---

期 刊 ：中国中药杂志 2006年 31卷 03期 页码：232.

关键词：筋骨片；骨性关节炎；木瓜蛋白酶；丙二醛；

Keywords:Jingu tablet, osteoarthritis, papain, MDA,

摘 要 ：目的：观察筋骨片对骨性关节炎（OA）病变发生发展及其修复作用的影响。方法：将4％的木瓜蛋白酶与0.3 mol·L-1的半胱氨酸混悬液注入大鼠膝关节进行造模,分别给予蒸馏水、阳性对照药骨刺宁胶囊以及筋骨片药液灌胃治疗。连续给药4周后处死动物,进行各项指标的测定。结果：筋骨片对模型大鼠膝关节活动范围有明显的改善作用,各剂量组与模型组比较均有显著性差异;筋骨片各剂量组对模型大鼠膝关节滑膜厚度肿胀有抑制作用,能较好缓解OA的炎性症状,对制动后膝关节内滑膜及软骨的病理变化也有显著的改善作用。筋骨片各剂量组还能明显降低滑膜组织中的丙二醛（MDA）,减轻细胞损伤程度。结论：筋骨片减轻关节软骨的退变,明显抑制滑膜组织的炎症,减轻细胞的损伤程度,因而对OA具有一定的治疗效果。

Abstract:Objective: To observe the influence of Jingu tablet(JGT) on the develop ment and repair of osteoarthritis(OA).Method: The admixture of 4% papain and 0.3 mol·L~(-1) cysteine was injected into the rat‘s knee joint to make the model of rat OA,and distilled water,Gucining Capsule and JGT was given ig simultaneously to treat for 4 weeks in succession,and then animals were killed to measure every index.Result: JGT could obviously improve the scope of activities of knee joint.There were significant differences between every dosage group and model group.In every dosage group,JGT could suppress the swelling of thickness of slippery membrane of joint,alleviate the inflammation symptoms of OA and obviouslical improve the pathologicol changes of slippery membrane and cartilage.JGT could also obviously reduce the content of MDA of slippery membrane and lighten the degree of cell damage. Conclusion: JGT can lighten the retrograde affection of joint cartilage,obviously suppress the slippery membrane‘s inflammation and alleviate the scathing degree of cell.Therefore JGT has definite remedial effect to OA.

---