免费文献传递   相关文献

Anti-inflammation effect of Danggui Shaoyao San on Alzheimer‘s diseases

基于抗炎作用的当归芍药散抗阿尔茨海默氏症的实验研究



全 文 :#4]
#
s–—E›[Θ™Ç~–b>š
&›œ[§¨ƒ„
;±ó
P
#
ɖf
W
#
*¹‘
O
#
Ü%º
P
!
!Pf
\ïI¯K ]^_`¯öMü
#
ŽÜ a4
W^PMMO%
Wf
9#
œ_ ïý
WPMMON%
Of
\ïI¯K L7öMü
#
ŽÜ a4
W^PMMO
$
;
%!

&
±–—[`
!
ƒ„Θ™Ç~–b>š&›œ
$=&`#(I(%r050($0(0! =R%
[×Ü

ƒ„
&
³[&6
~?t #
;
T¦út
P;^W$=
#
P;^W
%
¸¹ê
=R
¸¹mâ
!
§¨¸¹Ö×6êmâÙ
#
Θ™Ç~ë
#
ÆÛ·Ù
!
>©ÑÙ¸¹³
[&6~?t‡·œÛ
!
‡H§¨Ñ¤ˆ‰§¨lnΘ™Ç~A³[&6~?t
=
#
P;^W
[
=R
¸¹mâ]½ÑˆŠÞg[
@A
!3@;83
`%¸¹&6ÙÊr
:B;P
#
!:B;X!@>J;

I3>=!
·{”`%
>T
¤~
!
ÈI²Àˆ”
$@,>-B%
`%&6ÀË
8ýþ

…†
&
imâÙj·
!
¤ˆ‰§¨r
!
Θ™Ç~ë
#
ÆÛ·ÑÐÙ¸¹[‹¸¸Œ•u¡¢Ü
$=lMfMP!=lMfML%!
]vÀ¥#~©7šu¡ªx
$=lMfMP!=lMfML%&
]‡H§¨r
!
Θ™Ç~ë
#
ÆÛ·ÑÐÙ¸¹[\¸Œ•u¡¢
Ü
$=lMfML%!
Θ™Ç~ëÛ·ÑÐÙ[Ž-5(u¡¢e
$=lMfML%
Θ™Ç~ÑÐÙ¸¹&6ÙÊ~
:B;P
#
!:B;X
Ñ
@>J;

I3>=
[¼kþmâÙu¡{Æ
$=lMfMP%
þgmâÙ
!
Θ™Ç~ë
#
ÆÛ·ÑÐÙ¸¹&6ÙÊ
>T
[ÄÚu¡
¢e
$=lMfMP!=lMfML%
Θ™Ç~ÑÐÙu¡¢m&6ÀË8[ýþ
$=lMfMP%
…‡
&
Θ™Ç~¢m¾~—
!
¢e®¯ýþª¾5
=R
¸¹[(íÞg[×Üg|

$
ˆ‰Š
%!
Θ™Ç~
&
–—E›
&

&
ýþ
$
8‹$f
%!WMPMPWM[MMN
$
Ž>
%!
!
t1’
!
®*X
!
ƒ„…†êrÇËѾ°±i¾À
ËÊɛ tÝ
! @(&. $ MLLO % O_OW^XN! -;I$&. H)K$/I(P_LX PXOfG/I
$
>‘
%!
5§¤
!
­.
!
®*X
!
ƒ„…†êrÇËѾ°±i
¾ÀËÊɛtÝ
!@(&.$MLLO%O_OW^XN!-;I$&. #`/)*0#4 #`WMMX0/#4fG/I
!!
b>š&›
$=&`#(I(%r050($0(0!=R%
Â|
 rõÀËFãÊɛtÝ
!
jªÝ¥×Üj£
!
v
h‡,èé[ÑÐÇÌ

rÇj…Θ™Ç~Kl
,
t&«
-!
¤›Ñ±éèG®tè
!WM
•ö
NM
÷ô;
!
¥¤x‘’8€W›ï…Ñб÷›
’“
!
>#&¨WÐé

3h®™7«Aªr×Ü
åÉír†

è]Fƒ„¼.
!
ï…g9aÅL±
\6¹&6óþÀË8(·Ñ@A&6ÙÊút[
¼k
&
_àqþ®¯
[)=G#3
[¼k
!
•Ü
B81
ø
Ï6ÍY®¯U\Ñ
@>J;
[6u
P;^(

EF3h
[ƒ„`¼.
!
ï…èþ:[–È\E›
!
*•Ü
<=T;7
[UN
!
9aH£¨ÀËÁY[Z·

”÷
;
!
ҙ™Â¼.
!=R
[ãæi—\3 


챖—[`‘nΘ™Ç~–
=R
[
Ðé
!
>,7«1I

¤ƒ„ #
;
T¦út
P;^W
$=
#
P;^W
%
³[&6~?tê
=R
ÊÌmâ
!
±—[
`
!
‘n&6~—jL[¼kÑÀË8ýþ
!

