免费文献传递   相关文献

Advance in studies on TRPV1 and analgesic effect of traditional Chinese medicines

TRPV1与中药止痛作用研究进展



全 文 :?>@A
‡$,ˆ‰Š‹ƒ„…†
012
!
34
!
567
!

wxC0B yz{¸|}ý7~¼€‚ƒ  q}ý̈́|B…w†€‚ƒ
‡ˆ‰Š=q‹Œ¸Ž 
!
w
$$(%#

de
#!
SQu¡¿WUQ ¡Ï
V!QSN11PHT1QST-T\Q.S\.QT1QHNVkN1HV.HU $?>@A
ýA@õŒw³¢TŽBÁ
$
ÎÎ
§¨¸uUvww:
$
VySQu¡¿WU
!QSN1PHT1QST-T\Q.S\.QT1QHNV$?>@
Kñ—y¦A
)
>¡ÏGž²W³XX
$
¢³
XXj8@³xCXã
$
Y¬Ô‰YZ
$
¬“²Ï¹º§¨
)
$C…Çԉc”²øÇ

~B€‰
($
[³Û¼•4|
\]–º¬“|®~B`ԉ
$
זÄ$,4?kDû#×Ø
$
¾^,•ã|¢4,kDB_|®Š‹
)
§
$
’fê
û#íjB®í
$
זÄ,
&
¾^,•ã|¢4,–kDˆ‰Š‹
)
>ëÃ
?>@A
Ç`R
$
:E
)
ß$,ˆ‰Š
‹ƒ„…d‡àE
)

fgh
#!?>@A*
$,
*
ˆ‰

ij)(
#!*$)5$5*&

klmP
#!
%K

/J,ƒø
(
&(/xN
!*$* _`$4$)5
*$

nopq
#!
!
Ìë”
$
PY
$
VW”¬[
$
ƒ„}-Çvwad³h
ԘŽ²ø¦vw,z
$?TV# ! $$ #**$$##4$X5/NHV#Z+P2
^1WcTUWc-1

pqrs
#!
*F3
$
ZWƒ„”
$?TV# !$$ #**$*(*$X5/NHV#
V7V((2#)c-./
!!
ÉÏA[mbuUvwwc4‹¸¨d³u¡¿
$
G&–
&
¢•²W³XXYZÝ$evwÿ{
$
¼†‰U
$
­fœ²Ïv”‰Š³à0
) 44%
o
C
+,
¤¥&
A@ºžgIë
!-N\PNH-H1
Xã¡Ï
$
…ÇgIë¡Ï
)
gIëǝQ
!kN1HV.HU
h”»
$
ip…ǝQ ¡Ï
!kN1HV.HU ST-T\Q.SPW^Q6\T$A>V$
ò…SQu¡¿WUQ
 ¡Ï
V!QSN11PHT1QST-T\Q.S\.QT1QHNVkN1HV.HU $?>@A)
j
ý
?>@A
0KñtAIž¤¥è
&)*
I2x þ—B
Á„›
$
pýO˃„­4
?>@
Kñ—y¦A
)
!?>@A
‡Ô‰
?>@A
ýA@Ï7uõŒw³¢TŽBÁ„›
$
kD
#
Iìk÷3Å
$;

<
\–¸r8
$;
\kD
)
Il„›3“UR
$<
\kD
?>@
3ʼn
$
èt

•t
#
k
÷3ʼnšlŗõŒw³¢TŽmÁ
$
>mÁʇÇÚ
ugIëXã
?>@A
¡Ï¼†¢TŽ8t´9
)
o²Ï
¡g%ŸXXQ
$
BÁ¤$
Ër%¢TŽ
!
Î΋ŒnT
Ž•oTŽ

8t
$
Š$r;8oTŽÔ±´
$
ϡo
TŽŠÇtÜlœ
$
œ
@
»;
!PW^PQN1-T@$8@
•Ðoë
Ïçxp
!-NV-HQ.1H1 MT1TSTVNQTU \T\QHUT$@
)$
¼c
AÿÌ/Δ»àÀ
)
ŠÇut%Ÿ¨d³XX/ΡÏ
$?>@A
¸mbu
Uvww:Ër:´§¨
$
B´qrs
3
t_•’
rs
<
t_YZ¨d³XX
+*5),
) ?>@A
GÞ²W³
&
¢³
!
|
\Bmc4
•¾
! f&) n
CXX
)
4@XX³
¢“».GÃXã
?>@A$
¸#³‰$
$?>@A
›GÞË
#ōŽjY;|ËÌmë
&
ÎXpC6”Xãjb”±
/
+&,
)
§
$?>@A
ýu¡%Ÿ¨d³XX
$
YZԉl<
/ÎTŽBÁ„›
)
ªø
?>@A
jªœ>BÁÙ/GÃ
¨gÎĕ\3ԉl)

