免费文献传递   相关文献

Effect of traditional Chinese medicines with different properties on thermoregulation and temperature-sensitive transient receptor potentialion channel protein of rats with yeast-induced fever

不同寒热药性中药对酵母致热大鼠体温调节及温度敏感瞬时感受器电位离子通道(TRPs)蛋白的影响



全 文 :!O=
!
23pq,¡$,árstquv!wÅx»wy
z{|P{}~VuA€
!A>?D
>yóô
e3

!
45±

!
!
9‚6

!
ΐ,
*
!
ڂö

!
Øù

!
c
y²y¢£¤¥ y¦µ¶·
!
–—
$$%$$& *c
y²y¢£¤¥ E—¢¥ F÷£
!
–—
$$$*#
!!

kl
#!

#
èûÂÃ
&
Ó4­p
%
q,¡$,árstuvbq0­!wy{ÇóôÖ»wyz{|P{}~V
uA€
!A>?D
>yÅxȋ
*
•–
#
ì1’Ǫmrs§ÛBåæuvbq0­
$$(
s
8@
uvR¼dGt3]sÁ
%
0­Á
%
u°Á
%
°RÁ
%
ÌïðÁ1õôÁ
$
t‰št0Û7
&$($* N
“ÇC*1삟 x
$
A¶—>Á¸1
EHDFHP1
[R.F
‚ƒK¬ÇC*1삟 x$wyz{|P{}~VuA€>
A>?Z
1
A>?9(
ycd
*
—˜
#
¥]sÁ
Â
$
ªmrsÛ0­Áuv!w†‡Òf
$( N
÷õ±r
!Pt$c$+
ÇC*1삟 x$
A>?Z
cd‡ñfõ
$A>?9(
cdކ‡úù
*
¥0­ÁÂÃ
$
u°1°RH‡ñúùrsÚyuv!wfõ
$
ÇÅÇC*1삟 x$
A>?Z
c
d
$
ÒÅ
A>?9(
cd
!Pt$c$
·
Pt$c$+
Ìïð1õôábquvy!w1
A>?D
Gp†‡óô
*
—™
#
p¡$,u°
1°Rzúùrstquvy!w
$
¦È‹Hz¥¦áÇC*1삟 x$
A>?Z
1
A>?9(
yCÊÅxC
+
q¡$,
Ìïð1õôpȋ
*

mno
#!
pq,¡
+
rs
+
‘qȋ
+A>?Z+A>?9(

pq)(
#!*$&5$)5$

rstL
#!
%Ù®š&™…!û
!)$%)$

uivw
#!
!
¬°
$
—˜{
$J5/GIR#RI11G(((2#),-./+
!
†¦í
$
ð—˜{
$J5/GIR#W.1MS$$2#),-./

vwŒ
#!
ØÚS
$
LH—˜=
$J5/GIR#PHQRHGO*$2#),-./
!!
$ny
$
™š$,,¡
5
,ʲy—˜È3$
,,¡—˜yóö‚ƒ2Ø
$
S÷âÒÓy
ª
,5*-
*
$,:Cpq2¡
$
~p¡
%
q¡$,„
ÅI¼!q¡
%
p¡¿$5í¶·$÷Ô%ȋ
$
_‹È‹
$
ֻȋy·y_‹
$
*—˜$,pq
,¡Ê¼•y#
*
Ørïy
$
,¡3y$,
:C3·by,Ê
*
Ï|P{}~VuA
€>
!A>?D$
*$nybøׄš“”÷”8
“”~ÃÒy¡qÈ¡auA€
$
Ûل$`ï
ÙÕ¹{:Cwy{9y=$$
úÎÏüA¶
*
¯4­p¡$,1
*
¯4­q¡$,árstb
quv0­!wy{ÇóôÖ»áwyz{
A>?D
yÅxȋyÂÃ
$
¿ØïÍyÁyy~Öp
%

$,y<Ê1,¡ŸÈy²
$
3,¡yøQ&
,-’ZæçyÎÏäƒ
*
!
Ž³
a!
ìû
!8@
¥¡uv
$(
s
$
!=
!*$$ m$
M$
I$%$%´¯‘v¹¹ËB&ÇÎÏìû
$T’Z
$
ìûiH°<
8<_a!
¹
*$$%5$$&*
a!
,–¥.×
!

