&

def
#!
“”•
*
÷V|}

‹˜™É

–š01

›œ

gh)(
#!*$&5$5&

ijkP
#!
%øù&‰úû
! ()%)(%

lmno
#!
!
Å}Í
$I5/GSW#7W0$4$&2?0RO?0/XOFVXO-1
!!
ÂaËÀº2}ïXžƒ
%
¾ªÊË
$
opØ/
›¾8HSd}
&
opKôaí8Zgƒ‡‹
˜
*+
&
¹ÝOPF
$
ïX‡‹˜018\ޛL
àN?
!@Q
ѱÏÞ?
$
W´¾ÅÐ\Z‹˜
­€‡‹è$
**+
&
3gƒ‹˜˜g‘\ZÅ«Q
$
81œ\Û\Z³‹˜­€$
*)+
&
í8gƒ‡
‹˜³‹˜­€‡™ÉC–š¯@°Ñ !01Ù
ÅêëÁ¯‚*
*&+
&
‹˜WC
%
ϓ=á]¤­
€‡™ÉÍÐіš¯@°
*+
$
‹˜–—‡™É
ÍÐÑ !01ÙŎ”Ñ›œ
*#+
&
“±opC
*
÷V
|}‡c¹Á¯‚*
$
×ÊË܂‹˜™ÉDI›
¾ÈÔ
*
÷V|}‡ÿ„…
*%+
&
ƒ>‡²v†c
º
$
“”•ÍDPÔ̔a
*
÷V|}
$
‘´‰R±®
‡ÑGHÏô,
$
´‰z3ÍÅÑÊËWC
%
ϓ=
%
U=‡‹˜™É
%
_`–š¯l<\êëD*
*(54+
$
‘c«L2®‡
5
GH¾
*s
Q¾.
*$+

YZ†c
º
$
αŠV[3â.‡
*
÷V|}Å>
$
’‰“”•
!
®‡
5
GHc«L¾
*s)
Çp
$
ŠVÍ[\Ό
$
ÕwUhO[1WC‹˜ðÐ([FÎ
*+
&
¬“”•
Ζ—‹˜™É
%
–š01›œ‡ÔÕ]rar
$

×
$
ƒ>¼î”a
*
÷V|}÷
$
ž8¼¥¦“”•
–—‹˜™É
%
–š01›œ‡ÔÕ
&
!
ÏéC£¤
_!
ª}
쉴«¦z¤q¿
NST?GU
”a
&(
Ä
$
¦
*
p
C
$
íä
$ m($ E&
ED”aô“k2åÆ}
È[3$U(l
$
JV{é“]$&(”ãÖC
lz{ª}$U(l
&
_!
,}Ñ,Í
“”•“®‡
%
GH­›
$
‘,ÏôX±k2å
$,ÏFG
!
®‡‚HÉ(
$
GH‚H9
$
/k
2$C,”,l¹,ü†é$z•ü!üò¾
GH
®‡
<.]?SVST>RS[./G$
“ã
ÖCl$MCÞᆝE3Â
&
$,Õ£3Â
#
*“”•AÍ
!
®‡
5
GH
*s$
)®‡
4$ E$
GH
& E$
’
$
)íÉèAÝ
*
2
$
t


* R$
t
*
2
R$
AÝgö‰cà(
)?()cà
$
_²èA¡
$
á¾cà
&$
E&
+×>Dš³W}¡±³ªè$‹›
)$ E,C
k
‡O.¡
$

& r
…\‰
&
ŠV,͛
$
Š‹k±
ÏÞ
!@<%
LàN?
!@Q%
ËÁ‹ø±ÏÞ
!\ZC5<
,͛ôXùMJÉú¹}röDEF
G
%
ŒÁ‹ø±ÏÞ
!CZC5<
,͛X±23
2Þ«”YZ,ÍDEFG
%
¥´‹˜>
!MM3
,
,#$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
͛ôXù93¼›¹}röDEFG
$
–š¯€
ª,͛Xù23BõË&T()ˆ‰ÈDEF
G
&
B‚Z[TA>Jc¤
!@A;IC
,͛X±
µÓFG
!>.-RF&
_&!
ª}÷‡¼îќ­
”aJV{ékˆ¿;ì

¤W
$
ÂzìŽ
(
ĔaJV{é;ì
$
ù“ž2
%
žè´¾^æ­
&
1F‡
&$
Ĕa5
)$ /E,KE
k
ÍÐBgx«¬
8@a$
ÛWÃB{é;ì
*
¤W‘
Q^@@
z{
$
ª}
p2
* R
W
$
2
$j
ÔÕVè5
*O* E,KE
k
ÍÐ
BC
$
œ ±BC²BCW
$* R
®B)Š
$

