Abstract:The experiment results showed that Salvia miltiorrhiza(SMB)had a protective effect on the isolated perfused liver injured by CCl_4 of rats, made the activity of GPT in perfusate of SMB group lower than that of intoxicated group, and relieve the hepato-pathohistologic lesions of SMB group as compared to the intoxicated group. SMB had no significant effects on both the activities of SGPT in vitro and the portal vein of rats.