免费文献传递   相关文献

Apoptosis effects of drug sensitivity leukemia cells induced by nano-realgar

纳米雄黄对药物敏感性白血病细胞的凋亡诱导作用



全 文 :®;¯¬¾,Ž°±Ô=즧~¨©£¤Š°
! 8

!
Ÿ9:
*
!
™;<
)
!
c
ûüq—abrsc —ˆ‰{
!
ûü Ie
%)$$$% *c
ûüq—ac ¸‰o
!
ûü Ie
%)$$$$%
)c
IeÍ* ~óa*c ûüqfbhiýrsyzˆ‰{
!
ûü Ie
%)$$$$#

gh
#!

#
‡ˆ®;¯¬¾,Ž°±Ô=즧~¨©£¤Š°

…†
#
ï°Uµ‡ñžôõ®;¯¬

ÆÔ=
ì,Ž°±
a#*
¦§Ëצ§
$
ï°
9CC
žçÈ®;¯¬¾
a#*
¦§~=¯‘ôŠ°
$311I6M1D=A:
e§ñžçȦ§¨
©
$
¦§Fƒ¦§)çÈ
TG6$T-F4*$A4HY$T<>A$A4)
hÔ~äå»+
$G

‡ˆ
#
¯¬•u#÷ñU÷ñ
$ e$
L$
ö÷ZO
!8E9
§ÿàZO
!CE9
5,
$
ZOÈή;¯¬~+wª)Ë
!%*c%* m**c( 1/$
Š®;øª~¼·†

®;¯¬¾
a#*
¦§GŽ~=¯‘ôŠ°
*&$&($%* L
~
:<
$
ªóË
&)c&($*$c*$#c$% /H+B
k
*$$$ /H+B
k
®;
¯¬Š°
&( L
J
311I6M1 D=A:
§ña¨©¦§Ž=u
$
¨©ÔªóË
$c*g$%)c*g
®;¯¬Š°
&( L
J
TG6

äå6¾V~
!%c($ m*c&$g
6uÜ
!(%c$ mc*$g
§
!77c#$ m$c$g(T-F4*
hÔäå6¾V~
!%)c( m$cg
6u
Ü
!7&c($ m*c$$g
§
!7%c% m$cg *$$$ /H+B
k
®;¯¬1y
a#*
¦§
*& L
J
$a#*
¦§
hÔäå»
+6¾V~
!)c& m$c*&g
6uÜ
!(c(% m*c%&g
§
!%*c mc&g(
¦§~
T<>A$A4HY

$A)
hÔäåmßÕ6
áé
$
ãäåNßÕ6áé

‡‰
#
®;¯¬<Ɛ€£¤Ô=ì,Ž°±
a#*
¦§e¨¨©


ijk
#!
®;¯¬
(
Ô=ì
(
¦§¨©

lm)(
#!*$*4$74$&

nopP
#!
^N÷$ü,&()‡ˆ!
!?]a4*$*4%(
^
N÷’ô&‡ˆîz0õö
!$7#>U]3$)&

qrst
#!
!
5MÀ
$
%&
$E4/GMF#+ILSFGM2FWS,IRS,-1
!!
Ô=ì
!FISXI/MG
Ò @W,=R¦§~
ì
$
áìßkÚq(ì$6W„º
)*

¯¬Ò
$ü8lö°t°,UÓ
$
ëˇ5W
/
”LZê
•
0$
uU,y‡ˆäŽ¯¬7G„ã
%
„ìí
%
„…†Š°
)**

¯¬~ÃÄDŪÒ
3N
&
8
&
z
3N
*
8
*

6W¯¬ZkÒ»ƒ#¿W»~
$
›Æ¯¬
ß°W‡ˆUõݳÄôõÅ®;ý~øª
$
uU
,y‡ˆ{Ž®;ý¯¬~,~ÄTWV®;ý
ó~¯¬
$
퉊°NÄh:
$