ÔÕVÀÞX¤ñònQˆ…ŠV
!MJQ$BQ5 R$
BQ5* R&
ëìV|ÐÜæ>
*&
Ä´¾›”a
!
n^æ”aŠV÷xyŽ
4j
Íl‡^æq
ã
$
D
*
ÇQˆ…ŠV÷˱‚ˆQˆ…ŠV^æ
qãME
$
uD

ÇQˆ…ŠV÷˱‚ˆQˆ…
ŠV^æqãME
*$j$
ªÈ¾ÓV|ÐÜæ”
a
&
Âzœ¾÷­
%
“”•­
%
Dš³W­
$
’
M^æ­w
&
­
$

(
Ä
&
BCãQºàˋË
˼B2
!
á{é
%*O%j$

*$j$
®
j$
±ÏÞ
*j$
±×
$O)j

&
^æ­Ñ÷
­uq2¹Ý×èBC
&
56ÿєaí‘QÉV
y‡áPÍÐxyŽ”auq‰,ÍÐ
$
“”•­
5
) E,KE
k
,V
k
‡Íк”aB‚“”AÍO.
¡

Dš³W­5
() /E,KE
k
,V
k
‡Íк”a
B‚Dš³WO.¡

ÔÌ­Ñ÷­ÔÌvˆ
ô;2ˋËÀº{é
$
^æ­;2ÃB{é
&
n
­”aÖ
(
¤Wd
Q^@@
z{
&
W+ÔÌ

¤
$
p2
* R
W
$

$
dŸ²p2
* R$
¾ºà
$j
§

/C,KE
k
nc«¬Ed
$
n¸ªx)Š
( m
$ /C
eX´U4
$) $$$ U,/S1
k
´U
/S1$
œ
´Š¦
$
Áß
k($ r
˜Z
$
‰±^ñnúIJ
&
)
–—­€kÐ
$
1œZ±¡K$
$

&j
ƒ\šU
Ïò
$
…fçg¯y
&
_)!
ÝÞIJñò£¤
_)_!
8eOP
!
çèÝޔa‡2—
$
íä
$
d
¾
$
ŒŠ
$
‹cŸœOP
$
z{ÞìdŸª}Q
$
ï
íä
&
_)_!
Š¦ÝÞIJ
!
ŠV‰ÔÕVÀÞX¤ñ
ò
@<$@Q$\ZC5<$CZC5<
9‰X£¤^ñ

¥´
‹˜>
!MM3
‰ß[=¤ñò

ôIJ56,͛
ç(hžd
&
€¬ªJ¤ñò
M:;8$
xy–š¯@
°I?
!\^ 935:>oMJQqM:;8=**O&
_)_&!
–—­€
@Q
ðЇñò
!
nj
M.W-R
¤
**+
$
ï)
$$ /E
–—
$
±…ᇨ;?$
$
’
$$
)
C
­€‹Ó¨;ƒP¡
!$$ /C
­€‹Ó¨
;ƒP¡‡3
#
j
$O* //.W
]Þ^
$ * //.W
IZ@3$ //.W
²>^’³ªè
$$ /C
lmô
¨
$
j

%O&$
…è™$nœ¨;
$
)
$
)
C
¨;¡±
O /C
‡
IB
4$
$
’X.ÊÞ
$
)
C$ @US?.1b5$$
њÞOá¡
!s
)
C$
˜™O
¨
#$ /S1$& r& ) $$$ U,/S1
k
´U
$ /S1$
)M
¦
$
‰X¤žd–—­€
@Q
ðЇñò
&
_)_)!
}Ý^ñ
!
ææ
\I
1=
$
ôêFÝޖ
š‹ŠÑ–—­€‹˜™ÉOP
&
_)_$!
B‚Z[TA>Jc¤
!@A;IC
^ñ–š
01›œ
!
)MÛ¯y
#$ r
š R$
ææÙf
$
5,͛ç(¬´
$Z3J
[=
$
¦³¯Õ1
&
ôê
F–š$01TŽºyŒo®=¹>¾°¿a
=
$
x›œ01
&
ô[¯ê
! &$$
)

FÝÞ
$
u$¯yÂzì)
&
ÇìN
&
x?uÇìN–š$
Jc‡°¿›œ01?–š01k?
&
n›œ
01?´–šk01T?œœ«xy›œI?
!G]5
.]?.TSTS1VF7$3:$
)eô÷
&
_$!
ñx£¤
xБé‰$
Gu#
‘1
$

