免费文献传递   相关文献

Study on detoxication and mechanism of vinegar-processed Euphorbia pekinensis on normal liver cells LO2

醋制降低京大戟对人正常肝细胞LO2的毒性及机制研究



全 文 :OÑPQ3/R±G`SH‘’
?@*
}TŒÅNс‚
CÈ
!
Š‹Œ
!
ˆN‰
!
}]
!
ÉÊÊ
!
Ž^
!

hMGHPqI 8w`$“Qš›RS[W\]^
!
8w hM
*$$&##

mn
#!

#
ÃÄ3/ROÑQ¸±G`SH‘’
?@*
}TŒ€
$
C¢£úž;}€NÑ
*
“”
#
ӏº¶
?@*
‘’
$
€âãþÖ}3/Ršš Oš±úƒfè~
$9DD
åGÎp˜š±
?@*
‘’JK}FÑ€
+B.P-JLM))*(
Ïö
*刉‘’ëì};]g!
+311P6K1Z=C:
ö*}?‘’)FG
?@*
‘’ëì
+C:
ö*}?‘’)ˆ.ú±‘’éx}
“”
+
FG‘’º¶°È†@UAZñ
!3?D
@£AZñ
!38D
B2CDñ
!?AB
‹·
$
‘’­xȆ£&DŽDñ
!8@A
‹·

Ut1
!9A3
 @ìçØ
!F8B
34
*
•–
#
ê*Œ±®ÃÄ
$
3/Rššpþ֮ӞFÑ
?@*
‘’JK
$
ÍΑ’ëì
$
†¤‘’
8
xv}
!,g$c$+
;6²q‘’º¶°È†
3?D$38D$?AB
‹·
!,g$c$$
6PQ‘’­
xȆ
8@A
‹Œ 
F8B
34


9A3
34
*
OѸ
$
ê3/Ršš®ÃÄ
$
ž6PQ‘’ëì’

PQ‘’éxv}
$
6PQ‘’º¶°È†
3?D$38D$?AB
‹·
!,g$c$$
6²q‘’­xȆ
8@A
‹Œ 
F8B
34

6PQ
9A3
3
4
*
•—
#
OўPQ3/R±
?@*
‘’}TŒ
$
úNў;½•2&Dcd
$
%öPQ‘’éxv}
$
•ˆ‘’ëì
*

opq
#!
3/R
+

+?@*
‘’
+
ëì
+
&Dcd

rs-F
#!*$*$%$

tuvP
#!
KïM(Bqj‚š&ïò¬X
!*$$4&#%+
9
3$b,/
*$
q/šlÚïò$ô¬X
!;W5<*(

wkxy
#!
!
wpY
$
½¾
$
úûšÎZ
$DPR# !$*((*)$
T4/IKR# I+QK1H$2#)c-./

xyz{
# !
XMõ
$
Yû‚š
$DPR# 7$()*)$T4/IKR#
#$7%%#)#2aac-./
!!
3/RÉ/R&/RR…†/R
!FC$/:& F*.
@&2*2+&+>SYOc
}ZA­
,-
$
É$b†‡S€}¦+
Y,
$
Œ¹
$
Ij
+
GT
+


4


*
†‡ÈS
€¥y#vY
$
.xs»kXY
$
H™DXYÅ
$üˆ­Úç
,*-
*
‚×Ø3/R¦+€¦3
$
ç1ž†¤Í¤]

Þåä|ùú
,)-
$
úY
°žÎb/÷H:;cd
,&-
$
9þOѸò+
€â 
$
TŒPQ
,-
$
¨Ì
$(
$%,A
)*$$
qB~
¿Ð
%
æÑ
&
ð+t8
%
O3/R
&
,#-
*
öóQÎ<
=±3/ROÑPQHTŒNс‚}ØDcÕ
$
¨Ì
$
ý‚Ãӏº¶}
?@*
‘’Ɂ‚±ž
$
F~ˆ‰3/ROÑQ¸±
?@*
‘’}TŒ€
C¢£OÑPQ
?@*
‘’TŒž;}€NÑ
$
Ã
xÉ3/ROѕTNс‚¯í½›
*
!

