免费文献传递   相关文献

Effect of parthenolide on leukemia K562 cells and its leukemia stem cells

小白菊内酯对白血病K562细胞及其干细胞的作用



全 文 :?¸)=:¸^_
P#+
[\«6³[\„?‡
Üb

JÝ
ÞÝ

ßàá!
8âã
+
!K
^õ³× XY¹×» ¹×âãÂð Z[øò¼\]^½¾àáâãä
Z[õ$* +K ÕÖ_`¹×» Âa¼ÍbXYÎ熴#Þ7ßàáâãä $ ÕÖ + ‡| ,! Qˆ # /0?¸)=: !ABC@?S2/WTVS$ EOL ¸^_ P#+ [\«6¸^_³[!WSX\S0TBJ@S0.SWJ$ L8< „ ?‡ ) ‰Š # ð¸^_ P#+ [\DO[$ öSUT !9OO ÿ”ÙÚÛ[\S™( $422S7T2 . =E: (”ÙÚÛ[\Dƒ * Ÿø[\)[Ú L8< —Ÿ  $ ޝßuå³6•¬Ù[Ú[\„ÒKàþýS™‡Æ ) ‹Œ #EOL Ž­WÊ P#+ [\„ S™ $+&$&($%+ ? „ :< $ D %K$(K#%$*K&+ ! 0/W%L e )
!
0/W%L
e
EOL
¥ƒ
&( ?P#+ [\„DƒHD !&*K# jKi!%K(( j+K+i)
…¿³[\UV73‘
$P#+
[\$
L8<
Ž
!m
e

[\„DƒHD
!+K#) j&K&i!%K j&K&%i) P#+
[$
L8<
„—Ÿ £ÿÏSú
EúiÏ ! ! 0/W%L e EOL ¥ƒ L8<
Ÿ
 ASú

T
) K k&K
!
0/W%L
e
EOL
Ž­WÊ
P#+
[\„³6•¬‡Æ
³6BEF +&Ki k(*K+i* k ! 0/W% L e EOL K¥ƒ
Ÿ(
P#+
[\„³6•¬BSú
Ki kKi) ‹ # ?¸)=:tWÊ P#+ [\«6³[\„S™( 
Àæ6Dƒ
)
+
Ž
,!
¸^_³[*
?¸)=:
*
³6•¬
*

+
‘y)(
,!+$$*5$)5+
+
’“†Q
,!
€7ËÒÓ&/0ÝÞß
!$*#>Yb4$)&*

,ðª#–§C‡M6ªµ!ó
!
78*ý-.

¥†
ûÄ
!$($*
€7Ëþ,òó×/0ªµ!ó
!
¡OF

¥†û
Ä
!H8PaPO5$($+
+
 f”
,!
!
5‰½
$OSW# !$*)(*$(+$ aB7#!$*)(*$(+$
G50BTW#,ST?XWBT3WZXKSVXK.2
+
”•–
,!
iZ
$
0ƒ/0Ï
$G50BTW# 6T13WZXKSVXK.2
!!
¸^_³[!WSX\S0TBJ@S0.SWJ$ L8<
=C
ô,>†^³[\s:¥ocñG„÷„†^[
\tG†½
$
6ËoUV73D
m
e
m
*L8<
JÒKàþ‡Æý[KS™‡Æ
ûeÓ»Z,ðý†c‹!g
JÔT„‚Ÿ(
8
‡oGŠý†Š/‚Ÿ·½†¬D¾b„# C +5), ) ?¸)=: !ABC@?S2/WTVS EOL
+2ð,Š
€)„ç«(¬
¾ôT×øû=:G¿ð
Õ
½/0by?¸)=:JjT„»QR(
t æ…VZ & ©Z & b(8R & ¸^_éQR[ \Dƒ
À6ä»Z,ðJS›ÄW
+&5,
)
/
0z{
EOL
¸^_
P#+
[\«6
L8<
„]E
ÄW
)
!
š›–lÙ
Y!
C=–@A
!
?¸)=:
!M:R9RL
LM
*
>E9:#&! Ú% HT^./ LM * þ‚?N^L ! ¡O ¡Š‚ð&(JKØÙLM * ޝßuå !&$$Ú%
49>G8LM
*EG.6
7·„G
»’
Ȑ
&a:O<
7·„G»’
Ȑ
&
G7·„G»’
»êí%Ò
LM
*
EG
7·„G»’
»ê%Ò
SMT/J.TS2.S
L
M
*EG
7·„G»’
:DH$G7·„G»’
:DH$a:O<
7·„G»’
:DH
ý
EG.6
7·„G
»’
:DH
D
LMÿ©
*422S7T2
.
=E:
Dƒ[
ÚC=E%Ò
SMT/J.TS2.S
LM
)
ÒÅõ7@
!MT/5
OS\ E/,SC,BdSQ*
Ÿø[\@
!a<9 MS.\0B25 ŽŽ~ !RW60AXJ:Q() Y! O[\ý[\s !P#+ [\:¡OF- !;MŸ
)
[\\ôŸ
i
þ‚N^L
„
>E9:#& sd
Ž )% li+
ýl‚µ
¶·s
ÃB‚‘w[\‡ôC ) Y&!P#+ [\S™(„ÚÛ !P#+ [! g

