免费文献传递   相关文献

Chemical of Vitex trifolia

蔓荆的化学成分



全 文 :!XY
!
1D@-/S.0AK8*-)# -0*9,3*
C:A X`G156X

$ <\I;P.1E5TRF1E

$ N3;QMFS

$ <\I;8RS5+X
*
$ a\3;QP.1E5R.1E

!
!OA&++0+,D$%3$&:$ Q=7/$) 1./&$08)/9%#/*:$ Q=>+= )$$$&$ (/)$
*OA&++0+,D$%3$&:$ N$)>+= 8)/9%#/*:$ N$)>+= %)$$$$$ (/)$
!!*5MJCF.SC+!31F+T?FU.SVGWFT?FU$
!
5U.TG?FU.W]GW/S?G?F! GW.1E+S?R ?F1 K1.+1 -./].X1VT$ XeG.W!$ )5F/5XUT.WS-G-SV
!&$ *
#
$ )
!
$ *&5?USR6VU.76.WFG15*5F15*(5.S-G-SV!)$ *
#
$ )
#
$ *&5?USR6VU.76XUT5*5F15*(5.S-G-SV!$$ *
#
$ )
#
$ *&5?USR6VU.765
.WFG15*5F15*(5.S-G-SV!*$ *
#
$ )
#
$ *&5?USR6VU.76.WFG15*5F15*(5.S-G-SV5*(5C2
!
2@5EWX-.]6UG1.T6WFT?FU!%$!L545RF7GVF-F1.S-
G-SV!b$ .-?G-.T6WGW-.R.W!#$
!
5TS?.T?FU.W!(G1V
!
5VGX-.T?FU.W!$ RGTDFF1 ST.WG?FV HU./?RFT?F/TG1V WFGeFT.H?/*G*%/,+0/$O
@RFSUT?UX-?XUFT+FUFFWX-SVG?FV XTS1EG-./DS1G?S.1 .HZG1V *Z;9>?F-R1ScXFT!<^ 8P$ \9` <$ G1V \9J5I8:598 G15
GW6TFTO<./].X1VT5% +FUFST.WG?FV HU./?RST]WG1?H.U?RFHSUT??S/FO
*]@E XAFGJ+!?/*G*%/,+0/$ T?FU.SVT ?US?FU]F1.SVT
*9@S@/Q@GG.C@+!*$)5*5
* ;HBG/BT + ! ;G?XUGW 8-SF1-F M.X1VG?S.1 .H MX0SG1 BU.eS1-F
!*$$Y$%4 ?RF8-SF1-FG1V @F-R1.W.E6BU.0F-?.HMX0SG1 BU.eS1-F
!*$*P$$)
*1AFF@JLABG/BT .HCDAF+!
!
a\3;QP.1E5R.1E$ BU.HFTT.U$ @FW=MG7#
!$4**(#*$#$ I5/GSW# [RG1E6R2/GSWOH0/XOFVXO-1
!:1?U.VX-?S.1
?/*G*%/,+0/$ !_FUDF1G-FGFST+SVFW6VST?USDX?FV
S1 8.X?RFU1 *+
O@RFHUXS?.H?RST]WG1?+GTXTFV GT
G?UGVS?S.1GWG-RF$eFU?SE.$G1FT?RFTSG$R6]FUKS1FTSG$F?-
**+
O:1 ]UFeS5
.XTUF].U?T$T./FVS?FU]F1FTG1V HWGe.1.SVTRGeFDFF1
ST.WG?FV HU./ ?RSTT.XU-F
*)5&+
O:1 ?RF-GXTF.H.XU
TFGU-R H.UDS.W.ES-GW6G-?SeFTXDT?G1-FTHU./ ?RST
]WG1?$G1F+T?FU.SVGWFT?FU$
!
5U.TG?FU.W]GW/S?G?F!
!MSEO$+GTST.WG?FV HU.//F?RG1.WF7?UG-?$?.EF?RFU
+S?R TS7K1.+1 ?US?FU]F1.SVTXeG.W! $ )5F/5XUT.WS-
G-SV!&$*
#
$)
!
$*&5?USR6VU.76.WFG15*5F15*(5.S-G-SV
!)$*
#
$)
#
$*&5?USR6VU.76XUT5*5F15*(5.S-G-SV!$$
*
#
$)
#
$*&5?USR6VU.76.WFG15*5F15*(5.S-G-SV !* G1V
*
#
$)
#
$ *&5?USR6VU.76.WFG15*5F15*(5.S-G-SV5*(5C2
!
2
@5EWX-.]6UG1.T6WFT?FU!%$?+.HG?6G-SVT!L545RF7G5
VF-F1.S-G-SV!b G1V .-?G-.T6WGW-.R.W!#$G1V ?+.
T?FU.SVT
!
5TS?.T?FU.W!(G1V
!
5VGX-.T?FU.W!O:1
?RST]G]FU$+FUF].U?FV ?RFST.WG?S.1 G1V T?UX-?XUGWFWX5
-SVG?S.1 .H?RFTF-./].X1VTO
!>FTXW?G1V VST-XTTS.1
<./].X1V +GT.D?GS1FV GTG+RS?FG/.U]R.XT
!!
MSEO!8?UX-?XUF.H-./].X1V
].+VFUO/] (5(% r$ *
#
+
*
@
l &O$ !-$O$$
<\)
$TR.+FV ].TS?SeFCSFDFU/G115JXU-RGUV UFG-5
?S.1O\SER5UFT.WX?S.1 I8:598 TR.+FV ?RF/.WF-XWGUS.1
G?3V>#%O(# ( S1 GEUFF/F1?+S?R ?RF/.WF-XWGUH.U5
/XWG<
&
($
^
*
;G
l
!]FGK G?3V>)4# -.XWV T?F/HU./FWS/S1G?S.1 .H]GW/S?5
S-G-SV$WFGVS1E?.G-.10XEG?FV VSF1FT6T?F/S1 ?RFT?F5
U.W/.SF?6O@RF:>GDT.U]?S.1 /G7S/X/G? %&$ -/
k
?.EF?RFU+S?R

