免费文献传递   相关文献

Perspective and application of metabonomics in modern study of traditional Chinese medicine

代谢组学在中药现代研究的应用与展望



全 文 :QŽv,Qz| ‘’56/!!!7!89

!
:;<
)
!
)=/

!
>?@
)
!
ABC
!*
!
c
µ–®ª¶¡é €‹²·¸®¶¹“úz›º`»›¢e³¼®˜
!
~® µ–
*)#%
)c
µ–®ª¶¡éÂê£ ~®¾®ª£
!
~® µ–
*$$*4#

fg
#!
QŽ+z{›³QŽ‘’†QŽc¬Ê³ax·8vaxJ¾|æ7×Ø
$
‘$,|z{ØOCÞ£
|Æ4¶
+
v$,Qx|z{9:$
$
˺Ì5QŽ|z{×Ø
$
fH\X4$,‘Q°«&|zî
$
¹ƒ$
,Qx|b
+
BC97\QŽ|ÍÂ
&
QŽv$,0¶‹~›%
&
$,×½µ¶›%
&
$,×½,*‹~›%
†$,Ë%›%Lz{$|}~ΡÏG
+
jzEQŽv$,Qz{$Qv|ÒÓ
$
š’Eb_P
+

hij
#!
QŽ
,
$,
,
›%

kl)(
#!*$&5$)5**

mnoL
#!
%JKõ&“çLM
!(*%&$#,
fMÐKõ&
“çLM
!JF*$),
fMÐÑA­Çz{°¸ÐI::ÒLM
!fMÐñ«Ó

ÔYìÛ­ö
(
:ÒLM
!G85*4  pdqr #! ! ÕÖá
QR
ST°ÃU @LX# !* #(4)#%5 (K5/RTX#^--RT2*#c-./ qrst #! ¥×µ $ STz{° $K5/RTX#`T1[/*)2*#c-./ !! QŽ !/LHR^.X./T-U=/LHR^.1./T-U + *$ ×Ø 4$ n QÙrÚ]bÂD|Þ7Ш& $ +¯4°¬ !U6UHL/ ^T.X.Q6 z{|æ7Q1º + 444 n $ QŽ:Û $ Ü %Ý%|IY YLWL/6;T-S.XU.1 QR -. +{„3QŽ Í # QŽ+°¬³vs|°|”•†ÞXu‚€a| ãäw $ vÀbPÉ & ´×[£ÙÕ¸¸QŽax $ A9¸£ Ê6›³|QŽf.D“ß“uŒ‰à›%|& + Q Ž97A9´ÄÛF $ z{°¬³v8 & -u‚ ! hýsij & ,¬ª & N§axL ‹~w8?¶:ºÑ QŽ¬ ! ÞãÄ 9Gn ›! & >Ù|axJ¾·ÆÇ ®¯ -*5). + QŽá쳋ªÞ6{Ê|¯4Dz{ $ v ×Ø,`Câʳ & ƒÃ & Fî & º””Þ³|ï² $ ¼” ãÿ•-¶ýs|›%†,¬|QŽæû`C´ï|åä + }~QŽDÝqýs9: $ ‘$B|ʳî & ¯4î† åY}™Àæ–î
\–èB,•-|}³¯|z{„H EÐ|ØO†×Ø -&5. + +gn%JKõ&“ç & %Jæ ²“fz{b:Ò !4%) LçÓÉDE´6çÓ
¬~Q
Ž()¼BYè|} & BÛܚ*¡·,,*¬ Ô·‹~›%Œcz{ -#5%.
6¬EŸ3Qþ
˺ÿEQ Ž()vB,éê|ßµ}~_P
+
!
QŽ|z{8¢‘‚:
QŽz{Ü@97ŒcQŽ÷뺔
Ý9Àºb 
M_
QŽz{97¯ & 6N{z{ # ñ 6N{ ªQŽ¬(Ûº” !/LHR^.XTHLHRWQLHR1RX6UTU
MÛ+£Ùº
”Þ6(Ñ=|o¬†
=
Òc¬
,
ñ
*
6N{ªQŽ÷ëº
”
!/LHR^.XT-CW.VTXT1QR1RX6UTU ý~¼¶|º”()
¼ ï£QŽ9:|z{Ò¶ÔÆ®|ªÀQŽ¬¯¼Œc
£Ù¸£
,
ñ
)
6N{ªQŽÄ-º”
!/LHR^.XT-VT1QLWCWT1H5
T1QR1RX6UTU ÀºØ5£`³òޏQ
£¶šÙ£Ùº”
UV-
&
UV8l1QŽ¬
,
ñ
&
6N{ªQŽ
£¶† £Ùº”Þ6°¬¯4l1QŽ¬ -(. + {Ê|QŽz{|‚:@AµÓ|%& & >b|ý *†>b|º”·ÌŠ
Rf
+
¸µÓ97+­4
&
t˜Ò

&
ì4¡·UV†¹|„64
+
µÓ|%&@AµÓ
|„6
&
ª|†xî¬|ºØ
+
µÓA-~zÒC›Ó½
ôf
&
íL„6
+
º”:_
µÓ-,~üÆU56 & üÆ 56Ò&†?.Lª| + —îpï !;9>& ?. 5 Ô.+ ~L+Ü-~|º”×Ø + /0VíðLñVØ()|3 
Ô.+~4òDò´G}~”QŽ|z{

5
Ô+~
!?<598?<5N5@\_598=98& 4 5 Ô+~ !M<598bO5
M<598$bOM<598=98&
VO
5
Ô.+~
!†LØѳ
Ô.
!:L+~()
-4.
+
.°}ý~󛺔()
QŽ³7|IÙ|¾ô>bk)
A94:|
˺õ„>b|½vk)
ÌÅ>bö—|°¬¡
÷
£+QŽz{|®Ê8¢ + QŽz{Ä¡ø¬YÙ| & ´äk) + ªE˺õ „ãø¬>b|½vk)
¼>b|º”Ñ7}~Þ¯¼ |×Ø + +,ùú¼>bŒcª|
@AlÞx†/û
`r|>b|97ý~æûqì()
@A9Qºº”
!CWT1-TCRX-./C.1L1HUR1RX6UTUO<3& Å*ú3 !1.1XT1LRW /RCCT1Q;M9&
ü!º”
!STLWRW-ST-RX-XDUHLWR1RX6UTUI<3 LŜý !D15UDCLWdTULE ×؆ 8:9<3!U.VHT1ELCL1EL1H/.E5 LXT1Q.V-XRUUR1RX.Q6OM85A3!OM8 ETU-WT/T1R1HR1RX6UTU /)/ ñ )4 äñ # r *&
n
(
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
].Xc)4 :UUDL!# 3DQDUH *& !! f ! ,QŽz{‚:
_TQc!_X.+-SRWHV.W/LHR^.1./T-UWLULRW-S .VHWRETHT.1RX1LUL/LET-T1L
3;;!RWHTVT-TRX1LDWRX1LH+.W[
LCœý
!UDCLWdTULE
×Ø
-. + (! QŽv,Qz{|}~ (c! ,GÓÔ?@z{
!
,|Ôّ¸Ó› & cG & ý þr & ,~1[LYIÆ®
M_
,GD?ˆª!
˜
ÔÙÒþÀû
hä?@,ÓÔQªÞ6®ÊÒÓ + X4|,ÓÔ?@×Ø97ªý~m›º”×ؼ97
QºŒcº”
w¡lEÌ,|ÓÔtu
+
ªE¼, òó,ùH[ë|z{
A9QŽz{òó,|


