Abstract:This paper reports the general situation of the investigation and study on the ethnodrug resources of the Tujia and Miao nationalities in the west area of Hubei Province. There are 431 ethnodrugs, which belong to 616 species (including varieties) of plants and 117 families (including the rich, rare, newly recorded and cultivated species). These drugs are used frequently and extensively in the west area of Hubei Province. The authors have made some suggestions on the rational protection, exploitation and utilization of these ethondrug resources.