Abstract:The results showed that the level of hemolysin (HC), the numbers of plaque forming cells (PFC) and specific rosette forming cells (SRFC) in primary response to sheep red blood cells (SRBC)were markedly lowered and the lipoperoxide level in brain, liver and serum was increased in aging (over 18 months) and malnourished mice fed with ground corn in comparison to normal controls, while HC and the numbers of PFC and SRFC were significantly increased and the lipoperoxide level was markedly decreased after treatment with bee pollen 10 g/kg/d orally for 3 months and with 20% bee pollen-containing ground corn for 3 weeks respectively. The reduction of total protein and albumin contents of serum, DNA, RNA and protein contents of spleen and thymus in mice fed with ground corn can be prevented by adding 20% bee pollen in ground corn diet.