免费文献传递   相关文献

Effect of ginseng polysaccharide-induced Wnt/β-catenin signal transduction pathway on apoptosis of human nasopharyngeal cancer cells CNE-2

人参多糖介导Wnt/β-catenin信号转导诱导人鼻咽癌细胞CNE-2的凋亡



全 文 :uåævwx
J1K=
!
4-LKM1N1
n<¤x
yxuz{|¢}
<;D4*
…~
äåæ

!
4çè
*
!

*
!
mMK
*
!
Wêë

!
0aì

!
d
w;mn%o —˜äÛmp ìíîïðñòn
!
w;
&$$$#%
*d
w;mn%o óôo¶õöoÄ{ ÷›œ¶óô9„…{
!
w;
&$$$##

hi
#!

#
0¹uåæv
!UN1?M1UI.X5?L--RLSNWM$ TA8
ôuz{|¢}
<;D4*
…†‡ö~…ùúa¶œ‘…ƒ„
†‡

‰Š
#<¯0¹uåævôuz{|
<;D4*
¢}Ë…ùú

;ô?Ëx…
<;D4*
¢}
$
ˆàá#ʵ¶uå
æv
!TA8$$$d$$d*$$d)$$d& U)C
m
[ªˆ
&( R
“
$
Ôg¢})8‚Íô
<;D4*
¢}~…yxªˆ
(B.M-R?K4))*(
Ü
ÝöZ.0¹¢}…Û€yY
>MLX4KN/MA<>
8‚¢} !
4-LKM1N1 />;3
…·¸

ˆšØúIÜÝ8‚¢}$ !
4-LKM1N1$
H<@&
9¬%ȶ·¸Ê…YD
JM?KMS1 _X.K
8‚¢}$ !
4-LKM1N1$F-X4*$FL6
9¬…YD

‹Œ
#<¯‚™uåæv‘Ú
p„
<;D4*
¢}…†‡
$
͝„ªˆ8¦Ê
%
T§›ºÂ
$TA8
À¢}
&( R
…
:<
$
,
$d)7 U)C
m
(
#ʵ¶[,
$d$
$d*$$d)$$d& U)C
m
…
TA8
ªˆuz{|
<;D4*
¢}
&( R
“¢}~ø[,
!d#7 v$d*7j$!$d) v$d#)j$!d& v
$d%&j$!)d% vd(#j$
œôØÏ
!*d$( v$dj
ËÌ9Gp}Â12
!Dr$d$(B.M-R?K4))*(
ÜÝì+pq¢}~
Ö$

Z.ǜ°
$d& U)C
m
TA8
yx
&( R
“œ˜
<;D4*
¢}¨š~:Þ
>MLX4KN/MA<>
pq !
4-LKM1N1 />;3
·¸Úp


ZI·G±ì+pquåævªˆ
&( R
“ !
4-LKM1N1
ö
H<@&
®}ß$·¸ÚpE
$
!
4-LKM1N1
·¸O£ö}ßß}6
¤Ù
JM?KMS1 _X.K
ì+pq:µ¶i¶†‚…uåævªˆ
<;D4*
¢}
&( R
“
$
!
4-LKM1N1
ö§~9¬
F-X4*
·¸ÚpE
Ñ
(
)¬~9¬
FL6
·¸…o
!Dr$d$
‹
#
uåævœÚp„
<;D4*
¢}†‡¬”¢}~
J1K=
!
4-LKM1N1
n<
BS…h+œ‘Í
TA8
yxuz{|¢}
<;D4*
~…JKHӃ„


jkl
#!
uåæv
(<;D4*
¢}
(
¢}†‡
(
~
(J1K=
!
4-LKM1N1

mn)(
#!*$)4$&4$%

opqP
#!
%Œ9>&p?@
!(%7*7$)*%)#((

4y{‘?@
!GZ$)$(

rstu
#!
!
—ð5
$D4/LNX#RYL1U0NL1U0Y2U/LNX,-./

tu{|
#!
úŒÑ
$D4/LNX#VL1+RN-R2#),-./
!!
z{|͖%9â<°…悃¦J
$
Í
—ôÀ¹¸b
$
݊-G
)$j f&$j
…z{|Î
™{z{|€eöŒÀ¤Ù

@CaÀ
%

¸¹z{|
$
ˆV‘˜´q’ø¸¨
$j f
%$j$
z{|ÀD¹Fhö¸¹âe3OHùú
¸¹”+

‘‡
$
fmôz{|¸¹yG”
%

x–Äy:…,Š
%
ù»¹”ÍQR¸¹ÍKU
ÓÃ.…êë

Œq8
$
uåG”§‚ƒªˆãhh¨z
)

