Abstract:Deinococcus radiodurans is one of the most radio-resistant organisms discovered so far. PprI, a protein which was found in Deinococcus radiodurans plays an indispensable role in the processes of DNA damage repair, it also acts as a general switch to orchestrate the expression of a number of DNA damage response (DDR) proteins which involved in numerous cellular pathways. To provide theoretical basis for further study on the mechanism of Deinococcus radiodurans’ radiation resistance. The biological functions of PprI in radio-resistance and anti-oxidation, its structure function and effects on stress resistance in other prokaryotic and eukaryotic organisms were discussed, the prospect of its novel potential function and significance.