GΘ™Ç~Aª[@A

!
ÁÂ
!W!
Ç|içÛ
!
Θ™Ç~
$R11%
…r¿ÇŒ
plýùØÙÇ(0Öè#–$
!
>Ër­Çö¸
]rǙ¬]*ƒ’”Ï–*XÕÔ
!
Θê
=);
*(&G$(1)()003$5K&
tÑê
=2%$G2A&/50<$G%/;
G(U#$&$(3#`/I$&
t™ê
8$(/)G$(3$5K=&b$&
•(
ê
8/%$&
Œ1ê
=&0I$203#`/I$&
P–ê
#4$)K;
/)*3#`/I$
7
PMM *
j…ZΘ
POfX *!

PNfW *!

PNfW *!
•(
PNfW *!

POfX *!
Œ1
PNfW *
j…’jÓ1(
#

#
­iÜڂÌT
!
ޛh›³¼¤µÚj\<œu
!
§¨r²›Û
·Œ’ãÇ·.
=
#
P;^W
pl
1*I$
–$
$
Ãf
7=
M[XW % @4)(&
çۗpl
3/G#($

!
˜f
PPXN^NP[_M%&>T
`%çۗplýùnÚã̃
/LLPO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
„²
$
Ãf
WMM[MNMO% 83
“Ìû_&ãNãÌ
N|÷Ñè#–$
$1$)*/)!
_&
%
ÄÚ

!W#
ßàiáÝ
!Ra;L
⸹¾oþÔIß
$
Ú
„ö™ö÷è#–$
%&R@@;W
¸¹‡Hß
$
r­{
]ö]iÇ̃„²
%&¤ˆ‰
$

%&J9;
WMM
ëL6~a$×
$
_&šùßàè#–$
%&
H
}ëL#:qß×
$1*I$!
š­
%&R?OMWW=
⦷
¹)`%ß
$@#(%I/-&(G2%/)
–$
!
š­
%&
n®ÔÍ
Ú0Fã
$7:T;3=R
–$
!
š­
%&
ðŸû¤~.M
ß
$
ýùöâßàƒ„²
%
!W$
ÊÌ
!1R
¸¹
!
¤›
!
þi
$WNM kWM% *!
ûr
­ö]i_&§¨ÊÌrßµo
!
ÊÌÒ*Æf
1-CWMMO;MMM^
ÊÌ6›œf
!

PW #
²á
ë
!
’+
$WW kP% i!
lû줞E

#
…”
#W!=
#
P;^W
Ÿ‘þ‘Ä̜u[ÜÝ
!
V
=
#
P;^W
œ

P hPM
Q^
I/&/B
QP
[ø@›«vu
$871&PM
II/&/B
QP
>$.
W
8T
^
Z>$
W
.8T
^
! PMM II/&/B
QP
>$&! U.[fL
œèqL³¼¤r
%!
Y·<ê
P
*/B
QP
=
#
P;^W
œu]
WO i
 á6Ê
OX #!MfWW
!
I
X)³ß¡³
!
6g
!QWM i

!
ݛ

#W#
³[&6~?t
=
#
P;^W
øÏ
=R
ÊÌmâ[Ü
Ý
#
6ÙGÛÇ
!1R
¸¹%\*÷
P
ò¾
!$
¤Ä

$OWL I*/V*
QP
%
Žg
!
¾oþÔIßùÔW
Ø
!
ьoÇ
!
!rn€—Wá
!
á6eWY

ù

QOfN II!
rnå
kWfM II!
ÔI
!
íö¢¢—
£Y
PM
!
B
X·?tàû«×åm
!
åm¸
ê7ߪ
WfL II!
ùÔ
!
«×?t
!
?tLê
MfOO
!
B/I)
QP

7[&6?t
L
!
B=
#
P;^W
œu
&
>©ÑÙ¸¹?t
L
!
B
,e
871
?t€
!
©m
L I)!
«×Êm

íöÍh—6)

6ßhȹ›


ê˱ N˜g
!
Ѿ
$
¥—
$^M MMM ,/
V*
QP
%
Ѿ
^N #!
V³[&6?t
=
#
P;^W
¸¹Ö×

O
Ù
.R11
Æ
#
ëÛ·Ù
#
mâÙ

ÛÇÙ¸¹
78
7
Û
R11!
Û·6[ê
Mf[L!PfL */V*
QP
$
’
ãÇ·.
%!
mâÙ
#
>©ÑÙ¸¹78
7
ۇ·
¼e¤


WP 5
#W$¤ˆ‰§¨
!
ÛÇ0Õ¾
!
åÉ
¤ˆ‰§¨
!
wþ§¢“7«
!
>«E½¾
L(


^ 5
%·¸¹]
_M 0
~§¨~H[7š
$
‹¸
¸Œ•
%!
‘nª]½gN
!
{
L
8¦Â~H¾
!
%·¸¹]
XM 0
~
!
]È;hì~H¥#©[7
š
!
`%ªˆŠgN

