全 文 ：this plant fo r the fi rst time. The four examined compounds exhibi ted certain anti fungal activ ities against
six strains o f fung i in v itro.
Key words: Pogostemon cablin ( Blanco) Benth. ; f lav onoids; antifungal activ ity
广藿香中的黄酮类化合物
张广文 1 ,马祥全 1 ,苏镜娱 1 ,曾陇海 1 ,王发松 2 ,杨得坡 2⒇
( 1. 中山大学化学与化工学院 ,广东 广州　 510275;　 2. 中山大学生命科学学院 ,广东 广州　 510275)
摘　要:目的　对广藿香全草进行研究以筛选天然抗真菌新药。 方法　用色谱技术进行分离 ,通过 IR, UV , MS,
NM R(1 H, 13C, DEPT)分析以及与标准品对照的方法鉴定化合物的结构。 利用培养基药物浓度稀释法进行体外抗
菌实验。结果　利用抗菌活性追踪 ,从广藿香中分离得到 8个黄酮类化合物 ,鉴定为: 5-羟基 -3′, 7, 4′-三甲氧基二氢
黄酮 (Ⅰ ); 5-羟基 -7, 4′-二甲氧基二氢黄酮 (Ⅱ ) ; 3, 5-二羟基 -7, 4′-二甲氧基黄酮 (Ⅲ ) ; 5-羟基-7, 3, 4′-三甲氧基黄酮
(Ⅳ ) ; 5-羟基 -3, 7, 3′, 4′-四甲氧基黄酮 (Ⅴ ); 5, 4′-二羟基 -3, 7, 3′-三甲氧基黄酮 (Ⅵ ) ; 5, 4′-二羟基 -7-甲氧基黄酮
(Ⅶ )和 3, 5, 7, 3′, 4′-五羟基黄酮 (Ⅷ )。并对化合物Ⅰ ,Ⅲ ,Ⅴ ,Ⅵ 进行了体外抗真菌活性研究。结论　除Ⅴ和Ⅵ 外 ,均
为首次从该植物中分离得到。 受测的 4个黄酮类化合物具有抗真菌活性。
关键词: 广藿香 ;黄酮类 ;抗真菌活性
中图分类号: R284. 1　　　文献标识码: A　　　文章编号: 0253 2670( 2001) 10 0870 05
　　 Pogostemon cabl in ( Blanco ) Benth. (广藿香 )
is w idespread in southern China. The plant ha s
been used as Chinese herbal medicine to remove
dampness, reliev e summer-hea t, ex terior syn-
drome, stop vomiting and stimula te the appeti te.
The essential oil of P. cabl in collected by steam
disti llation was found to exhibi t significant antifun-
ga l and antibacterial activi ties in vi tro ( M IC=
0. 08～ 1. 0 mg /L ) [1 ] . Its alcoholic ex t ract also
show ed some anti fungal activi tes ( M IC< 2 mg /L ) .
Bioassay-guided fractiona tion of this activ e ex t ract
has led to the isolation and cha racteriza tion of eight
f lav onoids as 5-hydroxy-7, 3′, 4′-trimethoxyf lav a-
none (Ⅰ ) [2 ] , 5-hydroxy-7, 4′-dimethoxyf lav anone
(Ⅱ ) [3 ] , 3, 5, -dihydroxy-7, 4′-dimethoxy flavone
(Ⅲ ) [4 ] , 5-hydroxy-3, 7, 4′-trimethoxy flavone
(Ⅳ ) [5 ] , 5-hydroxy-3, 7, 3′, 4′-tet ramethoxy-
f lav one (Ⅴ ) [6 ] , 5, 4′-dihydroxy-3, 7, 3′-trimeth-
oxy flavone (Ⅵ ) [6 ] , 5, 4′-dihydroxy-7-methoxy-
f lav one (Ⅶ ) [ 7] , and 3, 5, 7, 3′, 4′-pentahydrox-
y flavone (Ⅷ ) [8 ] . We report herein on the st ruc-
tural elucidation of the iso lated compounds and
prelimina ry screening o f the antifungal activ ities of
compoundsⅠ , Ⅲ , Ⅴ , a nd Ⅵ .
