免费文献传递   相关文献

Studies on new hydrolysate of aconitine using HPLC-MSn and quantum chemistry calculation

高效液相色谱-质谱联用结合量子化学计算发现乌头碱一新水解产物



全 文 :•é_j{–
;
Y–·›0Ä·Z\]
.PR—˜™|ŠpmäÌ
ßä
#
¼:è
#
ž
#

#
Ÿ~
#
ÓԜ
!
!
ɸ8HKA¯
#
ɸ
PMMPMW
$
„;
%!

&
•é_j{–
;

Z

$.8B;<1
)
%
0Ä·Z\].PR—˜™[ŠpmäÌ

žŸ
..8B;<1
)
…
”ÿ›bõ›
!
Y–›»gZB}

ÿ›3ÆŔ
!
]
7OBc8ZX;OP?$5%
pH_
!
A*g[äÌ01EÉ.P

 ¡
.

.8B;<1
)
[-%R—˜™pmäã6ZgZ6ê
^NW
[\ÄÌ
!
<%01ê›p—˜È™
!
·Z\].P0•‡è
N

PL
Iã4}[äÌ&ì%>?g·1!
6‹<%6ZgZ6ê
^NW
[\ÄÌê
PL
Iœs[›p—˜È™

 t
.
p5R—˜™aÀpmãڛp—˜È™
!
<%%—˜™pm[=»Špm¼¢

$
…†‡
%!.8B;<1
)
&
·Z\]
&
—˜™
&
›p—˜È™
&
pm
$
8ˆ$f
%!WMPMPWWMMMP
$
–—Eq
%!
­æléö]stuv
$OM_MP_L_%&
­æi-s©ƒ
„F.ï
$_[O%
uv
$WMM_7LWWNMM%
$
‰‚>Š
%!
!
Ä3°
!
kn
!
vÏã½w
!@(&.$MPM% N^[ONXWM!
-;I$&.AH]$/\WXOg)(2
$
>Šš›
%!

!
Åw
!
‚&ƒ„…†êènrÇ{ܳnG¯
¥ƒ„
!-;I$&.2$)U()*2GI\PXOgG/I
!!
—˜™üZ
#
ç—
#
K—‡—˜¹rÇ[‚&
n›Ú6g|
!
]C¨rÇ[{Ü¡|r
!
—˜™ä
ãpm
!
ÍrÇn›®?

C¨rÇ{ܳnÈ
¥üm¡apaÀÖ¥
!
͗˜™
N
I_[íî
spm
!
&ìñ‚ș
!P^
I_[ñ‚îs
ÖE|(pm
!
&엘ș

è7«1(
P(
!
V
—˜™Hþpm
!
‚&pmäÌêñ‚ș
ї˜È™

*¤F]§¨rR—˜™pm¡|
‚aj£
!
¤7›
.8B;<1
)
[…”R—˜™p
mäÌrè+6ZgZê
^NW
Ñ
LNX
[\ÄÌ
!
>
ÿ›·Z\]3ÆÃ¥,
$RJ@%
…”]
7OBc8Z
X;OP?$5%
pH_EÉ%.P
!
(/Ô%äÌ0
1
!
<%—˜™pm[Š¼¢

!
—˜™pmäÌ[
.8B;<1
)
-%
![!
ÁÂ
!

=*&()2PPMM B;<1R@3=8+@
U&40

!
Z]n)c›à¯
#
ü8bÀ
#
lÊE
à
#
¸u0
#
ü7ÚÁJ-%à
#
.?Ò
$-1:%
M
Ö
!.8#(I02$2/)3(D=MgNMO
{–NE¹

—˜™
A“ö
$
r­ÇöãÌÜö-Ô²
!
Ãf
PPM[LO;
WMMWPW!

s_Nh%
íÃ
$

J0#(%
–$
%!
w
p
$
6‹.
%!
pêüFp

![#
oçös_[ÜÝ
!
93P#—˜™s.
:pr
!
ê|Ú¡úÑps_
!
]
PMM r

P #
¾#KÔ·[s_
!
¾X¾›Xi¥Û¡¥
!
Eêo
çös_

![$
{–»qG6‹…”
!=*&()2dT37=+17
PN
{–¸
$WgP IInPLM II!L
!
I%&
qÊj
MgPh
wp
$=%;
íÃ
$7%&
n›bõ›
M I)! [Lh =&OW I)!
^Mh =&LL I)! XMh =&[L I)! [Lh =&
qL
MgL IB
/I)
QP
&
¸u
WL r&
-%ùx
WOM )I
-%…}
$ u%;-1:&
NÐàqL
PM B/I)
QP
&
Ò\ðM
W[LgN V8$&
Ò\u
OLM r&
ȸÚ.M
^ MMM (S&
E·
PM
!
B&
h‰2r
6VI^MM i[MM
![%
-%0•
!
oçös_]j\[{–
#
Y–»

!