ñ
=0L

*#
ôs.
Ҏ¡¢iτ
EOL s +&&(%+ ? / 9OO Ù +#, [Ú ) ÒÅõ7 @ô % 20
¥ÚqØÏ
K

]x[\S™WÊH !T2?T^T@T/2 CB@S ý×BWÊiÏ !:<
)
Y`!422S7T2
.
=E:
¼7·[Ú
P#+
[\„Dƒ
!

EOL
¥ƒ„
P#+
[EM8 ô’
5«[D
g # ñ =0L
Ҏ
a:O<
7·„
422S7T2

E: óò*Ø(”
Ÿø[\@[Ú,>
&
gwDƒ
%*+%
u
)
Hu
+
w
+ n o !!!!!! ! ! ! ! !!!!!! ! ! ! ! ]/W-)$ :JJXS!+ YB2XBC6$ +
ý‹wDƒ[+%,
)
Y$!422S7T2
.7·[Ú
m
e
[\„D
ƒ
!

EOL
¥ƒ„
P#+
[EM8 ô’
5«[
\D
g # ñ =0L
Ҏ
ý
Góò*ØV
EM8 ô’
ªÉô…¿r¡d

ÎҎ
a:O<
7·„
422S7T2
.
óò*Ø(” 0T2
[\ªÉ
$a<9

m
e
[$„

!422S7T2
.
m

[)
ð
EG.6$G7
·„G»’
:DH
D¢Ç`
[Úª¾ ) º ) YU!L8< —Ÿ [Ú ! r³`« EOL ¥ ƒ„ P#+ [
5«[\D
g # ñ =0L
v[Ú
yíҎ
óò
*ØV
+ 0T2EM8
ô’
ªÉô EM8
a<9 [ Ú +(, ) ð EG.6EGa:O< 7·„G»’ :DH D¢ Ç`
[Úª¾
)
º
)
Y%!
ޝßuå×Qês[Ú³6•¬
!
Ã
B‚‘w„
P#+
[ õ g
)
ñ
=0L
\ôŸ
+i ?N^L &+ 00/W%L e F5 ¢œDá & ! 0/W% L e
5
‹®°ý
K*i ޝßuå„×Qês  ) \ô +& ô[\s.
vôÒޝ
iÏD
K+&
!
0/W%L
e
„
EOL$
vñiÏB
)
ñ¾ô
) )% l i+
«(ý‚ϵ¶·s
V
ŽŽ~·]B³6•¬„BßÀz{6•
Þ
ðFô &
ñ[\„[\PD

ñ³6
+(5*,
)
!
ª¾
)
º
) P#+
[\J
%K ! 0/W%L e EOL K¥ƒ &( ?$ r³ $ ‡+T(”ªþ]B([ $ õ g$ ) ñ =0L \ô $K*i ޝßuå×Q êss $ V) ŽŽ~·]B³6Býz {³6•Þ +(5*, ) Y[! Ø]‘ ! ] §›…ž‡ $ Lj0 -. ) = ‡ 8E88$K$ Ø]ó¶˜cØ]‘ $ <òíBno =‡ ( [ * —˜‘=‡;‹½{ ) ! …ž Y!EOL WÊ P#+ [\„S™( !EOL ÉiÏ ÿ¤NWÊ P#+ [\S™ $+&$&($%+ ? „ :< $  D %K$(K#%$*K&+ ! 0/W%L e ! f $)h$K$) Y!EOL  P#+ [\«6 L8< Ž[\„Dƒæ ÄW P#+ [\J
!
0/W%L
e
EOL
¥ƒ
&( ?422S7T2 ]=E: (”Ž.Dƒ[\¶ŽSú
[
\jDƒH
!
gwDƒH
m
‹wDƒH