8B88 #O$
µÐ
$
n
­ˆ«Ê9‰Ï¯£Qœ†
!3;^ _3$
2
Dp
$O$
¾D[\ñxKL
&
!
Þù
_!
n­”aíä«Ê
C^æ­«Ê
$
÷­”aíäTË
!Dp
$O$
C÷­«Ê
$
“”•­
%
Dš³W­”a
íäôΌ
!Dp$O$
“”•­CDš³W­”
aíä­[\¿QÜ
$

&
‘
!
n­”aíä«Ê
!
$
Gu#$)o(
@GDWF!<./]GUST.1T.HUG?T+FSER?G/.1E?RFEU.X]T!
$
Gu#$
)o(
­ 
!!
íä
=E

!! )($O u*%O

!!
&$O u)O$

“”•
!
)($O) u(O(
*
Dš³W )%%O& u#O(
*
!!
«
#
C^æ­«Ê

Dp$O$$
)
Dp$O$
C÷­«Ê
*
Dp
$O$$
&
Dp$O$!
‘
* m&
ã
&
,%$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
_!
n­”a
Q^@@$M:;8$\^ 935:>
èe«Ê
C ^ æ ­ « Ê
$
 ÷ ­ ” a Š ¦
MJQ$
RBQ$ *RBQ$ M:;8$ \^ 935:>
ô T Ë
! D p
$O$
C÷­«Ê
$
“”•­
%
Dš³W­
”aŠ¦
MJQ$RBQ$*RBQ$M:;8$\^ 935:>
ô
DâãöÎŒ
!Dp$O$
“”•­CDš
³W­”a
Q^@@$M:;8$\^ 935:>
èe­[¿QÜ
$

*&
‘
*!
n­”a
Q^@@$M:;8$\^ 935:>
èe«Ê
!
$
Gu#$)o(
@GDWF*!<./]GUST.1T.H^ Q@@$ M:;8 G1V \^ 935:>G/.1E?RFEU.X]T!
$
Gu#$)o(
­ 
!!
MJQ=//.W,C
k
RBQ=//.W,C
k
*RBQ=//.W,C
k
M:;8=/A,C
k
\^ 935:>

!! )O*$ u$O)% O)( uO$& )O4$ u$O&# &O uO** *O$* u$O)

!!
#O44 uO$
)
)O( u)O(
)
#O4$ u&O*4
)
*)O*$ u*O%*
)
%O*% uO%%
)
“”•
!
O$& uO*
*
$O& uO()
*
%O uO$
&
&O4% u*O(
&
)O) u$O4*
&
Dš³W O$ uO$&
*
4O%4 uO*&
&
#O4) uO&#
&
&O( u*O#
&
)O)* uO)
&
_&!
n­”aŠ‹Þù«Ê
C^æ­«Ê
$
÷­”a
@<$@Q$CZC5<
ô

!Dp$O$$\ZC5<
Ό
!Dp$O$
C÷­
«Ê
$
“”•­
%
Dš³W­
@<$@Q$CZC5<
ôΌ
!Dp$O$$\ZC5<

!Dp$O$
“”•­CD
š³W­”aŠ‹Þù­[\¿QÜ
$

)&
‘
)!
n­”aŠ‹Þù«Ê
!
$
Gu#$)o(
@GDWF)!<./]GUST.1T.HDW..V WS]SVT]U.HSWFG/.1E?RFEU.X]T!
$
Gu#$)o(
­ 
!!
@<=//.W,C
k
@Q=//.W,C
k
CZC5<=//.W,C
k
\ZC5<=//.W,C
k

!! *O(% u$O)% $O)& u$O$ O)$ u$O*( O& u$O*4

!!
%O%& u$O%#
)
O*( u$O4
)
&O%* u$O((
)
$O($ u$O)
)
“”•
!
)O$4 u$O&&
&
O$* u$O*
&
O)4 u$O*4
&
O u$O
&
Dš³W )O$( u$O&
&
O$ u$O
&
O& u$O*(
&
O$4 u$O&
&
_)!
n­”aŠ¦
MM3
èeі—
@Q
ðЫÊ
C^æ­«Ê
$
÷­Š¦
MM3
èeі—
@Q
ðÐ[\TË
!Dp$O$
C÷­«Ê
$
“”
•­
%
Dš³W­Š¦
MM3
èeі—
@Q
ðÐ[
\Ό
!Dp$O$
“”•­CDš³W­”aŠ
¦
MM3
èeі—
@Q
ðЭ[\¿QÜ
$