#W%
‡H§¨
!
¤ˆ‰0Õ¾
P 5!
åɇH§¨
!
wþ§¢“7«
X(
{
P
8`%¸¹C.à¾
‡_~H[7šÑÖ5‡ª~H[5(
!
‘nª
]½gN
!
{
W
8¸¹]~H_©[7šÑ‡ª
~H§Ž-5(ʪˆŠgN

#W&3>=
µ#
!
Éê]§¨0Õ¾
!
»›¨©
üª”Ö«¸¹
!
¼_ÖL#K¾ÙÊ
!
6q&6Ù
Ê
!
#|[›µ#
3>=
V&6ÙÊoӂÐg
è
P IB@%`/&
[a$àr
!
¼¬a$
!
Va$KÐ
PfL IB
qß!
!PL mOM i
ªhì
L I)!^ i
ª
PW MMM %/I)
QP

PL I)!
#_4¤j
^MM
!
B
K
Д|
PfL IB
qß!
!
aÐE„v
MfL IB!PL mOM
i

PM I)!PW MMM %/I)
QP

PM I)!
b_ó
¾
!

[Lj
¼#[¢v
P IB!
á6`a
!^ i
[ LMM %/I)
QP

L I)!
6ßGb_ó
!
V!5[
t{w’+ª­i
L mPM I)!
œ
WM
!
B
R-8
¤

#
PM
!
B
5
3>=
¦|
!
œ¥
MfP^ IB
MfPjR-8
¤r
!
`a
!

MfPjR-8
¤êct
!
%
L
WXM
!L
WXM
ZL
WNM
G
3>=
[<

¤§¨µ#[
3>=
ª
L
WXM
ZL
WNM
Œ]
PfN mWfM
V
3>=
¦|àŽ
P */
B
QP
ݛ

#W
}K%ÜÝ
GR>=!

W
!
*
5
3>=
êm
!
›
T&*/$5@%
}K%ÄÚ
GR>=
{
P
T
wþÛ
­ûª
.
pØV
W
!
B$P */B
QP
%
5
3>=
¦|
#W
!
B
T&*/$5@% $MfL */B
QP
%
i
_
!
BR-8
Ö¥¡[,
3>=
¦¤`a
![M i
¤¬aÃ
L I)
V—mü
¼01
!
oÓì
^ i
¼¬Ë±ü¼01Ö|Ú
!
Ü
®qß

龦5aЪJ`ÄÌ
.L h<;}
K%¦«vu
L
!
B!5>@8$PM II/&/B
QP
% L
!
B&
3>$0) P
!
B!<;}K%¦
P
!
B!
Í\/þU
ê
WL
!
B
`a
!
ܮq߾
!

^W i
XM I)!
龝
_L i

L I)
r±!
oÓ켬#
F
!
Ü®qß¾ì
QWM i


#W(83
!:B;P
# _|“Ì
Lr;====?=@;
?==?@?@@@=??;Or!
ª | “ Ì
Lr;@?;
?=?====@@?@@?@=;Or!
ä̸6
O_P
bU :B;X
_ | “ Ì
Lr;=@@?=??=@@;
=?;Or!
ª|“Ì
Lr;@@???@=????@??@@=@;
@?;Or!
ä̸6
OOW bU @>J;
_|“Ì
Lr;=?;
?=@???@@?@=;Or!
ª | “ Ì
Lr;=@@;
???=?=@@?=;Or
#
;$G2)
_|“Ì
Lr;=?=?;
/XLPO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
==?=?=??=@;Or!
ª|“Ì
Lr;@????@?@;
@?==??@@;Or!
¸6
WP[ bU
#
83
äÌ
PM
!
B!

W
!
B
ÔÍ_¦«vu
$
Z
MfMWj b%/I/;
U#()/&b&4(!MfMWj KA&() GA$)/&JJ!LMj *&AG(%/&
G
Pj 1R1
[¤œu
%!
é¾_¦
Wj
ðŸûÔÍ[
¦|)r
$
Z
-7MfL I*/B
QP
%!
.M
P #$@=-
«v
uZ
^M II/&/B
QP
@%0;$G(2G$G5! P II/&/B
QP
-R@=!U.NfM!
MÊ.M
[M S%!
.M€¾ÔÍl
ÊÚ0Fãlnш%6‹§¨0•

