Abstract:Objective: To study the chemical constituents from leaves of Sapium sebiferum. Method: The compounds were isolated and purified by silic gel column chromatography and preparative HPLC. The structures were identified by various spectral evidence. Result: Nine compounds were obtained and they were shikimic acid (1), kaempferol (2),quercetin (3),isoquercein (4),hyperin (5),kaempferol-3-O-β-D-glucopyranoside (6),kaempferol-3-O-β-D-glueopyranoside (7),gallic acid (8), rutin (9). Conclusion: Compounds 1, 5, 6 and 7 are isolated from this genus for the first time and
compound 9 is isolated from this plant for the first time.