j
`[\Âú
%K( Tý #K) T
[\Dƒðgw
DƒDç
!
-
)hK$*
…¿
ý
UV
!!
f
!EOL

P#+
[\S™„WÊ?‡
7·‘
$P#+
[\$
L8<
Ž
!m
e

[
„Dƒ !422S7T2 ] m [\Sú #*K( T ý (K T ! - )hK)
Â.
EOL
tæ
P#+
[\«6¸^_³[\Dƒ
)
-
!EOL
æ/
P#+
[\«6³[\„
DƒH
!
Lj0#f)
EOL
=
!
0/W%L
e
P#+
[=i
m
e
[=i
K&# jK) K) jK+% &*K# jK +K#) j&K&
%K(( j+K+

%K j&K&% !! b # –` !
!
0/W%L
e

ÿj

)hK)
Y&!EOL

P#+
[$
m
e
m
[
\—Ÿ „…†
!$$$
!
0/W%L
e
EOL

&( ?
/
$ P#+
[\$
m
$ m
$ m
e
ð«
m
e
m
[!L8<
„—
ÿ~
!
Ÿ 

í¡¢ùÏNSú
ESú„?ÏÀ ¡Ž­ * úiÏ ! ! 0/W%L e EOL ¥ƒ/AŽ­ Sú ! - +)hK)
Â.
EOL

P#+
[\² „⦠= MŒ[\«¸^_³ = [\íJ]EÄ W
EÓÓ[Ù#J
L8< 6 L8< +z†46— Ÿ Âú ) Y`!EOL WÊ P#+ [\„³6•¬‡Æ ! K k&
!
0/W%L
e
„
EOL
;\?‡tŽ­WÊ
P#+
[\³6„•¬
³6•¬HEFt‰ (*K#i ! - ) )hK ) k
!
0/W%L
e
EOL
K¥ƒ
&( ? Ÿ( P#+ [\„³6•¬B A¶ŽSú
7út‰`„
K
T
!
-
) )
[
\³6j?
&
<¬[\Bj…
}ÎÉì•

s%ò+˜ã¾SF
!
f
+ )
!…žˆ¶
EOL

P#+
[$JÒKàþýúS™ê‡
„[!L8<
Jjф]EÄW
)
%++% u ) Hu + w + n o !!!!!! ! ! ! ! !!!!!! ! ! ! ! ]/W-) :JJXS!+
YB2XBC6 + -+!EOL  P#+ [\$ L8< —Ÿ „…† !
Lj0$#f) i
EOL=
!
0/W%L
e
m
m
m
m
m
e
m
e
m
&K)% jK# &K% jK+ +K)) jK )K*) jK#% K& jK+#

+K+% jK#& &K&) jK*
K&) jK+ +K jK# K+% jK
#K% jK%

+K#) jK(% +K)% jK#
#K)% jK&

K) jK) )(K%) jK#&
+
)K* jK+ + +*K) jK*+
+
)K() j)K))
+
++K& j+K&# + !! b # –` !
!
0/W%L
e

ÿj

)hK + )hK! - ) ¢ ) - )!EOL  P#+ [\³6•¬„…† !
Lj0#f) ¥ƒ iÏ = ! 0/W%L e ³6B =g
)
EOL
;\?‡
+%K#% j+K+ K +#K#% j&K*)
K +K j)K +K
)K)) jK)
+
&K )K jK + EOL K¥ƒ +K j&K( K +K j%K*
%K +K j&K*) $K$ +K j&K K$ )$K j*K$%

4K
`
* MK+
!
0/W%L
e
EOL
;\?‡
*
!
0/W%L
e
EOL
K¥ƒ
)
f
+!EOL
?‡/
P#+
[\„³6•Þ
! g &! š´ L8< ‚ðˏ„áŽ/0’! L8< –¸^ _b‚ & ¾bý!,˜p΀ +(, ) H؄GŠ, ð€G(Žo[\Vw„¸^_â¦
=
MŒ[
†¥o[\Vw«1 !H


L8<
?‡w6
JK
) L8<
Ë´„‚ðˏ
t46žHØG Š,ðs†c‹„]E?‡†Ÿ(·½
}¸^
_„!,«¾b
+5)(,
)
Õn½%=×ÅK
CYñ,ðs®H½LJ
L8< S 4M< tìê„W Ê= & Oè L8< -§“ý6S™GkAHE V5ꐓ„,ðé
ðwEüLJ
L8<
½‰»#
J¸^_„ß„
+5, ) /0’! EOL
¡£WÊ
P#+
[\„S™ý
æ6Dƒ
$
†û‡jÑNæ
P#+
[\$
L8<
Ž
!m
e

