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期 刊 ：中国中药杂志 2008年 33卷 23期 页码：0.

关键词：青叶胆；酮；木脂素；三萜；

Keywords:Swertia mileensis, xanthones, lignans, triterpenoids,

摘 要 ：目的：对龙胆科獐牙菜属植物青叶胆Swertia mileensis的干燥全草进行化学成分研究。方法：青叶胆的干燥全草用50%乙醇提取，依次用石油醚、氯仿、正丁醇萃取，对氯仿部分采用各种柱色谱进行分离纯化，通过波谱数据分析进行结构鉴定。结果：从氯仿部分分离鉴定了12个化合物，其中8个酮，1，5，8-三羟基-3-甲氧基酮(1)，1-羟基-2，3，5，7- 四甲氧基酮(2)，1-羟基-3，5，8-三甲氧基酮(3)，1-羟基-2，3，4，6-四甲氧基酮(4)，1-羟基-2，3，4，7-四甲氧基酮(5)，1，8-二羟基3，5-二甲氧基酮(6)，1，7-二羟基-3，8-二甲氧基酮(7)，1，3，5，8-四羟基酮(8)，1个木脂素，balanophonin(9)，3个三萜，齐墩果酸(10)，山楂酸(11)，苏门树脂酸(12)。结论：化合物1，3，7～9，11，12为首次从青叶胆中分离得到。

Abstract:Objective: To study the chemical constituents of Swertia mileensis. Method: The air-dried whole plants of S. mileensis were extracted with 50% EtOH. The EtOH extract was suspended in H2O and extracted with petroleum ether, CHCl3 and n-BuOH successively. The compounds were isolated and purified by column chromatography from the CHCl3 fraction, and identified based on spectral analyses (MS, 1H-NMR, 13C-NMR). Result: Twelve compounds were isolated from S. mileensis, and were elucidated as 1, 5, 8- trihydroxy-3-methoxyxanthone (1), 1-hydroxyl-2, 3, 5, 7-tetramethoxyxanthone (2), 1-hydroxyl-3, 5, 8-trimethoxyxanthone (3), 1-hydroxyl-2, 3, 4, 6-tetramethoxyxanthone (4), 1-hydroxyl-2, 3, 4, 7-tetramethoxyxanthone (5), 1, 8-dihydroxy-3, 5-dimethoxyxanthone (6), 1, 7-dihydroxy-3, 8-dimethoxyxanthone (7), 1, 3, 5, 8-tetrahydroxyxanthone (8), balanophonin (9), oleanolic acid (10), maslinic acid (11), sumaresinolic acid (12). Conclusion: Compounds 1, 3, 7-9, 11 and 12 were obtained from S. mileensis for the first time.

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