^!
‘’Ä
!
G`SH‘’
?@*
Á93$b,/
mÐfBÔ
*
)^!
,<
!
3/R,<“¥pȜ¸,<4®
$
þ
93$b,/{Qr½¾’ÎÉ/R&…†3/
R
!cF*@&2*2+&+
}a­
*
3/Rššíݚ
!8VAV
É3/R,<
$
Й
$
œ
*

$
¸á
$ H
´ÐÃ
#
Ý4jô¦}¯á
)
Š
$

* J$
¦tjô
$
ˆ3
/Rššô¯®n
!
’É
#c&7f$
jô®n€
Yg`
$
g`† Š€$¬W

j2j­^á
$
ˆ“
ˆ$¬W1Ï
!
’É
#c))f$
j2j­1Ï®
n
!
’É
%c)f$
(CÒ1ˆ®n
$
šš®n
*
3/ROšíݚ
!‘
(
$%,A
)*$$
q
B
$
á°3/R
$$ H
ÇÀO
)$ H$
Ê[
* J$
ÇYÊ
Ô|
*$$ /?$
Ê[
* J$
CBéý|Os°
$
EÎ
8X
$
á±
$
g|/

܇Z
$&$ q
•|ZA
( J$

OÑ3/R
*
Й
$
œ
*

$
¸á
$ H
´ÐÃ
#
Ý4jô¦}¯á
)
Š
$

* J$
¦tjô
$
ˆ3
/ROšô¯®n
!
’É
7c*#f*
>ô¯®n
€Yg`
$
g`† Š€$¬W

j2j­^á
$
ˆ
“ˆ$¬W1Ï
!
’É
)c&#f$
j2j­1Ï
®n
!
’É
#c#f$
(CÒ1ˆ®n
$

®n
*
$¯¸áÃȚš Oš®n
$
€
A98@
Ì
x
$
’‡
*$$ H.?
e
}…°
$
b€†}º¶°
.##(.
v
)(
ºv
#
x
*$)
q
)
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)($:LLSP!#
9IO-J$ *$)
ÊÔ
$
‡p˜šÓÉ
($$$#$$$&$$$*$$$$$ /H.
?
e
ç

y¸Ö
$$c**
!
/
‘¢VœV)é
$
æ
*
&^!
Ý©
!A9T9
Z궤
!FK[-.
IJ
+
}D
†
!
x¸_ò©š†t±<óGHIJ
+
{2P
‰
!CU8
Ö°8ñ
9DD!8.RIO[K.
IJ
+>:C3
­x°
!
$
$
°8FÑ©
C98]$B.P-JLM))*(
ö*
Ý©þ
!
Æözš†()‚<
+311P6K1Z4]:D<=
C:
ëìFGÝ©þ
!\[K
IJ
+C:=>;ILPLMIK1K1H
USNPO!UACJIO/K1HP1
IJ
+
B2CDñ
!?AB
G
ÎÝ©þ
!
ë<
*$*$&*)
@UAZñ
!3?D

Ý©þ
!
ë<
*$*$&*&
@£AZñ
!38D
GÎÝ
©þ
!
ë<
*$*$&*&U<3
°8GÎÝ©þ
!
ë<
*$*$&*%
£&D†ŽDñ
! 8@A
GÝþ
!
ë<
*$*$&#
‘4Ut1
!9A3
GÎÝ©þ
!
ë<
*$*$&%
‘4Yÿ©@ìçØ
!F8B
GÎÝ©
þ
!
ë<
*$*$&(!
93¯‡š†t±‚<
*
_^!
îð
!3G**$
Z¼ˆ.zš
!
sý×/
+
£
°tÆ
!
︰D«ÒGHIJ
+
ZÿæXY^
!
ÈM$àlÞ«ÒGHIJ
+
šuÆ«‘È
!