%
°R
%
Ìïð1õôG
I233ˆ‰,֒Z
$
 $%$B&Ç$,—
˜JéH¬IJvw
$&
¯$,G3€G,Ž
$
•¹
c’B
$
$g½‹
+
rs6®×÷rsDCDE
F
+
ÃË
A>?Z
Ë!1ÃË
A>?9(
Ë!G6®Ö

GR./.1HRG[D
EF
$
ׂ+,wöËÃ
:ML
6
®23$…Ø=û()CDEF
+>:?3
‘B
%
TPGQO.PQ
>w+.×?1
Jb«BG6®23
ñ7ÌEF
+
l烗>Á¸K¬.×?1
@3T
‡
e.×?G6®ª?GHµEF
+
¦¼.×G3%
útª:
*
a&!
˜~
!T8**&8
Vuhd
,
Ù`7/&˜~
!
23

CDEF
-+A@35E8
ùØËT¼
!
ê
UژT¼˜~CDEF
+9<5)&%
Vu!w¼
,
ýÜo
!
uR

CDEF
-+?.+HP?G-
A9
TGDI-
V,˜
!
V%
T:Y5>3@
EF
*
!
‚ƒ
a!
rstbq0­
!
©kÜ«‚ƒ
,)-
$
1¼¹
n
8@
¥¡uv
$
ì1’Ǫm
!3&*$l
rs§ÛB
$ /C. WM
k
*
÷>ákÁuv
3&
?!:=$
Ác
*
.)().
7
)4
Ô7
4
r
*$&
n
$
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)4$:DDSH!4
Y-F.[HP$ *$&
a!
tÁ¥g,
!$(
s1¼¹n
8@
¥¡uv
$
R¼t3
#
Á
#
]sÁ
%
0­Á
%
u°Á
%
°RÁ
%
Ì
ïðÁ1õôÁ
$

(
s
*
uvÎÏg,‚
ƒ
#
4]sÁY
$
JCìûêø
!2/
gŊ,
û
$ N
Û
3&
rs§ÛB
$
t0Û
)c N
Ûbg,
!
‚Ë»×+3œb
*
mÁqb
2/
gÅ,û»×
+t‰3
#
u°Á
!
u°c’B
)c M.WM
k
$
°R
Á
!
°Rc’B
*c( M.WM
k
$
ÌïðÁ
!
Ìïðc
’B
&c* M.WM
k
$
õôÁ
!
õôc’B
# M.
WM
k
$
]sÁ10­Á
!
yzc
* /C.WM
k
*
a&!
!w8¬
!
ÎÏNe3s/p;Èr
$
Ðw
!** m* g$
áøy
!$ m*l$
®IÎå
%
Bc
*
áuvÎcɊ¡Lä
!
šÎÏNe$0üÎÏi
È
) Q
Û
$
hå2hc
* N$
ÎÏlp
$

N
¬
w

b
$
¬
)
b
$
“GQÈ3™é!w
$)
b!wÜ
ìx¶
$c g
&-Á
*
šÛmÁœbgŊ,
û
$ N
Ût0
$
t0Û
( N
uv!wfõ
o$c( g
30­•½¹<
$
qÈÎÏìûÑÁ
*
t0Û
)c N
Ûbg,
*
t0Ûq
N
¬w

b
$
6÷ÎÏ
|X
*
a)!
—>Á¸îe
!
t‰št0Û7
&$($* N
ù
ììû
$
“*1삟 x
$&l
`9ÔäVB/w
%* N$
ŸÛ
$
•¹


/
˜5˜RÕ3–
*
“ÁÂO
Ü3–
$
ÜEc
$?T8
ºo
)
b
$
݋
$c$ /.R.
C
k
ÝÞ๺BÎc˲ÿ^
$)l
y¶Ã¸·x
[8?¡¶Ã¸ûÐw¨©
$ /I1$?T8
oÙÛ
‹
l
$
m]ØË
!r$$
NU
$
ž
& g