\5;9>G1V
)
<5;9>T]F-?UGWVG?G.H
S1VS-G?FV S??.DFGT?FU.SVGWFT?FUO@RF

\5;9>T]F-5
?UX/TR.+FV G/XW?S]WF?DF?+FF1
$
$O## G1V *O HU./
+RS-R G1X/DFU.H/F?R6WEU.X]TF/FUEFVO3?US]WF?G?
$
*O*( -.UFT].1VS1E?.?RF<*
<^ ^/.SF?6+GT.eFU5
WG]]FV +S?R G1.?RFU/XW?S]WF?$ DX?T?SWVST-FU1SDWFO
9XW?S]WF?TG?
$
&O#) G1V O)( .USES1G?FV HU./\5) G1V
\5&$UFT]F-?SeFW6O@RFTSE1GWG?&O#) ! \$ VV$Jo
&,4$*,# \[+GTVXF?.\5) -W.TF?.G-GUD.16WHX1-5
?S.1GWEU.X]O@RF
)
<5;9>T]F-?UX/RGV ?RFH.W.+S1E
-RGUG-?FUST?S-UG1EFTG1V TSE1GWT$ GTTSE1/F1?RGeS1E
,&*$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
DFF1 GSVFV D6GZIB@T]F-?UX/#
*
O( ?.4O( !%
/F?R6WEU.X]T$
+
*O$ ?.#O%!% <\G1V *$ ]WXTVST5
-FU1SDWF<*
EU.X]THU./?RFGW-.R.WG1V G-SV /.SF5
?SFT$
,
%)O#!<5)$
-
**O G1V )4O%! t< G1V
.
%)O* !< ^O@RF

\5G1V
)
<5;9>T]F-?UGW
VG?GH.U-./].X1V +FUFSVF1?S-GW?.?R.TF.H
!
5U.5
TG?FU.W
*)+
$+S?R ?RF/G0.UVSHFUF1-FDFS1E?RG? TR.+FV
G1 GVVS?S.1GWEU.X] .H<*
TSE1GWTHU./
$
*4O ?.*4O#O
@RST-WXT?FU.H<*
EU.X]TST?6]S-GWH.UGHG?6G-SV
-RGS1O@RF.1W6.?RFUVSHFUF1-FT+FUF.DTFUeFV S1 ?RF
)
<5;9>T]F-?UGWVG?GH.U<5*5<5# G1V <5*&$S1VS-G?S1E
?RG??RFFT?FUEU.X] RGV UF]WG-FV ?RF^ \EU.X] S1 G?
<5)O@RST].TS?S.1 +GT-.1HSU/FV D6\9J<-.UFWG?S.1T
.DTFUeFV HU./\5 ?.<5) G1V \5) ?.<5f!MSEO*$G1V