@R5/YSL
IJ
+]3<8}?‘’î
!
D
%
UA
IJ
$
q ˜XN
!
D%
?I[;PM
IJ
+Y.+4
PO+IdP^ )&$
oóJñÛî
!
D%
UK.4DPX
IJ
+
<@
*
æXº¶^
!DJPO/.
IJ
+DF?4#9
q Æ?
]ИXN
!
JmÑî˜XNîðGHIJ
+
C*

!
93/(#&îð‚<
*
)!
äå
) ^!?@*
‘’º¶
!
€3
$f
}D†}
A9T9
q𺶤
$
u
)% q$f <@
*
} ƒÖ}º¶^
8S¬º¶
*
) )^!9DD
åGÎ3/ROÑQ¸±
?@*
‘’JK
}FÑ€
!
á±?šJx}쑒g°
$
—Í‘
’¯ÖÉ
s$
&
y
=/?$
…²¥
7#
¢Ÿ$
$$
!
?=
¢
!7#
¢ŸéÈÂüÇé
CU8
°
$*$$
!
?=
¢
$
u
)% q$f <@
*
} ƒÖº¶^$º¶
*& J$
Ýÿ
º¶°È†
$
Ç
*$$
!
?=
¢3,†º¶°
*
3
/Rš

Oš}{þֈ“É
($$$#$$$&$$$*$$$
$$ /H.?
e
$
«*Œ±®
$
ÇÆ3
$c&f A98@
}†º¶°
$
ãT«‘’±®
$
Ù)ë#
Œ
*
wyþÖ«

yp¢
$

)% q$f <@
*
}
 ƒÖº¶^$º¶
*&$&($%* J
¸
$
ˆ“Çòª’
Ñ}
H.?
e
}
9DD*$
!
?=
¢
$
& º¶
& J$
22
sMȆ
$
Ç
A98@$
!
?=
¢
$
Yš^‡>P
$
ñ
Ûî¥
&7$ 1/
óJèGÎsÖ
D*
‘I?¬a
3/ROÑQ¸±
?@*
‘’JK}Fђ
!:> r
! eD
q,®ÓÔ
=D
*Œ±®ÓÔ
s$$f*
) &^!B.P-JLM))*(
Ïö*ˆ‰‘’ëì
!

é}áSÐu¥
#
¢Ÿ8
$
á±?šJx}쑒

$
—Í‘’¯ÖÉ
s$

y
=/?$
…²¥
#
¢Ÿ
$
$

* /?$
«q,® *Œ±®
$

)% q$
f <@
*
Å ƒÖ™á+‘’º¶^$º¶
*& J
¸
$
q,®ÇÆ{þÖÉ
#$$$&$$$*$$ /H.?
e
3
/Rš


$

/?$
*Œ±®ÇÆçÓv}
†‘’º¶°
$
w®«
)
yp¢
$
>º¶ŸuÆ
)% q$f <@
*
º¶^$º¶
* &( J
¸sݺ¶°
$
ÇÆ
$c /?
«Î°
$& q
«Î
)$ /K1*
ݫΰ
$
€
CU8
¯
*
à
$

) /K1$
s°Ó
*
ÇÆ
$c /?
B.P-JPM))*(
ö*°
$
~^‡Èö*
/K1* CU8
¯
*
à
$

) /K1*
¢

¢ûÏâҺа¥8
SÐÈ
$
áÈãG‘’}áSÐ
$
‡‘’…zºÐ
°
*
€Ï‘È~feóJ
)$ 1/
Þ^
$
e¡ó
J
&#$ 1/
Þ^FGCޏ
*
) _^!C:
ö*FG‘’éx
!
á±?šJx}ì‘
’g°
$
—Í‘’¯ÖÉ
s$

y
=/?$
…²¥
#
¢
Ÿ$
$

* /?$
«q,® *Œ±®
$

)%
q$f <@
*
Å ƒÖ™á+‘’º¶^$º¶
&( J
¸
$
q,®ÇÆ{þÖÉ
#$$$&$$$*$$ /H.
?
e
3/Rš


$

/?$
*Œ±®ÇÆç
Óv}†‘’º¶°
$
w®«
)
yp¢
*

¶ŸuÆ
)% q$f<@
*
º¶^$º¶
* &( J
¸½
DtK‘’
$
€
CU8
¯
*
Š
$
ÝȆ
$
N€[]}
%$f

& q
«Îœ¹
$
ÇÆ
C:=>;ILPLMIK1K1H[SNPO
)$$
!
?$
€ö*
)$ /K1$
°æ€}?‘’îFG
*
) $^!311P6K1 Z4]:D<=C:
^öå}?‘’)ˆ.‘
’ëì
!
‘’º¶äåã
) _^$
º¶
*& J
¸
$
q,®
ÇÆ{þÖÉ
#$$$&$$$*$$ /H.?
e
3/Rš