;
*
‹l烗>Á¸K¬.×?ÎcÇC*1ì
‚Ÿ x—>Á¸îe
* @3T
‡e
$
c
$
©†
$

*
Š‹ÿþf/tªâ¾
:/GMHXP.XRSD#c$
¬S
—>Á¸f/$a¡Kà
EB
Q
$
ÇC*1삟 
xÁÂt‰„
*$$
a1
&$$
a1¯ÇÎc¸¼
*
a$!EHDFHP1 [R.F

!
t‰¿ÇC*1삟 
xÁÂ$’“>
$
‹
TPGQO.PQ
>*w+‚ƒ
$
Î
c>w+
*
î‹*+t>3
*l
y
8@85?3LJ
V,K¬
$
øƒžeE
?Z@b
Ã
$
5ßÿÐwBº
* N$
t‰]ÑØË
!
ÃË
A>?Z
·ÃË
A>?9($r
$$$
„
& g
Ǩ©¶;
* AT8A
oÃÛ]Ñ`Ë
!B>?
+,wöËÃ`Ë
$r) $$$$
Ðw¨©
* N*
݋ÃË
L3?@B
Ÿ ¡Ë!È38©ákK¬
*
݋
Jb«ƒK¬Ÿ ¡Uh
$ S^G1FI8-G1 )c$
tªâ¾tªUh
EB*
ûy>y
EB
4Ö]sÁ
y
EB
Ö}]ڄ
$
JS|ýQŽûy>áŽ
+
*
a`!
¸¼‚ƒ
!
>ƒÖ $
Im3
Žf
$
î‹
8?88
4c$
â¾Îc¸¼tª
$
Á%ÂË9œÑ‚„t
ª
$Pt$c$
ŽfC‡ñ¡„ 
*
&!

&a!
23pq,¡$,árstquv!wyó
ô
!
¥]sÁÂ
$
0­Áuv rsävÛ7
& N
WW!wAøfõ_¥
$
7
( N
÷õ±r
$
2ÛA
¹nÇú_¥
$
7
& N
WWEèûrC
$
0­ÁÃ]
sÁuv!wfõ
$
:¸¼d³
!Pt$c$$$
T
f
*
@AgÅu°1°RÛ
$
uv!w®rsä
vÛ7
& N
WWÃ0­Á†‡úù
$
„7
& e( N
ú
wȋ)3‡ñ
!Pt$c$$
·
Pt$c$*
š
°R
$
u°yúwȋ0ÕP%P­
$

* N
u
HTu°yúwÊý
!Pt$c$*
•y
$
Ìïð
1õô„èûr8âT†‡y!wÅxȋ
*
&a!
—>Á¸ƒK¬23pq,¡$,árst
quv
A>?Z
Žyóô
!
 rsävÛ7
&$($
* N$
uvÇC*1삟 x$GHT
A>?Z
Ž
†‡¹õ
$
)Ö7
( N
¹õP]‡ñ
!Pt$c$$*
„7
& N
°RÁuv삟 x$
A>?Z
Žc
dÃ0­Á‡ñúù
$
τ7
( N
17
* N
ÛÁu
vÇC*1삟 x$GHT
A>?Z
Žcd
y‡ñúù
!Pt$c$*
š°RÁ
$
u°Á
A>?Z
ŽcdyúùP]†‡
$
@)Ö7
( N
1
7
* N
‡ñ
!Pt$c$*
Ìïð1õôÁ¥0­
ÁÂ
$
ÇC*1삟 x$
A>?Z
ŽcdG
p‡ñ¡„ 
$
Tf
**
&a&!
—>Á¸ƒK¬23pq,¡$,árst
quv
A>?9(
Žyóô
!
¥]sÁÂ
$
rst
quvÇC*1삟 x
A>?9(
Žcd„7
&$($* N
G‡ñúù
!Pt$c$
·
Pt$c$$+
¥0
­ÁÂ
$
u°ÁuvÇC*1삟 x$
A>5
?9(
Žcd„
)
ï23P%žG‡ñfõ
$

„7
( N
삟 x$ŽfõP]†‡
!Pt
$c$$$
°RÁ
A>?9(
ŽÖÃ0­Á‡ñfõ
$
Õ¦fõ·yùšu°Á
!Pt$c$
·
Pt$c$+
ÏÌïð1õôÁ
A>?9(
Ž„èûr$¥0
­ÁÂp†‡„ 
$
Tf
)*
&a)!EHDFHP1 [R.F
K¬23pq,¡$,árst
quv삟 x
A>?D
A€>Žyóô
!
 
