---

作 者 ：冯学花;张国升;陶阿丽;曹殿洁

期 刊 ：植物研究 2014年 34卷 1期 页码：103-107

关键词：厚朴；厚朴酚；和厚朴酚；响应面法；提取工艺；

Keywords:magnoliae cortex, magnolol, honokiol, response surface method, extraction technology,

摘 要 ：为探讨响应面法优化厚朴中和厚朴酚与厚朴酚的提取工艺。以溶媒比、乙醇浓度、提取时间为自变量，和厚朴酚与厚朴酚总提取百分含量作为因变量，通过对自变量各水平的多元线性回归及二项式拟合，用响应面法选取较佳工艺，并进行预测分析。确定最佳提取工艺为溶媒比60 mL·g^-1、乙醇浓度为72%、提取时间78 min，和厚朴酚与厚朴酚总提取百分含量达2.29%。说明响应面法优选厚朴中和厚朴酚与厚朴酚成分提取工艺，方法简单，结果可靠。

Abstract:Response surface method was used optimize the extraction techniques of magnolol and honokiol from Magnoliae. Solvent/solid ratio, ethanol concentration and extraction time served as independent variables while the total extraction yield of magnolol and honokiol served as the dependent variable. Based on multiple linear regression and binomial expression, central composite design and response surface method were employed to optimize the extracting process, and predicative analysis was conducted. The optimized extraction conditions showed that solvent/solid ratio 60 mL·g^-1, ethanol concentration 72% and extraction time 78 min gave the total extraction yield 2.29%. The optimum process was simple in methodology and reliable in extraction yield.

---