$
®;¯¬~=
‡ŸEͯ¬ghƒ,U+,e¨€~ÃD
$
=‡Ù=àåHÁÙå:
))*

®;¯¬„…†Š
°UôŒ-å=;
$
‡ˆäŽ®;¯¬ÃÄÒBÝ
‘ô¦§¨Ï
%
£¤¦§¨©
%
þ‰…†¦§Å9
%
ªD
%
£¤¦§1ªªD
%
‘ô…†=Ԩł6Ú
l†Š° „…†Š°
)&*

®;¯¬BÝÕï
ƒ¾Ô=즧 Ü¨©£¤Š°§6Úl 
Š°

!
X°Ÿž
\!

!>A9:#&$!
ê%
?M[-.
IJ
(
@¨:
ë=I
!
²%U¶¨Ž&(GHŠ’IJ
(AE-5
]A~r„.
„
%E]A~r„.
„¯’
IJ
(AE
]A~r„.
„
¯’
ITM.N-MI1-I
IJ
(AE
]A~r„.
:H?

$
E]A~r„.
:H?

§
AE-5
]A~r„.
:H?

Ë
IJ×Ø
(\:C<
]A~
T<>A
¯’
TM.iMNM.1
IJ
(311I6M1
,
=A:
¨©çÈåÒͯ’
ITM.N-MI1-I
IJ
(\:C<
]A~r„.
T-F4*

!
ê
%
]A~r„.
TG6

!
ê%
ITM.4
N-MI1-I(\:C<
]A~
VEDV4\9a
Ë
TM.iMNM.1
IJ
×Ø
(
„
A4)

$\:C<
]A~j„r
:H?
¯’
TM.iMNM.1
IJ
(A4HY

!9>a#$aG/M5GTM./IRM-4
GF
IJ
$AE
]A~j„r
:H?
*
#
!IJ

¯
¬‹,¯’P4$,ä®IJ

\(!
®;¯¬ôõ
!
Eͯ¬òW×V,Ø
*$$$
qq眍5

ï°f³ƒu#÷ñU
!b94)8A*
“
$
93àÞß»

÷ñžôõ
$
qG
&$$ Q+
/M1
k
%
÷°g
&$d%
§ñÒË»
$
֖
$ e$ L
J
•Ý»R2Û

ö÷ZO
!UE94#%$Âãeà“
$
sZZËIJ

§ÿàZO
!UE94*)$
“
$
sZZË
IJ

5,®;¯¬~¼½§ª)
)4#*

BÝö÷
ZO§ÿàZO5,ȹ
$
ôÛ®;ý¯¬ò$
$$ 1/
øªó·~òW<å
(g
ÆÕ
$
ƒ­¦µ
+*$**+
v
)(
šv
)
x
*$)
q
%
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
D.Fc)($:NNSI!)
USF5$ *$)
¶Ë
*$ 1/
Ɓ~¦:ꪧƒîé~Vê

ôõŽ’ô%RJ‡ä

ôÛ~®;¯¬°
aɧuú¿Â¿m
$
;GZ@
Ð
Y@
9
%c$$AT8
¹8
$

* H+B
k
~rq
Â
$
ÝÄÁã
$& f
¡qõ°

\&!
צ§§¦§8#
!a#*
¦§6²%àü
vœ$X¡q

¦§Ú¯WÍ
g
@¨ë=I
!
²%U¶¨Ž&(GHŠ’IJ

~
>A9:#&$
8#Â
!
ê%
?M[-.T>B
IJ

$
$
Æ
)% f$g*
§oʹº8#
$
ñ¾?¨Ïx¦§°Wvœ

\V!
®;¯¬¾
a#*
¦§=¯G~ÆÇ
!
Ø
a#*
¦§
! h$

?
=/B
Ú¯W
7#
E8#F
!<.NOGQ
$
$
²Zb/ãH~®;¯¬
$
8#
*&$&($
%* L
J
9CC
žçÈ

’+Þ]Þ
!TM.4CIX A.+IQ
+GiI^
W
%$ 1/
1È=æH
$$
zø¦§=¯‘
ôÔ§¿?‘ôãH
!:<
$

\$!
®;¯¬£¤
a#*
¦§¨©çÈ
!
ªó‡
äb/€ÎãH
!*$$$ /H+B
k

®;¯¬1y
&(
L
~
a#*
¦§
! h$

?
=/B$AT8

$
ÚôW
TM1RM1HTSPIQ
$
$
²Z
311I6M1 D

B
§
A:

