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作 者 ：黄芸,董蕾

期 刊 ：中国中药杂志 2011年 36卷 19期 页码：2727.

关键词：马齿苋；溃疡性结肠炎；三硝基苯磺酸；

Keywords:purslane, ulcerative colitis, trinitrobenzenesulfonic acid,

摘 要 ：目的: 考察马齿苋对溃疡性结肠炎的治疗作用。 方法: 雄性SD大鼠72只随机分为6组。用2,4,6-三硝基苯磺酸灌肠制备大鼠溃疡性结肠炎模型。马齿苋高(10 g·kg^-1)、中(5 g·kg^-1)、低(2.5 g·kg^-1)剂量组和柳氮磺吡啶组(0.5 g·kg^-1)从造模后第3天开始灌肠给药,每天1次,连续10 d。观察大鼠结肠组织形态学改变并进行评分,测定结肠组织内髓过氧化物酶(MPO)含量。 结果: 马齿苋中、高剂量组能够改善溃疡性结肠炎模型大鼠的大便性状,显著改善大鼠结肠组织的病理损害,降低大体形态损伤评分,降低髓过氧化物酶(MPO)含量。 结论: 马齿苋对溃疡性结肠炎急性期有良好疗效,能够改善溃疡性结肠炎模型大鼠的肠粘膜损伤,减少MPO含量,减轻肠道炎症。

Abstract:Objective: To evaluate the protective effect of purslane on the acute injury caused by intra-colonic administration of trinitrobenzenesulfonic acid (TNBS) in rats. Method: Seventy-two male SD rats were separated into 6 groups randomly. Rat model of ulcerative colitis was established by intra-colonic administration of trinitrobenzenesulfonic acid (TNBS). Purslane (2. 5, 5, 10 g·kg^-1) and sulfasalazine(0. 5 g·kg^-1) was administered by enemata, 3 days after TNBS instillation and daily during 10 days before killing the rats. Colons were removed for histological analysis and measurement of myeloperoxidase (MPO). Result: Rats treated with purslane (5 and 10 g·kg^-1) were significantly healthier than TNBS-alone rats, as shown by improved food intake and reduced diarrhea, corrected the disorders in morphology associated to lesions, significantly reduced myeloperoxidase (MPO) levels. Conclusion: purslane exerts protective effect in experimental colitis, the effect seems to be related to relieving inflammatory reaction and repairing lesions.

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