Results and discussion
Compound I w as crystali zed f rom acetone as
co lorless needles. The IR spect rum show ed ab-
so rptions typical o f carbony l g roups, and benzene
ring , and the UV spectrum was typical o f a
f lav onoid. The 1HNM R spectrum show ed the pres-
ence o f th ree methoxy g roups (δ3. 81, 3. 90 and
3. 92) , and a downfield signal (δ12. 01) due to a
hydrogenbonded hydroxy g roup at 5 posi tion. The
aroma tic pro tons of meta-coupled doublets ( J= 2. 5
Hz) atδ6. 06 and 6. 08 corresponded to 6, 8 pro-
tons o f ring A, th ree more aromatic protons atδ
6. 90, 6. 98 and 6. 99 show ed the presence of a
pa ra-substituted aroma tic ring. The
13
CNM R spec-
trum show ed signals of four o xygena ted aroma tic
ca rbons (δ164. 2, 168. 0, 149. 3 and 149. 6) and
one carbony l carbon (δ195. 9) . These assignment
w ere further confi rmed by the DEPT spect rum
which indicated the presence of one methylene,
th ree methoxy, and six methy lidyne. And wi th the
po sitiv e-ion FABM S show ed a quasimo lecula r peak
[M+ H ]
+
at 331, the molecular fo rmula w as de-
termined a s C18 H18 O6 . All these data suppo rted
tha t the structure o f f lav anone I is 5-hydroxy-7,
·871·中草药　 Chinese Traditiona l and He rbal Drug s　 2001年第 32卷第 10期
⒇ 收稿日期: 2000-12-01基金项目:国家自然科学基金资助项目 ( No. 29872060)作者简介:张广文 ( 1975-) ,男 ,中山大学化学与化工学院在读直博生 ,现从事天然药物研究。
3′, 4′-trimethoxy flavanone (Ⅰ ) [2 ] . Compounds
Ⅲ ～ Ⅵ were determined as flavone f rom i ts simi lar
spect ral data ( IR, 1 H, 13 C and DEPT) to those of
compound I except wi thout the signals atδ2. 81
and 3. 11 in
1
HNMR, but wi th an addi tional peak
o f methoxy o r hydroxy a t posi tion 3. Al l the for-
mulae w ere determined by the aid of FABM S.
Compounds Ⅶ , Ⅷ were confi rmed by comparing
w ith their
13
CNM R spect ra repo rted in literature.
Chemical structural fo rmulae of compound
Ⅰ ～ Ⅷ were show n in Fig 1.
Fig. 1　 The chemical structure of compoundsⅠ ～ Ⅷ
Experimental section
General experimental procedures. M el ting
points w ere determined on a 5X micromel ting point
appara tus and w ere unco rrected. UV spect ra were
obtained on a Ray leigh UV -1200 spectropho-
tometer in MeOH. IR spect ra w ere recorded on a
Bruker EQU INOX-55 inf rared spect ropho tometer
w ith KBr pellets. FABM S were measured on a V G
ZAB-HS mass spectrometer. NMR (
1
H,
13
C,
DEPT) spect ra were obtained on Va rian Unity IN-
OVA-500 spectrometer wi th CDCl3 o r DM SO-d6 a s
solvent and TM S as internal standa rd. The chemi-
cal shif t s a re expressed on theδscale. TLC analy-
ses w as perfo rmed on precoated Silica g el 60 F254
plates ( Qingdao Haiyang Chemical Group CO. of
China ) . Si lica g el 60 H ( particle size, 38μm,
Qingdao) w as used fo r v acuum liquid chromatog ra-
phy ( V LC) and preparative T LC. Spo ts on the
plate were observ ed under UV 254 lig ht and v isual-
ized by spraying wi th vani llin-H2 SO4 fo llow ed by
heating. All solv ents w ere AR reagents purchased
from Guang zhou Chemical Reagent Factory.
Plant material. The plant P . cabl in were co l-
lected in Wuzhou, Guangxi autonomous region,
PRC in 1999.
Extraction and isolation. The w hole plant ( 2
kg ) w as ex t racted th ree times wi th 95% EtO H at
room temperature. Evaporation o f the EtO H in
vacuo gave a gum ( 71. 8 g ) w hich was par titio ned
betw een petroleum ether ( 60℃～ 90℃ ) and 90%
M eOH-H2O. The M eOH-so luble portion was fur-
ther pa rtitio ned betw een CHCl3 and 65% MeOH-
H2O. Each fraction w as submit ted to a bioassay a-
gainst fungi: Crytococus neoformans , Candida albi-
cans, Mucor globosus , Chaetomium globosum , Rhi-
zopus nigricans and Scopulariopsis brevicaul is.
