Abstract:Phosphatase of regenerating liver-2 (PRL-2) is a member of protein tyrosine phosphatases family. As a protein phosphatase， PRL-3， the third member of PRL family， has attracted much interest due to its specific high expression in tumor tissues. However， as PRL-2 is widely expressed in normal adult tissues， researchers have become more and more interested in PRL-2. Here， we provide an overview of the physcial function of PRL-2 and its role in cancer.