B$
>˛æ§ñ
/M1$
Fƒ¦§Þ
!\<9$ TI-X/G14
<.SFOIQEYM-N^ B
çÈ`t
%
Ëx¨©§qx¨©
¦§

\c!
®;¯¬¾
a#*
¦§
TG6
hÔäå~ȹ
!
‡äb/€ÎãH
!*$$$ /H+B
k

®;¯¬1
y
&( L
J~
a#*
¦§
$AT8


²Z¦§y¹
Ò§BÿÒ
$
²Z
AE
]A~r„.
TG6

$AE
]A~r
:H?

˾V
$\<9
çÈ
T3^
hÔ~z
Ô§+wèæ>H

çÈڌ
)
Î

\%!
®;¯¬¾
a#*
¦§
T-F4*
hÔäå~ȹ
!
‡äb/€ÎãH
!*$$$ /H+B
k

®;¯¬1
y
&( L
J~
a#*
¦§
$AT8


²Z¦§y¹
Ò§BÿÒ
$
²Z
\:C<
]A~r„.
T-F4*
B
„
$\:C<
]A~r
:H?

˾V
$\<9
çÈ
T-F4*
h
Ô~zÔ§+wèæ>H

çÈڌ
)
Î

\!
®;¯¬¾
a#*
¦§
A4)
hÔäå~ȹ
!
‡äb/€ÎãH
!*$$$ /H+B
k

®;¯¬1
y
&( L
J~
a#*
¦§
$AT8


²Z¦§y¹
Ò§BÿÒ
$
²Zr„.
A4)
B„›æðÖ
)$
/M1$AT8


ôJ²Z
\:C<
]A~j„r
:H?
Š„›æðÖ
)$ /M1$AT8

\<9
çÈ
A4)
h
Ô~zÔ§+wèæ>H

çÈڌ
)
Î

\#!
®;¯¬¾
a#*
¦§
T<>A=A4HY
hÔäå
~ȹ
!
‡äb/€ÎãH
!*$$$ /H+B
k

®;
¯¬1y
&( L
J~
a#*
¦§
$AT8


w¾V
Ô²Z
AE
]A~r„.
:H?

WX÷hÔ
$\:C<
]
A~r„.
:H?

WX÷hÔ

çÈÔªó²Zr
„.
A4HY

9>a4# !
ӄ
$
>˛æðÖ
*$
/M1$AT8

$
ÚôW
$$

BAT8
ôJ²Z
AE
]A~j„r
:H?
*
#
!
Š„
$
>˛æðÖ
*$ /M1$
AT8

$
²Z
$$

BAT8
Úô¦§

ëJªó
²Z
\:C<
]A~r„.
T<>A
„
$
ðÖ
)$ /M1$
AT8

$
ÚôW
AT8
$
\<9
çÈ

ڌ
)
ÎçÈ

\)! GçÈ
!
‡äb/€ÎãH
!*$$$ /H+B
k

®;¯¬1y
*& L
~
a#*
¦§
$
AT8


²Z
\:C<
èæ]A~GD
·
f‘ôŽ
VEDV4\9a$)% f$g *
ð^$ð
Ö
$c e L$) $$$ Q+/M1
k
MXmÕI
$+GNL [SPIQ
$c /B
J
*
Î
$
ÚôW
$$