Ä-f.
( À˜1z{,¬8?¶QŽ¬|ax
卪
l?@,ÔلHÄÔ|×؆Bb + +nD
%8-
¶Jý~QŽ×ؼ´›,Œcӛ?@z{
97
z{R©
+
(c(!
,Úä,*‹~›%z{ ! ,Úä+BÛܐ ×,
Þ+¡Q,ªQ©|#cÓ|¾;, + òó,
Þ+Þ6:•×
-óC´›xQº
m›xQº³C
´›,|‹~
bP
´›Qº:ÉåC*b†öƒL‹~

ãÿ,|,*¬Ô“f·‹~›%+Þ6w² + M _
´>,|‹~›%ZÀµ3
X4|,|âÖ×Øÿ
!!
©
!
$,GÓÔ?@|QŽz{
@R^XL!9LHR^.1./T-UWLULRW-S V.W` DRXTH6LdRXDRHT.1 .VHWRETHT.1RX;.,
,! º”µÓ º”<# >b|×Ø zþº” ÒICï m> & => #¼Y°æçt¹ bOM<598 ! 9Qºº” & KÜ: ž%캔
!
m>†=>|ƒ#‹~`CË̶þÏ
Ä¡~ ”ÓÔ?@ -. * &úö ! Àbbâ./„ 64 ?<598 ! 9Qºº” & KÜ: ž%캔
!
Àbbâ./QŽmƒÃax“ä
,
‘X4ý
þr
*
oµÓƇ
$$


o|µÓ‘
*

ˆ+
-*.
) !
9Ðц2
ÐÑ
!
9
&
2ÐÑ%&
|(•ÜµÓ

I5;9>
KÜ:ž$%캔
!
9
&
2ÐяQ|(•ÜÀ`CµË|ƒtu‹
~
$
.9ÐяQ(•Ü|ƒtu*þ·Â*PÉ
å”2ÐÑ
-).
& !

&
¯€
&
})
ˆb°µÓ
?<598 !
9Qºº”
&
KÜ:
ž$%캔
!&
6Qº})q
&
©}))*q
&
})¦q
&
:A
qÄ¡+$|Kº
)
›$,
-&.
!
nL
&
¸L
&
´Ñ
ôf„64
! bOM<5N5
@\_5IA98
æûqì
!
nL†´ÑC
**
6pCQŽ¬
$
nL†¸LC
)
6pCQŽ¬
+
´Ñ†nL$CÏ,z£
&

M%
&
Ü·(L-?
$
–¸LÍC
-.
# !
®«Õ
&
n
«Õ
&
é«Õ
ôf„64
IOM<5K8:5
@\_98
9Qºº”
!
Àb«Õ¬“+$|Kº
$
šá°“Ù.‚L
$
6ïð¶Qº
-#.
vÞ£:ë,ãÿ$,|,|‹~›%
$
QŽz{À˜
z{,¬hÉ|QŽax
$
–áz{,¬ÁÂ|8?¶QŽ¬
|ax
$
6`›³8°¬x9:†ßÃ|ax
+
A9Ýq
³4

QŽÄ-f.
(
ax¾u
$
ϵ,¬‹~(²Ò³
+
+
nD
$
%8-¶J¼´›$,,*‹~›%Œc|QŽz
{
$
6¬EC¡÷|z{zþ
$
Q©¶z{QþR©
*+
(c&!
$,Ë%›%z{
!
$,Ë%z{|—T+ϵ$,
Ë%›%
$
Èãÿ$,Ë%_`xQº·,*‹~|ax
J¾·8v›%
+
0”$,+´Qº•-³¯
$
vË%9:
$
$
ùõb°E•-|xax
$
–häãÿË%9:´›
•-|ax+$,Ë%z{|w²
+
X4|ý~x†,
|Œc$,Ë%›%z{
$
w¡ãÿUîN´Qº|ax
·¸J¾
+
QŽÄ¡\ʳ,ãÿ$,Ë%_`hÉ
·¼›³QŽ¬|ÇÈ
$
Œ–ªÏµ$,Ë%›%/£“
f
+
+nD
$
%8-¶Jý~QŽ()¼´›$,|Ë
%›%ŒcEz{
$
6¬E¯¼z{Qþ
$

)+
(c*!
$,•×µ¶J¾z{
!
$,•×+$BÛÜ~,|
97úû
$
9¡$BåY}™ªÄÃ
$
0û?1%—|×
¾qµ¶–Q
+
$,•×0”,óˆ´
$
Àbµ¶:ÉQv
•-|‹~
+
QŽ`CÅy2¶
&
ʳ¶
&
ƒÃ¶Lï
²
$
Ä¡¯4z{QŽ‘’|ʳ¶†ƒÃ¶ax
$
ûîz
{$,•×Àbµ¶ÁÂ|8?¶QŽ¬|ax
$
A9Õ
/$)/
ñ
)4
äñ
#
r
*$&
n
(
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
].Xc)4$ :UUDL!#
3DQDUH$ *$&
!!
©
*!
$,Úä,*‹~›%|QŽz{
@R^XL*!9LHR^.1./T-UWLULRW-S V.WLVL-HTdL/L-SR1TU/U.VHWRETHT.1RX;.c
,! º”µÓ º”<# >b|×Ø ,*‹~›% ÒICï Z2ô «ü3Y°t¹ I5;9> ! ]4KÜ:ž
º”
!
Řü3›³ô“Ž¦›}
€ÙQŽ
³Ž
“‚QŽ—˜
.¼èð±²°µË‹~ -%. * ¹5Ò ¹Ôº»Y°­4 !bOM<5 98=98 9Qºº” ! A9‰ŠÙQŽ & èð±QŽ & “‚QŽLQR ª«lԕ‚¶¹Ôº» -(. ) ÐÑ Y°t˜ ?<598 ! 9Qºº” & KÜ: ž%캔
!
Ì/‹~|›%č+ìÝ£Ô
&
ÿQŽ
&
“‚
·ÙQŽL´N*bbˆ‹~
-4.
&

