Abstract:The haploid stem cell is a novel type of artificially established cells. Supported by the Stem Cell and Regenerative Medicine Strategic Priority Research Program of the Chinese Academy of Sciences， Chinese scientists have made a serial of achievements on derivation and application of haploid stem cells， which enriched the haploid stem cell types， established multiple new techniques for genome modification and assisted reproduction， and brought great prospects for studies of reproduction， development， genetics and evolution. Here we review the progress on haploid stem cell research in past five years supported by the Strategic Priority Research Program.