From this bio assay , the CHCl3 ex t ract ( 15. 2 g )
w as found to have antifunga l activities ( M IC< 2. 0
mg /L) . Bioassay-guided fractionation of the
CHCl3 ex t ract ( 15. 2 g ) w as subjected to V LC us-
ing a step g radient of petro leum ether ( 60℃～ 90
℃ ) and EtOAc to yieldⅠ ( 39 mg ) , Ⅱ ( 6 mg ) ,
Ⅲ ( 21 mg ) , Ⅳ ( 12 mg ) , Ⅴ ( 70 mg ) , ) , and Ⅵ
( 25 mg ) . Fraction 17 ( 56 mg ) eluted wi th 30%
Pet-EtO Ac w as further purified by preparativ e
TLC ( eluent 20% M eOH-CHCl3 ) to yield Ⅶ ( 8
mg ) , andⅧ ( 5 mg ) .
5-Hydroxy-7, 3′, 4′-trimethoxyflavanone
(Ⅰ ) [1 ]: co lorless needles, mp 153℃～ 154℃ ;
UV ( M eOH)λmax ( logε) nm: 228 ( sh , 4. 41) , 286
( 4. 30) , 333 ( 3. 52) ; IR ( KBr) νmax cm- 1: 1 638,
1 517, 1 265, 1 158, 1 026; FABM S m /z: 331
( 100) [M+ H ]
+ ; 1 HNMR ( CDCl3 ) δ: 2. 81 ( 1H,
dd, J= 3. 5, 17 Hz, Heq-3) , 3. 11 ( 1H, dd, J=
12. 5, 16. 5 Hz, Hax-3) , 3. 81, 3. 90, 3. 92 ( all
3H, s, OCH3 ) , 5. 36 ( 1H, dd, J= 3. 5, 13 Hz, H-
2) , 6. 06 ( 1H, d, J= 2. 0 Hz, H-6) , 6. 08 ( 1H, d,
J= 2. 5 Hz, H-8) , 6. 90 ( 1H, dd, J= 1. 5, 7. 0 Hz,
H-5′) , 6. 98 ( 1H, dd, J= 2. 75 Hz, H-6′) , 6. 99
( 1H, d, J= 2 Hz, H-2′) , 12. 01 ( 1H, s, 5-OH);
13 CNMR ( CDCl3 )δ: 43. 4 ( C-3) , 55. 7 ( 7-OCH3 ) ,
56. 0 ( 3′, 4′-O CH3 ) , 79. 2 ( C-2) , 94. 3 ( C-8) ,
95. 1 ( C-6) , 103. 2 ( C-10) , 109. 4 ( C-5′) , 111. 2
( C-2) , 118. 8 ( C-6′) , 130. 8 ( C- 1′) , 149. 3 ( C-
3′) , 149. 6 ( C-4′) , 162. 8 ( C-9) , 164. 2 ( C-5) ,
168. 0 ( C-7) , 195. 9 ( C= O) .
·872· 中草药　 Chinese Traditiona l and He rbal Drug s　 2001年第 32卷第 10期
5-Hydroxy-7, 4′-dimethoxyf lavanone (Ⅱ ):
colo rless needles; mp 115℃～ 116℃ ; it w as iden-
ti fied by compa ring various spectral data wi th
those repo rted in the li terature.
3, 5,-Dihydroxy-7, 4′-dimethoxyflavone
(Ⅲ ): yellow needles, mp 184 ℃～ 186℃ ; IR
( KBr)νmax cm- 1: 3 437, 1 661, 1 596, 1 497, 1 348,
1 210; FABM S m /z: 315 ( 50) [M+ H]
+
;
1
HNMR
( CDCl3 ) δ: 3. 89, 3. 90 ( all 3H, s, OCH3 ) , 6. 37
( 1H, d, J= 2. 5 Hz, H-6) , 6. 49 ( 1H, d, J= 2. 5
Hz, H-8) , 6. 58 ( 1H, s, 3-OH) , 7. 03 ( 2H, d,
J= 9 Hz, H-3′, 5′) , 8. 17 ( 2H, d, J= 9 Hz, H-2′,
6′) , 11. 76 ( 1H, s, 5-OH); 13 CNM R ( CDCl3 ) δ:
55. 4, 55. 8 ( 4, 7-O CH3 ) , 92. 2 ( C-8) , 97. 9 ( C-
6) , 104. 0 ( C-10) , 114. 1 ( C-3′, 5′) , 123. 2 ( C-
1) , 129. 4 ( C-2′, 6′) , 135. 7 ( C-3) , 145. 7 ( C-2) ,
156. 9 ( C-5) , 160. 9 ( C-4′) , 161. 2 ( C-9) , 165. 8
( C-7) , 175. 2 ( C-O) .