!
6¶«Œ7|Y
°­µ
!
\]4Æ
?.
5
Ô.
9Qºº”
!
A9¡ÀY°t4KL‹o!¬Ô°Q & Ÿ‚ƒ !¬ÔºÌ
—³8QŽ8•]-
-*. ìÒ ! ­sT±sæç Y°­µ >>M<5N5 @\_598 9Qºº” ! A9¼§¨‚ZN & ÿ9‚QŽ†nx}•z‘| ‰Š‹~
€tÿ
&
t·nx}•z‘
-*.
#
:;l «sæçY°t¹
bOM<5N5
@\_598
!
9Qºº”
&
KÜ:
ž$%캔
!
¼±#
6°¬Ûº¬C‰Š‹~
¹¸‘Ÿÿ & Ù†“‚QŽC® -**. % ·¸ Y°t˜ M<598=98 KÜ:ž%캔
!
,‰’Øh=‚†·‚zîh=‚|º^
$
“
Ì0‹~
-*).
(
¹5Ò «3Y°­µ
bOM<598
9Qºº”
!
¼>Š‚
&
?‚
&
±%
6°¬Ûº¬CÇ
È
„ÿ¼Ù & “‚QŽC‰Š‹~ -*&. 4 @A #¼Y°t˜ ?<598 ! 9Qºº” & KÜ: ž%캔
!
ƒ#‹~°¬Ûº¬@ABC‚
&
°‚L

6QŽ
¬
¹¸‘ÿ9‚†hüfQŽC® -*.
DEF Y°t¹
M<598
KÜ:ž%캔 ! ƒ7½‹~‘GÿÔQŽ†ƒnx‹~Æ®
[
·
*
6°¬Ûº¬
-*#.
©
)!
$,Ë%›%|QŽz{
@R^XL)!9LHR^.1./T-UWLULRW-S V.WCW.-LUUT1Q/L-SR1TU/U.VHWRETHT.1RX;.c
,! º”µÓ º”<# >b|×Ø Ë%›% ÒICï HøÑ °Ó & ÀbË%Ó bOM<5N5 @\_598 ´s4:º”() ! Ë%_`Ä-f.QvµËþÏ
xQºÛ.¬+
XTQDUHRX.UTELJ ¸vË%Ó|óÙ­”°Ó
-*%.
*
‘. °Ó
&
ÀbË%Ó
!

I5;9>
†
bOM<
9Qºº”
!
ÀbË%Ӂ“‚ & C›‚·!axˆY , ƒ! xî¬ ) #h5
žIэ“ƒv·¸%‘.óÙÚ !
J‘.Ü! -*(. ) Kö Kö°Ó & Ë%Ó bOM<598 9Qºº” ! Ë%_`´Qºb°ax
Ä¡‹ªË%:ë|°¬
Ûº¬
hKöƒô & Kö^51L -*4. & nL ÀbË%Ó >OM<5N5 @\_598 ´s*¶º” ! nLË%_`Qºb°ax
0¶Ú!
Ë%_` ** 6ïð¶Qºb°ËÌax -).

nL nL·¸Ë%Ó
bOM<5N5
@\_5IA98
!
æûqìLx:Ù
×Ø
!
L-†´ÑÄ¡ÁÂþæ|T•0¶
°ÓA9Ë% Ä¡¡0
ºìC
6† ( 6®Ê°¬Ûº¬ -). # ìÒ ôf„64 bOM<5N@\_5 98=98 ! 9Qºº” & KÜ: ž%캔
!
,Òïð¶QºªìÒñò
>Q
)
*!K5>S

,
ìÒï
ð¶QºªŠž“ìÒñò
>^

>Q
ÀbHI×û
¼ìÒÔÙCÇÈ
-)*.
¸³4|QŽ¬†º”ÁÂQŽ.ax|¾u
Ä¡?@
,•×Àbµ¶¼›³|°¬*}
\–ÏŠ,•×µ¶

ÄÃÛÜî|~, + +nD%8-¼,•×µ¶J
¾|97QŽz{QþR©
&+
(c! ,•×,*‹~›%z{
!
,•×+vB,|
}|ÄÃw
0û×µ¶¾q
,|,ó†~Ù: `–Q|
+BÛÜ~,|97úû†ó/ + ,•× ×,ãóxQº•-
m6Qººìzî“KL|‹ ~(²bˆ‹~
–á‹~9:Gu‚M´
£W%£
E,•×|,*†‹~›%`C´Qº & ´N{ & ´(² & ´QŽQR|ï² + häϵ,•×‹~|¬Ô“f·
¸‹~›%
+M_,z{|Þ6®ÊÒÓ
+
,•×Œ ë°¬¯4`
Â*|+•×|¾úQºÒQŽc¬
Ò
‘›³‹~úQ|ÐQº
Mø{Q³8,•×Qº|Q
Ž¬
Œ–A9´(² & ´¯4Fîªì³8?¶QŽ ¬D™šýs + u™
A9¼ì³°¬µÓ|QŽº
”
Ýæûqì|
Ä¡œ¸QŽ‘’v,•×ªw |ax9:
\–ª,•×|‹~›%z{·*}¬Ô“ fz{„H()NÅ + +nD%8-¼,•×,*‹~
›%|97QŽz{QþR©
+
(c!
,w¶Qº,*›%z{ ! ,w¶QºÄ,
bˆ,*‹~|xQº
+ϵ,‹~|®Ê
+
YÙz
{©µ
òÞ|xQºÀQ©,|ʳŒ*†‹~›
%
ÿCO¿bˆ°¬‹~|,x¬ÔÛč+, w¶Qº + ¬~QŽz{,w¶Qº|,*‹~›
%
Ä¡vÞ£:ë,ϵ,|,*¬Ô†‹~›%
+
!
wL
-%.
ý~

I5;9>
zîQŽ×Øz{EYƒP‚¼
a•|…†‹~
zþb
YƒP‚Ä¡—Y°­µ /*)/
ñ
)4
äñ
#
r
*& n ( o !!!!!! ! ! ! ! ! !!!! ! ! ! ! ].Xc)4 :UUDL!#
3DQDUH *&
!!
©
&!
$,•×µ¶J¾|QŽz{
@R^XL&!9LHR^.1./T-UWLULRW-S V.W-./C.D1E -./CRHT^TXTH6.VHWRETHT.1RX;.c
,! º”µÓ !! º”<# >b|×Ø µ¶›% ÒICï ß«Lµ¶€Æ Y°­4 I5;9> 9Qºº” ! ß«Lè,`Ä,Q«Œ|µË§t
µ¶€ÆC
¼ƒ¸§¨‹~
-)).
*
€Í
5
QÑ,¼ Y°­4
bOM<598 !
9Qºº”
&
KÜ:
ž 5 %캔 !*&5
žn“>‹p/sYèæç
4%
6°¬Û.¬
¸,¼¼
)
6°¬Ûº¬`CµËª‹~
-)&.
)
RSѵ¶€Æ Y°­4
bOM<5@\_598 !
9Qºº”
&
KÜ:
ž 5 %캔 ! RSÑdrè,Ä,QaŒ§t
µ¶€Æ``C
¡0‹~
-).
&
T5µ¶Uä Y°t˜
?<598
9Qºº”
!
T5µ¶UäÄ¡‰Š‘_¤tC®|°¬Ûº¬
-)#.
!
V€Ì0äÀ
bµ¶
Y°t¹·­µ

I5;9>
!
9Qºº”
&

5 %캔 ! Y€ & € & W¨†·¸Ä¡A9‰ŠÙQŽ & h?QŽ†“‚QŽ
ˆX€|0¶‹~
-)%.
#
€Í
&
°G€ ­sY°­µ
?<598
9Qºº”
!
€Í
&
°G€µ¶_`ÀÚ!­t
3£ * 6þÏQŽ¬‘­sÆ® -)(. % ! ÒqÞyÀ
bµ¶
Y°t¹