$
Ã
?>@A
Ç`R,»ƒ„•¤c°‡AÐ…†
$
GÃ

?>@A
$,—˜ƒ„p{z{4
$
¹~£Çց
ԉ)I‡=uËv
$
pÇ$C,ցԉzfƒ„)
I‡J^P
)
(!?>@A
‡–³$,ƒ„
–³$,4kD…|1wO
&
[ˆ‰Š‹
)
²Ï
B´¾u¡¿ut8%OŒ¾@¢
$
Dƒ„§É
$
§
¨³•õ§¨³¾XX˜Žxe¹D.ý¾Xã
?>@

+5(,
$?>@A
ý§¨³–XXu¡¿
$
Xã}Gv”
–u
$
xy³Ô‰
$
5gu¦z{
+4,
)
$C…Ç

~B€‰
(&

B€~‰
($
[³Û¼|] ¬“

~B
(
ýv”Ô‰
ÎÎÔzxe
)
(_!
gIë
!
¾^,45–}~
$
kD/é
&
/‰CŠ‹
)
gIëGÃXã÷TŽBÁ
?>@A$
BÁ¤\oTŽ
!

ŒnTŽ

…HËr
$
r8oTŽÔ9´`¼†‰U
$
¸§
´9$6ü(d]³)8@
•
@
Cvwpß»;•
³2x 
$
lQ›Gº€DO적Ù
!-6-VH-MWN1.PH1T
/.1.\O.P\ONQT$-K9@
•A¦¢‚
!1HQSH-.7HUT$;]
ʇ
)
±vÀ‹¬“
?>@A
å/
$
¨gցԉO
)
Š²
øGºý@yo•oڄ›d]¿ì ¢¦WÑd]
oTŽBÁ±Q9\3
+$,
)
-%%-
t
)4
Öt
$
v
*$&
o

p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
A.Vc)4$:PPWT!$
9N6$ *$&
(_(!
Ÿ—
!
Ÿ—ǃ&º»žŸØ}„—
$
kDcÍÄ
¥
$
¾Bw®
$
„¢¢j
$
[ˆ‰¹×
)
a‡F!c
$
ŠÎΗ˜ÇŸÜ…
)
¸kü|Ÿ—PŽk
&
:b$k
&
†
ÆQk$Ÿ—–kD[/‰Š‹
)
`
?>@A
ŠÇ‰U
u¡¿lQpý¾Uu¡¿
$
Š‡²Ï[–u¡¦Ï¾Ú
ۇõÏç
+5*,
)
ˆ­C
+),
S‡[–$,—˜‡
?>@
K
ñ$
?>@A
•
?>@9(
BÁ„›lœ
>;3!/TPPT1MTS>;3$
/>;3
§¨Ï糃„
$
‰B´6Rç~Šr‹ƒvw
Û
!U.SPNVS..QMN1MVHN$Y>K
vww
$
€‹†’Ð(
@<>

¿ŸÜ…¸~l¾¶·
?>@A
x§¨(™š
$cò
$
–³$,—˜ŸÜ…´ü(þ
!#$
!
/.V-F
g
&
$ü(þ
!)$
!
/.V-F
g

–º:Ú
?>@A />;3
§¨
$

[
!4 n
‰z}
Y>K
vww
?>@A />;3
§¨:
ڊ‹ÒÇÉÊ
$
ÿŠý´ü(þGÊ=Hªø[ “

?>@A />;3
§¨Ú
)
(_&!
ªŒ
!
ªŒÇI&º»ªŒ
&
Ý8jÃLª
ŒØ}_—ŽØÆ
)
kD[ˆ‰
$
Џˆ
$
„¢ˆ
Ϲ×
)
Š¢—˜$ªŒJkD/‰®#
&
ϾÚ
ÛCŠ‹
) 9NQPWUN
C
+&,
ƒ„‡ªŒJû¨d³u¡
àÀ™š
$
€Æ‡Æ…ÆÇËvˑdÇVtQb’™
š
$
]¸}vVtQbDÊ=ªøŠ‹
$
,ׇû¨d
³u¡Õ‡×G’Ãϓ
)
ˆ­C
+),
ƒ„§ÉªŒJ