&&
‘
&!
n­”aŠ¦
MM3
_Ñ–—
@Q
ðЫÊ
!
$
Gu#$
)o(
@GDWF&!<./]GUST.1T.HTFUX/MM3WFeFWTG1V ]G1-UFG?S-@Q
-.1?F1?TG/.1E?RFEU.X]T!
$
Gu#$)o(
­ 
!!
MM3=
)
/.W,C
k
–—
@Q=
)
/.W,E
k

!! &*)O# u#$O# &O u$O#*

!!
#(O) u#&O&
)
4O) u$O#)
)
“”•
!
#&O*& u4)O$%
&
#O*) u$O&
&
Dš³W ()O)) u#$O#%
*
O#4 u$O#&
&
_$!
n­”a–—­€}Ý^x
ôêFÝÞ
$
^歖šñ‹01í
$
ϴ
—ZHˆ
$
–š”:â8
$
µœ¥
$
01a=wm
$
ñí÷Œœ¥
$
–š01ÁË
$
‹Šæ‘

÷­
r–š²:
$
–š01ÁÊË
$
–š01Ï¿
$
ñ
‡ZŒŠ
$
Dʃ‡01ŽºTϲ
$
š]‡—Z
01$GD܏ઃ
$
d–š]D”Ћ˜­€
­®

“”•­
%
Dš³W­–š01Þߏ9^
æ
$
%0Ï¿‡01ÊË
$
¤û摝R
$
–š01
ÁÊ÷­Dʔ‡ž’
$
]r‹˜­€­®
$
r
g
&
_*!
n­”a–š01›œ«Ê
ôêFÝÞ
$
^歖š]r([›œ01


÷­–š›œ01
!
01TŽºyŒo®=¹>
¾›œ01

([žƒ
$
›œI?ž’

“”•­
%
Dš³W­–š›œ01Ê÷­([ÊË
$
›œ
I?ÊË

“”•­ÑDš³W­–š01›œI
?­[\¿QÜ
$
rg
*$
‘
&
&!
¦0
“”•
$
Žù(Rs›
/
sÓCB
0$
“®‡
%
,($*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
!!
3O
^æ­
J$<$ZO
÷­
IO
“”•­
MO
Dš³W­
&
g
!
n­”a–—­€}ÝÏÞ
!\I
1=
$q&$$
MSEO!@RF]G?R.W.ES-GW-RG1EFTS1 ?RF]G1-UFG?S-?STTXFT.HUG?T
G/.1E?RFEU.X]T!\IT?GS1S1E$ q&$$
3O
^æ­
JO
÷­
“”•­
ZO
Dš³W­
&
g
*!
n­”a–š !01›œ
!@A;IC$q&$$
MSEO*!@RFG].]?.TST.H]G1-UFG?S-STWF?-FWTG/.1E?RFEU.X]T
!@A;ICT?GS1S1E$ q&$$
‘
!
n­”a–š01›œI?‡«Ê
!
$
Gu#$)o(
@GDWF!<./]GUST.1T.HSTWF?-FWG].]?.TSTS1VF7G/.1E?RF
EU.X]T!
$
Gu#$)o(
­ 
!!
›œI?
=j

!! $O($ u$O*$

!!
*#O#$ u)O*
)
“”•
!
*O4 uO%$
&
Dš³W )O$ uO(
&
GH
*
ô,­›
$
£$®‡ˆ¿XU
$
¦ÎU<2F
“Ôè
$
GH¬ÀXÔ
$
ÅTÔè2MÖU<
$
ÓÔ
ÌUÔâ“Hۜž‡/ú£Í
&
‚3±
(
Ú
Y
)
‡V|}‡}z߅BæªÈ¾ÓÊé¾9
%
ÏÀ¾J
$
¬ÓYZzÌ$
$
ƒ>ÝÞ,ƒ?
*
÷
V|}Å>ÍDâãö‡UîâŸ
%
U âÀ
%
¨
¡Q¢
%
£>Ëk
%
óUîÀáUÔⓇiŒ
$
d
1œÅ>|vxŽº°éÚy
$
kЇŰ,æÈ
[P
&
×
$
j“”•ˆ‰±V|}‡ÔÌ
$
cº
Å>¤œ_`‡ãQ
$
V‹R¬stGÉ,âãö
‡¥^
$
¬Ó‘z3](
&
†‘(
$
³‹˜­€gƒ‡‹˜™ÉC–š
¯@°Ñ !01ÙÅêëÁ¯‚*
&
Ë¥´‹˜>
!MM3
|v֞–š–š¯œ¢
$
Wv–š¯ø¦
%
‹©¿Ž !01›œ
*)+
MM3
ÍÅBg$/œÕ
u8ÀÞKghŽ ! 01›œ
*&5+
&