I5;9>
!
KÜ:ž 5 %ì º” ! ÒqÞy¼”Þ3|‰Ê‹~³v“‚Q
Ž·ÙQŽ8•×
-)4.
( !
ÈY)ìàÀ
bµ¶
Y°­µ†t¹

I5;9>
!
KÜ:ž 5 %ì º” ! ÈY)ìàÄ¡t%òÞÈY¼a•†«•0¶ ‹~ -&.
©
!
$,•×,*‹~›%|QŽz{
@R^XL!9LHR^.1./T-UWLULRW-S V.WLVL-HTdL/L-SR1TU/U.VHWRETHT.1RX;.c
,! º”µÓ º”<# >b|×Ø ,*‹~›% ÒICï _…A ! _¤t¥¦2Y °t˜ —îpï() 9Qºº” ! Ú!Y°t˜Óo
&
Võ‚
&
€‚
&

,
„
­ÿ!
&
hüf
&
Ӂ‚
&
h?|z‘
-&.
*
ÔóG€à ôZæçY°t¹
!bOM<5N5
@\_598
!
KÜ:žØ 5 % 캔 ! w‰¸‚ & Ÿ‚ž¡“Šq & “vò‚ & · °Mƒ & ÓtŸÿ & hüfL -&*. ) €Æ234 ! _¤tæçY° t˜ IOM<598598 KÜ:ž%캔
!
‰ŠY°t˜“‚©ª
—Ž‚ & ôú‚ & · o‚L°¬Ûq¬8]-z‘“+ -&). & Ak…Uà ! ¤t¶Õæç
Y°t˜
?<5@\_598
Ü:žØ 5 %ìº ” ! w‰Y°t˜|Šq‚
&
Võ‚
&
¡?‚
,


&
·°‚
&
þ
&
?‚†×‚
-&&.

ÐѺaÜ
!
tu¼æçY°
­µ
!bOM<5N@\_5
98
!
KÜ:žØ 5 % 캔 ! ‰Š[­‚ & €­‚ & ?‚L 4 6QŽ¬|°Q
葍ÙQŽ
&
?‚QŽLC®
-&.
#
€ÍÌ0y ®Š#Y°t˜
M<5N5@\_598
]4KÜ:žØ 5 %캔 ! ¼ ( 6½v°¬Ûº¬C‰Š‹~
[··°Ÿ
ÿ
&
ÿ9‚
&
?‚L
(
6QŽQR
-&#.
%
‘a×
!
Kb¶­tY
°æçt˜
bOM<598
9Qºº”
!
¼·h‚
&5
Ÿ‚\fL
%
6°¬Ûº¬C‰
Š‹~
[·\ÿQŽ & ÿ9QŽ -&%. ( T5…Tà ! T±¨©Y°æ çt˜ M<5N5@\_598 ! KÜ:žØ
5
%
캔
!
¼
*%
6°¬Ûº¬C‰Š‹~
[· ) ãQŽA O
@AÙQŽ
&
“‚QŽL
-&(.
4
(•Ü a§¨:°t¹
?<598
9Qºº”
!
ªa§¨›%+¹pK0“
t%ÿÔ9nx
8
•“‚QŽ
&
­‚QŽAO
-&4.
¦œ× T±¨©Y°­µ !bOM<5N5 @\_598 ! 9Qºº” & KÜ :ž%캔
!
Ä¡‰ŠM]‚ZN†Ÿ‚^QR
µ¸ËÌ T±¨©†T±ÙQŽC® -.

²³y T±¨©Y°­µ
!

I5;9> bIOM<598 9Qºº” ! ¼ 4 6°¬Ûº¬C‰Š‹~
[·§¨‚
&
“
‚
&
_`†abQŽ
-.
*
AT’—á
!
tq8l§¨Y
°­µ
!b_M<5985
:@5@\_
9Qºº”Ø
!
¼¤¥;‚ƒ
&
A­‚
&
—€‚L
#
6°¬Ûº¬C
‰Š‹~
¹¸‘ _` & >Š‚ & —€‚LQŽA OC® -*. ) .T× T±¤tY°­µ bIOM<598 ! 9Qºº” & KÜ :ž%캔
!
¼
%
6°¬Ûº¬C‰Š‹~
¹¸‘QŽ & À c†ÿ9‚ & c†ÿ9‚QŽC® -). & wéty aSäxY°­µ ?<598 ! 9Qºº” & KÜ :ž%캔
!
‰Š‘ÙQŽ
&
“‚
&
ÿ9‚QŽÆ®|
6 °¬Ûº¬
Œ–“™š‹~
-&.

tÄxyy
!
­tÿY°æç


I5;9>
!
9Qºº”
&

%캔 ! Ä¡Ú!q³†Ñ=|ž)
ÅHÓd·“°Q
‰ŠÙ†ÿQŽ—˜ -. # öG€à ! ­s«sY° t¹ & ­µ & «¹ I5;9> 9Qºº” ! A9‰Š´ãQŽAOË̐­s«s
@At%

&
ÿQŽ
ŘôoQŽ -#. M]‚ZNÉc¬§¨‚
&
!
5
q^ž‚
&
¥¦‚óÙm
3,Ù­`x58•|“ä
Œ–…†a• + ?D P L -(. ý ~ bOM<5N5@\_598 zîQŽz{E:e?™š­s |‹~›%
zþb
:e?Ä¡—­sdøt˜
)
6’Øÿ9‚óÙËÌwÚ
Œ–ÁÂtÚ!
Rf
*+
BSR1Q3
L
-4.
ý~
bOM<598
()zîQŽz{Efg
8ƒ™ša§¨|›%
zþbfg8ƒÄ‰Ša§¨Y °|h=‚QŽ & abQŽL
—:8•]-ßÃ
+
/))/ ñ )4 äñ # r *&
n
(
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
].Xc)4 :UUDL!# 3DQDUH *& f*! :e?Út‹~›%|QŽz{ _TQc*!9LHR^.1./T-UWLULRW-S V.WS6C.QX6-L/T-R-HTdTH6.V^LW5 ^LWT1L (c%! ,0¶‹~›%z{
!
,`C0 & *žæ¶

|0¶+—›³QŽwƒb°ax
£¿ax詐v“ uÒÑ=z‘
Œ–ÇȳhQŽc¬|ax
+
,Qº• -
¸0¶‹~·›%w¡~òÞ#iҏ¹D?@
}~ QŽ×Øz{ÀbPɲ°¬³4 $ º”QŽ.|€ a $ ăÃÕ¸›³°¬³4|QŽf.ax $ ?@$,0 ¶‹~›% + +nDQŽ()³´}~”,0¶‹
~›%z{
¼”ãÿ,|0¶‹~›%
,|)
lC*—~`CÄá÷
+
+nD%8-¼,0¶‹~ ›%|97QŽz{R© #+ &! ,QŽz{Qv|ÒÓ·’ +nD
QŽ6¬Eˆ\|b
v,Qz{
\“j“x(Qk
v,,*¬Ô“f·‹~›%z{ $³ÝËÿ3¸´ï|åä $ ¼”ãÿ$,,*¬Ô“f· ‹~›%LםCßà|}~_P + õ–
0”QŽh
!!
©
#!
$,0¶‹~›%|QŽz{
@R^XL#!9LHR^.1./T-UWLULRW-S V.WH.7T-TH6/L-SR1TU/U.VHWRETHT.1RX;.c
,! º”µÓ º”<# >b|×Ø 0¶‹~°¬Ûº¬ ÒICï lm Y°t¹ bOM<5N@\_598 ! 9Qºº” & ]4KÜ:ž %캔
ÓtŸÿh?!
&
ÿ9‚!xî¬
-#. * ’ÜÑ Y°­4 bOM<5N@\_598 ! ]4k<Ç] 5 KÜ:ž
Ø
5
%캔
!
Ÿh?
&
CE
N&
žònžÔ‚L