?>@A />;3
§¨
$
[
!4 n
‰z}
Y>K
vww
?>@A />;3
§¨DÉÊ:ڊ‹
)
ÝJåC
+,
ƒ„
cò«”v>έ®þ••
Y>K
$
?>@A
§¨(+Ð
ñ
$
X‹ªŒJ}«”v>έ®þ••
Y>K
$
?>@A
§¨+±Í
$
Ǻá«”Çc|Ò«Ã
)
(_)!
žŸ
!
žŸÇƒ&º»žŸØ}Ü
)
kDh~„
¢
$
[ˆ‰
$
¾wB®
$
¼~‘6¹×
)
ŠÎΗ˜ÇŸ
܅
$
M
*c4*i j#c*$i)
Š‹y
?>@A
$,—˜²
ǟ܅
$
kϊ‹¸Ÿ—$ºS‡‚E
)
&!?>@A
‡[³$,ƒ„
[³$,
$
4kDû#Š‹
$
ԉÇ#ÅÎβú¦A
)
?>@A
ý²ƒ§¨•˜Åy%ò¨d³u¡¿
$
ʇ•Y¬
‡%ò#ÅQ¨d³mbYHt_/¢´9
$
GžË#Å
»;jY;|
B
h
&
vw”±Ž
!1TSkTMS.+QO RN-Q.S$;KI&
ËÌmë
!\S.PQNMVN1UH1P$@KP&
ÎXp
!^SNU6[H1H1$DG
C6
”jb”Xã
$
¸#³‰
&
Lc‰
&
‰/u$†Ýç/Î
Š‹
)
&_!
‘
!
‘Ç–^&º»‘Ø}ƒ
)
kDז}
3
&
Ï~Ä
&
ˆ|
&
<—¹×
)
ŠÎǘ‘ÙkD=
+ûÌ
+#5%,
$
ûÔ
+(,
$
Ė
+45*$,
$
û#
+*,
CŠ‹
)
ʮ5
C
+**,
&‘Ù‡vvwËrš˜Q
$
cò‘Ùº™š
Ër8
*h
)\¦r%
*h
8t
)
ˆ­C
+*),
cò
‘ÙGÚ
?>@A />;3
§¨
$
ÿŠý–
!)4 n
‰z
}
Y>K
vwwBÁ§¨™š–ÒÇÉÊ
)
€Æ‘Ù
û#ˆ‰×؇ªø
?>@A
¡Ï§¨Dç
)
&_(!

!
Ç™&º»Z[
&
/š²j,‹
Ø}ƒ¦ƒ^
)
kDÏ›¢
$
זÏ~
$
œ|Ä
$
!4Bw¹×
)
ëÇjkßh”»
$
ý$,Î
ÎD×ÐÏ
$
kD4@,zŠ‹
)
ëÌ
&

…žŸ ÌDªøŠ‹
$
›DÊ=Hû#Š‹
+*&,
)
èo‘
&

&
`D
&

&
^,C
$
Â7$,þ—®üÿ•è

&
&
7,þ—y¡ü–kDû#/‰Š‹
)
ëº¨Ê=Hªøí¢£ñ “:v•v¤çÛü
¥
)
ë›ºªøɈ: ÿ÷Ër›Yë


!H1QTS5
VTW[H15

$:F5

$
›Yë
#!H1QTSVTW[H15#$:F5#
¦üý¦§
Ž
5
#
!QW/.S1T-S.PHPRN-Q.S5
#
$?;I5
#

”—
+*,
)
ˆ­C
+*#,
còëGÚ
?>@A />;3
§¨
$
ÿŠý–
!)4
n
‰z}
Y>K
vwwBÁ§¨™š–ÒÇÉÊ
)
)!?>@A
‡ã|¢4$,ƒ„

~B
(
²j| d¨©
$
~º^aHÅò¶
)
$C…
Ç

~B€‰
(&
B€~‰
($
ã|¢4,kDÃB|®
&
2
4ˆ‰Š‹
)
)_!