.&().
7
)4
Ô7
4
r
*$&
n
$
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)4$:DDSH!4
Y-F.[HP$ *$&
!!
¥]sÁÂÃ

Pt$c$$+
¥0­ÁÂÃ
*
Pt$c$$
)
Pt$c$$
&
Pt$c$$*
f
!
23pq,¡$,ársävyuv!wyóô
bIMc!JOH-F.OQIOHPH1FXP.XHPFIHD.OFPGQIFI.1GRrsävuv삟 x$
A>?Z
Ž†‡fõ
$
A>?9(
Ž†‡úù
!Pt$c$$+
°RH‡ñÕË
IrsÚy
A>?Z
Žyfõ1
A>?9(
Žy
úù
!Pt$c$$
¥°RÁÂ
$
u°Á
A>?Z
y
fõ1
A>?9(
yúùP]‡ñ
!Pt$c$$+
Ìï
ð1õôársÚy
A>?D
yŽp‡ñó
ô
$
Tf
&*
)!
}
úÎÏqÈâ
*
¯p¡$,1
*
¯q¡$,á
—˜¦árstquv0­!wÖ»
A>?D

>yóô
*
q,²Þ*
#
Jq$,™T3
(
$%
,4
)
J6(
+
pq,¡™T†<
%
pà‚
+
pq,
¡™T4­
%

+
Jq$,y®€GúG
*
rstuvbq0­*ØÓs‹ybq0­
$
I¦Jtbqyìûl£Žø¥ýþsT†‡#±
y7q°b
$
s‹šúû!q$,y‘qÈ
‹
,&-
*
úÎÏèû÷
$
uvªmrs§ÛBÛ
& N$
!wWWAø†‡Òf_¥
$
7
( N
÷õ±áÎ
0dØr
*
@AgÅu°1°RÛuvšrsäv
Û7
& N
WW‡ñúù
$
¦úwȋ„7
& e( N
9
ØP%4.3‡ñ
$
¥Ü«`€b
,5#-
*
Ï@Ag
ÅÌïð1õô
*
¯q¡$,Û
$
uv!wº¸
Ã0­Áp¸¼d³
*
|P{}~VuA€>*$nybø×
„š“”÷”8“”~ÃÒyau¡qÈ¡A
€
* A>?
ل$`ïÙÕ¹{:Cwy{9y=$
$
CÜ«`€
,%5(-
$A>?Z
1
A>?9(
t‰*œ
v!Yq1${þy#A€
*
ú;}Á„-rÎ
ϗ˜y¶·$bø
$
1ty®p¡$,y¹tH
ÒÅ
A>?9( />;3
yŽ
$
ÇÅ
A>?Z/>;3


$
)¦áq
!)4 g
<æy
/>;3
Ž+yóô
P3‡ñ
$
Ï1ty®q¡$,y¹tHÇÅ
A>5
?9( />;3
yŽ
$
ÒÅ
A>?Z />;3
yŽ
$
á
p
!4 g
<æy
/>;3
Ž+yóôP3‡
ñ
,45*-
*
9Ùøb’f
$
$,ypq¶¡1Åxp
qyȋŸžHz¥¦ápq{}A€>yŽ
ÅÆ
*
—˜`€
$
È3ýþs‹‘q$,
$
u
°1°R:C†,)5-
$
՘á9
.().
7
)4
Ô7
4
r
*$&
n
$
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)4$:DDSH!4
Y-F.[HP$ *$&
!!
¥]sÁÂÃ