6°¬
Ûº¬
-#.
)
€,Ñ Y°­4
bOM<5N@\_598
9Qºº”
!
¹¸ƒ¬›³|´6QŽQR¼a§¨o3
E}™
-#*.
&
pVÑ Y°t˜
bOM<598
9Qºº” Ót¨Ÿÿ
&
\ÿ!¬Ô
&
>Š‚
-#).

·q Y°t˜

I5;9>
!
]4k<Ç]
5
KÜ:ž Ø 5 %캔 ! ·qÄÁ›³ÙQŽ & “‚QŽ†ÿ QŽ—˜ -#&. # ¦€Í234‡K[t¹ I5;9> 9Qºº” h? & Ÿ‚h? & o‚†Võ‚ -#. % pVÑ Y°­µ bOM<598 9Qºº” * 6°¬Ûº¬Ä‹ª«0¶|°¬Ûº¬ -##. É|•-¶
M_W”Àºb†x({|./
QŽ v,Qz{WvQvÞ¿972¡|ÒÓ + +,
C|º”()ZÀâ¼°¬³8|ãCQ
ŽQR|ãCQŽc¬Œcl|£¶†£Ùº”
,Q
QŽz{QvdD¶
ý~Àb|º”×Ø+ø¬À
b|zþ
hþÍúùC¼¶|×ØÑ7ŒÞ(“j
,
b
P
¯QŽz{ãÑ7|Õ¸<#À&@Kr6
s
‹ìp|¶Ã¶˜
¼QŽ()|¹ß}~CÞ£| D% + ¸{
QŽz{Þ¿ÅâÖ¶u‚¼zþCˆY G + âÖ©µ
m›°|u‚
h¶ì & nt & ÚÉ & #ß Ã & ƒ¬Ó¯ & .ëL”•
uÞèN§|€a
ÀÄÇÈ °¬³|QŽc¬·QŽ.
u™ª>b|º”¬DÞ£|

,
bP
vQŽ>bº”
vq³Cg6ˆª-~ |>bº
.+þ*|QŽc¬>ÙåCX{
+´z{ 9:b|QŽ¬M_°ØA9>bºŒc3Ý
+

QŽ>bºÑ7ŒÞ({ + ¥{
vQŽ>bº”9:
-~9Qºº”
&
K
Ü:žØL4:º”×Ø
£¿×ØY´û~”*¶>b
*
hä\Å*¶>bC*„6QŽ¬|axJ¾Þ+Q
ŽãÛ|ÒÓ
+
£Ñ7QŽz{7˺Ì5 †]þ> & 4:éê|ÜÐz{Qþ + /0,GÒÓ|x(Ì%
wøÆkQŽ1ªl
ÏŠ,,*¬Ô·‹~›%„Hù|()‘x
+
p
Ev,Gz{éê|}~-
QŽåÄ¡~”,„ 6IÂåx & ,%½IÂz{
&
BY胬æçÍúL ם`Cßà|}~_P + /0m›,Œ|QŽº” ()|ßà}~ & >b|QŒ¼`¡·QŽ>bº |{
QŽÄ¡ù|Œc,Qz{
1ªÏ Š,‹~›%„HÐ|ØO†×Ø
Œ–C„G¹ƒB
,ðÐQx|Œ:
+

uvwx
#
- .!;T-S.XU.1 YF MT1E.1 Y< I.X/LUKco9LHR^.1./T-Uo# D1ELW5
UHR1ET1QHSL/LHR^.XT-WLUC.1ULU.VXTdT1QU6UHL/UH.CRHS.CS6UT.5
/&)/ ñ )4 äñ # r *&
n
(
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
].Xc)4 :UUDL!# 3DQDUH *& X.QT-RXUHT/DXTdTR/DXHTdRWTRHLUHRHTUHT-RXR1RX6UTU.V^T.X.QT-RX ;9>UCL-HW.U-.CT-ERHR-Y.caL1^T.HT-R 444 *4!#(c - * .!8S6DWM_ PR1Q;8c9LHR^.X./T-UV.WCS6H./LET-T1LWLULRW-S
R1E EWDQELdLX.C/L1H-Y.c##c
- ) .!1./T-CSL1.H6CT1QR1E CLWU.1RXTZLE EWDQHWLRH/L1H-Y.c;RHDWL *# &&!%(%#%)c - & .!MR.P9YTR1QY?$ PR1 Mc3CCXT-RHT.1 .V/LHR^.1./T-R1RX6HT5
-RXHL-S1T`DLUT1 HSL/.ELW1TZRHT.1 R1E H.7T-.X.Q6WLULRW-S .VHWR5
ETHT.1RX*(c
- .!BSR.MO ;T-S.XU.1 YF MD 3O$ LHRXc@RWQLHT1QHSLSD/R1
QL1./L5/T-W.^T./LR7TUV.WEWDQETU-.dLW6#T1UCTWRHT.1UVW./QX.^5
RXU6UHL/U^T.X.Q6R1E HWRETHT.1RXHL./L>LU ** !%#)4c
- # .!?.1QO$ /RH-ST1QRCCW.R-S H.LXD-TERHT1Q^ T.X.QT-RX/LHR^.XT-1LH+.W[U.V
-./CXL7/T7HDWLU-Y.c31RX- % .!MTa MD.aaMD a$LHRXc9LHR^.X./T-UUHDE6.VETR^LHT-WLHT5
1.CRHS6DUT1QQRU-SW./RH.QWRCS65/RUUUCL-HW./LHW6# R-./CRWT5
U.1 .VUHRQLUR1E UD^H6CLUETRQ1.ULE ^6GLUHLW1 R1E /LET-T1L-Y.c9.XJT.U6UH * %!%#***(c - ( .! !ߓ
MBµ
yI‘
L
c
QŽ()vB,®Ê &ÒÓz{$|}~_Pº” -Y.c %ôõ,¬
*(
#!*#(4c
- 4 .!K^^LXU@9cOWLET-HT.1 R1E -XRUUTVT-RHT.1 .VEWDQH.7T-TH6DUT1Q
CW.^R^TXTUHT-/.ELXT1Q.VHL/C.WRX/LHR^.XT-ERHR#HSL-.1U.WHTD/
.1 /LHR^.1./T-H.7T-.X.Q6U-WLL1T1QRCCW.R-S-Y.cYOW.HL./L
>LU *% #!#&&%c -.!H.7T-TH6T1 WRHU-Y.cYOW.HL./L>LU *# !,c
-.!
NzB