<1
gZqd
!
Yd
P
6î]YZ[7
š
!
äã%+6ZgZ
^NW!LMM!XM^!LNX!X^X
ê
)7«
W(
/Ô+6ZgZê
X^X!XM^!LMM
[äÌ
6îꗘ™
!
ñ‚ș
!
—˜È™


O(
1(—˜™pmäÌr6gÕÔ%äÌė˜
™
$PX;(U;UA%/$G/)2)(%!
ª6ZgZ6ê
LNX!
<%
¤7r6ZgZ6ê
LNX
[äÌêė˜™

f6
ZgZ6ê
^NW
\ÄÌ¡Y1(
!
ª™NY–dY
d
W!
]»gZB}ª
!
+6ZgZê
^NW!
ê
.(
u
[gZ
!
´rYgZAªEÉÆǼ½mg
$G/&0/) )54G(5 500/G$2/)%

!
&ì|FJã
rgZ
^LM!^PN!
¦5›ï
OW
Ñ
OW W
r›6Z
!
/__MW/
{
OX
ï{
PL
•
WMPP
÷
N
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&gOX! :004(!PL
=4*402! WMPP
/ė˜™âã̙[Y–,mÓë
!
i—˜È™
Y–,mÓë|Ç
^(

6Z·i—˜È™
LMM
j
q
!
e%
PN!
]01_<%\q—˜È™e
P
6Z
p[\ÄÌ

01ûd
O
d
P!
—˜™pmäÌ[
<1
»gZqd
=gP
NY–d
&7gW
NY–d
&gO
NY–d
&Rg^
NY–d

d
W!
›p—˜È™[
<1
P;^
NY–d
#
·Z\].P
#[!
.P…”ÑBâ
!
²è[¥,.Psü͛
?$400$)MO
|ewÚ[

.Pr@›3ÆÃ
$RJ@%
…”
!
>ÿ›%
X;OP?


E‘ø\6‹
ü]
7OBc8ZX;OP?$5%
pHªÚ[

#[#
›pIC[·Z\].P
!
¢Y–()*
Y
!
äÌr—˜È™01e|6Zp

6‹—˜
ș[01
!
6î]
PO!P^!N!PL
Ièj
s
!
Y‘bäã
6VI^ NW
\ÄÌ[¡|
!
ª>0
1\ê
PO;T.
i
P^;.
›pJF
PL;T.
i
N;.
›p
!
¥,_›pIC\‰üäÌg·r
?[IC
!
Üê›p*|ÚoÖ
!
o֔*E|
(K\ڜsäÌ
!
²6î.P%
PO;T.
i
P^;.
›p
!PL;T.
i
N;.
›p[oÖ}ќ
s}
W
 äÌ[ø\01Ñg·


PO;T.
i
P^;.
›p[oÖ}01Ë¡
g·ø\¾
!
01ã¾D
!_
i
P^
gšã
,
!
f
_
Ñ
PO
gšjlڊ
!
2GÍÈ;[ñ8
*01
$PO;P^;_;N;PL;PX%
ìG²
!

%|–8*
$_;PM;PW;PO%!
ÜC*<%
PO;T.
i
P^;.
›p[oÖ}01JY“Ô
!
]
§1rJ}Œ]
PO;T.
i
P^;.
›p[œs}
01Ë¡g·ø\¾
!
Z01ã¾D
!PX
i
PL
gšã,
!
f
PX
Ñ
P^
gšjlڊ
!
2
GÍÈ;[ñ8*
$PO;P^;_;N;PL;PX%
ì

!
|Ú%|ƒ8*
$PO;P^;PX%!
ÜC*
d
O!
—˜™pmK\Š¼¢
/MMPW/
{
OX
ï{
PL
•
WMPP
÷
N
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&gOX! :004(!PL
=4*402! WMPP
<%
PO;T.
i
P^;.
›p[œs}01`JY“
Ô
!
]§1r`J}Œ]
PL;T.
i
N;.
›p[
oÖ}01Ë¡Z…”.P¾
!
&ì>6g·1
!.JYQP XOWgWNP N PL;T.
i
N;.
›p[œ
s}01Ë¡g·ø\¾
!
&ì>6g·1!
.JYQP XOWgOW^ W^
 01Yd
^
.P0•¼
.
!
—˜È™›pJ*gã]
N
Ñ
PL
I
!
Ž*
gK\ê
PL
Iœs}Ñ
PL
oÖ}= äÌ

”Üê
PL
Iœs}[g·?
PL
oÖ}[g
·
!
ÜC*<%
6VI^NW
[\ÄÌ*gê
N!PL
I
›pœs}—˜È™

=gPO!P^
I›poÖ}—˜È™
& 7gPO!P^
I›pœs}—˜È™
&
gN!PL
I›poÖ}—˜È™
&RgN!PL
I›pœs}—˜È™

d
^!
›p—˜™*g01[·Z\].P0•
$
†,
m¡·Z\].P*ø\\ÄÌ01
!