[\Dƒ
)
¡¢iÏ
EOL

/
$P#+
[\$
L8m
e
m

„—
Ÿ J1Sú
’! EOL  P#+ [\²
L8<
«6Gø„¸^_â¦
=
MŒ[\íJ]EÄ
W
EG¬¡¸^_[\ EOL „›8«úô L8<EOL
[ِó#J
L8<$
6+Ÿ·½†46
—Ÿ J1Sú
)
ޝßuå×Qê³6•¬
!!+ê×
[Ú[\ÒKàþýS™ê‡„JÄlÙ
Fw s¥y„gw³6:G„÷j‹ & S™‡ÆJ K„[\•¬
†‘ws„‹w³6Aç«:³
=
[\•¬
€J„+³[\„ÒKàþ‡ÆýS ™ê‡ +(5*, ) /0
K k& ! 0/W%L e „ EOL ; \?‡tŽ­WÊ P#+ [\³6„•¬
†‡
k
!
0/W%L
e
„
EOL
K¥ƒ
Ÿ( P#+ [\„ ³6•¬BA¶ŽSú
%+:ô
EOL
K¥ƒLJ
øj›8„G¬¡/¸^_[ Ÿ( P#+ [ \$ L8< —B S҆4³6•¬B Sú ) Â. EOL t]E P#+ [\$JÒKàþýúS ™ê‡„ L8< [\²
EÓ+J6
EOL
J»
„
L8<
+Ÿ·½
)
Â.
EOL

L8<
Jjúj
k„]EÄW
EÀ¡‡ªlLJ ) J˜ EOL ¸ ^_³[\„;\?‡«6“´Ê
J.Õ
&
Ü
G
L8<
/˜ã¾áŽ/0
)
+
—˜™š
,
+ ,!Y/CVB2 %++%
u
)
Hu
+
w
+ n o !!!!!! ! ! ! ! !!!!!! ! ! ! ! ]/W-)$ :JJXS!+ YB2XBC6$ +
@X0/CJ+Y,K+ + ,!>BdB2VT]$ GJ@C/dbKGCBVT.B@T/2 /UWSX\S0TBJ@S0.SWJBJB
2S,D/BW/U@?SCBA6T2 WSX\S0TB+Y,KSJ +# +
!+# )&K + ) ,!VSaTDXSTCSV/5E/2@SJLL ET2@B/9< RWTdSTCBL< S@BWKFS5
@SC0T2B@T/2 /UE5DW6./AC/@ST2 9F>5CSWB@SV AC/@ST2 ^CSBJ@
.B2.SCCSJTJ@B2.SAC/@ST2$ B2V WX2D5CSJTJ@B2.SAC/@ST2 S7ACSJJT/2
T2 WSX\S0T.J@S0.SWJ/UB.X@S06SW/TV WSX\S0TB+Y,K<6@/0S@C6
M+ & ,!P2TD?@F[KaSdSCUS,# ;B@EC/V >SA ** +# +%K
+ ,!b?B2D8 LT2 b; _B2DB2V JXJ@BT2SV Y;PB.@TdB@T/2 ./2@CT^X@S@/@?SJS2JT@TZB@T/2 SUS.@
/UABC@?S2/WTVS@/O;a53BWA?B45T2VX.SV BA/A@/JTJT2 ?X0B2
.B2.SC.SWJ+Y,K+ # ,![STIL 8X IQ _B/QYKMT/W/DT.BWUSB@XCS/U?X0B2 O5B.@T5
dB@SV \TWSC.SWJ+Y,KSJ*** !+# K
+ % ,![TW\T2J>< PX@Z2SCM< OCX/2D9 S@BWK42BW6JTJ/UCBVTB5 @T/25T2VX.SV BA/A@/JTJT2 ?X0B2 W60A?/.6@SJ# aW/,.6@/0S@C6X5 JT2D422S7T2 ]B2V AC/ATVTX0T/VTVSdSCJXJ@?S2SX@CBW./0S@ BJJB6+Y,K<6@/0S@C6 ++$ &(!# &K + ( ,! iZ $  « $ « $ é K ¸^_ P#+=4F9 [\!,–¸^ _³[\«!,i¸-‰„˜p +Y,K $5-23 $+* (*!+# %&K + * ,!806@? 9Y PCBJ/dJ\TJG 8X@/2 ]> S@BWKO?SVCXDSUWX7
AC/@ST2 E5DW6./AC/@ST2 BVVT@T/2BW6 AC/@S.@J VCXD5CSJTJ@B2@
@X0/C.SWJUC/00XW@TAWSU/C0J/U.BJABJS5VSAS2VS2@BA/A@/JTJ
+Y,KEC/;B@W4.BV 8.T **( *!+# %+&K +,!G6WSCT.? Y;K8XCdTdBW/U@?SUT@SJ@# @?SCBASX@T.CSJTJ@B2.SB2V B2DT/DS2SJTJ+Y,K+## +()*K
+,!
ÂZ
ÈT
¿á
é K QR³[\„!,«6‰Š•– +Y,K %þ,–òó23
+# +!# (#(K
)II>QA?IJ,DAB>@?.-E>?@.>FV>+-, ]#+ Q>.H,@E-AH.>FV>+-, HA>+Q>.H
_:YXB2