àt´
L c m>†=>ƒ#‹~| bOM<5 98 QŽ(z{ -Y.c %,-. *$$ )#!##
#4&c
-*.!
{zˆ
$
!g|
$
¶Iö
$
L
c
“”ÞÔ+~|&úöƒÃ
bâQŽïðº”
-Y.c
$%$,-.
$ *$*$ )%!4#
*(#)c
-).!
ñ¸}
$
›=°
$
dDï
$
L
c
9Ðц2ÐяQ|(•
܃tu‹~|

I5;9>
QŽz{
-Y.c
$¸,
$ *$*$
&)!#**$4c
-&.!aTR1QB$ GR1QaN$ `DRXTH6-.1HW.XR1E ETU-WT/T1RHT.1 .VHSWLL>+%.+6- UCL-TLU^RULE
.1 QRU-SW./RH.QWRCS5/RUUUCL-HW./LHW6-Y.cOS6H.-SL/31RX * **!#&c -.!8D1 I GR1Q9 BSR1Q3 LHRXcbOM<5N5@\_5IA98 R1RX6UTU
.V-.1UHTHDL1HUT1 HSLW..H.VH+.[T1EU.VG.&!+6 DUT1QR /LHR^.X./T-URCCW.R-S -Y.cOS6H.-SL/31RX *) *& !)#
*#)c
-#.!MTPP GR1Qaa BSR.M$ LHRXcITQS5CLWV.W/R1-LXT`DTE
-SW./RH.QWRCS65LXL-HW.UCWR6T.1TZRHT.1 HT/L5.V5VXTQSH/RUUUCL-5
HW./LHW6R1RX6UTU.V>RET78RC.US1T[.dTRLV.W/LHR^.X./T-WL5
ULRW-S-Y.cY-%.!
~
]C
ŽNN
L c Z2ôÒ«ü‹~|t¹Q Žz{ -Y.c %,-. ** )%!##(*c
-(.!
Œ,,
øT€
%1
L c ¹5Òf„¬¼¹Ôº»ª «‹~|Y°­4 bOM<598=98 QŽz{ -Y.c % ,-. ** )%!##(c
-4.!
!5W
T¸B
Œ&°
L c “” ?<598 QŽ()| õ]ÐÑÌ/‹~z{ -Y.c ¸,
*) &&!#%&c -*.!
T»‚


L c “”QŽ()|Y€™š6 ¶«Œ7||‹~›%z{ -Y.c ¸,
** &)!*# )*c -*.! Óç1
V=
lÑV
L
c
­4QŽ×Øz{ìÒj
ñò™š­sT±sY°‹~›%
-Y.c
º”x
*) &!)#)%c -**.!BSR.PP _L1QPM JRTa LHRXcbXHWRCLWV.W/R1-LXT`DTE
-SW./RH.QWRCS65^RULE /LHR^.1./T-UHDE6.VHSLWRCLDHT-LVL-H.V
HSLUDWVR-LXR6LW.V0&%!- .&.&2.1 REL1T1L5T1ED-LE -SW.1T-[TE1L6
ETULRULCW.dTELU1L+T1UTQSHT1H.R1HT5VT^W.UTU/L-SR1TU/-Y.,
OM.8 \;K*)E.T# c)%=0.DW1RXcC.1Lc4#%c -*).!NTR.a$ PL9$ aTR1Q<$ LHRXc9LHR^.XT-WLQDXRH.W6LVL-HU.V XT-.WT-L# R^ TXLR-TE /LHR^.1./T-UHDE6^ 6XT`DTE -SW./RH.QWRCS6 -.DCXLE +THS HR1EL//RUUUCL-HW./LHW6-Y.c8HLW.TEU$ *$*$%%# %&c -*&.!MD a$ aT.1QB$ MTY$ LHRXc9LHR^.1./T-UHDE6.1 hFTE1L65PR1Q ALVT-TL1-6U61EW./LhR1E T1HLWdL1HT.1 LVL-HU.V>STZ./RAW61RWT5 RLL7HWR-HUT1 WRHUDUT1QDXHWRCLWV.W/R1-LXT`DTE -SW./RH.QWRCS6 -.DCXLE +THS /RUUUCL-HW./LHW6-Y.c@RXR1HR$ * () !)#
%c -*.!NTP$ ND M$ GD P$ LHRXc3CXRU/R/LHR^.1./T-T1dLUHTQRHT.1 T1H.HSLT1HLWdL1HT.1 .Vd.XRHTXL.TX.VH-1&5!- :!&/!CR/C .1 WRH /.ELX.VR-DHLT1VXR//RHT.1-Y.cYKHS1.CSRW/R-.X$ * )%#
&(%c
-*#.!PR1 8 GD J MT1 B LHRXc9LHR^.1./T--SRWR-HLWTZRHT.1 .VRQ5 T1QR1E T1dLUHTQRHT.1 .1 HSLR1HT5RQT1QLVL-HU.VH.HRXVXRd.1LU.V KCT/LETD/-Y.c9.XJT.U6UH *4$ !$#*$&c -*%.! ñƒ $ ̵ $ çô $ L c “”A­*4Æ 5 icPÉÔ.() |$,HøÑQŽz{ -Y.c $%âÖ×½-. $ * #!#)c
-*(.!
!g|
T„…
{zˆ
L c “”œ¬QŽ()|‘ .ÀbË%ÓÔÙà%z{ -Y.c ¸,
** &) !4# %*%c -*4.!?L1QM 9R< BSR1QM LHRXc9LHR^.1./T-UHDE6.V?L1[+R
_X.U5T1ED-LE SLCRH.H.7T-TH6R1E LVL-H.VSLW^5CW.-LUUT1QCW.-L5
EDWL.1 H.7T-TH6-Y.cOS6H.HSLW>LU *) *%!&#*c -).!MTPGR1QP 8D M$LHRXcK7CX.WT1QC.HL1HTRX-SL/T-RX/RW[LWU
^6/LHR^.X./T-U/LHS.E V.WUHDE6T1QHSLCW.-LUUT1Q/L-SR1TU/.V
HWRETHT.1RXOM<5N5@\_=98# R-RUL
UHDE6.V>RET73-.1THT-Y.c/)/ ñ )4 äñ # r *&
n
(
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
].Xc)4 :UUDL!# 3DQDUH *& -).!GR1QaY GR1QIP BSR1Q3I LHRXc9LHR^.X./T-UUHDE6
.1 HSLH.7T-TH6.V3-.1THLW..HR1E THUCW.-LUULE CW.ED-HUDUT1QDX5
HWR CLWV.W/R1-L XT`DTE5-SW./RH.QWRCS6=LXL-HW.UCWR65T.1TZRHT.1
U61RCHSTQS5ELVT1THT.1 /RUUUCL-HW./LHW6-.DCXLE +THS CRHLW1 WL-5
.Q1THT.1 RCCW.R-S R1E T1QL1DTH6CRHS+R6UR1RX6UTU-Y.cYOW.5
HL./L>LU ** !*#*(&c -)*.!BSR1QI9 MT8 M BSR1QI LHRXcI.XTUHT-` DRXTH6LdRXDRHT.1
.V-.//LW-TRX+STHLR1E WLE QT1UL1QDUT1QRbOM<5N@\_598=
985^RULE /LHR^.X./T-URCCW.R-S -Y.cYOSRW/JT./LE 31RX ** #*#*(c -)).! Á†
Ž‡
ˆ‰
L
c
ß«Lµ¶€Æ«0¶|QŽ
z{
-Y.c
efB,Y` *$$$ )&!#&*c
-)&.!
ŠdV
$
¾‘‘
$
øÁ
$
L
c
“”QŽ()|€ÍÌ
0yµ¶J¾z{
-Y.c
$%âÖ×½-.
$ *$*$ (
!)#&%c
-).!
ýµ
$
‹â
$
”Iœ
$
L
c
“”QŽ|RSѵ¶€Æ
`¡0‹~z{
-Y.c
$,,|‘ÛÜ
$ *$*$ *(!*#4(c
-)#.!