O
š
$

/?$
*Œ±®ÇÆçÓv}†‘
’º¶°
$
w®«
)
yp¢
*
>º¶ŸuÆ
)% q$
f<@
*
º¶^$º¶
* &( J
¸½DtK‘’
$
€
CU8
¯
*
Š
$
ÝȆ
$
ÇÆ
[K1QK1H[SNPO)$$
!
?$314
1P6K1 Z4]:D<)
!
?$C:)
!
?$
€ö*
/K1$
°æ
€}?‘’îFG
*
) (^!
H:;Å&DcdÚÛGÎ
!
‘’º¶äå
ã
) _^$
q,®ÇÆ{þÖÉ
#$$$&$$$*$$ /H.?
e
3/Rš


$

/?$
*Œ±®ÇÆçÓv
.%#(.
v
)(
ºv
#
x
*$)
q
)
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)($:LLSP!#
9IO-J$ *$)
}†‘’º¶°
$
w®«
#
yp¢
*
>º¶Ÿ

)% q$f<@
*
º¶^$º¶
* &( J
¸tK‘
’Ȇ°
$
­óÝ©þžØjFG‘’º¶È†°
$
3?D$38D$?AB
‹·
$
bw¢€
CU8
¯
*
à
$
ÇÆ
>:C3
‘’­x°
$& q
­x
J$
tK‘’­x°
$&
q$* $$$ O./K1
e
˜X
$ /K1
¸áȆ
$
­óÝ©
þžØjƒf°8Î4Å
8@A
‹Œ
9A3
 
F8B
34FG
*
) %^!
§¬è~
!
lÞ?óɀ
8C88 %c$

ƒf§¬ˆ.
$
p®Î4FG?óà %
1p+
×õ
$
®
®ÃÄɀ
?8A

$,g$c$
É«ÝG§¬
‚ƒ
*
&!
ÌÛ
& ^!
3/ROÑQ¸±
?@*
‘’JK}FÑ€
!
Ái

ž=
$
~
$$ h($$ /H.?
e
$
ê*Œ±
®ÃÄ
$
3/Rššè~
?@*
‘’
*&$&($%* J$
×
ֱؐ}‘’JKFÑ€
!,g$c$$
ۍ
©4 T® ¡Œ
+
ꚚpþÖ®ÃÄ
$
Ošpþ
Ö®ž6PQ‘’JKFђ
!,g$c$*
걏®ÆÃ

,g$c$$
*
,g$c$+
ê
8VAV
®ÆÃ
)
,g$c$$
&
,g$c$!
×
h)
ã
*
i
!
3/ROÑQ¸±
?@*
‘’JK}FÑ€
]KHc!:1JK[KM.O5PNP-M.N[PN.OPI1Q INMPOYO.-PLLPQ .N!FC$/.
:& F*@&2*2+&+.1 ?@* -PR
& )^!B.P-JLM))*(
Ïö*ˆ‰‘’ëì
!

±®‘’$
‘’£;]¬†
$
̾†
ö
$
ç+ÓP}QÞÖ§*Ï
$
ö3/Rššè
~‘’¸‘’ëì֞ؐ
$
‘’£ö*,«WQ
ö
$
K¥£+„™­‡b¯}¯°Â
$
çí§*
ÞÏ
$
‘’£«W
+
ꚚpþÖ®ÃÄ
$
Ošp
þÖ®ž•ˆë쑒?ó
$
=i
**
3c
*Œ±®
+Uc
3/Ršš
!#$$ /H.?
e
+3/Ršš
!&$$ /H
.?
e
+Ac
3/Ršš
!*$$ /H.?
e
+Tc
3/ROš
!#$$ /H.?
e
+
]c
3/ROš
!&$$ /H.?
e
+Fc
3/ROš
!*$$ /H.?
e
*
i
*!B.P-JLM))*(
Ïö*ˆ‰‘’ëì
! s&$
]KHc*!B.P-JLM))*( LMIK1K1HM.QPMP-M?@* -PRIY.YM.LKL! s
&$
& &^!
3/ROÑQ¸‘’TŒ1φ¤
?@*
‘’
éxv}
!
ɀ
C:
ö*å
$
¶€}?‘’îFG
#$$$&$$$*$$ /H.?
e
3/Rš