5-Hydroxy-3, 7, 4′-trimethoxyf lavone (Ⅳ ):
y el low needles, mp 146℃～ 148℃ ; 1HNMR ( CD-
Cl3 )δ: 3. 86, 3. 88, 3. 90( all 3H, s, OCH3 ) , 6. 36( 1H,
d, J= 2. 5 Hz, H-6) , 6. 45( 1H, d, J= 2 Hz, H-8) ,
7. 02 ( 2H, d, J= 8 Hz, H-3′, 5′) , 8. 08 ( 2H, d,
J= 8. 5 Hz, H-2′, 6′) , 12. 72 ( 1H, s, 5-OH) .
5-Hydroxy-3, 7, 3′, 4′-tetramethoxyflavone
(Ⅴ ): yellow needles, mp 162℃～ 164℃ ; UV
( MeOH) λmax ( log ε) nm: 254 ( 4. 53 ) , 268
( 4. 46′) , 351 ( 4. 50) ; IR ( KBr)νmax cm- 1: 3 426,
1 656, 1 594, 1 512, 1 433, 1 380, 1 324, , 1 272,
1 253, 1 235, 1 211, 1 192, 1 159, 823; FABM S m /
z: 359 ( 75) [M+ H ]
+
;
1
HNMR ( CDCl3 )δ: 3. 87,
3. 88, 3. 97, 3. 98 ( all 3H, s, OCH3 ) , 6. 35 ( 1H,
d, J= 2. 5 Hz, H-6) , 6. 44 ( 1H, d, J= 2 Hz, H-
8) , 6. 99 ( 1H, d, J= 8 Hz, H-5′) , 7. 69 ( 1H, d,
J= 2. 5 Hz, H-2′) , 7. 73 ( 1H, dd, J= 2, 8. 5 Hz,
H-6′) .
5, 4′-Dihydroxy-3, 7, 3′-trimethoxyflavone
(Ⅵ ): yellow needles, mp 171 ℃～ 173℃ ; IR
( KBr)νmax cm- 1: 3 312, 1 650, 1 595, 1 506, 1 350,
1 159, 833; FABM S m /z: 345 ( 100) [ M+ H ]
+ ;
1 HNM R ( CDCl3 )δ: 3. 86, 3. 88, 3. 90 (all 3H, s,
O CH3 ) , 6. 00 ( 1H, s, 4′-OH) , 6. 36 ( 1H, d, J= 2
Hz, H-6) , 6. 44 ( 1H, d, J= 2. 5 Hz, H-8) , 7. 04
( 1H, d, J= 8 Hz, H-5′) , 7. 67 ( 1H, dd, J= 2, 8
Hz, H-6′) , 7. 70 ( 1H, d, J= 2 Hz, H-2′) , 12. 61
( 1H, s, 5-OH);
13
CNM R ( CDCl3 )δ: 55. 8, 56. 1,
60. 2 ( 3, 7, 3′-O CH3 ) , 92. 2 ( C-8) , 97. 8 ( C-6) ,
106. 0 ( C-10) , 110. 9 ( C-2′) , 114. 6 ( C-5′) , 122. 5
( C-1′) , 122. 7 ( C-6′) , 138. 9 ( C-3) , 146. 3 ( C-
3′) , 148. 3 ( C-4′) , 155. 9 ( C-2) , 156. 7 ( C-5) ,
162. 1 ( C-9) , 165. 4 ( C-7) , 178. 7 ( C= O) .
5, 4′-Dihydroxy-7-methoxyflavone (Ⅶ ): yel-
low amo rphous powder, mp 286 ℃～ 288 ℃ ;
1
HNMR ( DM SO-d6 ) δ: 3. 87 ( 3H, s, OCH3 ) ,
6. 34 ( 1H, d, J= 2. 5 Hz, H-6) , 6. 68 ( 1H, d, J=
2. 5 Hz, H-8) , 6. 74 ( 1H, s, H-3) , 6. 89 ( 2H, d,
J= 9 Hz, H-3′, 5′) , 7. 91 ( 2H, d, J= 9 Hz, H-2′,
6′) , 12. 93 ( 1H, s, 5-OH) ; 1 3 CNM R ( DM SO-d6 )
δ: 55. 8 ( 7-O CH3 ) , 91. 8 ( C-8) , 97. 3 ( C-6) ,
102. 7 ( C-3) , 103. 9 ( C-10) , 115. 8 ( C-3′, 5′) ,
121. 1 ( C-1′) , 128. 3 ( C-2′, 6′) , 157. 2 ( C-5) ,
161. 0 ( C-9) , 161. 3 ( C-4′) , 164. 0 ( C-2) , 164. 8
( C-7) , 181. 6 ( C= O) .
