Abstract:The oyster mushroom and button mushroom are important cultivated edible fungi, and the yields of them are 2488 and 1330 thousand tons respectively per year in China. The bacterial brown blotch disease deteriorated and caused heavily economic loss when the cultivation scale was enlarged with year-round technology during last several years. The typical symptoms were that there were superficial brown lesions on pileus. The pathogen factor is tolaasin produced by P.tolaasii. The review presents recent studies about P.tolaasii, disease mechanism and control strategies.