#W)
|È\Œ
$>T%
Z·[%Ô
!
ê)Zè
>=R8.
Ñ
J=R
[|È\Œ4ȦèV-@›KÚ2-@›[U›
!
#&6a$
LM
!
B!
¯¤r¤¬
L I)!PW MMM %/I)
QP

L I)!
#_ó
OM
!
B
a
Ð\þFr
!
é¾7)aÐÀ+ßu
$
Z
C>T
W
PM II/&/B
QP
[ø@›«vu
%PN
!
B!
-@›4È
¦
L
!
B!
-@›4Ȧ«vu
L
!
B!>=R.W
!
B!
`
a
!OM i
WM I)
Ö¾]\þFraÐ
?%(;
00%($*()2:LM
!
B!
`a
!
ÖaÐ
?%(00%($*()2:LM
!
B!
`a
L^M )I
%ÔGI
!
ê)À+|.PK
¦|r|È\Œ[Z·
!
HIê!
I/&/I*
QP

#W*
¾ÙÊ r[ÜÝ
!
Éê]§¨0Õ¾
W #!
7Ùr#K
O m^
?¸¹
!$
¤ÄAç
$OWL I*/
V*
QP
%
ŽgÊÌ
!
ËÅߒÅLH?
O[ i
㥛¤
WMM IB!
$fH?
^j
™‘¯çœu
$
›
871
µÜ
!
U.[f^%^MM IB!
êë
_M mPWM I)!
ûŽÊÌ_°
#
¨u
#
ª°±7¾
!
W
!

!
6qK³[&6ÙÊ
>½š
!
V¾½šÀˆ¾ì
^j
™‘¯çœur
ùÔ
^N #
_

Û¢vü¤
!
5.
!
S‘w²¾
!
)ëT#
O
H r
!
 rIì6[Ih¡¾
OfO!
OfN!^fO II!
rJª
PM
!
I
#W!+@,>-B
g{”`%®¯ýþ
!
#S‘ r
!
¼e¤z
L I) hO
5
&
›
Oj .
W
T
W
¯vu’+Ö
¥
OM I)$
•Ü~¬›¡È\̦
%!
ø@›«vu
$871%
mz
&Pj
út¦
CO[ i
o^M 0&
$a¡È
\̦
$@,>-B%
\u
!O[ i
XM I)&
$a
8TR
\u
!O[ i

OM I)&R=7;.
W
T
W
Š*÷ª
u{
L mWM I)
]&6
=P
([
@,>-B
\›®
¯*û
;R

;
“j×Ú0FãÚ0

Iv
ln
!
]
WMM
ýh¸ý(ª
!
›d0Ö¥Ìq.(&
6
=P
(7~$®¯n[\›®¯(
!
®¯~Zk
{yzJšëÌê\›®¯

7H r&6
=P
([ršÑ=[(7~$®¯n\›®¯([Œ_
.Eï r[\›®¯(
!
7?ÊÌ[
@,>-B

®¯(<ë
O
H r[\›®¯(Œ_.

#W!!
()ã.
!
§¨0•
¼½

¤ˆ‰
‹¸¸Œ•›ij%·[³j—…C6‹
!
ªç(
)Ö¥Œ»›Hj—…C6‹

ٚ·þ»›
R4)G$)r0<4&2U&(3$)*(@(02!

=lMfML
êCEè
ã.]@Y

$

$W!R11
A
=R
¸¹‹¸¸Œ•ÑcšrÝgN
[@A
!
i>©ÑÙj·
!
mâً¸¸Œ•u¡
ªx
&
imâÙj·
!
l{
O
8—˜
!R11 Mf[L! PfL
*/V*
QP
ÛÇٌgu¡¢Ü¸¹‹¸¸Œ•

i>©ÑÙj·
!
mâÙ]vÀ¥#©7šu
¡¢Ü
&
imâÙj·
!R11 Mf[L!PfL */V*
QP
<
ëÛÇٌgu¡ªx¸¹]vÀ¥#©7
š
!
š¼
P
¼
P!
Θ™Ç~A
=R
¸¹]¤ˆ‰§¨r‹¸¸Œ•ÑcšrÝç¨[@A
$

Ù[
Û·
Z*/V*
QP
‹¸¸Œ•
Z0
{
P
8 {
W
8 {
O
8 {
^
8
vÀ¥#©7š
Z0
>©Ñ
Q X[F^ kNFL O_FX kXFX W^FW kLFL PXFL kOFO ONFW kLF[

Q
NLFX k_F_
P%
[LF[ kNF[
P%
XOF^ k[F_
P%
LMFO k[F[
P%
PNF^ kOF^
P%
Θ™Ç~
MF[L NWF^ k_FX XXFO kNFN
LMFX kNFO
W%
^WF[ kXFW
W%
WLFX k^ F[
W%
PFL [NFO k_FL
L_FL k[FN
O%
ONF[ kXFO
O%
OXF^ kLFO
O%
W_F[ kLFW
O%
!!
?
.
i>©ÑÙ·
P%
=lMfMP&
imâÙ·
W%
=lMfML!
O%
=lMfMP$
¼
W mL
Z
%
$W#R11
A
=R
¸¹]‡H§¨r¸Œ•Ñ
L I)
Ž-5([@A
!
]{
P
8[]½gN%çr
!
m
âÙ¸¹[C.à5(.u™>©ÑÙ
&R11 PfL
*/V*
QP
ÛÇÙC.à5(u¡emâÙ