3, 5, 7, 3′, 4′-Pentahydroxyflavone (Ⅷ ):
ye-llow amorphous powder, mp> 300℃ ; 13 CN-
MR ( DM SO-d6 ) δ: 93. 8 ( C-8) , 98. 7 ( C-6) ,
103. 6 ( C-10) , 115. 2 ( C-2′) , 115. 4 ( C-5′) , 119. 9
( C-6′) , 121. 8 ( C-1′) , 135. 9 ( C-3) , 145. 0 ( C-
3′) , 147. 2 ( C-2) , 147. 7 ( C-4′) , 156. 0 ( C-5) ,
156. 0 ( C-9) , 163. 9 ( C-7) , 175. 8 ( C= O) .
Antifungal assays. The test o rganisms w ere
Crytococus neoformans , Candida albicans , Mucor
globosus ( AS 3. 349) , Chaetomium globosum ( AS
3. 963) , Rhizopus nigricans ( AS 3. 31) and Scop-
utariopsis brev icaulis.
Antifungal assay s w ere carried out by the dou-
bling dilutions method using a modi fied procedure.
Fungi suspensions w ere obtained from 5～ 10 days
cultured in Sabouraud agar to ca. 10
5～ 107 cells /
mL in f resh steri le w ater. The four pure com-
pounds w ere dissolv ed in EtO H o r DM SO to 10
mg /mL as stock solutions. The required amount of
stock solutions w as pipet ted into 50 ℃ steri le
Sabluraud aga r in o rder to obtain 1. 0 mg /mL solu-
tions. Af ter so lidi fied and inoculated, the cul ture
pla tes w ere kept in a thermotank, and cultured at
their respectiv e tempera tures for 48 h ( see table 1,
below ) .
·873·中草药　 Chinese Traditiona l and He rbal Drug s　 2001年第 32卷第 10期
Table 1 Ant ifungal act ivities of compoundsⅠ ,Ⅲ ,Ⅴ andⅥ
Fungal s t rain
( culture temperature and hour)
Ⅰ Ⅲ Ⅴ Ⅵ
Crytococus neoforma ( 37℃ , 48 h) - - - +
Cand ida albicans ( 37℃ , 48 h ) - + + +
Mucor globosu ( 26℃ , 48 h) + - + +
Chaetomium g lobosum ( 26℃ , 48 h ) + + + +
Rh izopus nigricans ( 26℃ , 24 h ) - - + -
Scopular iop si s brevicat tl is ( 26℃ , 48 h ) - - + +
　　 Inhibitory concen tration w as def ined as follow s: - = less than
1. 0 mg /mL; + = more th an 1. 0 mg /m L.
　　 Inoculation meth ods w ere performed as d escribed in th e li tera-
tu re1
References:
[1 ]　苏镜娱 ,张广文 ,李　核 ,等 .广藿香精油化学成分分析与抗菌
活性研究 [ J] .中草药 , 2001, 32( 3): 204-205.
[2 ]　 Ch ristopher O, M iles L M. Kinet ics mech anism of the cyclis-
tion of 2′, 6′-dih ydroxych alcone and derivativ es [ J] . Chem Soc
Perkin TransⅡ Polyace, 1989, ( 11): 1623-1632.
[3 ]　 Lam J, W rang P. Flavonoids, and polyacetylenes in Dahl ia
tenu icaul is [ J] . Phytoch emis t ry, 1975, 14( 7) : 1621-1623.
[ 4 ]　张秀尧 ,凌罗庆 ,毛泉明 ,等 . 西河柳化学成分的研究 [ J] . 中
草药 , 1989, 20( 3): 4-5.
[5 ]　 Vidari G, Finzi P V , De Bernardi M . Flavonoids and quinones
in s tems of Aframomum gig anteum [ J ] . Ph ytoch emist ry,
1971, 10( 12): 3335-3338.