$
’Ã
‡ !01âÅè~z퇖š¯R7
$
Žº
*
÷V
|}
&
–—Ó8H“]œ¢—Ñ8œ¢—­›‡Õ-
‡?W
$
–š÷´‘íɇ
j m*j
*#+
&
Ý0M
Ⱦ
$
–—‡‹˜™Éç薚 !01
%
—Z01‡
‹˜Ï¿
$
Gç苘­€
!
Á±8C‹˜

‡­
®
*%+
&
Ø/cº
$
ùc¿V|}
aX-KFU
op”a
Ç–—çè—Z01
%
–š ! 01fŽº‹˜™
É
$
dt±ËŠV‡c¹
*(54+

Õw U ¥ O
!

\59>8
(1ŠV^æop>
%:Q@$@*Z9
Å>–
—
@Q
ðÐ01žË
$
dC ! 01ÙÅêëD*
$
ü
4

\59>8
­¤Lœ‹˜Óå@±–š ! 01
%
—
Z01WӖ—8‡‹˜­€
*%+

ßàô(1‹©
¿ !01ÙÅêëћœ‡c¹$ÑäÙ´‰
&
9†$
$
/:ÍÐ
8@a
ÑˋB2Ž‡”
a
*
÷V|}÷›Ù
$
”a‘º¾[\‡op
%
Ë
ŠV
%
ˊ‹
%
–š¯@°
$
–D
MM3
ž’
$
–—­
€}ݯy[1–š²:
$
–š01?ÊË
$
–š0
1Ï¿
$
ñ‡ZŒŠ
$
–—‹˜­®
$
–—­€
@Q
ðÐ([TË
$
–š01›œž’
&
“”•“®‡
%
GH­›
$
ºR†cº“”•$®‡‘DP›
œ:ŒˆDΌŠV‡´‰
**$5*+
$
GHGÍΌŠ
V
%
_`–š¯@°Ñ_Ïí8‹˜œ¥
***5*)+
$

×YZMî£æ‰±ÔÌ
*
÷V|}
*+
&
ƒ>s
2Úz
$
“”•
%
Dš³WôÍDPÊ˖—
@Q
ð
Ð
$
+ÛÊa‹©¿Ž‡–š01›œ
$
ßÍÅÓ
‘ÔÌ
*
÷V|}‡z3H8
&
¬Ó
$
,{GZ8àeE¿
&
st
$
–š01
çè
&
Hâã‡01
$
ÛND–š¯œ¢ÙŇ !
01´–š01k?‡
%$j&
ƒ>Bg
@A;IC
¤
ÝÞ,–š01›œ
$
¬ÓáÅj–š ! 01ѳ
!01’2ü 
$
³W‡z{$
$
Í29‰³1=
‡£¤åLœ
&
‘2
$
íª}ŽÏ]‹©¿
,4$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
Ðч–š01›œÓ³æëÁ‡
$8@a%
ËV
%
Ë
‹á¯ô͎ ! 01›œ
$
ß Ó>‰
8@a
PQ
&
Dar”ÍÐ
8@a
͎ ! 01HŸ
$
Û
:ÍЎ ! 01›œ
& 8@a
5
&$ /E,KE
k
ÍÐ
Ï2Bgx«¬
)
pW
$
”a¦•¹/01›œž
’

5u€
&$ /E,KE
k
nc«¬‡‰
V
W
$
Í^
ñ, ! 01›œ
**&5*%+
&
ü49†
8@a
‰ÐÊ:
$
¾
)$ /E,KE
k
Ï2Bgx«¬
$
d”•Ë‹B2
(
¤Wžd›œ^ñ
$
¬‚âŤó
8@a%
ˊVáG
C–š01›œ‚*
$
×
$
9†÷Í(1“”•
ƚ01›œD_`´‰
$
_`‹©¿ÍÅ÷÷
ÓBH8
&
,݆‘(
$
®‡ðDƒH¹}ˆ
$
¸ÙÓ
:Œˆ
$
ðÐ˒
)O#j
2M
&
:ŒˆÓFȇ—
A>¾Þ‡ø—X
!39BL
—¾Í
$
‘ÔÌ
*
÷
V|}DP‡YZÑz{†ØDʃar
**+
&
GH‡¸Ù›œ¾H
$
ØÚzGH>
Í֞ !01‡–š¯œ¢
**(+
&
¬Ó
$
®‡$‘‹
›œ®‡ˆ
%
,ˆ
%
øJ>
%
%
‘:Œˆ
$
2
GH¸Ù›œÔÌ
*
÷V|}‡z3‚÷ɞ8
¼¥¦
&