!
KåÇLª&º»KåjNKåØ}ƒ
$
k
Dזœ|
$
4ˆ‰¹×
)
èN@
&
ÊH
&

&
KåC
4Ç$,þ—24Ӊ!•¬­®œ:
!
¯°Q
&
±œ¢
&

&


kDóôû#/‰Š‹
)
KåÎ΢—
˜å,ÙkD/é
&
û#ˆ‰Š‹
)
²
+*%,
còå,Ù
x‰z
BNËr•
BXG*4)?5?>@AV
Ërs
O
}
$
³´
gIëXX
$
å,Ùº¨ÐñgI뫬
?>@A />;3
¬¯9´
$
r8oTŽ8tpDAЪøŠ‹]ý‚
ƒ³~Ê=
$
2¿å,ُgI뫬9´Ër8oTŽ
™šŠ‹Gº‹¸ŠBÁ
$
Gºb”‡
?>@A
Ïç
)
?PNHU
C
+*(,
ƒ„§Éå,Ùº¨6”uø¯°¥Ër
Gk
B
Á
$
œ÷Ž³¢
$
…`ªøoTŽ8t
)
)_(!
N@
!
N@Ç8Í&º»N@Ø}ƒ
)
Vyˆ|ã
|,
$
ƒºˆ|
$
´º¢4
$
kDˆ|~µ4²R
$
kDd
¦³
)
N@ž¶Ç¨&Î,
$
Gâ4ˆ|
$
ã|Љ
)
ƒ„§É
+*%,
ÉÊáÙ
>^


BNËr•
BXG*4)?5?>@AV
Ërsx‰z
O
}
$
³´gIëXX
$>^

º¨ÐñgIë
«¬
?>@A />;3
¬¯9´
$
r8oTŽ8tpD
Ê=ªøŠ‹
)
dzº¨Øx
?>@A
Y¬IŽ #
D
!1W-VTNSRN-Q.S
#
D$;I5
#
D
ã¢
$
œ›Yë
(!:F5($:F5#
•
ËÌmë
X
*
!\S.PQNMVN1UH1 X
*
$@KX
*

˜0¬¯Ð
) BNO1
C
+*4,
€ÆÉÊáÙ
>R

K5
„›º·õ
&
Gªø
;5
˜
•Š´¸Š
*h

)
ºü(d]³ªøgIë«
cvuUvwwBÁWt
$
…`\3‰UYZ
)
)_&!
ÊHŽ
!
ÊHŽÇ¹º&º»ÊHŽ»ƒ
$
75
&
y
&
¾
)
kDã|
$
dj
$
ˆ‰¹×
) .
aQ¼O
/
½¦

º
d|$j]
$
j$|]
$
ixÖA¶:Z‰
$
‹¦$
$
¾
~Gþ
($
G¿ÊHŽˆ‰×ØÇúRCK F…
)
ÊH
-(%-
t
)4
Öt
$
v
*$&
o

p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
A.Vc)4$:PPWT!$
9N6$ *$&
ŽÆë•ÊHŽSëýŠ/‰/Î㳗˜
)
B´v
µ³Àò¨d³ÁÂvw‰—˜ÊHŽÆ
&
S냄
$
§ÉÊHŽÆë•ÊHŽS븊r¬¯B´ªøŠr
‹íL
?>@A
¡Ï§¨`º¨#Óvw‰
+)$,
)
)_)!
Í|«
!
Í|«ý֓&Í|Vº»Â[Í|
F휙w)°gí
)
kDã|4
&
Љˆ|
&
Ã
Ĕ¥C¹×
)
$—,Í|«ñ?•Í|«C–kDã
|4
&
Љˆ|¹×
)
Í|«Î΢—˜‹ŒÂ[
Í|ë
3
•Â[Í|ë
D&
Í|ë
D
C—˜
$
¹
)
I—˜.