$
8 ;`YT2D [G:IXWBT

!
8I:YTB2D/2D + !KF&C2&(2+1/#(/42>/6,&%!,/#,/ !,-22%24>/6,#/ F&#.-2 :#;/0(+ H/+F&C2&(2+24)/,%#,&%!(6+42?/GW3024*� )2;#,/ F&#.-2 %) 1-#&*
+K)/R#3 :#2# >/6,&%12%/3/ 7/9#3 1-#&
+3KHAD,QA,!5K_>QA-O># O/T2dSJ@TDB@S@?ST2?T^T@/C6B2V BA/A@/JTJ5T2VX.T2DSUS.@J/UABC@?S2/WTVS!EOL /2 ?X0B2 WSX\S0TB
P#+ .SWJB2V T@JWSX\S0TBJ@S0.SWJ!L8AB?E# 9OOBJJB6,BJXJSV @/VS@S.@@?SAC/WTUSCB@T2DB.@TdT@6/UP#+ .SWJ$ B2V @?S
.SWXWBCBA/A@/JTJ,BJBJJB6SV ,T@? 422S7T2 ]=E:V/X^WSJ@BT2T2DKaW/,.6@/0S@C6!a<9 ,BJS0AW/6SV @/VS@SC0T2S@?SCSWB@TdSAC/5
A/C@T/2 /UL8!HF.A# M6XJS/U9OOBJJB6 ,SU/X2V EOL?BV JTD2TUT.B2@T2?T^T@/C6SUS.@/2 @?SAC/WTUSCB@T/2 /UP#+ .SWJ @?S
i T2?T^T@/C6./2.S2@CB@T/2 !:<
dBWXSJ,SCS%K(K#%*K&+
!
0/W%L
e
U/C+& &( B2V %+ ? CSJAS.@TdSW6K4U@SCBV0T2TJ@CB@T/2
,T@?
!
0/W%L
e
B2V ! 0/W%L e EOL @?SBA/A@/@T.CB@S/UP#+ .SWJ,BJ!&*K# jKi B2V !%K(( j+K+i B2V !+K#) j&K&i B2V !%K j&K&%i T2 L<85WT\S!m
e
.SWJT2 P#+ .SWA/AXWB@T/2$ CSJAS.@TdSW6K4JWTD?@W6T25
.CSBJS/UCSWB@TdS./2@S2@/UL8@SV .SWJKO?S0S@?6W.SWXW/JS./W/265U/C0T2DX2T@JBJJB6J?/,SV B+&Ki @/(*K+i VS.CSBJST2 @?S,T@? K ! 0/W%L e @/&K
!
0/W%L
e
EOL$ B2V @?S.SWJ,SCSACS5@CSB@SV ,T@?
!
0/W%L
e
@/
!
0/W%L
e
EOLU/C&( ?K/?@Q.FH-?@# EOLS0T2S2@W6T2?T^T@JAC/WTUSCB@T/2 /UP#+
.SWJB2V L8+]>C \?DEH,!WSX\S0TBJ@S0.SWJ* ABC@?S2/WTVS* ./W/26U/C0B@T/2* BA/A@/JTJ
E?-# (a`U[NQ_Q++(((&
+
›œ-0
!
ÅÆÆ
,
%+++%
u
)
Hu
+
w
+ n o !!!!!! ! ! ! ! !!!!!! ! ! ! ! ]/W-)$ :JJXS!+ YB2XBC6$ +

  鄂ICP备06018747号 Copyright @ 2017
  植物通 All Rights Reserved
  Email:23198511@qq.com
回顶部
51La