pqrs
#
* +!;EX6F1 Z9$ IW58FUGE\J,@RFF]SVF/S.W.E6.H.DFTS?6*Y+,
QGT?U.F1?FU.W* * +!JF-K/G1 9,)!%##*)*,
* ) +!3WS3@$ MFUSTNM$;GUG1 ;\$F?GW,:1TXWS1 UFTST?G1-FS1 ?RF
-.1?U.W.HD.V6HG?VST?USDX?S.1# G1F+R6].?RFTST*Y+,\.U/
9F?GD >FT$ *$$&)!*#%%,
* & +!eG1 \FU]F1 ;3$ 8-RUGX+F15\S1VFUWS1E_J,CS]SV G--X/XWG5
?S.1 S1 1.15GVS].TF?STTXFG1V WS].?.7S-S?6*Y+,BR6TS.WJFRGe$
*$$($4&!*#*),
* +!CGUG5WSeFUG1V /XT-WFG1V ?RFS1TXWS1 UFTST?G1-FT61VU./F*Y+,I1V.5
-US1.W9F?GD * # +!8RS/GDXKXU.9$ \SEG9$ aR.X P@$ F?GW,CS].G].]?.TSTS1 DF5
?G5-FWT.H.DFTF]UFVSGDF?S-HG=HGUG?T,>.WF.HTFUS1F]GW/S?.6W5
?UG1THFUGTF.eFUF7]UFTTS.1 *Y+,YJS.W)*&(%,
* % +!Q.WG63$ PDGUGY,CS1K DF?+FF1 .DFTS?6G1V ?6]F* VSGDF?FT
*Y+,JFT?BUG-?>FT* ( +!
V¸I
$
ó¸Q
$
º­
$
á
O
“”•‘Ïô,Î
*
÷V|}
”a܂‹˜™É‡ÔÕ
*Y+O
$%$MCÞá-.
$*$$$
)$!*# *4%,
* 4 +!Z.1E\$ NG1EY\$ CX MI$ F?GW,YSG.?GS+G1 F1RG1-FTS1TXWS1
TSE1GWS1E?RU.XER ]R.T]RG?SV6WS1.TS?.W)5KS1GTF]G?R+G6S1 TKFWF5
?GW/XT-WF.HVSGDF?S-UG?T*Y+,##(,
*$+!
Ú´•
$
ó¸Q
$
º­
$
á
O
âãc«L“”•Î”a
*
÷
V|}‡ÔÌ´‰
*Y+,
$%$,-.
$*$$)#!##**%,
*+!\XG1EaP$ bX b\$ CX MI$ F?GW,YSG.?GS+G1 G?F1XG?FTRF5
]G?S-WS]SV G--X/XWG?S.1 S1 ?6]F* VSGDF?FT/FWS?XT*Y+,IeSV
JGTFV <./]WF/F1?3W?FU1G?9FV$ *$)$ V.S# #%$&,
**+!M.W-R Y$ CFFT9$ 8W.G1F8?G1WF6Q\,3TS/]WF/F?R.V H.U?RF
ST.WG?S.1 G1V ]XUSHS-G?S.1 .H?.?GWWS]SVFTHU./G1S/GW?STTXFT*Y+,
YJS.W*)+!9-QGU6YZ,JG1?S1EWF-?XUF*$$# V6TUFEXWG?S.1 .HHG?6G-SV
/F?GD.WST/S1 ?RFF?S.W.E6.H?6]F* VSGDF?FT*Y+,ZSGDF?FT$
*$$*$!#%,
*&+!8X//FUT8 3,*Y+,BU.ECS]SV >FT$ *$$#$&!#&*,
*+!\GDFUIB$ BU.-.]S.Y$ $ F?GW,;F+S1TSER?TS1?.
HG?6G-SV /.VXWG?S.1 .H]G1-UFG?S-DF?G5-FWHX1-?S.1*Y+,:1?>Fe
<6?.W$ *$$#$*&(#,
*#+!@GKFVGY$ PG1.\$ I1E8$ F?GW,3/.WF-XWGUS1eF1?.U6.HRX5
/G1 ]G1-UFG?S-STWF?T# TFcXF1-FG1GW6TST.H$$$ -Z;3-W.1FT
*Y+,\X/9.WQF1F?$44)$*!#%4),
*%+!@XTRXS[F1 9I$ JX1-K 9<$ B.X+FWTBY$ F?GW,BG1-UFG?S-HG?
-.1?F1?G1V DF?G5-FWHX1-?S.1 S1 /F1 +S?R G1V +S?R.X??6]F* VSG5