Pt$c$$
*
Pt$c$$+
¥0­ÁÂÃ
)
Pt$c$$
&
Pt$c$$

Pt$c$$!
f
)
3
*
f
*!
23pq,¡$,ársävy
A>?Z
Žyóô
bIMc*!JOH-F.OQIOHPH1FXP.XHPFIHD.OFPGQIFI.1GR?Z I1 6HGDF5I1QS-HQ PGFD
f
)!
23pq,¡$,ársävy
A>?9(
Žyóô
bIMc)!JOH-F.OQIOHPH1FXP.XHPFIHD.OFPGQIFI.1GR?9( I1 6HGDF5I1QS-HQ PGFD
Ù,û„bqìû0­Òz§Åxwyz{
A>?D
yŽ
$
¦!wÅxûü¥á
A>?D
ÅxȋCp
¡
$
û-øpÜ«`€
*
úÎÏèû÷rsä
v
& N
Û
$
uvÇC*1삟 x$
A>?Z
Ž
cd†‡¹õ
$A>?9(
Žcd‡ñúù
*
@
A>?D
Žcdyº¸¥wyº¸CØwy¡
$
x
A>?Z
Žcd¥wyA]
$A>?9(
Ž
cdÞ¥wyA<
*
@A$,u°·°RÛ
$
R8úwȋyÊì10Õ
$
bquvÇC*1ì
‚Ÿ x$
A>?Z
Ž†‡úù
%A>?9(
ŽC
.#().
7
)4
Ô7
4
r
*$&
n
$
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)4$:DDSH!4
Y-F.[HP$ *$&
!!
¥]sÁÂÃ

Pt$c$$+
¥0­ÁÂÃ
*
Pt$c$$
)
Pt$c$$*
f
&!
23pq,¡$,ársävÛ삟 x$
A>?D
Žyóô
bIMc&!JOH-F.OQIOHPH1FXP.XHPFIHD.OFPGQIFI.1GR-I1H.1 A>?D.1 6HGDF5I1QS-HQ PGFD
Êfõ
*
šÏ
$
Ìïð·õôyA,áIrsÚ
y
A>?D
yŽº¸Þp‡ñóô
*
(
Ñ|EYöu}
)
’ä
&
p&q2
$
q&p2

y=öIÞ
$
u°1°R
*
¯p¡$,HzA¶Ç
ÅÇC*1삟 x$
A>?Z
Žcd
%
ÒÅ
A>?9(
Ž¿Ï÷â]q°ìû0­bq±5
yȋ
*
ÏÌïð1õô
*
¯q¡$,,¡
•
$
JÖ2:Cȋ
*
9Hz3ÄÅp¡$,
y‘qȋ’ZâØïÍy1Á
$
Ör323pq
¶¡$,,¡ÎŒZHzy=û+.
*

A>?Z
1
A>?9(
„u°1°RÅx!w$yŸ 
¡_‹
$
¦¼p¡$,*§ÖC3·byȋ
$
øõP`—˜ÎØçÏ°
*

xyz{
#
, -!

$
!?%
$
ýaß
c
$,<Ê¥pq,¡¡—˜y
‚ƒão
,U-c
»~&()
///
$B,øQ¸
$ *$$)
!#*4c
, * -!
>
$
Œtd
c
™š,û=ûʊy$,pq¶¡t—˜
’“
,U-c
$%$,-.
$*$&$)4!#*&4c
, ) -!BG[I[ 9$ EGNHHQ :cJfGRSGFI.1 .OG1FI51.-I-HXFIfH$ G1FI5I1ORG/5
/GF.P6G1Q G1FIX6PHFI-G-FIfIFIHD.OB$#+!232 3&-1$2 N6QP./HFN5
G1.RI-H7FPG-F,U-cUJFN1.XNGP/G-.R$ *$)$ &!# (c
, & -!
­É±
$
Ää!
$