?>@A
kDmûŠ‹
)
ƒ„cò
$
Í|ë
D
WÑ7u
nBÁWtDÉʪøŠ‹
$
…`\©‰UYZ
)
]o
Í|ë
D
•gIëšlŠ‹Q
$
WÑ7unBÁªøŠ
‹Í>
$
oŠ$¥ÞA@,»ÔúÐ
$
šA@,»Ô
î@Q
$
nWt­Šªø¶+2¹@,»Ô±Í`
Í>
$
-¿³¢}-¦t9•ÍõnBÁåã9.
+2¹@,»Ô±Í`#:
+),
)
Š
?>@A
mû
Š‹Ç~ºB´±´gIëö1Ô`ž¤X
)
§
$
2
¿Í|ë
D
¸
?>@A
Š‹UR‡gI늋UR~
l
+)*,
$
Í|ë
D
B´>Š‹UR‡
?>@A

$
¬“
?>@A
Řî@
$
œX­ü‡
?>@A
3“.•Õ‡ã³
Ð
$
…`v”mûŠ‹
+)),
)
ƒ„cò
$
Í|«¦Š¹
)
@
—˜
Y>K
ËrµÑë~/u˜
!QTQS.U.Q.7H15STPHPQN1Q$
??_5>
nWtkDÚøŠ‹
$
Š$Í|«ªø
$i??_5>
nWt­ŠÔъªø
$i
gIë«c
?>@A
Wt
­ŠÔ´
$
ËÉÍ|«Š‹y
Y>K
Ërpp†Š‹
`Rý
?>@A$

??_5>
nBÁ
)
$!
†`
?>@A
BÁ„›ŠÇu¡vww:u¡%ŸXXA
ß/ÎTŽBÁ
$
ýցԉ/Î`R
)
¾
&
#ÅY
;
&
|1wO¨©–ºB´
?>@A
¡Ï¼†²Ïԉ
)
Ã
?>@A
Ç`R
$
ƒ„$,ˆ‰Š‹×ؕ²økDT
ôzfŠ•ÆfÀ‹01
)

tuvw
#
+ ,!-H1 ST-T\Q.S# NOTNQ5N-QHkNQTU H.1 -ON11TVH1 QOT\NH1 \NQO+N6
+C,,;NQWST$44%$)(4!##)# (#,
+ * ,!9TZT6X$ P`WZPN11NX?$YN1HTV;<$TQNV,YHPQSH^WQH.1 .R/>5
;3R.SkN1HV.HU ST-T\Q.SPW^Q6\T !A>$N1U A>5VH[TH//W5
1.STN-QHkHQ6$ H1 QOT-T1QSNV1TSk.WPP6PQT/.RQOTSNQN1U OW/N1
+C,,@S.-;NQV3-NU 8-HE83$ *$$$$4%!%# )#,
+ ) ,!8N1-OTZCI$ GSNWPTCX$ <.SQSHMOQY;,?OTUHPQSH^WQH.1 N1U
STMWVNQH.1 .RkN1HV.HU ST-T\Q.SA> N1U A> oP\VH-TkNSHN1Q
>;3T7\STPPH.1 H1 SNQ+C,,;TWS.P-HT1-T$ *$$$$%!)# )%),
+ & ,!
ÅsÛ
$
´%Æ
$
½
,
gIë¡Ï
A>
¸e1#ÅóD
/¢²ø
+C,,
vwÄÇ-.
$*$$&$*$!)#)*,
+ ,!9.SHP.1 8 I$ ;N[N/WSNG,STMWVNQH.1+C,,IS.1QDH.P-H$*$$##%&,
+ # ,!9N1UNUH8$ 8.[N^T?$ 8OH^NPN[HG$ TQNV,?>@A) H1[TSNQH1.5
-6QTPQSN1P/HQPQT/\TSNQWSTH1R.S/NQH.1 Q.PT1P.S61TWS.1PkHN3?@
+C,,@RV1MTSP3S-$*$$4$&(!##$4),
+ % ,!8-OT\TSP>C$>H1M[N/\ 9,?OTS/.ST-T\Q.SPN1U QOTS/.PT1PHQHkT
NRTST1QP+C,,;TWS.P-HDH.^TONk>Tk$*$$4$))!)#*$,
+ ( ,!FW/\[H1 X3$ H1 QOTP[H1+C,,;NQWST$*$$%$&&!%)$#((,
+ 4 ,!QH.1 N1U \NH1 PT1PNQH.1H1 /H-TVN-[H1MQOT-N\PNH-H1 ST-T\Q.S+C,,
8-HT1-T$*$$$$*((!&#&#)$#,
+$,!9.ON\NQSN@Y$ >NW <,>TMWVNQH.1 .R*h
5UT\T1UT1QUTPT1PHQH5
ZNQH.1H1 QOTkN1HV.HU ST-T\Q.S?>@AV^6-NV-H1TWSH1 N1U -39@5
UT\T1UT1Q\S.QTH1 [H1NPT+C,,CDH.V)&*&,
+,!\N1QPH1 QOTS/.PT1PNQH.1 N1U QOTS/.STMWVNQH.1+C,,3/C@O6PH.V
>TMWV:1QTMS<./\ @O6PH.V$*$$%$*4*!#>#&,
+*,!>./N1.kP[633,?OTS/.STMWVNQH.1# P./T-.1-T\QPONkT-ON1MTU,
IW1-QH.1NVNS-OHQT-QWST.RQOTQOTS/.STMWVNQ.S6P6PQT/+C,,3/C
@O6PH.V>TMWV:1QTMS<./\ @O6PH.V$*$$%$*4*!#>)%,
+),!
ˆ­
$
Շ
$
Ì_X
$
C
,
[–³$,—˜
?>@A
•
?>@9(
BÁ„›x§¨™š
+C,,
$%$,-.
$ *$$$)
!*# 4&,
+&,!
æÈ
,
ªŒJ•ªŒìJû¨du¡Š‹‡û#Š‹
+C,,
%%C
-
$C$,˜É
$444$*!)#&*,
+,!
ÝJå
$
ÊËÌ
$
ª^
,
ªŒJ«”Çc|ҫÊ
‹ƒ„
+C,,
$%,zBa
$*$$*%!*##(%,
+#,!
Õ°Í
$
HJ?
$
³Ì
,
‘Îw•‘ΏÜÏŻË
̪øŠ‹ƒ„
+C,,
$,™
$*$$$$*)!#*%*,
+%,!
ªé
$
H5
$
!¤ž
,
‘•‘ُÐ7ѝÌÏ%ûÌ
㳃„
+C,,
$,™
$*$$($)!#%$%,
+(,!
ªÒ
$
C[Ó
$
ªÔ
$
C
,
‘ÎǘÏ%ûƘtuÔ
Š‹ƒ„
+C,,
23$C,a
$*$$$))!(#&,
+4,!
Õ
$
ª•Ö
,
‘ُ’“Ër˜0
?KI5