DF?FT*Y+,ZSGDF?FT*(+!CFFP$ \SU.TF\$ R^1FVG9$ F?GW,JF?G5-FWWS].?.7S-S?6S1 ?RF
]G?R.EF1FTST.H1.15S1TXWS15VF]F1VF1?VSGDF?FT/FWS?XT.H.DFTF
UG?T# S/]GSU/F1?S1 GVS].-6?F5DF?G5-FWUFWG?S.1TRS]T*Y+,BU.-
;G?W3-GV 8-SA83$ 44&$4!*)#$(%(,
*4+!CFFP$ CS1EeG6:$ 8[-[F]G1SGK C8$ F?GW,BG1-UFG?S-T?FG?.TST#
RGUDS1EFU.H?6]F* VSGDF?FTS1 .DFTFU.VF1?T*Y+,:1?Y D^FT
!C.1V $*$$$)&!*#)4#,
**$+!PS1 Y$ bS1E\$ PFY,IHS-G-6.HDFUDFUS1FS1 ]G?SF1?T+S?R ?6]F
* VSGDF?FT/FWS?XT*Y+,9F?GD.WST/$ *$$($%!#%*,
**+!Z.1E\$ NG1E;$ aRG.C$ F?GW,JFUDFUS1FS1 ?RF?UFG?/F1?.H
?6]F* VSGDF?FT/FWS?XT# GT6T?F/S-UFeSF+G1V /F?G5G1GW6TST
* Y+,IeSV JGTFV <./]WF/F1?3W?FU1G?9FV$ *$*$ V.S#
4#&,
***+!LSUKRG/8$ 3KSWF1 >$ 8RGU/G8$ F?GW,@RF].?F1?SGW.H-S11G5
/.1 ?.UFVX-FDW..V EWX-.TFWFeFWTS1 ]G?SF1?T+S?R ?6]F* VSGDF5
?FTG1V S1TXWS1 UFTST?G1-F*Y+,ZSGDF?FT^ DFT9F?GD$ *$$4$
!*#$$,
**)+!<.X?XUSFUL$ JG?G1VSFU<$ 3+GVG9$ F?GW,S1TXWS1 TF1TS?SeS?6G1V GW?FUT?RFD.V6-./].TS?S.1 S1 G1 G1S/GW
/.VFW.H?RF/F?GD.WS-T61VU./F*Y+,3U-R JS.-RF/JS.]R6T$
*$$$$!#(,
**&+!8GS1SL8$@R./]T.1 <$NS1?FUH.UV <9$F?GW,8?UF]?.[.?.-S1 G?
W.+V.TFTS1VX-FTG].]?.TSTG1V G?RSER V.TFT-GXTFT1F-U.TSTS1 G
/XUS1F]G1-UFG?S-DF?G-FWWS1F$ :;85 *Y+,JS.-RF/9.WJS.W
:1?$44#$)4!##**4,
**+!,$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
-F]?SDSWS?6?.T?UF]?.[.?.-S15S1VX-FV DF?G5-FWG].]?.TSTG1V VF5
WG6FV GX?.S//X1FVSGDF?FTS1 GWK6W]XUS1F5Z;35K5EW6-.T6WGTF5VF5
HS-SF1?/S-F*Y+,9.W**#+!L.R B ,^8?UF]?.[.?.-S15S1VX-FV VSGDF?FTS1-UFGTFTG].]?.TST
?RU.XER Y;L]R.T]R.U6WG?S.1 G1V JG7G-?SeG?S.1 S1 UG??FT?FT*Y+,
Y_F?9FV 8-S$*$$%$#4!4#4#4,
**%+! ~^JUSF1 J3$\GU/.1 J_$ ?.TSTSTUFT].1TSDWFH.U?RFVFeFW.]/F1?.H:ZZ9S1 ?RF/XW?S]WF
W.+5V.TFT?UF]?.[.?.-S1 /.VFW*Y+,YBG?R.W$44#$%(!*#%#,
**(+!3VSTGK+G?G1G8$ 9..1TG1 B$ PSD-R.K531X1 8,:1TXWS15UFWFG5
TS1E]U.]FU?SFT.HGTFUSFT.H-S11G/S-G-SV VFUSeG?SeFT/) 9/*%+G1V
/) 9/9+*Y+,Y3EUS-M..V +K@SCAK6/.AC./L/0ABL.BSF@.C/SK.C.SSH-H0.C/AB.BG/J0@CS@0
.LALCAJ/J/BF.CJX/CDCEL@* G/.M@C@J
a^AbS1