B
~
+GNL [SPIQ
$
$
\<9
çÈGD
~ÍÎ

çÈڌ
)
Î

\!
Íz1y
!
zΗ°µæï° %
Km<
äa

æ°
8A88 )c$
Ízƒº‰fÍzª«

(!
µæ
(\!
®;¯¬~¼·†
!
¯¬•u#÷ñU÷
ñ
$ e$ L$
ö÷ZO
!8E9
§ÿàZO
!CE9
5
,
$
3¦4òøªßö¼
$
à:ZӜ
CE9
ªçhÑ
$

8E9
5,TGŽ~®Ÿu

ZOÈή;¯¬~+wª)Ë
!%*c%* m**c(
1/$
Š®;øª~¼·†
!
i

3c8E9! h&
h
(TcCE9! h*
h

i
!
®;¯¬~ZO¼½
\MHc!CLI/.QYL.F.H5.P1G1.4QIGFHGQS1RIQIFI-OQ.1 /M-Q.4
N-.YIN
(\(!
®;¯¬‘ô
a#*
¦§~=¯G
!
®;
¯¬¾
a#*
¦§GŽ~=¯‘ôŠ°
*&$&($
%* L
~
:<
$
ªóË
&)c&($*$c*$#c$% /H+B
k
!
i
*$&v$c$
+)$**+
v
)(
šv
)
x
*$)
q
%
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
D.Fc)($:NNSI!)
USF5$ *$)
i*!
®;¯¬¾Ô=즧
a#*
¦§~=¯‘ôŠ°
\MHc*!CLIM1LM[MOM.1 .Pa#* -IFNM1RS-IR [51G1.4QIGFHGQ
(\&!
®;¯¬£¤
a#*
¦§¨©
!$$*$$$ /H+
B
k
®;¯¬Š°
&( L
J
311I6M1 D=A:
§ña¨
©¦§Ž=u
$
¨©ÔªóË
$c*g$$c*g$
%)c*g$
Æqx¨©¦§ËÃ

(\V!
®;¯¬ÕÐ
a#*
¦§
TG6
hÔ»+
!$$
*$$$ /H+B
k
®;¯¬1y
a#*
¦§
&( L
J
$
TG6
hÔ»+6u
$
zÔJ¾V~
! %c($ m
*c&$g
6uÜ
! (%c$ mc*$ g
§
! 77c#$ m
$c$g
èæ>HJ¾V~
!*c$% m$c$&
6uÜ
!*c# m$c$&
§
!*c# mc!
ä

ä
!
®;¯¬¾
a#*
¦§
TG6$T-F4*$hÔäå»+~ÆÇ
!
%
Km<$-l)
CG[FI!EPI-ON.P1G1.4QIGFHGQ.1 TG6$ T-F4*$ %
Km<$-l)
®;¯¬
=/H+B
k
TG6!&( L T-F4*!&( L
=g
èæ>H zÔ
=g
èæ>H zÔ
=g
èæ>H zÔ
=g
èæ>H
$ %c($ m*c&$ *c$% m$c$& %)c( m$c c#$ m$c$ )c& m$c*& *c&* m$c7# &)c$ m$c% c)* m$c$
*$
(%c$ mc*$

*c# m$c$&
7&c($ m*c$$

*c)$ m$c
(c(% m*c%&

c m$c$
%$c7$ m*c$$

c# m$c$
$
77c#$ m$c$

*c# mc
7%c% m$c

)c%* m$c%(
%*c mc&

*c#$ m$c$
7)c&$ m$c*$

*c$( m$c$*
!!
‘
#
Ÿ¾V
!$ /H+B
k

gh

&v$c$!
ä
*
/

(\$!
®;¯¬¾
a#*
¦§
T-F4*
hÔ~ÆÇ
!$$
*$$$ /H+B
k
®;¯¬1y
a#*
¦§
&( L
J
$
T-F4*
hÔäåzÔJ¾V~
!%)c( m$cg
6