g·>6[01
!
¤7ÿ›
RJ@
3ÆÃ[…”
!
*]r•[9/$´ª
!
³e.P·

<%—˜
ș›p[äÌ\ü
PL
œs}›p—˜È™
!
*
Y
!.8B;<1
)
0Ä·Z\].P[…”*›<%
¡í\ÄÌ[01
!
ì>c&ÿ›\]…”6g
ÕÔ
!
&ìC\ÄÌ
!
¨Æ¥,.P[0•


O(
r1(%—˜™[6mäÌė˜™
$6VILNX%!
ªpm
P^
I[ñ‚@¾
!
Ó*&ì¤
7/Ô[
6VI^NW
[\ÄÌ
!
<®—˜È™ûM›
p`*&ì›p—˜È™
!
ÜC<%—˜™pm[
W
»Š¼¢
!
Yd
O
—˜™[pmäÌqrj£
!

L;X(
r`
R5—˜™
#
r—˜™pm¾`äã%¡íäÌ
!
Ü
C™Ðƒ„—˜™âã̙pmäÌÑpmÓë
!
Gpm|An›ÑÇé[LM
!
=g./‰}
Z‡rÇ[{ܳnŒéÈ¥
!
µ•—rY·

$
‹ŒŽ
%
P(!
cÈw
!
Æɵ
!
‘Ê
!
‡
g
—˜™pmK\Óë[ƒ„
9(g
r­rÇ£¤
!WMM[!OW$WM%.WP^Og
W(!
.
!
ÆÑ!
õ†­
!
‡
g
Ëþ~—˜™ôDäÌ[ƒ„
9(F
Ç]]1
!WMMW!O[$PM%.[NPg
O(!
c$
!
Ì7
!
tǥ
g
—˜™pmäÌ[ƒ„
9(F
6‹]
!WMM_!O[$PM%.RMX[g
^(!
LǙ
!
LS
!
ÆÑ!
‡
g
•é_j{–
;
Y–·›”ƒ„
—˜™[pmäÌ
9(g
r­ŠÇ£¤
!WMM[!PX$^%. OMOg
L(!
ÍÀ²
!
LǙ
!
ÆÑ!
‡
g.8B;<1
)
”ƒ„5—˜™]pr
[\]}9(g
øùr,Çh]]1
! WMM[! OM$N%. LO_g
X(!
LǙ
!
kv
!
$‡Å
!
‡
g.8B;-1:;<1
)
”ƒ„r—˜™
]pr[\]}9(g
r­ŠÇ£¤
! WMMN! P[$W%. PLOg
=DIH0AKBCCAVEFHGB1FK/DABM/UBC0D0CAIK0CL 3P;2->=
C
/CHXI/CDI.UEA.0KDGF U/1UI1/D0BC
@=>8()*! B:,c/)**$)*! ?,=>94)! B:J(! RT>?B)*! e:=Tc$)H$)*
!
$9-(:(,; =,(>-5)(!7&3%+(,-)-4-.(*(,-! 9-(:(,; PMMPMW! %+(,0%
6OKDG/UD( 8O\AUD0SA. @/ 0245A 2#( )(E #A5%/&A0$2( /6$G/)2)( 40)* .8B;<1
)
$)5 ]4$)24I G#(I02%A
G$&G4&$2/)g>ADEBH. @#(.8BI(2#/5 E$0$UU&(5 ) *%$5()2(&42/) U%/*%$I$)5 2#(I$000U(G2%/I(2%AE$0) U/02D(/) I/5(g
?(/I(2%(0/62#(U/00b&(#A5%/&A0$2(0E(%(/U2I`(5 $2RJ@ZX;OP?$5% &(D(&g:AKI1D. @#()(E#A5%/&A0$2(E$06/4)5 $)5 20U%/2/;
)$2(5 I/&(G4&$%/)0E$0$26VI^NWg@#(]4$)24IG#(I02%AG$&G4&$2/) %(04&200#/E2#$22#(U%/54G2/6(&I)$2/) %($2/)0$2N $)5
PL */22#(&/E(02()(%*AG/)6/%I$2/)F@#(G/IU/4)5 $26VI^NW E$05(G&4G(5 2/b(2#(#A5%/&A0$2(/6G$%b/)A$2PLF2BCU1IK0BC.
R(&A5%$2/) $G/))(E$05(2(G2(5 6/%2#(6%022I($)5 2#()(E#A5%5A00U$2#E$A0/6$G/)2)() E$2(%E(%(5(54G(5F
A^F VBGHK(!.8B;<1
)
& ]4$)24IG#(I02%AG$&G4&$2/)& $G/)2)(&#A5%/&A00$G/))(& #A5%/&A00
HB0.!+_%#)RU\U..#+!!!&!*
$
$Q
!
¥Z¦
%
/PMPW/
{
OX
ï{
PL
•
WMPP
÷
N
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&gOX! :004(!PL
=4*402! WMPP