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作 者 ：王金兰,张淑霞,李铁军,张伟琦,王建军,张树军

期 刊 ：中草药 2008年

关键词：山核桃；山核桃酚；胡桃醌；萘酚；萘醌；

Keywords:Juglans mandshurica Maxim., juglamanol, juglon, naphthoquinols, naphth oquinones,

摘 要 ：目的研究山核桃树皮化学成分。方法利用硅胶柱色谱及重结晶等方法进行分离纯化,通过理化性质及波谱分析鉴定结构。结果得到15个化合物。鉴定为:4,8-二羟基萘酚-1-O-β-D-(6′-乙酰氧基)吡喃葡萄糖苷(Ⅰ)、双氢山奈酚(Ⅱ)、胡桃醌(Ⅲ)、胡萝卜苷(Ⅳ)、山奈酚(Ⅴ)、4,8-二羟基萘酚-1-O-β-D-[6′-O-(3″,5″-二甲氧基-4″-羟基苯甲酰基)]吡喃葡萄糖苷(Ⅵ)、山柰酚-3-O-α-L-鼠李糖苷(Ⅶ)、3,3′-二甲氧基鞣花酸(Ⅷ)、柚皮素(Ⅸ)、槲皮素(Ⅹ)、4,8-二羟基四氢萘醌(Ⅺ)、槲皮素-3-O-α-L-鼠李糖苷(Ⅶ)、柚皮素-7-O-β-D-葡萄糖苷(Ⅻ)、4,8-二羟基萘酚-1-O-β-D-吡喃葡萄糖苷(XⅣ)、4.5,8-三羟基-α-四氢萘醌-5-O-β-D-[6′-O-(3″,5″-二甲氧基-4″-羟基苯甲酰基)]吡喃葡萄糖苷(XV)。结论化合物Ⅰ为新化合物,命名为山核桃酚;化合物Ⅱ、Ⅶ～Ⅸ、Ⅺ、Ⅻ系首次从该属植物中得到。

Abstract:Objective To study the chemical constituents from the bark of Juglans mandshurica. Methods The compounds were isolated and purified by column chromatography on silica gel,HPLC,and recrystallization.Their structures were elucidated by the physicochemical and spectroscopic evidences. Results Fifteen compounds were identified as:4,8-dihydroxynaphthalenyl-O-βD-(6′-acetoxyl)gluco- pyranoside(Ⅰ),dihydrokaempferol(Ⅱ),juglone(Ⅲ),daucosterol(Ⅳ),kaempferol(Ⅴ),4,8-dihy- droxynaphthalenyl-1-O-β-D-[6′-O-(3″,5″-dimethoxy-4″-hydroxybenzoyl)] glucopyranoside(Ⅵ), kaempferol-3-O-α-L-rhamnoside(Ⅶ),3,3′-dimethoxylellagic acid(Ⅷ),naringenin(Ⅸ),quercetin (Ⅹ),reginolone(Ⅺ),quercetin-3-O-α-L-rhamnoside(Ⅻ),naringenin-7-O-β-D-glucoside(ⅩⅢ),4,8- dihydroxynaphthalenyl-1-O-β-glucoside(ⅩⅣ),4,5,8-trihydroxy-α-tetralone-5-O-β-D-[6′-O-(4″-hy- droxy-3″,5″-dimethoxy-benzoyl)] glucoside(ⅩⅤ).Conclusion CompoundⅠ(juglamanol)is a new compound.CompoundsⅡ,Ⅶ—Ⅸ,Ⅻ,andⅩⅢare isolated from plants of Carya Nutt.for the first time.

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