]{
W
8[ˆŠgN%çr
!
mâÙ¸¹[C.à5(
.u™>©ÑÙ
!
¸Œ•u¡¢Ü
&R11 PfL */
/[LPO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
V*
QP
ÛÇÙC.à5(u¡emâÙ
!
¸Œ•u ¡ªx
!
š¼
W
¼
W!
Θ™Ç~A
=R
¸¹]‡H§¨r¸Œ•Ñ
L I)
Ž-5([@A
$

Ù[
Û·
Z*/V*
QP
]½Ú³ ˆŠÚ³
\¸Œ•
Z0
Ž-5( ¸Œ•
Z0
Ž-5(
>©Ñ
Q OFNW kMF[L MFNL kMFLP WP[F[ kW_FX MF^^ kMFXW

Q
XFN_ kMFN[
P%
LF[M kPFOL
P%
PLMFO kWMFW
P%
WFNN kPFOL
P%
Θ™Ç~
MF[L
LFNO kMF[X
W%
^FOM kPFOX P[WFO kWWF^ WFPW kPFP[
PFL
LFO^ kMFXL
W%
OFNM kPFWL
W%
PNWFN kP_FN
W%
PFOX kPFMN
W%
$W$R11
A
=R
¸¹&6ÙÊ
@>J;

!:B;X!:B;P
#
I3>=
¼k[@A
!
mâÙ
@>J;

!:B;X!:B;P
#
I3;
>=
Œèþ:¼k
!R11
*u¡{ƪ¼k
!
šd
P!
¼
O
$W%R11
A
=R
¸¹&6ÙÊ
>T
Z·[@A
!
m
âÙ
>T
Z·u¡ë>©ÑÙ
&R11 Mf[L! PfL *
/V*
QP
ÛÇÙ¸¹&6ÙÊr
>T
¤~u¡Æm
âÙ
!
š¼
^
$W&R11
A
=R
¸¹&6ÙÊ®¯ýþ[@A
!
>©ÑÙ¸¹&6
=P
(ýþ®¯e
!
®¯*01
»j
&
mâÙ&6
=P
(KR¸·®¯ýþ
!
g{Y
Ô0
#
X
!
*ù¢
&R11 Mf[L!PfL */V*
QP
ÛÇÙ¸
¹&6
=P
(ýþ®¯u¡¢e
!
šd
W!
¼
L
R11P
Ñ
R11W
6[¼½Î˜™Ç~
Mf[L!PfL */V*
QP
ÛÇÙ

d
P!
Θ™Ç~A³[&6~?t
=
#
P;^W
¸¹&6ÙÊ
@>J;

!:B;X
Ñ
:B;P
#
I3>=
¼k[@A
¼
O!
¸¹&6ÙÊ}K%äÌjA #
;$G2) I3>=
}K%äÌ[÷I:
$

Ù[
Û·
Z*/V*
QP
jA÷I:
Zj
#
;$G2) @>J;

:B;P
#
:B;X
>©Ñ
Q PMM _XFO k[FL PWWFO kXFN PLWFW k[FW

Q PMM
PLWFL kXF^
P%
PLNF[ k[FW
P%
P_OFO kXF_
P%
Θ™Ç~
MF[L PMM
OOF^ kLFX
W%
PPWFO kXFW
W%
_LF^ kXFX
W%
PFL PMM
WXF[ kOFW
O%
[XF^ kLF_
O%
_[F[ kLF[
O%
¼
^!
Θ™Ç~A&6ÙÊ
>T
Z·[@A
$

Ù[
Û·
Z*/V*
QP
>TZ
!
I/&/I*
QP
>©Ñ
Q MFLX kMFPM

Q
MFNO kMFPW
P%
Θ™Ç~
MF[L
MFXX kMFPP
W%
PFL
MFXM kMFM_
O%
%
†,
&6]]½
#
ˆŠ
#
r˜‡(íUÊr“i&


]¤§¨r
!=
#
P;^W
?tи¹&6ÙÊ
!
“
³ï¾(ÀË8¸·«þ
!
¸¹]¤ˆ‰G‡H§
¨r
!
Œ¼RK]½ÑˆŠÞg2iC¸
!
i
=R
Ý
¥GÞß¼RèþW[ÄÄ

jf
!
Î|
=R
Ê
Ìmâ»ÚáÞ±ôCÑ»›
[(

—Âû¸Å›j—“³[
#
›ó¸ś

#
À«®¯ÑÙÊ[| 
ì”|…T
!
×
›—\jjäÏ^2i[ÙÊÀ«

¾Øכ
—Â
=R
[|uÝ¥¯H

ξØKR—7
!
6ÍY®¯
#
´|ÍY®¯
#
ÀË8„ä³K

U\¾[®¯ä㗝}Y
!
ûE—®¯jL
t}—
;P
#
$:B;P
#
%#
t}—
;X$:B;X%#
ãäÀ«jL
;