\$

\5<^ 8P-.UFWG?S.1T.DTFUeFV H.U\5) +S?R \5*
G1V \5&O@.SVF1?SH6?RFHG?6G-SV$-./].X1V +GTTG5
].1SHSFV$G1V ]GW/S?S-G-SV +GTSVF1?SHSFV S1 ?RFG-SV
HUG-?S.1 D6-./]GUST.1 .HS?TI:598 +S?R G-./]X?FUUFH5
FUF1-FVG?GDGTFO 1^ ?RFDGTST.HS?TT]F-?U.T-.]S-VG?G
G1V -./]GUST.1 +S?R ?R.TF.HU.TG?FU.W$ +GTSVF1?SHSFV
GT
!
5U.TG?FU.W]GW/S?G?FO
MSEO*!8FWF-?FV \9J<-.UFWG?S.1T.H-./].X1V
!!@RFK1.+1 -./].X1VT5 +FUFSVF1?SHSFV D6
-./]GUST.1 +S?R ?RFWS?FUG?XUFVG?GO
&!I7]FUS/F1?
&_!3]]GUG?XTG1V >FGEF1?T!9FW?S1E].S1?T+FUF
VF?FU/S1FV .1 GN>85JVSES?GW/FW?S1E].S1?G]]GUG5
?XTG1V GUFX1-.UF-?FVO ]^?S-GWU.?G?S.1T+FUF/FGT5
XUFV .1 GY38<^ 5*$ ].WGUS/F?FUO@RF:>T]F-?UG+FUF
.D?GS1FV .1 G;S-.WF?%$8bM@5:>T]F-?U./F?FUG1V
A_T]F-?UG+FUF.D?GS1FV .1 G1 A_5*$3T]F-?U./F5
?FUO

\5$
)
<5G1V *Z5;9> T]F-?UG+FUFUF-.UVFV
XTS1EGJUXKFU395&$$ ;9>T]F-?U./F?FUG?&$$ G1V
$$ 9\[$UFT]F-?SeFW6$+S?R @98 GT?RFS1?FU1GWT?G1V5
GUVO\>5I8:598 +GT.D?GS1FV .1 GJUXKFU3BIb
!
M@598 T]F-?U./F?FUOM3J598 +GT/FGTXUFV .1 G_Q5
a3J5\8 /GTTT]F-?U./F?FUG1V I:598 +GT.D?GS1FV .1
G\B54(( /GTTT]F-?U./F?FUO8SWS-GEFW!*$$5)$$ G1V
)$$5&$$ /FTRG1V 8F]RGVF7C\5*$ +FUFXTFV H.U<<
G1V TSWS-GEFWQM*& H.U@C@C<]WG?FX1VFUG1 A_WSER?.UD6RFG?S1EGH?FUT]UG5
6S1E?RF@C<]WG?F+S?R j *
8^
&
S1 <
*

\^O
&_!BWG1?/G?FUSGW!@RFT?F/TG1V WFGeFT.H?O*%/,+2
0/$ +FUF-.WF-?FV G?MX[R.X$MX0SG1 ]U.eS1-F.HS1 YXW6$*$$(O@RF]WG1?/G?FUSGW+GTGX?RF1?S-G?FV D6
BU.HOaRG1EP.1E5R.1E$ZF]GU?/F1?.HBRGU/G-6$MX5
0SG1 9FVS-GWA1SeFUTS?6O3e.X-RFUT]F-S/F1!*$$(*
+GTVF].TS?FV S1 ?RF\FUDGUSX/.HBRGU/G-6ZF]GU?5
/F1?$MX0SG1 9FVS-GWA1SeFUTS?6$MX[R.X$&_&!I7?UG-?S.1 G1V ST.WG?S.1!ZUSFV G1V ].+VFUFV
T?F/TG1V WFGeFT.H?O*%/,+0/$!O$ KE+FUFF7?UG-?FV
?RUFF?S/FT+S?R 9F^\O3H?FUFeG].UG?S.1 .H?RFT.W5
eF1?X1VFUUFVX-FV ]UFTTXUF$?RFUFTSVXF+GTTXT]F15
VFV S1 +G?FUG1V F7?UG-?FV +S?R ]F?U.WFX/F?RFU$I?^5
3-$G1V )5JX \^$TX--FTTSeFW6O@RFUFTSVXF.H?RF]F5
?U.WFX/F?RFUWG6FU!&* E+GTHUG-?S.1G?FV D6TSWS-G
EFW<I?^3-!$s5$s?.6SFWV TFeF1 HUG-?S.1T!MUO5%O
MU) +GT-RU./G?.EUG]RFV .1 8F]RGVF7C\5*$ FWX?FV
+S?R <\)
59F^\!sG1V H.W.+FV D6UF]FG?FV -.W5
X/1 -RU./G?.EUG]R6.eFUTSWS-GEFWFWX?FV +S?R ]F?U.WF5
X/F?RFU5I?^3-!$ s5s?..D?GS1 -./].X1VT
!)$ /E$( !$$ /E$# !)$ /E$& ! /E$b !
/EOMUO& +GT]XUSHSFV D6-RU./G?.EUG]R6.1 8F]RG5
VF7C\5*$ ?.ESeF-./].X1V !$ /EOMUO +GT
TXD0F-?FV ?.UF]FG?FV -.WX/1 -RU./G?.EUG]R6.eFUTSWS5
-GEFWG1V 8F]RGVF7C\5*$ G1V HXU?RFU]XUSHS-G?S.1 D6
\BC5^9F^\&$s#$$) /C, /S1
k
?.GH.UV
-./].X1VT)!$ /E$$! /E$*!( /EOMUO# +GT
]XUSHSFV D6-RU./G?.EUG]R6.1 8F]RGVF7C\5*$ ?.ESeF
-./].X1V !)$$ /EO@RFUFTSVXF.H?RF)5JX \^
WGEFU!)( /E +GTHUG-?S.1G?FV D6TSWS-GEFW-.WX/1
-RU./G?.EUG]R6XTS1EGT?F]5+STFEUGVSF1?.H<\)
5
9F^\!$s5$s?.6SFWV TS7HUG-?S.1T!MUO(5)O
MUO +GT-RU./G?.EUG]RFV .1 TSWS-GEFWG1V 8F]RG5
VF7C\5*$ ?..D?GS1 -./].X1V % !( /EO
,*$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
)!:VF1?SHS-G?S.1
<./].X1V !NRS?FG/.U]R.XT].+VFUO/] (5
(% r *
#
+
*
@
l&O$!&$O$$<\)
:>!LJU
%
/G7
* 4%$* ($$ %&$$ &#&$ )%($ *##$ **$ 4%$
%4($%*( -/
k
I:598 3V>#* !9
l,
! p$#)(
! p$)&! p$$(! p$&($! p$&*! p$
)#4 *95]GW/S?S-G-SV+
l
!$$$))( !)*$* !#$
&%!$$$% !($4 !$( !$% !$%
!*$&) !*& \>5I8:598 3V>#%O(# ( *9l
;G+
l
!-GW-V H.U<
&
($
^
*
;G$#%O( 4

