Optimization of Aqueous Two-phase System for Protease Extraction from Aspergillus oryzae by Response Surface Methodology Fractionation and Biological Activity of Aspergillus oryzae Elicitor Promoting Biosynthesis of Shikonin Derivatives Screening and Identification of a Sponge-associated Fungus HMP-F66 Inducing Oxidative Burst in Tobacco Cell Suspensions