$
RŒ$
ø¿
$
L
c
T5µ¶Uäªd¶_¤t
5
¥¦2§¨|QŽz{
-Y.c
$,G
$ *$*$ ) !(#
*%&c
-)%.!aD G$ GR1QI$
I;9>5^RULE /LHR^.1./T-U
UHDE6.1 HSLH.7T-TH6RXLdTRHT.1 LVL-H.V.HSLWHWRETHT.1RX/LET-T1LUT1 ;TDSDR1QYTLED HR^XLHH.WLRXQRW!3U
*
8
*
-Y.c
YKHS1.CSRW/R-.X *)&(!#((c -)(.! !D
ŽÑÁ
Tï¨
L
c
“”
?<598
QŽØz{€
Í
&
°G€™šç­s|µ¶›%
-Y.c
%,-.
*& )4!)#*#c -)4.! *îí
½
€‘
L
c
“”QŽ|ÒqÞy qÞÙü ( µ¶›%z{ -Y.c %âÖ×½-.
*& *!#)c -&.!GR1QI JRTY HSLR-DHLSLCRH.H.7T-TH6R1E 1LCSW.H.7T-TH6.VBSDUSR31USL1 GR1
-./CRWLE +THS -T11R^RWT1 WRHUDUT1Q

I;9>UCL-HW.U-.C6-Y.c
YKHS1.CSRW/R-.X *) &#!*#%*c -&.! ¾’

!“½
L
c
“”
;9>
QŽz{_…A
•×„6¬¼Y°_¤t¥¦2æç|ÇÈ
-Y.c
¸,
**&)!#4%c
-&*.!

§
\Cô
L c “”QŽ|ÔóG€àªY °ôZæç|‹~z{ -Y.c %,|A`
*) *4!# #)*c -&).! AB
­
T•–
L
c
“”4Æ?.
5
—+Ô.|“
‚QŽ×Øz{€Æ234™š_¤t
-Y.c
º”x
*)&!)#)&&c -&&.! DLj
–“Ã
!ߓ
L
c
Ak…Uતt¶Õ æçY°|t˜QŽz{ -Y.c %,-. ** )%
!%#*(c -&.!8D BI MT8 N B.D ?3 LHRXcbWT1RW6/LHR^.1./T-UUHDE6.V
R1HT5ELCWLUUTdLLVL-H.V/.ELX.VELCWLUUT.1 T1ED-LE ^6-SW.1T-dRWTR^XLUHWLUUT1 WRHU-Y.,
YOSRW/JT./LE 31RX * #))c -&#.!PDL> BSR.M ID P LHRXc9LHR^.X./T-UHDE6.V-.XRQL15T15
ED-LE RWHSWTHTUT1 WRHUR1E HSLT1HLWdL1HT.1RXLVL-HU.VIDR1Q5
MTR15YTL5AD5@R1Q$ RHWRETHT.1RXJRULE <./CXL/L1H3XHLW1RH9LE *) E.T# c=*)= &)4#4c
-&%.!YTR1QI;TLMMTPLHRXc3CCXT-RHT.1 .VDXHWR5CLWV.W/R1-LXT`5 DTE -SW./RH.QWRCS6-.DCXLE +THS /RUUUCL-HW./LHW6H./LHR^.5 1./T-UHDE6.1 UC.1HR1L.DUX6S6CLWHL1UTdLWRHUR1E T1HLWdL1HT.1 LVL-HU.VOT1Q?R1 CWLU-WTCHT.1-Y.cY8LC 8-T ** )!&#
&()c
-&(.!aTR1QM YTR1QO BSR1 <$ LHRXc@SLULWD//LHR^.X./T-UHDE6
.VT1HLWdL1HT.1 LVL-HU.VHSLHWRETHT.1RXJR.7T1 OTXR1E R/DXHT5-./C.1L1H/LET-T1LC.X6CTXT1 HSLHWLRH5
/L1H.V/6.-RWETRXT1VRW-HT.1 T1 WRHU-Y.c9.XJT.U6UH ** ( !4#*&)&c -&4.!MTR1Qa /LET-T1LUSDR1QX.1QV.W/DXRRUR1 LVL-HTdLHWLRH/L1HV.W/6.-RW5
ETRXT1VRW-HT.1 T1 WRHU-Y.cYOW.HL./L>LU * !*#%4c -.!@R1 ? MTR.G A.1Qa$ LHRXc9LHR^.1./T-CW.VTXLUELXT1LRHL
HSLLVL-H.VHWRETHT.1RX-RWETRXT1VRW-HT.1 T1 WRHU-Y.cOM.8 \;K ** E.T# c)%=
0.DW1RXcC.1Lc$$)&%,
-.!ARTG$ GLT<$ F.1QI$ LHRXcKVL-H.VHSLHWRETHT.1RX/LET-T1LH.1Q7T1XD..1 L1E.HSLXTRXE6UVD1-HT.1 WRHUUHDETLE ^6
DUT1QDWT1RW6/LHR^.1./T-U^RULE .1 XT`DTE -SW./RH.QWRCS65/RUU
UCL-HW./LHW6-Y.cYOSRW/JT./LE 31RX * #!#(#c -*.!GR1Qa GR1QN BSR1Q3 LHRXc9LHR^.X./T-UUHDE6.VT1HLW5
dL1HT.1 LVL-HU.VGL15aT15_.W/DXRDUT1QDXHWRSTQS5CLWV.W/R1-L
XT`DTE -SW./RH.QWRCS6=/RUUUCL-HW./LHW6-.DCXLE +THS CRHLW1
WL-.Q1THT.1 RCCW.R-S-Y.cYOSRW/JT./LE 31RX *) %&#**c -).!?.D a @R.N _L1QN LHRXcbWT1RW6/LHR^.1./T-U-SRWR-HLW5
TZRHT.1 .VXTdLWVT^W.UTUT1ED-LE ^6<&
T1 WRHUR1E T1HLWdL1HT.1
LVL-HU.VaTRPD aDLEL-.-HT.1 -Y.cYOSRW/JT./LE 31RX *) %&##*c -&.!?R.aa ELCWLUUR1HR-HT.1 .VaTR.6R.UR1 T1 WRHUDUT1QDXHWRCLWV.W/R1-L
XT`DTE -SW./RH.QWRCS65/RUUUCL-HW./LHW6-./^T1LE +THS /LHR^.5
1./T-U-Y.cOS6H.HSLW>LU *) *%!%#%&c
-.!8.1Qa GR1QY GR1QO LHRXc I;9>5^RULE /LHR^.X./T-U RCCW.R-S H.LdRXDRHLHSLLVL-H.VaDL5_D5BSD5PD EL-.-HT.1 .1 S6CLWXTCTEL/TRWRHUT1ED-LE ^6STQS5VRHETLH-Y.cYOSRW/JT./LE 31RX *)!%(=%4#**c
-#.!BSR.M?R.IBSR.PLHRXc9LHR^.1./T-R1RX6UTU.VHSLHSLW5 RCLDHT-LVL-H.VBST^RTATSDR1QCTXT1 HWLRH/L1H.VUHWLCH.Z.H.-T15 T1ED-LE ETR^LHT-1LCSW.CRHS6-Y.cYKHS1.CSRW/R-.X **
&*##&%c
-%.!
!w
ω
˜Ð=
L c;9> QŽØz{YƒP‚¼ Y°|‹~›% -Y.c ,` *$$4$ && !4# $4c
-(.!?D P$BSR1QP$ 8STa$LHRXcKVL-H.VHWRETHT.1RX-T1L^ LW^LWT1L.1 H6CL* ETR^LHLU^RULE .1 -./CWLSL1UTdL/LHR^.5
/#)/ ñ )4 äñ # r *&
n
(
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
].Xc)4 :UUDL!# 3DQDUH *& 1./T-U-Y.c@RXR1HR *$ (!)#%##c -4.!BSR1Q3$ 8D1 I$ A.D 8$ LHRXc9LHR^.X./T-UUHDE6.1 HSLSLCR5 H.CW.HL-HTdLLVL-H.VU-.CRW.1LDUT1QDXHWR5CLWV.W/R1-LXT`DTE -SW./RH.QWRCS6=LXL-HW.UCWR6T.1TZRHT.1 `DREWDCXLHT/L5.V5VXTQSH /RUUUCL-HW./LHW6-Y.c31RX6UH$ *$)$)(!#))c -#$.! Á¸« $ Œ™ $ њ $ L c lm®¶0¶|QŽz{ -Y.c ­LÇx` $ * )*!#)(c
-#.!

