Abstract:The changes of liver function and malondialdehyde (MDA) and glutathione (GSH) were studied in ratsintoxicated with azathioprine (Aza) 15mg/(kg·d) and in rats treated with Aza mixed Salviae 8g/(kg·d)- The resultsshowed that in the Aza group, the levels of ALT, AKP, MDA increased and GSH decreased significantly in week Iand week 2. But in the Salviae group the levels of ALT, AKP, MDA decreased and GSH increased significantly,approaching the normal levels. It follows that Salviae has protective effects on Aza hepatotoxicity in rats.