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期 刊 ：中国中药杂志 2007年 32卷 12期 页码：1161.

关键词：白芍；PFA；HPLC；色谱指纹图谱；

Keywords:Principal Factor Analysis, Paeonia lactiflora, chromatographic fingerprints,

摘 要 ：目的：探讨如何应用HPLC指纹图谱的计量技术对白芍炒制过程及白芍饮片进行质量控制。方法：中试生产研制白芍饮片,HPLC,PFA(principal factor analysis)。结果：获得了较稳定的白芍饮片HPLC图谱；在不同产地和不同饮片品种图谱的10个特征峰中,通过各个峰之间的联带变化在不同饮片中的分布规律,运用PFA的信息处理技术,抽取出能反映对HPLC谱中峰群有影响的2个公共因子,其累计贡献率为64.8%,根据各峰对因子的载荷和communality筛选出的7个峰可作为主要反映图谱形状变化的目标峰群。结论：HPLC指纹图谱和PFA可用于白芍的炒制工艺过程和饮片的质量控制。

Abstract:Objective: To explore the utility of Principal Factor Analysis (PFA) in chromatographic data for quality control. Method: Chromatographic fingerprints of processed root pieces of Paeonia lactiflora were determined by HPLC, the PFA was used for data processing. Result: The quantitative differences among different growing areas and different processing batches were found with the method. Conclusion: The method could be used in quality control for monitoring between-atch products of traditional Chinese pharmaceutical process.

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