$@>J;

%#
t}—
;N$:B;N%#
U›È
#
lûs
#

/NLPO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
!!
=f
>©ÑÙ
&7f
mâÙ
&f
Θ™Ç~
Mf[L */V*
QP
ÛÇÙ
&
Rf
Θ™Ç~
PfL */V*
QP
ÛÇÙ

d
W!
Θ™Ç~A&6
=P
(
@,>-B

ÀË8[@A
$@,>-B! h^ MM%
¼
L!R11
A&6ÀË8ýþh[@A
$

Ù[
Û·
Z*/V*
QP
\›®¯(
Z

>©Ñ
Q [FX k^ FO

Q
[NFW kXF[
P%
Θ™Ç~
MF[L
LWFX kLFO
O%
PFL
OOFW k^ FL
O%
\Œ‡

#
;
T¦út
$=
#
%
Eê‹![Èîj—
!
¾Ùʑé³K!
çdóÂΠèÅÌY
!
]3
¡|r
!
ää㸷[E—›ÌY

¤ç¨r
!
¸¹³[&6~?t
=
#
P;^W
¾
O
ò
!
ª&6ÙÊr
:B;P
#
!:B;X
Ñ
@>J;

I3>=
·èþ:
¼k
!>T
ãÚu¡9™
!
å|ÛƧ
=
# ]¾~ø
í6ÍY®¯[U!
!í á[—
êëU\[ÍY®¯äh¸·Ç›3ë[ÌY
!
ûU›È
$3T1%!>T!
út¤¥¦
#
‚þ‡f«Þ”
[ÀË8
&
—}YѾ~\!Tq¡;ä‹!
#
;
T¦úthþ
$=88%
[äã
!
•Ü*œ›
=
# [

!
|ÚV™[
=
#
P;^W
!
û3|Úµ›Ô*
@>J;
*!U
9>C
nfm+Ñ
J=RR
m+
!
øÏ®¯
«þ
&

!=
#
P;^W
]¾~䓳67[È\\!
!
ø
Ï®¯ýþ

]¤§¨r
!=
#
P;^W
]&6ÙÊrøÏ
ÀË8¸·ýþ

Θ™Ç~ûΘ
#
™Ç
#

#

#
Œ1
#
•
(
X
ZÇÙÚ

3hÑÐ
=R
[§¨™è
1I

AÎ˜™Ç~[*gU›Ú6
!
­~®]
F`åÉíþê67[ƒ„

™Çdg•Ü±iÙ
:B;P
# øÏ[±®òQH*®¯[¶·Þg
!

@>J;
ÑhJ¨—
-
W
$8?-
W
%
¤~
N(
&
f™Ç[”
|èéÚ6™Çvè3:[–È\ѕܗ[E
›
_(

b–@ÂΘÑP–[‚&U›Ú6
!
ºÛ
¤‡ƒ„(ê
!
b–@g•Ü
9>C!UON<=8
nfm
+
!
±f•Ü®¯ýþ
PM(

¤ç¨r
!
Θ™Ç~gu¡¾5
=R
mâ¸
¹[]½ÑˆŠÞg
!
ï…[YZÙ6
!
YZÚ6
!
*±™*áà
=
#
P;^W
“³[ÀËã\¾D
!
±fª«J•ÜªøÏ[Ý¥å|

fªE›×Ü
g|•Üû
=
#
P;^W
øÏ[ÀËÍY®¯U!
¢
e
:B;P
#
!@>J;
Ñ
:B;X
‡èŗjL[¼kÑ
>T
[¡·|Ú
!
¢e®¯ýþ

Îé
!=
#]¾~“
³[67È\\!ÑÈ\¸;`ªÏ^(íÞg
¸¹[|i&Èj

Θ™Ç~[–È\¸;Þ
gG×Ü4è…å|ۃ„

$
’“”•
%
P (!
úk7
!
ά
!
†ºã
!
‡
f
Θ™Ç~A
1=<;8N
6¹&
6
=P
(»ëÈóþ®¯[@A
9(f
¥%]ƒ„
!WMMN!OM
$L%.OLNf
W (!
¼½
!
Äÿ
!
ò7ñ
!
‡
f
Θ™Ç~AÅL±\mâ6¹&
6út¼k[@A
9(f
{ƒ¢{¸]]1
!WMMN!OM$X%.
^[[f
O (!
@&ñ
!
9¨K
!