\5;9>
!)
$&$$ 9\[
$
# $O#&5*O !/$59Fq%$5<*
5
G1V 5<\p]U.?.1T.HGW-.R.WG1V G-SV /.SF?SFT$*O*#
!*\$?$Jo#,4 \[$5<*
<^ 5^$&O#) !\$VV$Jo
&,4$*,# \[$ \5)$O)% !\$ V$Jo(,( \[$\5
#
)
<5;9>!)
$$$ 9\[
$
# )%O$ !<5$?$
*%O(!<5*$?$%)O#!<5)$V$**O !<5&$V$)4O%
!<5$T$)(O!<5#$?$)O4!<5%$?$)O(!<5($V$
$O$!<54$V$)#O# !<5$$T$*O$ !<5$?$*(O*
!<5*$?$&*O*!<5)$T$#O% !<5&$V$*&O* !<5
$?$)4O% !<5#$?$#O$ !<5%$V$O( !<5($
c$4O(!<54$c$)#O!<5*$$V$(O%!<5*$c$
))O4!<5**$?$*#O!<5*)$?$&O(!<5*&$V$*4O
!<5*$V$4O)!<5*#$c$4O$!<5*%$c$*)O$!<5
*($?$O4!<5*4$c$%)O*!<5f$T$)&O%!<5*f$
?$*O!<5)f$?$*4O5*4O#!<5&f5)f$?$)O4!<5
&f$?$**O#!<5f$?$&O!<5#f$?O
<./].X1V !NRS?F1FFVWFTO/] **)5** r
I:598 3V>&&*!9
l,
$&$*(#$*)&$*$)$(4$%$
&4$))$ 4$ ($ #4$ &)

\5;9>!)
Z^$ &$$
9\[
$
# O&!\$?$Jo*O& \[$\5*$)O!\$V$
Jo$O& \[$\5*(G$)O$* !\$T$Jo$O& \[$\5
*(D$)O& !\$ VV$Jo&O($O* \[$\5)$O(
!)\$T$\5*)$O* !)\$T$\5*%$O$) !)\$T$\5
*#$$O4% !)\$T$\5*&$$O(( !)\$T$\5)$$$O()
!)\$ T$ \5*4 $ $O%( ! )\$ T$ \5*
)
<5;9>
!)
Z^$$$ 9\[
$
# &$O!<5$*%O4!<5*$%4O%
!<5)$)4O(!<5&$#O%!<5$4O&!<5#$)&O$!<5
%$&O) !<5($&%O( !<54$)4O !<5$$*&O# !<5
$*#O)!<5*$&$O*!<5)$&)O*!<5&$*%O
!<5$*&O !<5#$)(O$ !<5%$O# !<5( $
&&O% !<54$&$O( !<5*$$)O( !<5*$)#O !<5
**$*(O% !<5*)$#O* !<5*&$#O) !<5*$%O4
!<5*#$*)O( !<5*%$%$O* !<5*($%O) !<5*4 $
*O%!<5)$O@RF]R6TS-GWG1V T]F-?UGWVG?G+FUFS1
G--.UVG1-F+S?R ?R.TFUF].U?FV S1 ?RFWS?FUG?XUF
*+
$G1V
+GTSVF1?SHSFV GTXeG.WO
<./].X1V &!3/.U]R.XT].+VFUO/] *$5**
r I:598 3V>&#!9
l,