G˜ÊïI)ïª,uåÒÓ,ˆ¦J…
uåæv
!UN1?M1UI.X5?L--RLSNWM$TA8
®Þ8öÞ
X9G§‚ƒªˆ
.4*/
$
›Íæ烄äà‘

J1K=
!
4-LKM1N1
n悃ee•ìKÎz
$
Í$ !
4-LKM1N1
Í
J1K=
!
4-LKM1N1
:nBS…HÓn$
’“·Ú
J1K=
!
4-LKM1N1
n4-LKM1N1
…ìÒö‘YD,$X

ìŽÎzC¿~5
$
N
Oz{|®8…æ×ïނƒ$9G
J1K=
!
4-LKM4
1N1
n<¤xBS¶ÍÇsBS…Z^
.)/

@CŽ
‰uåæv®§z{|â2…’“c¡
$
ͧz{
|ªˆÍpv¶o‹
J1K=
!
4-LKM1N1
nŽGI’“

⒓Å,uz{|¢}
<;D4*
¢}Ã,ï
Iô`
$
†‡
TA8
yx
<;D4*
¢}~¶Íô
J1K=
!
4-LKM1N1
n$
ªè`uåæ
vôz{|…ªˆa¶œ‘…ªˆƒ„”f†‡
$
,VeQ߸¹z{|…­>§‚ƒ,ŠùçïI
݊

!
™5
_!

!
uåæv)*ò,èPñD,þGH
IJ!
Òӏ,uåæv
$
=<
*$$%*$$
)*))))
v
)(
ªv
7
x
*$)
q
$
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Xd)($:??YM!7
]-K._MS$ *$)
) U)C
m

a
>A9:4#&$
ÕÈò«„‹Uµ¶
$
hÞJ£

_(!
å¦
!>A9:4#&$
ÕȐ
!
Ë%
TN_-.
IJ
(
Ҟ¨
!
Ë%
TN_-.
IJ
(7#
çÕÈq
!
Ë%
@LX-.1
IJ
(<å¦
!
sâá†D’“‹
(
311M6N14^=A:
Fܯ‚~å¦Ö
!
93ӐŠ
IJ
(
m
>;3
ù;å¦Ö
!
Ë%
:1cNKS.UM1
IJ
(
«¤w妶
A<>
å¦
!AS./MUL
IJ
(
EŠö™
´ÌIJŽ
A<>
EŠ¾*
#
!
4-LKM1N1 ?M1-Mi4
HT<<33THTTTHTTH3H3T3T4)i$ L1KN?M1-Mi4TH4
TTT3HTTHTTTHTH33T34)i T3AEB ?M1-M i
TH3T3TT<3TTT3HTHHÿß
%
2‘„
%
‰ð
²„9,ž^

§u !
4-LKM1N1$H<@&$FL6

F-X4*
+´µ§Þ9Ó9Ë%
DINK./N-?
IJ
(DeIå¦Ö
!9NXNI.SM
IJ

_&!
¢}ÕÈ
!
uz{|¢}
!<;D4*
¢}

öâ
ê8IõïIššÔ
$
®É
$j
Ҟ¨…
>A9:4
#&$
ÕÈò$$
â{
)% s$j<]
*
Ö×Ç
mAmBÕÈ^$ÕÈ
$
Å;ô?Ëx¢}”f
ïI

w
* f) W
«òEU

_`!
²ã
!<]
*
¢}ÕÈ^
!
Ë%
@.S/L?-NM1KNVN-
IJ
(
ÕôpP.
!

]X5/IY?(FN.4>LW 9&$
³3‚%Ý
!
Ë%
FN.4>LW(@3<8-L1
ØÔg¢}
Ý
!
Ë%
FM-K.1 EN-\N1?.1(&($$
Ø
A<>
r†Ý
!
Ë
%
FN.4>LW
IJ
(
ZI·G±pP.
!

]X5/4
IY?

(
DeIžõ¿
!FN.4>LW$FN.4
>LW CL_.SLK.SNM?
(!
â¯
(_!<¯‚%
TA8
ô
<;D4*
¢}†‡…ùú
!
¢}ÕÈkô?ËxT”fïI
$
„ã-,
g$
&
K
=C
…¢}ñò
$
wç‚ç
$$
#
C
¢}ñ
òÿ×{
7#
çq$
$*& R
“‚ç
$$
#
C
Éàáµ

TA8
…ÕÈò
$
,ôØÏ
!

