Abstract:Epigenetics refers to heritable changes in gene expression， caused by modifications which do not involve alterations in DNA sequence. Alzheimer’s disease (AD) is the most common age-dependent neurodegenerative disorder and shows progressive memory loss and brain atrophy. Intraneuronal filaments composed of aggregated hyperphosphorylated tau protein， called neuro-fibrillary tangles， along with extracellular accumulations of amyloid β protein (Aβ)， called senile plaques， are known to be the neuropathological hallmarks of AD. Recent studies have suggested that epigenetic mechanisms may play a pivotal role in AD course and development. In this review， we summarize recent advances on change of memory loss， APP hydrolysis， Aβ protein formation， tau protein phosphorylation， oxidative stress caused by common epigenetic modifications (DNA methylation， histone modifications， microRNA).