™š
+C,,
×MC-.
$*$$4$)(!%#($&,
+*$,!
Ø3
$
ÙÚ
$
*¬”
$
C
,
‘Ώ
;G
ۨ㳙š
+C,,
$,,z‡èé
$44)$4!*#)%,
+*,!
!/
$
*ª¯
$
ÌbÜ
$
C
,
‘ُ:v
?$D
ÝÞËr±Ñ
™š
+C,,
ÜMC§a
$*$$%$&%!##%,
+**,!
ʮ5
$
!O½
$
Þß
$
C
,
‘Ù,zŠ‹ƒ„…†
+C,,
×
M$C
$*$$*$*)!*#*%,
+*),!IT1M8$ .R^NH-NVH1 H1k.VkTU H1 H1QTSkT1QH.1 .R?>@A H1 Y>K1TWS.1P$1
5$).+C,,CXQO1.\ONS/N-.V$ *$$$*4!)# )#,
+*&,!.RT/.UH1 RS./kT1QHVNM.VTH.-NS\N+C,,3/C!*#)4,
+*,!GW.L<$ ?PNHJC$ 9T1MB<$ TQNV,://W1TST\.1PTPH1 OW5
/N1 /TPN1MHNV-TVPSTMWVNQTU# ^6T/.UH1 RS./,(*21/-*#?
(6!/]O+H+C,,FHRT8-H$ *$$$#(!#*%,
-4%-
t
)4
Öt
$
v
*$&
o