f9
‡›œ
L c QŽ?@’Üф6¬¼Y °0|‹~|(z{ -Y.c mÐX4B, *$ #!$# *$c -#*.!9R<$JTF8$BSR1Q9$LHRXc@.7T-.X.Q6LVL-HU.V/.W1T1QQX.5 W6ULLE T1 WRH# R/LHR^.1./T-/LHS.E V.WCW.VTXT1Q.VDWT1L/LHR5 ^.XT--SR1QLU-Y.cYKHS1.CSRW/R-.X$ * )!#)&c
-#).!

ðU
ÇÇ
L c ·q0¶|t˜QŽz{ -Y.c ñM¯BY` *& )#!#)(c
-#&.!PR1 ? BSR.P AL1QO LHRXc:1dLUHTQRHT.1 .VH.7T-.X.QT-RX LVL-HU.V8SDR1QSDR1QXTR1 T10L-HT.1 T1 JLRQXLE.QU^6/LHR^.5 1./T-R1E HWRETHT.1RXRCCW.R-SLU-Y.cK7C JT.X9LE !9R65 +..E*$*)!#)#c -#.!MTD P$ IDR1Q>$MTD M$LHRXc9LHR^.1./T-UUHDE6.VDWT1LVW./ 8CWRQDL5AR+XL6WRHUL7C.ULE H.IDR1Q56R.5ZTDUT1Q I5;9> UCL-HW.U-.C6-Y.cYOSRW/JT./LE 31RX$* *!#)#c -##.!9R<JTF 8D ALHRXc8LWD/R1E [TE1L6/LHR^.XT--SR1QLU.V
WRH1LCSW.H.7T-TH6T1ED-LE ^6/.W1T1QQX.W6ULLE-Y.c_..E @.7T-.X *$$ &(!$#*4((c
PAGKNAUD0SA/CH/NN10U/D0BCBM.AD/OBCB.0UK0C.BHAGCKDIHF BM
DG/H0D0BC/12E0CAKA.AH0U0CA
N:;FD15/T1Q
$*
$ G3;?JT1

$
BI3;?9R.5UL1 ) P3;??DR1Q5/T1Q

8IbPR5-SD1 ) <3:JR.5-SR1Q
* ! !cA1!%!1 >%&4<-H!!2%,&4A/+.-!& 4&%<-/-%/!8-!& &4>=!2H/!.!0%&.2!1 )-@!1 B!#%2!,&4>=!2H/!.! )-@!1 **) >=!-,
*cF%-/+-L&%M2-!& A%;%!22! N!-12+ 0%&#!. )-@!1 *-!.=-1 >=!2H/!.!F%&+;>&%;&%-!& )-@!1 *# >=!-,
)cG4!5!-/ *&2;!-5&4)-@!1 B!#%2!,&4>=!2H/!.! )-@!1 *$$*4$ >=!-
-6OKDG/UD.!9LHR^.1./T-UTUR1L+/LHS.E H.UHDE6.1 HSL/LHR^.XT-1LH+.W[ R1E HSLWLXRHT.1USTC ^LH+LL1 ^.E6R1E L1dTW.15
/L1H$ +ST-S -.1V.W/UH.HSL+R6.VHWRETHT.1RXL1-LR1E HL-S1.X.Q6 R1E CW./.HLHSL/.ELW1TZRHT.1 .V@<9c@STUCRCLWT1HW.ED-LHSLRCCXT-RHT.1 .V/LHR^.1./T-UT1 HSLWLULRW-S .V H.7T-TH6/L-SR1TU/.V@<9-./CRHT^TXTH6/L-SR1TU/.V@<9V.W/DXR$ CSRW/R-.X.Q6LVL-H.V@<9R1E CW.-LUUT1Q/L-SR1TU/.V@<9c
@STUCRCLWUD//RWTZLHSLCW.^XL/UT1 HSL@<9/LHR^.1./T-UWLULRW-S R1E CW.UCL-HTHU^WTQSHVDHDWLc
-_AF VBGHK.!/LHR^.1./T-U, HWRETHT.1RXHB0#)d*(+RU]U..()*)&

yz-0
!
†‡
#
/%)/ ñ )4 äñ # r *&
n
(
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
].Xc)4 :UUDL!# 3DQDUH *$&

  鄂ICP备06018747号 Copyright @ 2017
  植物通 All Rights Reserved
  Email:23198511@qq.com
回顶部
51La