!
‡
f
Θ™Ç~A6ÍY®¯[UE›
9(f
›nr{]i]1
!WMM_!P_$O%.LWf
^ (!
!

!

!
‡
f
Θ™Ç~ÀËAÉE›[§¨ƒ
„
9(f
Ìú{Ç
!WMMN!^N$WO%. Pf
L (!#() J! B$)*1 e! d4/88! (2$&f-6(G20/6;*$&$G2/0(/)
2#((KU%(00/) /6#UU/G$IU$&U(%U#(%$&;2AU(b() /`5$`(U)(%(;
G(U2/%$)5 0U$2$&I(I/%AU(%6/%I$)G(0) %$209(f80AG#/)(4;
%/()5/G%)/&/*A! WMMX! OP. NMLf
X (!
Á¤€
!
¾¾
!

!
‡
f
#
;
T¦út
P;^M
ÑA\^³­
b>š&›Ý¸¹mâ[no
9(f
r­ÙÊN|ƒ„i
ÞßØj
!WMM_!P^$O[%.X_P[f
[ (!#%02()0() 3!<$%G400() =7!av%2E() ?!(2$&f=
#
P;^W
)H(G;
2/) G$40(0I(I/%AIU$%I()2! &/E(%(5 G/%2G$&$)5 0(%4I7R;
>J&(D(&0! $)5 5(G%($0(5 #UU/G$IU$&L;.@W=&(D(&09(f-KU
>(4%/&! WMMN!WPM$P%.PX^f
N (!
 ¿
!
-+`
!
–¥
!
‡
f%#:B;P
#A±®òQH*®¯Þg[
@AG™Çd[•ÜE›
9(f
€{ö¸]]1
!WMM_!^^
$W%.WPXf
_ (!#/4 @f=)2;)6&$II$2/%A$)5 $)$&*(0G(6(G20/6U$(/)/&)
G$%$*(()$);(D/V(5 2#(%I$&#AU(%$&*(0$9(f7%98#$%I$G/&!
WMMO! PO_. PP^Xf
PM(!
ºÛ¤
!

!
2]
f
b–@BAT¦ #útr§
P m^ M
“
³[¸¹&6
<=8
!¦nf!Ïm+Gýþút¼k[@
A
9(f
r­Ç¥]iÇ¥]£¤
!WMM[!WP$L%.ONLf
/_LPO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP
6CD0-0CN1/../D0BCANATDBN@/CVVI0=E/BF/B =/CBC61YEA0.AG]KH0KA/KAK
d.T>?1#4 #`
P
! <=1#U)*
W
! .T>?d/)*A4$)
O
! 9:>+$/I(
P
!
$Pf5$#-!+5&!.A84!.).7(#&/ B+6-(.).7(! Z#&&#& ;5/,#)3.)575! Z*%* W^PMMO! 3%&#&
Wf5$#-!+5&!.A=%#-+#,.).7(.A3%&545;#!5-# ;5/,#! 3%&# =%#-+#,5*!,#)G&?5-4!(! 0#&K&7 WPMMON! 3%&#&
Of5$#-!+5&!.A=%#-+#,.).7(! Z#&&#& ;5/,#)3.)575! Z*%* W^PMMO! 3%&#%
6MKDG/TD(8M[ATD0LA. @/0245A2#(I(G#$)0I0/6R$)**41#$/A$/1$)$R11% /) =&`#(I(%r050($0(0$=R% 6/G40)*/)
$)2;)6&$II$2/)f>ADEBH. =R%$20E(%((02$b&0#(5 bA)2%$#UU/G$IU$&b&$2(%$&)H(G2/) /6=
#
P;^W
U%/2()f@#(=R%$20E(%(%$);
5/I&A5D5(5 )2/2#%((*%/4U0. =RI/5(&*%/4U! R11 #*#;5/0(*%/4U! R11 &/E;5/0(*%/4UfS(#G&(*%/4U %$20E(%()2%$#UU/G$I;
U$&b&$2(%$&)H(G2/) /60/&D()2E2# 2#(0$I(5/0(f@#(&($%))*$b&2A$)5 I(I/%A/6%$20E$0)D(02*$2(5 ) 02(U;5/E) U$00D(
$D/5$)G(2(02$)5 #
! :B;X! @>J;