Oš±
?@*
‘’
éx}“”
$
ê*Œ±®ÃÄ
$
3/Rššè~‘
’¸;6†¤‘’
8
xv}
!,g$c$$
ûG
F
*
=9
x
$
ãT
$
ž‡‘’}
A;3
34ˆI±Öëì
@A
$
æ±ÖqtÝÓ@
+
ꚚpþÖ®ÃÄ
$
O
špþÖ®è~‘’¸
$8
x¾ˆ’JÇ
$
±Ö
F
*
=
9
x
$

*
.(#(.
v
)(
ºv
#
x
*$)
q
)
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)($:LLSP!#
9IO-J$ *$)
×!
}?‘’)GÎ
?@*
‘’éx!D
!
%
1p+$2r)
DI[RP![5NR.+-5M./PMO5!
%
1p+$2r)
®“
©4
=/H.?
e
F
$
=F

8
F
*
=9
±
e #)c77 pc&$ *&c#% pc$& c#( p$c&
8VAV #$$ *7c)) p$c(*
%$c#% p$c(*
*
e
&$$ ))c) p$c(%
##c# p$c(%
*
e
*$$ #*c&7 p$c%*
)%c p$c%*
*
e
&*c#) p$c%&
&
&c** pc&
&$$ #$c* p$c%%
*7c7( p$c(
&
7c( pc))
*$$ #c7# pc*&
7c$& p$c7)
&
*$c#% pc*&
& _^!
3/ROÑQ¸ÍÎ
?@*
‘’‘’ëì
!
*
Œ±®Å
#$$$&$$$*$$ /H.?
e
3/Rš


è~®‘’þ
311P6K1 Z4]:D<=C:
}?‘’îFG
ž=1ˆ‘’ešëì
$
ë쒈“É
!#c)* p
$c#(f$ ! **c( pc* f$ ! *$c$( pc& f$
!*c$& p$c)) f$ ! 7c#& p$c) f$ ! )c&& p
$c(%f$!$c(* p$c($f$
걏®ÆÃ
$
3/R
ššè~‘’¸‘’ë쒐6JÇ
!,g$c$$
ÑÕ©4²qöJÇ
$
×Ø3/R¶GÍÎ
?@*
‘
’ëì}€
*
ꚚpþÖ®ÃÄ
$
OšpþÖ
®ž6PQ‘’ëì’
!,g$c$*
& $^!
3/ROÑQ¸±
?@*
‘’Ó͌}“”
!
ê*Œ±®ÃÄ
$#$$$&$$$*$$ /H.?
e
3/R
ššÓ6¯q
?@*
‘’º¶È†°$
3?D$38D$
?AB
‹·
!,g$c$$
ÑçÂÎ}©4ÆȌ
+
êš
špþÖ®ÃÄ
$
OšpþÖ®ž6PQ
?@*
‘
’º¶È†$
3?D$38D$?AB
‹·
!,g$c$$
Ñ
çÂÎ}©4ÆȌ
$

**
& (^!
3/ROÑQ¸±
?@*
‘’&Dcd}“”
!
ê*Œ±®ÃÄ
$#$$$&$$$*$$ /H.?
e
3/R
ššž6PQ
?@*
‘’$
8@A
‹Œ 
F8B
34
!,g$c$$
6JÇ
?@*
‘’$
9A3
34
!,g
$c$$
ÑçÂÎ}©4ÆȌ
+
ꚚpþÖ®Ã
Ä
$
OšpþÖ®ž6¯q
?@*
‘’$
8@A
‹Œ
 