\5;9>!)
Z^$&$$
9\[
$
# O4 !\$T$5<^ \^$O* !\$DUT$\5
*$)O$ !\$/$\5)$O$4 !)\$T$\5*%$$O4
!)\$T$\5*$$O(4 !)\$T$\5*#$$O(# !)\$T$\5
*&$$O( !)\$T$\5*)$$O%& !)\$T$\5*4$$O#%
!)\$T$\5)$
)
<5;9>!)
Z^$$$ 9\[
$
# )(O
!<5$*#O4!<5*$%#O%!<5)$)(O)!<5&$&O%!<5
$%O4!<5#$)*O#!<5%$)(O)!<5($&#O4!<54$
)#O&!<5$$**O%!<5$*&O!<5*$)(O!<5
)$&O# !<5&$*%O& !<5$*)O% !<5#$&#O%
!<5%$*O) !<5($)(O) !<54$)(O& !<5*$ $
)$O !<5*$)#O* !<5**$*(O* !<5*)$O !<5
*&$#O$!<5*$#O4!<5*#$*)O*!<5*%$%(O
!<5*($#O%!<5*4$*O$!<5)$O@RF]R6TS-GWG1V
T]F-?UGWVG?G+FUFS1 G--.UVG1-F+S?R ?R.TFUF].U?FV S1
?RFWS?FUG?XUF
*#+
$G1V & +GTSVF1?SHSFV GT)5F/5XUT.WS-
G-SVO
<./].X1V ) !3/.U]R.XT].+VFUOI:598 3V>
&(% *9k\+
k


\5;9>!)
Z^$&$$ 9\[
$
# O
!\$DUT$\5*$)O4)!*\$DUT$\5*&$)O#(!\$
/$\5*$*O4(!\$V$Jo4O# \[$\5)$*O#!\$V$
Jo$O* \[$\5($O$4!)\$T$\5*%$$O4(!)\$T$
\5*$$O%%!)\$T$\5*#$$O%&!)\$T$\5*4$$O#)
!)\$ T$ \5)$ $ $O#$ ! )\$ T$ \5*)
)
<5;9>
!)
Z^$$$ 9\[
$
# &$O!<5$#(O&!<5*$(&O(
!<5)$&*O(!<5&$&4O$!<5$(O*!<5#$)*O%!<5
%$)4O$ !<5($&%O) !<54$)%O% !<5$$*O !<5
$*O%!<5*$&)O(!<5)$&O4!<5&$*4O)
!<5$*)O& !<5#$&#O !<5%$&O !<5( $
&O4 !<54$*4O& !<5*$$))O# !<5*$)*O% !<5
**$**O% !<5*)$#O !<5*&$#O !<5*$#O%
!<5*#$*O !<5*%$($O !<5*($)*O4 !<5*4$
*)O*!<5)$O@RF]R6TS-GWG1V T]F-?UGWVG?G+FUFS1
G--.UVG1-F+S?R ?R.TFUF].U?FV S1 ?RFWS?FUG?XUF
*%+
$G1V
) +GTSVF1?SHSFV GT*
#
$)
!
$*&5?USR6VU.76.WFG15*5F15
*(5.S-G-SVO
<./].X1V $!3/.U]R.XT].+VFUOI8:598 3V>
,#*$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
&(%*9k\+
k


