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期 刊 ：中国中药杂志 2007年 32卷 10期 页码：965.

关键词：仙灵强骨口服液；骨质疏松症；卵巢切除；

Keywords:Xianling Qianggu koufuye, postmenopausal osteoporosis, ovariectomy,

摘 要 ：目的：观察仙灵强骨口服液对去卵巢大鼠骨质疏松症的治疗作用。方法：采用12月龄SD雌性大鼠,行双侧卵巢切除术,随机分为强骨口服液高、中、低剂量组(6,3,1.5 g·kg^-1))和阳性药(尼尔雌醇)组、模型组、假手术组。术后45 d开始给药,给药90 d后取出大鼠股骨及第四腰椎骨进行股骨骨形态计量学测定、股骨骨密度测量、股骨三点弯曲实验及椎骨压缩实验,同时测定血清中碱性磷酸酶(ALP)、抗酒石酸酸性磷酸酶(StrACP)水平。结果：仙灵强骨口服液可显著增加骨密度、降低血清StrACP水平,明显提高骨最大应力、弹性模量、刚度水平,同时对股骨形态计量学有改善作用。结论：仙灵强骨口服液对去卵巢大鼠的骨质疏松症有治疗作用。

Abstract:Objective: To study the curative effects of Xianling Qianggu koufuye (XLQG) on postmenopausal osteoporosis in ovariectomized female rats. Method: Sixty female Sprague-dawley rats aged 12-months were used, 50 of them were ovariectomized and randomly divided into 5 groups: ovariectomized (OVX), OVX+ Nylestriol, OVX+XLQG (high dose, middle dose, low dose), and the others were sham-operated group. Rats were treated with drugs starting at the 45 day after the operation for 90 days. Double in vivo fluorochrome labeling was administered to all rats. At the end-point of study, the blood was collected to detecte the contents of ALP and StrACP in serum, and the fourth lumar vertebra (LV4) and femur bone sections were cut and stained for bone histomorphometric analyses, biomechanical analyses and BMP analyses. Result: XLQGKFY decreased greatly the StrACP content, increased BMP and bone stiffness, and improved the bone biomechanical property. Conclusion: Xianling Qianggu koufuye has a curative effect on postmenopausal osteoporosis, which provides for clinical use.

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