F8B
34
!,g$c$$
6PQ
?@*
‘’$
9A3
34
!,g$c$$
ÑçÂÎ}©4ÆȌ
$
=
×
)*
_!
£À
‘’ëì½[Ÿ`S®Ä;] ÂÎ:;}¾
•ƒÅœ±
$
½~¤¨eÑ+‘Âα<ƒf}
‘’Íì
$
“}ªšGÙ²NÑ
$
‚×Ø
$
‹Œ&
!!
×
*!
3/ROÑQ¸±
?@*
‘’Ȇ°
3?D$38D$?AB
‹·}“”
!
%
1p+$2r#
DI[RP*!TNP-ML.N[PN.OPI1Q INMPOYO.-PLLPQ .N!FC$/:& F*.
@&2*2+&+.1 MJPI-MKdKMKPL.N3?D$38D$?AB.1 ?@* -PRK1-S[I4
MK.1 LSYPO1IMI1M!
%
1p+$2r#
®
“
©4
=/H.?
e
3?D
=\.?
e
38D
=\.?
e
?AB
=\.?
e
±
e c)) p$c7&* %c)&) pc)& *#(c%$( pc$$(
8VAV #$$
)c*$) pc((
*
%c)
p$c7*$
*
#$(c**
p*(c)% (
*
&$$
7c&(* pc#7
*
)c%#&
pc&#%
*
&%(c(*(
p(c#&
*
*$$
#c7&# p*c##
*
$c7*$
p$c)(&
*
)%(c&*7
p%c)&)
*
(c7%( p*c$$
)
*c(7
p*c&%)
&
#&c(
p**c)#
&
&$$
c&* p$c(%
&
$c#$7
pc$%*
&
)%c*&
p*c%
&
*$$
*c7 pc&($
)
7c7$
p$c)7
&
)$c%(#
pc7*$
&
×
)!
3/ROÑQ¸±
?@*
‘’
8@A
‹Œ 
F8B$9A3
34}“”
!
%
1p+$2r#
DI[RP)!TNP-ML.N[PN.OPI1Q INMPOYO.-PLLPQ .N!FC$/:& F*.
@&2*2+&+.1 MJPI-MKdKM5.N8@AI1Q -.1MP1ML.NF8B$9A3.1
?@* -PR!
%
1p+$2r#
®“
©4
=/H.?
e
9A3
=
!
/.R.H
e
F8B
=/H.H
e
8@A
=\./H
e
±
e $c**$ p$c)% *c7* p$c%%) c* p$c*&
8VAV #$$ c7
p$c)*#
*
c(&#
p$c*#%
*
*c$%)
p$c7))
*
&$$ c#*
p$c)&7
*
%c)(
p$c&#$
*
&c**
p$c((
*
*$$ c*(&
p$c)
*
%c%##
p$c&#%
*
(c)%
p$c77
*
p$c))&
)
$c$##
p$c#*&
&
)c(#*
p$c((
&
&$$ $c7#7
p$c)$
)
$c%)
p$c##(
&
(c$)%
pc$%(
&
*$$ $c#)
p$c&
)
c&%
p$c#$$
&
c*$7
p$c#$(
&
ÅúÎb}&D¶f½‘’ë쪚}NÑ$Â
*
‹Œ&~ÓQþÖTž¤ˆn€
$
9qþÖTžÎb‘’&Dcd
,%-
*
’8‹Œ
&}²q+E•llÛ÷¦§Ä±û‹Œ&}Ÿ 
²q
$
Up²Æ·Óâ;v꟠²q}‹Œ&T
$
NÓ>E•‘’ëìNц)œÖžd}‘’ÃÙ
œ®Ä ðñ`S:;}eu
,(-
*
&DcdTª
š}œÙ‹Œ&žTøH‘’È}â ˜Ã
2
$
†eœ&D5¶
$
½÷
8@A
 