\5;9>!)
Z^$&$$ 9\[
$
# O*)
!\$?$Jo$O* \[$\5*$)O4$ !\$VV$Jo)O*$
(O& \[$\5*$)O%&!\$V$Jo*O& \[$\5)$)O#&$
)O)(!FG-R \$V$Jo$O* \[$\5*&$*O*$!\$V$
JoO# \[$\5(
)
<5;9>!)
Z^$$$ 9\[
$
#
&*O#!<5$##O4 !<5*$%&O# !<5)$&O& !<5&$
&4O4!<5$4O) !<5#$)&O !<5%$&$O4 !<5($
&(O% !<54$)4O !<5$$*&O !<5$*#O# !<5
*$)4O%!<5)$&)O)!<5&$*4O!<5$*O*
!<5#$&4O* !<5%$&O) !<5($&$O& !<54 $
&$O& !<5*$$)O% !<5*$)(O$ !<5**$*)O$ !<5
*)$#O( !<5*&$%O& !<5*$%O# !<5*#$*&O$
!<5*%$(O4 !<5*($%O% !<5*4$*O !<5)$O
@RF]R6TS-GWG1V T]F-?UGWVG?G+FUFS1 G--.UVG1-F+S?R
?R.TFUF].U?FV S1 ?RFWS?FUG?XUF
*(+
$G1V $ +GTSVF1?SHSFV
GT*
#
$)
#
$*&5?USR6VU.76XUT5*5F15*(5.S-G-SVO
<./].X1V *!3/.U]R.XT].+VFUOI8:598 3V>
&(%*9k\+
k


\5;9>!)
Z^$&$$ 9\[
$
# O*&
!\$DUT$\5*$)O(4!\$VV$Jo)O*$(O& \[$\5
*$)O%&!\$V$Jo*O& \[$\5)$)O#&$)O)(!FG-R
\$V$JoO* \[$\5*&$*O(& !\$VV$Jo*O($
*O( \[$\5(
)
<5;9>!)
Z^$$$ 9\[
$
#
&*O!<5$##O4 !<5*$%&O# !<5)$&*O4 !<5&$
&4O4!<5$4O) !<5#$)&O* !<5%$&$O% !<5($
&(O( !<54$)4O* !<5$$*&O% !<5$*)O& !<5
*$&O)!<5)$&O&!<5&$*(O(!<5$*&O$
!<5#$&%O# !<5%$&*O% !<5($&%O* !<54 $
)O# !<5*$$)&O( !<5*$))O( !<5**$*)O !<5
*)$#O( !<5*&$%O) !<5*$%O# !<5*#$*#O&
!<5*%$(O4 !<5*($))O !<5*4$*)O4 !<5)$O
@RF]R6TS-GWG1V T]F-?UGWVG?G+FUFS1 G--.UVG1-F+S?R
?R.TFUF].U?FV S1 ?RFWS?FUG?XUF
*4+
$G1V * +GTSVF1?SHSFV
GT*
#
$)
#
$*&5?USR6VU.76.WFG15*5F15*(5.S-G-SVO
<./].X1V %!3/.U]R.XT].+VFUOI8:598 3V>
#&4 *9 k\+
k
$ &(% *9 k\kEW-+
k


\5;9>
!)
Z^$&$$ 9\[
$
# O* !\$DUT$\5*$O)#
!\$V$Jo(O$ \[$ EW-5\5f$)O#*5)O(( !\$/$
EW-5\5*f5#f$O# !)\$T$\5*% $ O$% ! )\$T$\5
*$$O4 !)\$T$\5*#$$O4* !)\$T$\5*4$$O4$
!)\$T$\5)$$$O%# !)\$T$\5*)
)
<5;9>!)
Z^$$$ 9\[
$
# &*O#!<5$##O4 !<5*$%&O# !<5
)$&*O(!<5&$&4O4!<5$4O)!<5#$)*O!<5%$
&$O!<5($&(O*!<54$)4O!<5$$*&O%!<5$
*)O#!<5*$&O#!<5)$&O&!<5&$*(O(!<5
$*)O4 !<5#$&(O* !<5%$&*O% !<5($&%O*
!<54$)O !<5*$$)&O4 !<5*$))O& !<5** $
*)O$ !<5*)$#O( !<5*&$%O) !<5*$%O# !<5
*#$*#O)!<5*%$%(O!<5*($))O!<5*4$*)O4
!<5)$$4O%!<5f$%)O4!<5*f$%(O)!<5)f$%O
!<5&f$%(O%!<5f$#*O&!<5#fO@RF]R6TS-GWG1V
T]F-?UGWVG?G+FUFS1 G--.UVG1-F+S?R ?R.TFUF].U?FV S1
?RFWS?FUG?XUF
*$+
$G1V % +GTSVF1?SHSFV GT*
#
$)
#
$*&5?US5
R6VU.76.WFG15*5F15*(5.S- G-SV5*(5C2
!
2@5EWX-.]6U5
G1.T6WFT?FUO
<./].X1V b !<.W.XUWFTT.SWOI:598 3V>*&
!9
l,
$*)#$*$$4%$()$#4$$&)