[ 6 ]　关　玲 ,权丽辉 ,徐丽珍 ,等 . 广藿香化学成分的研究 [ J] . 中
国中药杂志 , 1994, 19( 6): 356-358.
[7 ]　 Herr W , Gibaja S, Bhat SV , et al . Dihyd rof lavonols and oth-
er flavonoids of Eupatorium species [ J ] . Ph ytoch emist ry,
1972, 11( 9): 2859-2863.
[ 8 ]　李文魁 ,李英和 ,杨峻山 ,等 . 瓜子金化学成分的研究 [ J] . 天
然产物研究与开发 , 1996, 8( 3): 1-4.
木莓根部化学成分的研究
赵卫权 ,丁立生 ,王明奎⒇
(中国科学院成都生物研究所 ,四川 成都　 610041)
摘　要: 目的　研究木莓根部的化学成分。 方法　采用正、反相硅胶柱层析分离纯化 ,通过理化性质和光谱分析鉴
定其化学结构。 结果　从木莓根部甲醇提取物中分离并鉴定了 10个化合物 ,它们分别为: 胡萝卜苷 (Ⅰ )、乌苏酸
(Ⅱ )、 3β , 19α-二羟基 -2-氧 -乌苏 -12-烯 -28-酸 (Ⅲ )、 2α, 3β , 23α-三羟基乌苏 -12, 18-二烯 -28-酸 (Ⅳ )、 2α, 3β , 23α-三羟
基乌苏 -12, 19-二烯 -28-酸 (Ⅴ )、 2α, 3β , 19α, 23α-四羟基齐墩果 -12-烯 -28-酸 (Ⅵ )、 2α, 3β-二羟基乌苏 -12, 18-二烯 -28-
酸 (Ⅶ )、 2α, 3β , 19α-三羟基乌苏 -12-烯 -28-酸 (Ⅷ )、 2α, 3β , 19α-三羟基齐墩果 -12-烯-28-酸 (Ⅸ )和蔷薇酸 (Ⅹ )。结论　
以上成分均为首次从该植物中分得。
关键词: 木莓 ;悬钩子属 ;三萜
中图分类号: R284. 1　　　文献标识码: A　　　文章编号: 0253 2670( 2001) 10 0874 03
Studies on chemical constituents in radicular part of Rubus swinhoei
ZHAO Wei-quan, DING Li-sheng , WAN G Ming-kui
　　 ( Chengdu Institute o f Bio lo g y, Chinese Academy of Sciences, Chengdu Sichuan 610041, China)
Key words: Rubus swinhoei Hance; Rubus L. ; triterpenoids
　　木莓 Rubus swinhoei Hance系蔷薇科悬钩子属
植物 ,主要分布在陕西、江苏、安徽、浙江、福建、湖
北、湖南、台湾、广东、广西、四川、云南等。 其根有凉
血止血、活血调经、收敛解毒之功效 ,用于牙痛、疮
漏、疔肿疮肿、月经不调等症状 [1 ] ,但其药用成分未
见报道。为探索该植物的有效成分 ,揭示其生理活性
物质 ,使之在中医临床上应用更为广泛 ,并为悬钩子
属药用植物活性成分的研究以及深层次开发提供基
础资料 ,本文对木莓根部甲醇提取物的化学成分进
行了初步研究 ,结果显示其中主要成分为三萜类化
合物和鞣质。我们已经报道了其中一个结构新颖的
三萜成分木莓酸的结构 [ 2]。本文继续报道其余的 10
个成分。它们分别是: 胡萝卜苷 ( daucosterol , Ⅰ )、
乌苏酸 ( ursolic acid, Ⅱ )、 3β , 19α-二羟基 -2-氧-乌苏
-12-烯 -28-酸 ( 2-oxo-pomo lic acid, Ⅲ )、 2α, 3β , 23α-
三羟基乌苏 -12, 18-二烯-28-酸 ( pinfaenoic acid,
·874· 中草药　 Chinese Traditiona l and He rbal Drug s　 2001年第 32卷第 10期
⒇ 收稿日期: 2000-08-30基金项目:四川省青年科技基金会资助作者简介:赵卫权 ( 1975-) ,男 ,江苏六合人 ,助理工程师 ,硕士。 1997年 6月毕业于南京大学生物系获学士学位 , 2000年于中科院成都生物研究所获硕士学位 ,研究方向为植物化学。 现在成都军区防化技术大队工作。 Tel: ( 028) 6684044　 E-mail: w eiquanzhao@ 163.
com