F8B$
š‡/4˜
,œ&Dª†
$
„µ¶GU׌}
9A3$
Îb‘’
Ì¾!D

‘’BŠŒJÞ

‘’$
3?D$38D
 
?AB
ÔÕƍ
A;3
cd

‘’JKFÑä|Í
ì
,74$-
*
ýlÞÌÛ×Ø
$
3/Ršš~
$$ h($$ /H
.?
e
±
?@*
‘’Gؐ}‘’TŒ€
$
¨ÌU
.7#(.
v
)(
ºv
#
x
*$)
q
)
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)($:LLSP!#
9IO-J$ *$)
€¶GU׌}
)
y©4
!#$$$&$$$*$$ /H.?
e

ƒf‘’TŒNÑ}QƁ‚
*
‚ÌÛ×Ø
$
3
/Rššè~
?@*
‘’¸±ÖjA©}ë쑒
;]g!
+
Îb‘’éxv}~
8
x
$
FÑj‘’
JK
$
ÍÎj‘’ëì
+
²qj‘’º¶È†$
3?D$38D$?AB
‹·
$
PQj‘’$
8@A
‹Œ 
F8B
34
$
²qj‘’$
9A3
34
*
¯õ3/R
ššªš
?@*
‘’TŒ}Nў;É&Dcd
*
œÙ}‹Œ&Îb‘’BŠŒJÞ
$
‘’$
3?D$
38D
 
?AB
ÔÕ
+
½÷
8@A
 
F8B$
š‡/4
9A3+
ƒöÍÎj
?@*
‘’}œÖëì
*
OѸ
$
ꚚpþÖ®ÃÄ
$
OšpþÖ®‡‘’ëì?
ó•ˆ
$
PQj‘’éxFÑ
$
PQj‘’JKFÑ
’
$
•ˆj‘’ëì
$
PQj‘’º¶È†$
3?D$
38D$?AB
‹·
$
¯qj‘’$
8@A
‹Œ 
F8B
3
4
$
PQj
?@*
‘’$
9A3
34
$
¯õOÑPQ3
/R±
?@*
‘’TŒ}NÑ$½•2‘’&D
cd
$
%öPQ‘’éxv}
$
•ˆ‘’ëì
$
–É
ƒÂ©âØ3/ROѕT}Nѯíj ó
*

|f}~
#
, -!
$_ý£/û+
c
$_ý£$Uý
c
v
&
º
,9-c
ÈM
#
È
M&()±BÕ
$777#($#c
, * -!
KïM…†‚<
c
3/R€$ük}¨©‚
,V-c
K
ïb,
$77%$ $#7c
, ) -!
93$b,/
c
$,/ÔA
c
ÈO
,9-c
ÈM&()±

$ *$$## &c
, & -!
ªC¼
$
±Æ;
$

$
ç
c
ç£/R〱/÷XH]:;
Åk~;]}“”
,V-c
‡”$b,/c
$*$$)$*!#
)%c
, -!
ÀËÌ
c
3/ROѸTŒ €g!}¢£
,V-c
(K$
b-.
$7($*$!7#&*$c
, # -!
$%,A
c
Â1
,8-c*$$#*$7c
, % -!GV8SWSXK$ BV].O/I1$ 38PdI1KI1c@6KQI1MLILLMK/SRIM.OL.N
LKH1IRMOI1LQS-MK.1,V-c]OPP>IQK-UK.R9PQ$77%!**#*#7c
, ( -!
1öù
$
<¯º
c
É°Ó

‹Œ& ‘’ëì
,V-c
š†D
Ꚇ†~ƒ„
$*$$$*(!*##(c
, 7 -!

$
XD9
c
ª_m¯á†±H‘’ëì}FÑ€
,V-c
$%,~êT~-.
$*$$$!&#*(%c
,$-!

