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作 者 ：何康,曹团武,王洪玲,耿长安,张雪梅,陈纪军

期 刊 ：中国中药杂志 2015年 40卷 20期 页码：4012.

关键词：斜茎獐牙菜；环烯醚萜；酮；

Keywords:Swertia patens, iridoids, xanthones,

摘 要 ：对龙胆科Gentianaceae獐牙菜属植物斜茎獐牙菜Swertia patens90%乙醇提取物的乙酸乙酯萃取部分的化学成分进行研究。采用各种柱色谱方法对该部分进行分离纯化,通过¹H-NMR,¹³C-NMR,MS等波谱数据分析进行结构鉴定。从中分离鉴定了18个化合物,包括10个裂环烯醚萜及其苷、3个酮及其苷、1个少见的内酯烯胺酮和4个其他类化合物。分别为3,4-dihydro-1H,6H,8H-naptho[1,2-c:4,5-c‘,d‘] dipyrano-1,8-dione(1)、angelone(2)、gentiogenal(3)、erythricin(4)、红白金花内酯(erythrocentaurin,5)、秦艽碱甲(gentianine,6)、贵州獐牙菜苷B(swertiakoside B,7)、獐牙菜苦苷(swertiamarin,8)、2‘-O-actylswertiamarin(9)、amarogentin(10)、1,3,5-三羟基酮(1,3,5-trihydroxyxanthone,11)、1,3-二羟基-5-甲氧基酮(1,3-dihydroxy-5-methoxyxanthone,12)、1-羟基-2,3,5-三甲氧基酮(1-hydroxy-2,3,5-trimethoxyxanthone,13)、gentiocrucine(14)、3-羟基苯甲酮(3-hydroxyphenylketone,15)、4-羟基反式桂皮酸二十六烷酯(n-hexacosyl ester 4-hydroxy-trans-cinnamate,16)、4-羟基顺式桂皮酸二十六烷酯(n-hexacosyl ester 4-hydroxy-cis-cinnamate,17)、cholest-4-en-3-one(18)。其中化合物1~7,9~18为首次从斜茎獐牙菜中分离得到。

Abstract:Chemical constituents of Swertia patens. The whole plant of air-dried Swertia patens was extracted with 90% EtOH. The water extract was suspended in H₂ O and extracted with petroleum ether, EtOAc and n-BuOH, successively. The compounds were isolated and purified by column chromatography from the EtOAc fraction, and identified based on spectral analyses(MS, ¹H-NMR, ¹³C-NMR). Eighteen compounds were isolated and elucidated as 3, 4-dihydro-1H,6H,8H-naptho[1,2-c:4,5-c‘,d‘dipyrano-1, 8-dione(1), angelone(2), gentiogenal(3), erythricin(4), erythrocentaurin(5), gentianine(6), swertiakoside B(7), swertiamarin(8), 2‘-O-actylswertiamarin(9), amarogentin(10), 1, 3, 5-trihydroxyxanthone(11), 1, 3-dihydroxy-5-methoxyxanthone(12), 1-hydroxy-2, 3, 5-trimethoxyxanthone(13), gentiocrucine(14), 3-hydroxyphenylketone(15), n-hexacosyl ester 4-hydroxy-trans-cinnamate(16), n-hexacosyl ester 4-hydroxy-cis-cinnamate(17), and cholest-4-en-3-one(18)。Compounds 1-7, 9-18 were obtained from S. patens for the first time.

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