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期 刊 ：中国中药杂志 1991年 16卷 06期 页码：370.

关键词：β-肾上腺素受体；耐受性；异丙肾上腺素；甘草；

Keywords:β-adrenoceptor, desensitization, isoprenaline, Gly yrrhiza uralensis,

摘 要 ：以组织胺引喘试验和放射性配基结合分析法证明,豚鼠经反复应用异丙肾上腺素可见β-肾上腺素受体反应性降低和肺组织β-受体数目减少。腹腔注射甘草水煎剂或甘草提取物Lx66可以防止上述变化,而腹腔注射甘草次酸或甘草水煎剂灌胃则无此种保护作用。

Abstract:Histamine-induced wheezing test in conjunction with radioligand binding assay showed that after long-term administration of isoprenaline the reactivity and R, value(total receptor binding sites)of β-adrenoceptors in the lung tissue of guinea pigs were reduced. The decoction of Glycyrrhiza uralensis Fisch or its extractive LX₆₆ given intraperitoneally could prevent these changes, hut the decoction per os or glycyrrhetinic acid given intraperitoneally could not.

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