$
øÃm
$
CSº
$
ç
c
©‚ƒû¯á†ÅH@’ûH‘
’˜,œ&Dcd€‚
,V-c
z/$b
$*$$$$%!&#(c
1(A&(&$$ABBAF-.00/R@FK@0J:7*
!
!G&26+ 7*89:$/0$/8;$/U&6C <*#C2$($68$;I25&26 A2&3*/+&08$;BC&2*+*?*)&#&2*$ I25&26 *$$&#$ BC&2
!!,5NJCF.KC-!7N[@KC/R@# D.-./YIOPMJPM.6K-KM5.N!FC$/:& F*@&2*2+&+[PN.OPI1Q INMPO[PK1HYO.-PLLPQ [5dK1PHIO.1 1.O/IR
RKdPO-PRL?@*$ I1Q QKL-SLLKMLY.LLK[RP/P-JI1KL/c=@CDAG# ?@* -PRL+POP-SRMSOPQ &2 3&0/$$ I1Q YO.-PLLPQ +KMJ QKNPOP1M-.1-P14
MOIMK.1L.N-OSQPI1Q dK1PHIO4YO.-PLLPQ !cF*@&2*2+&+c9DDILLI5+ILSLPQ M./PILSOPMJPK1JK[KM.O5PNP-M.N?@* -PR+ B.P-JLM))*(
LMIK1K1H+ILSLPQ M..[LPOdPMJP/.OYJ.R.HK-IR-JI1HPLK1 IY.YM.LKL-PR+311P6K1 Z4]:DM.MK-OIMP.N?@* -PR+C:LMIK1K1HNR.+-5M./PMO5+ILSLPQ M.I1IR5WPKMLK/YI-M.1 -PR-5-RPcDJPRPdPR.O-.1MP1M.N3?D$38D$?AB$
8@A$ 9A3I1Q F8B+POP.[LPOdPQ IL+PRc9@JH0C# <./YIOPQ +KMJ MJP1PHIMKdP-.1MO.RHO.SY$ -OSQP!cF*@&2*2+&+IMIR-.1-P1MOI4
MK.1L-.SRQ .[dK.SLR5K1JK[KM?@* -PRYO.RKNPOIMK.1$ K1QS-P?@* -PRIY.YM.LKLI1Q -ISLP-PRIOPLMK1 8 YJILP$ +KMJ LKH1KNK-I1MQKNPO4
P1-PL!,g$c$c!cF*@&2*2+&+-.SRQ LKH1KNK-I1MR5K1-OPILPMJPRPdPRL.N3?D$ 38DI1Q ?AB!,g$c$ K1 MJPLSYPO1IMI1M.N-PR
-SRMSOPNRSKQ$ LKH1KNK-I1MR5QP-OPILPMJPRPdPR.N8@AI1Q MJP-.1MP1M.NF8B!,g$c$$ I1Q LKH1KNK-I1MR5K1-OPILPMJP-.1MP1M.N
9A3!Cg$c$c<./YIOPQ +KMJ MJP-OSQP!cF*@&2*2+&+HO.SY$ !cF*@&2*2+&+INMPO[PK1HdK1PHIO4YO.-PLLPQ -I1 LKH1KNK-I1MR5OPQS-P
-PRIY.YM.MK-OIMP$ -PR-5-RPIOPLM$ I-MKdKMKPL.N3?D$ 38D$ ?ABK1 MJPLSYPO1IMI1M.N-PR-SRMSOPNRSKQ !,g$c$$ I1Q OP/IOXI[R5
K1-OPILPMJPRPdPR.N8@AI1Q MJP-.1MP1M.NF8B$ [SMOPQS-PMJP-.1MP1M.N9A3K1 MJPLSYPO1IMI1M.N-PR-SRMSOPNRSKQc1ABK0HJ/AB#
ZK1PHIO4YO.-PLLPQ !cF*@&2*2+&+-I1 OPRPILPMJP-5M.M.6K-KM5.N?@* -PRc:ML/P-JI1KL//I5[POPRIMPQ M.MJPQP-OPILPK1 MJP.6KQIMKdP
QI/IHP.N?@* -PRL$ MJPOP[5OPQS-K1HMJP-PR-5-RPIOPLMI1Q IY.YM.LKLc
,X@E UAFGJ-!!FC$/:& F*@&2*2+&++ [PYO.-PLLPQ +KMJ dK1PHIO+ ?@* -PR+ IY.YM.LKL+ .6KQIMKdPQI/IHP
GA/#*Y_)(QK[K--)*&*(#

€-0
!
ƒ„„
#
.$%(.
v
)(
ºv
#
x
*$)
q
)
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)($:LLSP!#
9IO-J$ *$)