c
uvbq0­»bq¼•y—˜Î
x
,U-c
Ò5,Ç`
$*$$4$ *!)#)*%c
, -!
å±
$
XVA
$
¬°
$
?
c
u°23µ•–‘qȋ»¼•—
˜
,U-c
$%Îς×-.
$*$*$ (!##%c
, # -!UIG1MUb$ EG1MKL$ BS U$ HFGRc;.fHRHOH-F.O[HP[HPI1H.1
FNHP/.PHMSRGFI.1 I1 /I-H/.QHRI1QS-HQ [6N.FG1Q -.RQ H1fIP.15
/H1FGRDFI/SRGFI.1,U-c?C.8 Y;J$ *$)$ (!# H&*)&c
, % -!LGffG;>$TG11.1 3E$ 8SPGXG1H1I8$HFGRcANHfG1IR.IQ PH5
-HXF.PA>?Z IDF.1I-GR6G-FIfGFHQ I1 fIf.G1Q I1f.RfHQ I1 [.Q6
FH/XHPGFSPHPHMSRGFI.1,U-cU;HSP.D-I$ *$$%$ *%!)# ))##c
, ( -!@NGWG3$ 9SPG63;$ 9GFNSPU$ HFGRcA>?9( IDPH]SIPHQ O.P
-.RQ DH1DGFI.1 I1 /I-H,U-c;HSP.1$ *$$%$ &!)# )%c
, 4 -!
å±
$

$
âæÄ
$
?
c
pq¡$,¹tá
A>?Z
1
A>5
?9(
A€>™œŽyó
,U-c
$%$,-.
$*$$$)
!*#4&c
,$-!8SIb$ N`G1M.O[GI-GRI1 I1f.RfHQ I1 I1FHPfH1FI.1 .OA>?Z I1 @>L1HSP.1D2.
:2#$-,U-cUJFN1.XNGP/G-.R$ *$$$ *4# )#c
,-!8SIb$ CI1 ;$ LS.UK$ HFGRc/>;3H7XPHDDI.1 RHfHR.OA>?Z PH-HXF.PX.FH1FIGRI.1 -NG11HR
XP.FHI1 G1Q IFDOS1-FI.1 I1 XPI/GP6PGF@>L1HSP.1D2. :2#$-,U-c
U3DIG1 ;GF?P.Q >HD$ *$$$ *!# %#c
,*-!8SIb$ BS.B>$ N`G1MXPHDDI.1 .OA>?Z />;3G1Q IFDOS1-FI.1 I1 @>L1HSP.1D2.
:2#$-,U-c3/U,)-!
yë‡
$
!Ùç
$
!E5
$
?
c
23µ•‚ƒáu°MÇ
%
‘
q
%
Ë#ȋyóô
,U-c
$%Îς×-.
$*$$%
!)# %c
,&-!
¨¡Ó
$

$
!6Ê
c
°R‘Àq‘q
%
Ë#ȋ—˜
,U-c
$%Îς×-.
$*$$4!# c
,-!
å±
$
XVA
$
¬°
$
?
,
u°23µ•–‘qȋ»¼•—
˜
,U-,
$%Îς×-.
$*$*$(!##%c
.%().
7
)4
Ô7
4
r
*$&
n
$
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)4$:DDSH!4
Y-F.[HP$ *$&
*L?JB@LBE-F.B.@A-/0C.A?I?,?F.J.A?IW.BCF.L?E?ABME@M?EB.?I@A
BC?E,@E?VG/-B.@A-AFB?,M?E-BGE?+I?AI.B.Q?BE-AI.?ABE?J?MB@EM@B?AB.-/.@A
JC-AA?/ME@B?.A@LE-BIW.BCD?-IB+.AFGJ?FL?Q?E
E3;B.1M56H