!7&c($ m*c$$g
§
!7%c% m$cg
+w
èæ>HJ¾V~
!c#$ m$c$
6uÜ
!*c)$ m
$c
§
!)c%* m$c%(!
ä

(\c!
®;¯¬ÕÐ
hÔäå»+
!$$
*$$$ /H+B
k
®;¯¬1y
a#*
¦§
*& L
J
$
a#*
¦§
hÔäå»+6u
$
J¾V~
!)c& m$c*& g
6 u Ü
! (c(% m*c%& g
§
!%*c mc&g$
+wèæ>HþÎË
!*c&* m
$c7#$!c m$c$$!*c#$ m$c$!
ä

(\%!
®;¯¬ÕÐ
a#*
¦§
A4)
hÔäå»+
!
$$*$$$ /H+B
k
®;¯¬1y
a#*
¦§
&( L
J
$A4)
hÔäå6u
$
èæ>HNˆU6u
!
ä

(\!
®;¯¬¾
a#*
¦§
T<>A=A4HY
hÔäå
~ÆÇ
!$$*$$$ /H+B
k
®;¯¬1y
a#*
¦
§
&( L
J
$
¦§~
T<>A$A4HY
hÔäåmßÕ
6áé
$
ãäåNßÕ6áé
!
ä
*
&!
¡¨
Z‡ˆµæ䎮;¯¬Š°
a#*
¦§J
$
TG6=T-F4*
Ž=u
$hÔäå6u
$
ð
!!
ä
*!
®;¯¬¾
a#*
¦§
T<>A=A4HY
hÔäå»+~Æ
Ç
!&( L!
%
Km<$-l)
CG[FI*!EPI-ON.P1G1.4QIGFHGQ.1 T<>A=A4HY YQ.OIM1 I6YQIN4
NM.1 .Pa#* -IFN!
%
Km<$-l) g
®;¯¬
=/H+B
k
T<>A
r
A4HY
r
T<>A
r
=A4HY
r
$ $c m$c$ $c%% m$c$7 $c*$ m$c$*
*$
7c(* m$c#

*7c# m$c#

c& m$c*

$
(c( m$c)

7c mc(&

c) mc

a®;¯¬ÃÄBÝ
þÿ()£¤Ô=ì
¦§¨©
$
®;¯¬£¤
a#*
¦§¨©~Uô€
zŒ-
$
E‡ˆa
þÿ()£¤D,
Ô=즧¨©<#ÒëÃÄ~UôUÓ

®;¯
¬¾
a#*
¦§~
A4)
hÔäå Üþ‰Š°
$
J
徦§~|Œ ÜŠ°
$
þ‰í
a#*
¦§¨©

®;¯¬Bݾ
a#*
¦§~
T<>A
Ÿ
A4HY
ãäå
רÆÇ
$
Jå⦧~D,ר¸qŠ°
$
‰Z¨
©Ýû
)%4)*

®;¯¬¾,Ž°±Ô=ì
a#*
¦§7G
Ž~¨©£¤Š°
$
®;¯¬£¤
a#*
¦§¨
©ÒÓ?z()
$
zRÑ~Ýû
$
bv¾
A4)

§
TG6=[-F4*
hÔGÕЊ°
$
ånG¨©~æª
Ë
£¤¦§¨©
$
ÕÐ
T<>A
§
A4HY
ä
+&$**+
v
)(
šv
)
x
*$)
q
%
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
D.Fc)($:NNSI!)
USF5$ *$)
å$
Jå Ü£¤
a#*
¦§¨©~Š°