\5;9>
!)
Z^$&$$ 9\[
$
# $O(4 !)\$?$Jo#O( \[$\5
#$O*( !**\$DUT$5<*
5q$O#$ !*\$/$\5
$*O$)!*\$/$\5($*O)(!*\$V$JoO# \[$\5
*$O&!*\$/$\54$$O@RF]R6TS-GWG1V T]F-?UGW
VG?G+FUFS1 G--.UVG1-F+S?R ?R.TFUF].U?FV S1 ?RFWS?5
FUG?XUF
*+
$G1V b +GTSVF1?SHSFV GT!L545RF7GVF-F5
1.S-G-SVO
<./].X1V #!NRS?FHWGKFTO/] #&O45#O4 r
I:598 3V>)4* *9k*
+^
l
$)(%$)#&$*%($*#&$
*$$*)#$***$*($4$($#%$)$)4$*$$
4%$()$#4$%$ &) ! $$

\5;9>!Z98 5^.
#
$ &$$
9\[
$
# )O#) ! *\$ ?$ Jo#O \[$ \5 $ O*#
*!<*

1
$DUT$\5*5*%+$$O((!)\$?$Jo#O( \[$\5
*(
)
<5;9>!Z98 5^.
#
$$$ 9\[
$
# #)O!<5$
))O$!<5*$*4O45*4O)!<5)5*#$**O#!<5*%$&O$
!<5*(O@RF]R6TS-GWG1V T]F-?UGWVG?G+FUFS1 G-5
-.UVG1-F+S?R ?R.TFUF].U?FV S1 ?RFWS?FUG?XUF
**+
$G1V b
+GTSVF1?SHSFV GT.-?G-.T6WGW-.R.WO
$!3WKGWS1FR6VU.W6TST.H
<./].X1V !*O$ /E +GTUFHWX7FV +S?R j
L^ \59F^\!*O$ /CH.U& R G?%$ rO@RFUFG-?S.1
]U.VX-?+GTVSWX?FV +S?R *
!^$O$ /CG1V GV0XT?FV
]\?.%O$ +S?R \)
!$O$
/Cq*O@RF<\)
T.WX?S.1T+FUFVUSFV!G1R6VU.XT
;G
*
8^
&
$G1V ?RFUFTSVXFH.W.+S1ET.WeF1?UF/.eFV
+GTTXD0F-?FV ?.TSWS-GEFW--!&O E$ q& -/XTS1E
RF7G1F=I?.3-!#s&?.GH.UV WG!$O4 /E$+RS-R +GT
H.X1V ?.DFSVF1?S-GW+S?R U.TG?FU.WD6

\5$
)
<5;9>
,%*$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&
G1V I:598 -./]GUST.1T$G1V ]GW/S?S-G-SV ! D $O#
/E$+RS-R +GTSVF1?SHSFV D6-./]GUST.1 .HS?TI:598
+S?R G-./]X?FUUFHFUF1-FVG?GDGTF*I:598 3V>*#
!9
l,
$**%$*)$44$($%$%$&)$*4$$
G1V %)+O
<./].X1V G+GT.D?GS1FV GTG+RS?FG/.U]R.XT
].+VFUO/] *& m*% r I:598 3V>)#4