$ C:AZF5WSG1E
$*
$ CAMX5FU

$ Z^ ;Q\XS

$ bACS50X1

!
$ CA^ PX15RXG1

$ N3;QLGS5HX

!OM)#*/*=*+,M)*5%$*. -%$./*/+)$0(/)#$). Z#*%) 1./&/);,/0/$*. *+-+)57/P+#F/*$0$
-+)57/1./&$0(+05$ P=$>+)5 8)/9%#/*:+,A&/)&$). -&)+0+5:$ Z=$) &)$$)$$ (/)$
*OA)>) (0/)/&$01./&$0(+05+,E=$)5>+= 8)/9%#/*:+,-%$./*/+)$0(/)#1./&/)$ A)>)
-%$./*/+)$0(/)#1./&/)P+#F/*$0$ A)>) ($))$ (/)$
*5MJCF.SC+!:1 ?RSTT?XV6$ ?RFUG??6]F* VSGDF?FT/FWS?XT!@*Z9 /.VFW+GTFT?GDWSTRFV ?RU.XER ?GSWeFS1 S10F-?S.1 +S?R W.+
V.TF.HT?UF]?.[.?.-S1!8@a G1V RSER HG?VSF?H.U( +FFKT$ G1V ?RF1 ?UFG?FV +S?R YSG.?GSBSWO@RF.UGWEWX-.TF?.WFUG1-F?FT?! Q^@@$
HGT?S1ETFUX/S1TXWS1!M:;8$HUFFHG?6G-SV!MM3 WFeFWTG1V DW..V WS]SV +FUFGTTG6FVO\^ 935:>+GT-GW-XWG?FVOBG1-UFG?S-]G?R.W.5
E6+GT]FUH.U/FV,31V ]G1-UFG?S-?USEW6-FUSVF!@Q -.1?F1?+GTF7G/S1FV D6?RFWS]SV F7?UG-?S.1 /F?R.VOBG1-UFG?S-STWF?-FWG].]?.5
TST+FUFVF?F-?FV D6?FU/S1GWVF761X-WF.?SV6W?UG1THFUGTF!@V@5/FVSG?FV VA@B1S-K F1V WGDFWS1E!@A;ICO3--.UVS1E?.?RFUFTXW?T$
?RF/.VFWEU.X] TR.+FV GD1.U/GW^ Q@@$ S1-UFGTFV M:;8$ \^ 935:>$ MM3$ WS]SV VST.UVFU$ .DeS.XTHG?G--X/XWG?S.1 G1V TSE1SHS-G1?W6
S1-UFGTFV @Q-.1?F1?S1 ]G1-UFG?S-?STTXFT$ G1V F1RG1-FV ]G1-UFG?S-STWF?-FWG].]?.TSTO<./]GUFV +S?R ?RF/.VFWEU.X]$ ?RFYSG.?GS
BSWEU.X] VST]WG6FV S/]U.eFV Q^@@$ UFVX-FV M:;8$ \^ 935:>$ MM3$ UF-.eFUFV WS]SV VST.UVFU$ VF-UFGTFV HG?G--X/XWG?S.1 G1V TSE5
1SHS-G1?W6VF-WS1FV @Q-.1?F1?S1 ]G1-UFG?S-?STTXFT$ G1V W.+FUFV ]G1-UFG?S-STWF?-FWG].]?.TSTO:1 TX//GU6$ YSG.?GS]SW-.XWV FHF-5
?SeFW6?UFG??6]F* VSGDF?FTS1 UG?TO:?T/F-RG1ST//G6DFUFWG?FV ?.?RFUFVX-?S.1 S1 ]G1-UFG?S-HG?G--X/XWG?S.1 G1V STWF?-FWG].]?.5
TSTO
*]@E XAFGJ+!YSG.?GS]SW ?6]F* VSGDF?FT HG?G--X/XWG?S.1 STWF?-FW G].]?.TST
GA/#([)*bPSWS--()&

tu-0
!

#
,*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&