$ aY;L_IG1M56I1M

!
$ C:_IG.5/I1

$ B`\B.1M5+HI
*
$ 8\_IG.5NSI

$ C:;;G

!
!cE.3#2#,#+->*2.+3+A#+$2 A+82&$ *2. B&8+!0->*2.+3+A+82&49&2+.&+3$ C+2D2./ $$%$$$ *2.+
*c7+1$#!+.#->P#*-4-/0$ G./D2./ 5-312#4$ *2. B&8+!0->*2.+3+A+82&49&2+.&+3$ C+2D2./ $$$*$ *2.
,4KIBE-JB-!6K\?JB.Q?# A.-./XGPHFNHI1FHPfH1FI.1 HOH-FD.OO.SPFPGQIFI.1GRN.FXP.XHPF6.1 [.Q6FH/XHPGFSPHG1Q FH/XHPGFSPH5DH1DIFIfHFPG1DIH1FPH-HXF.PX.FH1FIGRI.1 -NG11HRXP.FHI1D!A>?D .OPGFD+IFN 6HGDF5
I1QS-HQ OHfHPcPG1Q./R6QIfIQHQ I1F.FNH1.P/GRMP.SX$ FNH/.QHRMP.SX$ FNH>NHI>GQI7HF>NIV./GFPHGFHQ MP.SX$ FNH<.XFIQID>NIV./GFPHGFHQ
MP.SX$ FNHJS.QIGHbPS-FSDFPHGFHQ MP.SX$ G1Q FNH3RXI1IGHYOI-I1GPS/>NIV./GFPHGFHQ MP.SX$ +IFN ( PGFDI1 HG-N MP.SXc3FFNH&
N$ ( N G1Q * N GOFHPI10H-FI.1 .O6HGDF$ FNHPGFD+HPHDG-PIOI-HQ F.-.RH-FFNHIPN6X.FNGRG/SDG1Q Q.PDGRP..FMG1MRI.1cANHH7XPHDDI.1D
.OA>?Z G1Q A>?9( +HPHQHFH-FHQ [6I//S1.NIDF.-NH/IDFP6G1Q EHDFHP1 [R.F/HFN.Qc8?IG/B#<./XGPHQ +IFN FNH1.P/GRMP.SX$GO5
FHPI10H-FI.1 .O6HGDF$ FNHFH/XHPGFSPH.OPGFDI1 FNH/.QHRMP.SX 1.FG[R6I1-PHGDHQ$ G1Q PHG-NHQ FNHXHGW GF( N !Pt$c$cANHA>5
?Z RHfHRI1 N6X.FNGRG/SDG1Q Q.PDGRP..FMG1MRIG!@>L .OFNH/.QHRMP.SX DIM1IOI-G1FR6I1-PHGDHQ$ +NHPHGDFNHA>?9( RHfHRDIM1IOI5
-G1FR6PHQS-HQc<./XGPHQ +IFN FNH/.QHRMP.SX$ FNH>NHI>GQI7HF>NIV./GMP.SX G1Q FNH<.XFIQID>NIV./GMP.SX DN.+HQ DIM1IOI-G1F
QH-PHGDHI1 FNHNIMN [.Q6FH/XHPGFSPH.OPGFD-GSDHQ [66HGDF$ Q.+15PHMSRGFI.1 I1 FNHH7XPHDDI.1 .OA>?Z$ G1Q SX5PHMSRGFI.1 I1 FNH
H7XPHDDI.1 .OA>?9( !Pt$c$ .PPt$c$cJS.QIGHbPS-FSDG1Q 3RXI1IGHYOI-I1GPS/>NIV./GNGQ 1.DIM1IOI-G1FHOH-F.1 HIFNHP
FH/XHPGFSPH.PA>?D.OOHfHPPGFDc0@AJ/GI.@A# >NHI>GQI7HF>NIV./GG1Q <.XFIQID>NIV./G$ [.FN GPHA<9D+IFN -.RQ XP.XHPF6$ -G1
PHQS-HFNHFH/XHPGFSPH.OOHfHPPGFDI1QS-HQ [66HGDF$ +NI-N /G6[HPHRGFHQ F.FNHIPHOH-FIfHPHMSRGFI.1 .OA>?Z G1Q A>?9( I1 N6X.5
FNGRG/SDG1Q @>L$ +NIRHJS.QIGHbPS-FSDG1Q 3RXI1IGHYOI-I1GPS/>NIV./GNGQ 1.PHRHfG1FHOH-Fc
,S?D W@EFI-!-.RQ G1Q N.FXP.XHPFIHD+ 6HGDF+ G1FIX6PHFI-HOH-F+ A>?Z+ A>?9(
F@.#([)`bPJ\J,,()#&(

|}-0
!
Ž
#
.(().
7
)4
Ô7
4
r
*$&
n
$
o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
Z.Rc)4$:DDSH!4
Y-F.[HP$ *$&