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作 者 ：何康,曹团武,王洪玲,耿长安,张雪梅,陈纪军

期 刊 ：中国中药杂志 2015年 40卷 18期 页码：3603.

关键词：狭叶獐牙菜；NFDE8 酮；芳香化合物；木质素；

Keywords:Swertia angustifolia, xanthones, phenols, lignin,

摘 要 ：对龙胆科 Gentianaceae 獐牙菜属植物狭叶獐牙菜Swertia angustifolia Buch.-Ham 90%乙醇提取物的乙酸乙酯萃取部分进行化学成分研究。采用各种柱色谱法对其进行分离纯化,得到14个化合物,包括4个 NFDE8 酮及其苷,7个芳香类,1个木质素和2个其他类化合物。通过波谱数据分析(¹H-NMR,¹³C-NMR,MS) 和文献对照分别鉴定为1,8-二羟基-3,7-二甲氧基 NFDE8 酮(1,8-dihydroxy-3,7-dimethoxyxanthone, 1),1,8-二羟基-3,5,7-三甲氧基 NFDE8 酮(1,8-dihydroxy-3,5,7-trimethoxyxanthone, 2),7-羟基-3,8-二甲氧基- NFDE8 酮-1-O-β-D-吡喃葡萄糖苷(7-hydroxy-3,8-dimethoxyxanthone-1-O-β-D- glucopyranoside, 3),8-O-[β-D-吡喃木糖-(1-6)-β-D-吡喃葡萄糖]-1,7-二羟基-3-甲氧基 NFDE8 酮(8-O-[β-D-xylopyranosyl-(1-6)-β-D-glucopyranosyl]-1,7-dihydroxy-3-methoxyxanthone, 4),(+)-丁香脂素((+)-syringaresinol, 5),阿魏酸(ferulic acid, 6),松柏醛(trans-coniferyl aldehyde, 7),芥子醛(sinapaldehyde, 8),松柏醇(trans-coniferyl alcohol, 9),3,4-二羟基苯甲酸(3,4-dihydroxybenzoic acid, 10),邻羟基苯甲酸(2-hydroxybenzoic acid, 11),间苯二甲酸(isophthalic acid, 12),2-糠酸(2-furoic acid, 13),2-甲基-4(3H)-喹唑酮(2-methyl-4(3H)-quinazolinone, 14)。其中化合物 2~14 为首次从狭叶獐牙菜中分离得到。

Abstract:This present work is to study the chemical constituents of Swertia angustifolia. The whole plants of air-dried Swertia angustifolia was extracted with 90% EtOH. The water extract was suspended in H₂O and extracted with petroleum ether, EtOAc and n-BuOH, successively. The compounds were isolated and purified by column chromatography from the EtOAc fraction, and identified based on spectral analyses(MS,¹H-NMR, ¹³C-NMR). Fourteen compounds were isolated and characterized as 1, 8-dihydroxy-3, 7-dimethoxyxanthone(1), 1, 8-dihydroxy-3, 5, 7-trimethoxyxanthone(2), 7-hydroxy-3, 8-dimethoxyxanthone-1-O-β-D-glucopyranoside(3), 8-O-[β-D-xylopyranosyl-(1-6) -β-D-glucopyranosyl]-1, 7-dihydroxy-3-methoxyxanthone(4),(+)-syringaresinol(5), ferulic acid(6), trans-coniferyl aldehyde(7), sinapaldehyde(8), trans-coniferyl alcohol(9), 3, 4-dihydroxybenzoic acid(10), 2-hydroxybenzoic acid(11), isophthalic acid(12), 2-furoic acid(13),and 2-methyl-4(3H)-quinazolinone(14). Compounds 2-14 were obtained from this plant for the first time.

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