\5;9>
!)
$&$$ 9\[
$
# )O&!\$/$\5)$O)$!\$
DUT$\5&$,$!)\$T$\5($$,4!)\$T$\54$
$,($!)\$T$\5*$$,%4!)\$T$\5*4$$,%(!)\$T$
\5*#$$,#) !)\$T$\5*%
)
<5;9>!)
$ $$
9\[
$
# )%O)!<5$?$)O(!<5*$?$%$O#!<5)$V$
*O!<5&$V$)(O% !<5$T$&*O4 !<5#$?$)$O4
!<5%$?$)O(!<5($V$$O!<54$V$)#O*!<5$$
T$*O# !<5$?$*(O* !<5*$?$&*O% !<5)$T$
#O*!<5&$V$*&O$!<5$?$)4O%!<5#$?$#O$
!<5%$V$O&!<5($c$4O)!<54$c$)#O%!<5
*$$V$(O%!<5*$c$))O4 !<5**$?$*#O$ !<5*)$
?$&O(!<5*&$V$*4O!<5*$V$4O$!<5*#$c$
(O(!<5*%$c$ *)O$ !<5*($ ?$ *O$ !<5*4$ cO
@RF]R6TS-GWG1V T]F-?UGWVG?G+FUFS1 G--.UVG1-F+S?R
?R.TFUF].U?FV S1 ?RFWS?FUG?XUF
*)+
$ G1V G+GTSVF1?S5
HSFV GT
!
5U.TG?FU.WO
*9@K@F@BS@J+
* +!aF1EQMOMW.UGUFS]XDWS-GF].]XWGUSTTS1S-GF*9+OJFS0S1E#
8-SF1-FBUFTT$ 44$# &$O
* * +!YSG1ETX ;F+9FVS-GW<.WFEFOZS-?S.1GU6.H?UGVS?S.1GWZUXET*9+O8RG1ERGS# 8RG1ERGS8-SF1-FG1V @F-R1.W.E6BUFTT$
4(# &(%O
* ) +!9GTG?FUX $^ \SU./S8$ PGTX6XKS:$ F?GWOZS?FU]F1.SVTHU./?RF
HUXS?T.H?/*G*%/,+0/$*Y+OBR6?.-RF/ST?U6$ *$$$$ !(# (%)O
* & +!9GTG?FUX $^ PGTX6XKS:$ L.S-RS9$ F?GWOM.XU1F+RGWS/G1F5
?6]FVS?FU]F1FT$ eS?F?USH.WS1TZQ$ HU./?RFHUXS?.H?/*G*%/,+0/$
*Y+O* +!9F[[F?S@$ U^[GWFTSQ$ >.TTS<$ F?GWO31F+?US?FU]F1.SV WG-5
?.1F$
#
5G/6US1 G1V XeG.WHU./P0/&%:#=3/*$0/&=3*Y+OBWG1?G
9FV$ 4%$$ (!&# )*#O
* # +!9SUG1VG>B$ ZFWEGV.Q$ _SeGU3>ZO;F+?US?FU]F1.SVTHU./
A$09/$ )/&+0#+)/$)$ *Y+OY;G?BU.V$ 4(#$ &4!*# **O
* % +!CGRW.X \I:$ \SUGS;$ @TXVG9$ F?GWO@US?FU]F1F]R6?.GWF7S1T
HU./1F-?GUS1FHUXS?T*Y+OBR6?.-RF/ST?U6$ 444$ *!&# #*)O
* ( +!8GKGKSDGUGY$ LGS6G@O@FU]F1.SVT.H!+.+.).%+) 7$F+)/&=3
*Y+OBR6?.-RF/ST?U6$ 4()$ **!# *&%O
* 4 +!L.0S/G\$ E^XUG\O@US?FU]F1.SVTHU./D%=)0$ 9=05$%/#*Y+O
BR6?.-RF/ST?U6$ 4(#$ *!)# %*4O
*$+!@SG1 Y$ bSG.aP$ eXWEGUTG].1S1 3*Y+O3-?GBRGU/8S1$ *$$$$ )!# *4O
*+!ZF/DS?TK6_9$ Z.U:$ 8RKU.D :$ F?GWOJUG1-RFV GWKG1FTG1V
.?RFUG].WGU-./].X1VT]U.VX-FV D6?RF-6G1.DG-?FUSX//S-U.-.5
WFXTeGES1G?XTHU./?RF;FEFeZFTFU?*Y+O>XTTYJS..UE*$$$ *%!*# $O
**+!aRG1EJJ$ZGSP$CSG.abO+F:53$$ *Y+O*)+!\X \J$aRF1EbZO8?XVSFV .1 ?RF-RF/S-GW-./].TS?S.1T.HD*%/#
3=0*/,/.$ B.SU*Y+O;G?BU.V >FTZFe$ *$$&$ #!# )%4O
45‡Þ›œ
K¦§

!
R¨©

!


!
R‰«
*
!
$¨W

!
O
ê~‚„I ƒIŽ
!
ê~ êÔ
)$$$&% *O
¤Ô„I ƒIŽ
!
ÒÓ ¤Ô
%)$$$$#

bc
#!
+45å°$œ´É,

Çÿ‡Þá}
...
ÉñÝÞoò>?
!$

$
ÇØ^Þá}
$
œ üò¾>ùÞ
!%)5
‘§¦>
!&%*
#
$ )
!
$ *&5
N™
5*5
¥
5*(5
Róù>
!)%*
#
$ )
#
$ *&5
N™
5*5
¥
5*(5
§¦>
!$%*
#
$ )
#
$ *&5
N™
5
*5
¥
5*(5
Róù>
!*%*
#
$ )
#
$ *&5
N™
5
Róù
5*5
¥
5*(5
>
5*(5
!
2@2
!4ÔÕV?A
!%%!L545
ôÑ¥>
!b%
D‚™
Þ
!#%
!
5
<ÝÞ
!(%
!
5
ÜõöA
!&
Þá}Þߌ‰TÕwUO
%
˜€ÓOáºRhÃ()ždüò
&
Þá}

¾ÿ
Þá}
$
Þá}
c%
s2+45$œ´É,
&

def
#!
45

Ýí


GA/#([)*bPSWS--()$

tu-0
!
}~~
#
,(*$*,
t
)4
~t

v
*$&
o
#
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
_.WO)4$:TTXF!
YX1F$ *$&