®;¯
¬¾Ô=ì~Š°‡ˆ¾‡ô®;¯¬ôÒðæ°
W€Ô=ì~lD7Gv°ø


wxyz
#
) *!JG1HB$ ]L.S ?T$ BMS A$ IOGFcVMNNI-OM.1 .P/I-LG1MN/N.P
OQIGO/I1OP.QYQ./5IF.-5OM-FISXI/MG)U*cAQ.-;GOF3-GR 8-M
_83$*$$($$!*#&(*#c
) * *!UMGKB$ BMU$ bM1 ]@$ IOGFc3SO.YLGHM-G1R GY.YO.OM-/I-LG4
1MN/N.P-SQ-S/M14M1RS-IR RIGOL M1 a#* -IFN)U*cU3NMG1 ;GO
AQ.R >IN$*$$7$!#7(c
) ) *!8I.FU?$ AGQX J@$ aM1 E8$ IOGFcA.OI1OMGFQ.FI.P-GNYGNI4)
G1R 47 M1 A<:4 LIGR G1R 1I-X -G1-IQ-IFN)U*c:1OUZ1-.F$
*$$$ (!*# *&7c
) & *!aMQN-L V?$ V.NIP3$ -FIGiGHI.PT-F4* YQ./.OINQIFIGNI.P-5O.-LQ./I-)U*cUTM.F

  • ) *!
    ̓Ó
    $
    }¸Æ
    $
    ƒv,
    c
    ®;¯¬‡ˆ‰Š
    )U*c
    D‰Š
    $
    *$$7$*!#7)&c
    ) # *!
    !“à
    $
    [UZ
    $
    )qÌ
    $
    ì
    c
    ®;ý¯¬ò~ôõ
    )U*c
    m
    ÿ$,c
    $ *$$*$(!)#*7c
    ) % *!
    lN
    $

    $

    $
    ì
    c
    :Ôç8’¾Ô=ì
    a#*
    ¦§‚ƒ
    R¦§~Š°
    )U*c
    $%$,-.
    $*$$$)!*#*7c
    ) ( *!
    #úR
    c
    ¯¬£¤Ô=즧Щ~‡ˆ
    )U*c
    ü,¤c
    $
    *$$$ *$ ! # #%(c
    ) 7 *!VSOG3$ 8I1 C$ FISXI/MG-IFNM1 YQINI1-I.PPM[Q.1I-OM1 I6YQINNING1R NI-QIOIN
    99A47 M1 NIQS/4PQII-SFOSQI/IRMS/)U*c:1OU*$$$)!)#*((c
    )$*!aS+G1GCcT-F4*4PG/MF5YQ.OIM1NG1R OLIQ.FI.P/MO.-L.1RQMGM1
    GY.YO.NMN)U*c)*!U.L1NO.1I>J$ FISXI/MG-IFNGHGM1NO-GNYGNI4RIYI1RI1O$ [SO1.O-GNYGNI4M1RI4
    YI1RI1O$ -IFRIGOL)U*cTF..R$ 777$ 7) !)# $%c
    )**!8GMO.9$ a.QN/I5IQ8 U$ 8-LFINM1HIQA@cTG64RIYI1RI1OOQG1N4
    Y.QO.P-5O.-LQ./I-QI-.1NOMOSOIR M1 YSQIFMY.N./IN)U*c;GOTM.F$ *$$$$ *# )c
    ))*!
    !p
    $
    lN
    $

    $
    ì
    c
    ®;¯¬¾D,Ô=즧~
    ¨©£¤Š°
    )U*c
    $,,yŸ€
    $*$$$*#!#))c
    4K@KB@I.I?J?RBI@JFEGT I?AI.B.P.BD /?Ga?,.- R?/I.AFGR?FLD A-A@+E?-/T-E
    J3;?K.1H4NLI1H