I3>=E(%(/b0(%D(5 bA%(D(%0(2%$)0G%U2$0(83$3@;
83%! &(D(&0/6>TE$0I($04%(5 bAG/&/%I(2%GI(2#/5 $)5 )(4%/) $U/U2/00) 2#(#UU/G$IU40E$0)D(02*$2(5 bA2$*I(2#/5 /6
@5@;I(5$2(5 ()5;&$b(&)*/66%$*I()2(5 R>=$@,>-B%f:AKI1D. R11 0*)6G$)2&A%(54G(5 2#((0G$U(&$2()GA$)5 )G%($0(5 2#(2I(
2#$2%$200U()2) 2#(2$%*(2]4$5%$)2) 02(U;5/E) U$00D($D/5$)G(2(02! %(54G(5 2#((KU%(00/) /62#(:B;P
#
! :B;X! @>J;

I3>=! $)5 2#(&(D(&/62#(>T5(U%(00(5 2#(
)(4%/) $U/U2/00) 2#(#UU/G$IU40f2BCT1IK0BC.R11 IU%/D)*G/*)2/) /62#(%$20I*#2b(%(&$2(5 2/$2()4$2()6&$II$2/%A%($G;
2/) $)5 %(54G(G(&$U/U2/00) 2#(#UU/G$IU40f
ZAF UBGHK(!R$)**41#$/A$/1$)& $)2;)6&$II$2/%A(6(G2& G/*)2/)& $U/U2/00
HB0.!+ %`#)RT[T..#+!!###+
$
–—$Q
!
¨©©
%
!
232456

ª«‘
­1`ÝÑH%
.1:;-
5ޓy5kD
^^O$WNL
!7«
%&
ޚ­
,
{]ݓ
-$<(5&)(Z84b<(5%
H%
!

<(5&)(
H
%[r­•§rƒM{
^
I
!
žò­Ç]Ñr{Ç]•§pI
&
ޚ­
,
\]7ˆ
$
¸²Â
%-$=!#(IG$&=b02%$G20a(b%!
]
ø§¼rƒM{
WOW
I

Z7
!
4ÞO®6Uµ>–$
,
;ëÀ;()Ý
-$1G/U40%!
š­
,
ãÌ]7ˆ
$
8
%-$7=8!7:T1:1
8%(D(E0%!
Áž;
,
7ˆ£¤
-$=9! =b02%$G209/4%)$&! S:>:@:%!
Ž­
,
­1ð(iãÌö]ƒ„7ˆ
-$=7:! ()2%(6/%=*%;
G4&24%($)5 7/0G()G(=b02%$G20%!
š­
,
­1Ç]7ˆ
- $:8=! :)2(%)$2/)$&8#$%I$G(42G$&=b02%$G20%!
š­
,
é¬?•§!ý
-
$,&%G# 8R!,&%G#r08(%/5G$&0R%(G2/%A%!,
¥¤ö]÷ÑÊi×1r­7«()Ý
- 91@#)$! 9$U$) 1G()G(w@(G#)/&/*A
=*()GA$#)(0(7b&/*%$U#GR$2$b$0(%(!,
Ž­Âæ\]]äFJ7ˆ
- $31!3/A$&1/G(2A/6#(I02%A%!
Ž­
,
O°ÉØ
-
$?.!?&/b$&.($&2#%!

,
{]7ˆ
-$-ëÃ
,
)ú~úQ({]ݓ
-$a83::)5(K<(5G40%
‡
P^
æ¿Z›«(7ˆJ()ÝH%

­~H%
.
ê
)
r­ö]“7()Ý
*#)
r­]ѕ§šÄ89()Ý
*
;¬•§
!
r­léö]*ߕ§
!
r­r7*ß
•§
!
r­ö÷*ߕ§
!

,
r­]ѕ§7ˆ
-
r
#
Ž7ÂH%

)r­í¸
$>C:%)
r­ö÷•§@AjL÷1
*
–G
.,
r­rÇ£¤
-
vh5ޓy5kD
P [MOX!
@AjL
Pf^WP!
st,7·Õ
Mf[W!
ªk·kD
O_fX_
}5
!
­~®ÉkD×1›i
O P_W

!
6G]
PL
­æÑQ(
!
±KF6G]
WO
­æÑQ(

)r­ö]÷Ñnƒ„²½ŠG[
,
r­ö÷•§“Æ1J
-$
*ßÂ
%
•§`Ýã.0•¼.
.,
r­rÇ£¤
-
5
ޓy5ê
L L^^!
@AjL
Mf[M[!
st,7·
MfXN!
O÷¼7œk
NMM
ç!

•§šÄ5ƒM±
WMPM
÷[{
LW
IΞ{
O_
I
!
]Ç]¨Gr{Ç]¨•§rIž{|
!
OØ!ÀAê™÷êë_3
!
]ò­Ç]Gr{Ç]‡]ö¯°ö÷•
§rŒMJhÕ

/MXPO/
{
OX
ï{
WW
•
WMPP
÷
PP
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&fOX! :004(!WW
>/D(Ib(%! WMPP