p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
A.Vc)4$:PPWT!$
9N6$ *$&
+*#,!IT1M8$ BNH5>W B$ T7\STPPH.1 .R?>@A />;3N1U HQPRW1-QH.1 H1 Y>K1TWS.1P$1
5$).+C,,3/C+*%,!
²
,?>@A
¸í;^—Ër)\#ÅY;$Š‹¦,»
Øxƒ„
+Y,,
:J
#
tܽC
$*$$4,
+*(,!?PNHBL$ FH1 L?$ ?PNHQOTR.S/NVH1%H1UW-TU 1.-H-T\QHkT^ TONkH.SH1 /H-T+C,,CXQO1.5
\ONS/N-.V$ *$$$%!*=)#*#%,
+*4,!BNO1 C$ ;NO 8 L$;NO CC$TQNV,KH1PT1.PHUTPH1OH^HQ-N\PNH-H15
N-QHkNQTU -ON11TVH1 SNQPT1P.S61TWS.1P+C,,;TWS.P-HVTQ$ *$$$$
*(%!# &,
+)$,!
ޕ¤
,
ÊHŽÆ
&
SëÁÂvw‰vˆ‰Š‹¦Šû
?>@A5
²zƒ„
+Y,,

#
=™$C,
$*$*,
+),!
¬s
,
Í|«¦Š—˜Í|ë
D
/‰²zƒ„
+Y,,
àá
#
$9ðñ
$*$$,
+)*,!

$
å¶
,?>@A
\3üƒ„…†
+C,,
%fÔz&
‡èé-.
$*$$($*(!)#**$,
+)),!
_Õâ
,
Í|«¦Š—˜gIë«c
?>@A
Wtª
ø×À
+Y,,
àá
#
$9ðñ
$ *$*,
4FP-AR?.AIBGF.?I@A=8MH -AF-A-/S?I.R?JJ?RB@J
BE-F.B.@A-/0C.A?I?,?F.R.A?I
F:E_HN.5VH$ FA!
!@)%)6A6*B%C.%).*+D%.)- @.+%!6,.!6767%1: E67.!6D!(2*$
F6$G$12 A6*B%C.%).*+,.)6!)$1 %1: 4)$($H%)$1 +<.%:$)$1%(8-$167696:$!$16E67.!67$ D12$166.$12 E676%.!-
861).6+;%).%(96:$!$16$ 9$1$7).*+D:!%)$1 +8-$1%$ F6$G$12 ;./%(41$56.7$)*$ F6$G$12 $$(%$ 8-$1%
+4LIBE-RB,!?SN1PHT1QST-T\Q.S\.QT1QHNVkN1HV.HU V!?>@A HPN1.15PTVT-QHkT\.PHQHkTH.1 -ON11TVQONQHP/NH1V6T7\STPPTU H1
PT1P.S61TWS.1PN1U N/T/^TS.RQSN1PHT1QST-T\Q.S\.QT1QHNV!?>@ RN/HV6c?OTST-T\Q.S-.WVU ^TN-QHkNQTU ^6/T-ON1H-NVHSHQNQH.1$
-OT/H-NVHSHQNQH.1 .ST1U.MT1.WPVHMN1U Q./TUHNQT\NH1PN1U -NWPTH10WS6Q.^.U6RW1-QH.1Pc?SNUHQH.1NVQOT/T-ON1HP/.R\NH1 HPQONQpPQNM1NQH.1 VTNUPQ.\NH1pc8\T-HRH-NV6$ ^.QO .RQOT-.1QSN-QWSTN1U QNWQ1TPP-NWPTU ^6-.VU N1U QOT
^V..U PQNPHP-.WVU STPWVQH1 ^V..U H/\NPPN^HVHQ6N1U \NH1c9.PQ.RQSNUHQH.1NVONkTQOTN1QH5H1RVN//NQ.S6TRT-Q$ +OHVTQO.PTR.S+NS/H1MH1QTSH.S$ N1U \S./.QH1M^V..U -HS-WVNQH.1 Q.ST/.kT^V..U PQNPHPONkTQOT
TRT-QH1 P/..QOT1H1M^ V..U kTPPTVPc?OTSTR.ST$THQOTS+HQO QOTN1QH5H1RVN//NQ.S6TRT-Q.SQOTTRT-QH1 P/..QOT1H1M^ V..U kTPPTVP$QSNUH5
QH.1NVTRT-Qc:1 QOHP\N\TS$ QOTNWQO.SPPW//NSHZTQOTN1NVMTPH-TRT-Q.RQOTN^.kTQOSTTQSNUHQH.1NV@A NPQOT
QNSMTQc
+T?D V@EFI,!?>@A* QSNUHQH.1NVF@.# )`(abORYR,,()(

xy-0
!
|}}
#
-$#%-
t
)4
Öt
$
v
*$&
o

p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
A.Vc)4$:PPWT!$
9N6$ *$&