    $ ]@Z_8M4O.1H
    *
    $ JE:@S4FGM
    )
    !
    !c+13?,0,/-37%2,-5<5>5?,4,-5M5<53142 V-<0,0605/9@3-<6 &1/.,-45$ %5-0137I3E/130/1=$ I3-A2/6 %)$$$$ %2,-3(
    *c+13?,0,/-37%2,-5<5>5?,4,-5B/<,037/9@3-<6 &1/.,-45$ I3-A2/6 %)$$$$$ %2,-3(
    )c!42//7/9L3<,4>5?,437!4,5-45$ I3-A2/6 ;-,.51<,0=$ H5=I3E/130/1=/9&1547,-,437!06?=9/1
    #5U*168)4LIBE-RB*!6Lb?RB.P?# C.I6YF.QIGY.YO.NMN4M1RS-M1HIPI-ON.PQIGFHGQ1G1.YGQOM-FI!1G1.4QIGFHGQ .1 RQSH4NI1NMOMiIFISXI/MG
    -IFNc/MG-IFN!a#* GNOGQHIO-IFN$ 9CCGNNG5+GNSNIR O.RIOI-OOLIYQ.FMPIQGOM1HG-OMiMO5.Pa#* -IFN$ G1R OLI-IFSFGQGY.YO.NMN+GN
    M1iINOMHGOIR +MOL R.S[FINOGM1M1H.P\:C<4311I6M1 DG1R YQ.YMRMS/M.RMRI!A: [5PF.+-5O./IOQ5c\F.+-5O./IOQ5!\<9 +GNI/4
    YF.5IR O.RIOI-OI6YQINNM.1 .PM1OQG-IFSFGQTG6$ T-F4*$ A4) YQ.OIM1 G1R OLIG-OMiMO5.PO.SFOQG4PM1IY.+RIQ[5[GF/MFM1H$ G1R OLIGiIQGHIRMG/IOIQ.POLI1G1.YGQOM-FI+GN!%*c%* m**c( 1//IGNSQIR +MOL IFI-OQ.1 /M4
    -Q.N-.YINc;G1.4QIGFHGQNMH1MPM-G1OF5M1LM[MOIR OLIYQ.FMPIQGOM.1 .Pa#* -IFN$ CQIGOIR P.Q*&$ &( G1R %* L.SQN$ OLI$g M1LM[MO.Q5
    -.1-I1OQGOM.1 !:<
    $
    +GN&)c&($ *$c*$#c$% /H+B
    k
    c3POIQI6Y.NSQIO.*$ /H+B
    k
    G1R $ /H+B
    k
    1G1.4QIGFHGQP.Q&( L.SQN$
    OLIGY.YO.NMN.Pa#* -IFNRIOI-OIR [5311I6M1
    ,
    =A:NOGM1M1H+GNM1-QIGNIR$ OLIGY.YO.OM-QGOI.Pa#* -IFN+GN$c*g G1R
    %)c*gc3POIQOLIOGQHIO-IFN+IQIOQIGOIR +MOL *$ /H+B
    k
    G1R $ /H+B
    k
    1G1.4QIGFHGQP.Q&( L$ OLII6YQINNM.1 .PA4)$TG6$T-F4
    * /GQXIRF5M1-QIGNIR M1 GOM/IG1R R.NI4RIYI1RI1O/G11IQc3POIQGR/M1MNOQGOM.1 .P*$ /H+B
    k
    G1R $ /H+B
    k
    1G1.4QIGFHGQP.Q&(
    L$ OLIYIQ-I1OGHI.PT<>A
    r
    $ A4HY
    r
    G1R -.4I6YQINNM1HA4HY G1R T<>A-IFY.YSFGOM.1 M1 a#* -IFNM1-QGNIR RQG/GOM-GF5c0@AR/G+
    I.@A# ;G1.4>IGFHGQNMH1MPM-G1OF5M1RS-IR GY.YO.NMN.PRQSH4NI1NMOMiIFISXI/MG-IFNc
    )d?D Y@EFI*!1G1.4QIGFHGQ( GY.YO.NMN( FISXI/MG
    F@.#)[V(cORbR,,()&&&&

    {|-0
    !
    ŽŽ
    #
    +$**+
    v
    )(
    šv
    )
    x
    *$)
    q
    %
    r
    !!!!!! ! ! ! ! ! !!!! ! ! ! !
    D.Fc)($:NNSI!)
    USF5$ *$)