Abstract:Aging is a complex biological process， embodied by functional decline of organs and tissues， and the increasing risk of aging-related diseases. Pluripotent stem cells (PSC) including embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC)， have the capacity of self-renewal and to differentiate into multiple types of cells. The blooming PSC technologies open up a new prospect for studying human aging and aging-related diseases， as well as developing relevant treatment. Additionally， gene editing techniques provide the feasibility of intervention of aging and age-associated diseases. Development in individualized treatment of human aging based on stem cell and gene editing techniques has broad scientific significance and social value.