ö
$d$
$d*$$d)$$d& U)C
m
£µ¶
TA8
ÀÂÏ
!
wϲ

Kۍ

[{
*&$&($%* R )
KTΔf
<ËÝïI

w•{ÀÂìYC
& R$
wç‚ç
<ñò
$
#
C$
‰_ÕÈ
& R
“
$
®
&$ 1/
À”fóI

<
‚%

!#pïIϝ„ø
w! m<
ïIÏ
=
<
ôØÏ
g$$j
‡ïIH€
)
•

(_(!311M6N14^=A:
Fܯ‚%
TA8
ô
<;D4*
¢}
~…ùú
!
uz{|¢}
<;D4*
?Ëx
$
«‰¨ÕÈòÕÈ
* R
˜¢}´xá
äD
$
²
$d$$d*$$d)$$d& U)C
m
TA8
ÏöôØÏ
$
ÕÈ
&( R
“
$
÷‘ôØ϶pµ¶
TA8
ϋG¢
}
$
ož¢}ì¶,
g$

K
=/C$
;
/C
¢}
$
$$$ S)/N1
m
šX
/N1$
ˆÝ@Ðfòþø

•
$
$$$ S)/N1
m
šX
/N1$
‚
>;3
³
$)% s
ðÑ

R$
Àçïтç
$d /U)C
m
ÖD‘×
!A:

314
1M6N1 $^
…Ôg¢}Ý8‚

ˆ
P
םž¢}~ø

(_&!B.M-R?K4))*(
ÜÝ
!
;ô?Ëx+÷1Ž
Õȅ
<;D4*
¢}
$
ˆ
$d*j
¹9¬³¥DâØÜ
+K¢}
$
„㏢}ì¶-,
g$
&
K
=/C
…
¢}ñò
$*&
çq
$
wç‚ç
$$
#
C
¢}ñò
$

}1Ž“
$<;D4*
¢}ˆàᵶ…
TA8
ÀÂ
&( R
“
‚ç
B.M-R?K4))*(
ñò
! U)C
m
$)% s
ðñ
% /N1$
ï…ëH
$
šXËÜò
$AF8

*
•
$
®kX
&$ 1/
À0¹ÚÝúI

`<ôØ¢}ö•™¢}8ÑÚ
Ý
$
~¢}8»ŠÚݯ0¹¨ßëœ

(_`!
9*Z.0¹¢}ۀ
!
;ô?Ëx…
<;D4*
¢}
$
²ôØÏ
!
‚
ö
TA8
ˆ,
Ï
!$d& U)C
m
$&( R
“÷‘¢}
$
ËÙÕÈòâ‚
ç
*dj
…hè–ë%
$AF8
þ
*
•“ˆ
j
Ù1ë
%
$
¼9*Z.%
Ì
9
%
N-
%

%
»îK…
%
ÚÛÜÝîj¾„ãŠ
Ö

9*gZ(pP.0¹¢}ۀ
%
ØÎ

(_$!>MLX4KN/MA<>

TA8
ÀÂC“
<;D4*
¢}
!
4-LKM1N1 />;3
…·¸ðà
!
;ô?Ëx
<;D4*
¢}
$$d$$d*$$d)$$d& U)C
m
…
TA8
yx
<;D4*
¢}
&( R
“
$
‚¹³¥DšX÷‘pÏ¢}
HSN[.X
¯ù;
>;3$>MLX4KN/MA<>

<;D4*
¢}$
!
4-LKM1N1 />;3
…·¸
A<>
–ÄäŠ
#>MLX4KN/M
–āˆ
$
#
C
Þõ
#
fq
*d
#
C$
…ÇEŠX9
!
£µ¶
)d)) U)C
m

“;
*d
#
C$8PF>
úI³

#
C
:RÖ×,
#7d$ s $ ?
~YÂ
$7 s ?$(
s ?$%* s ?$
·
&$
K:R

?äÀˆ
3F:ASN?/%$$$ 8E8 8.VK+LSM
ž
$
Îô
/>;3
·
¸
w*
m

:
K
$

:
K
w
Q‘
:
K
m

!T3AEB:
K

a
T3AEB
ª,8åØ
$
áTa`<ôØ
<;D4*
¢}
ª,L
$
pÏ¢}Q‘
/>;3
…·¸Ê·q
`<ôØ
<;D4*
¢}…
5
Q
$5 w
ŠÖ·¸Ê
=

L·¸Ê
w*
m
Šâ
:
K
=*
m
L
:
K
$
wÏ9z
)
KŠâ
$
;
9?

))))))
v
)(
ªv
7
x
*$)
q
$
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Xd)($:??YM!7
]-K._MS$ *$)
(_a!
ZI·G±pP.0¹yxC“
<;D4*
¢}
!
4-LKM1N1$H<@&
9¬…·¸ö%È
!
;ô?Ëx
<;D4*
¢}
$
²ôØÏ
!

ö
TA8
Ï
!$d& U
)C
m

ÿ×{Éõ
#
çq$
$)% s$<]
*
ÕÈ
^$ÕÈÞò1Ž“
TA8
Ïk‚
TA8!
£µ¶
$d&
U)C
m

ÀÂ
&( R$
ôØςáoÕȐ‰_ÕÈ

&j
æGg–ë%šAë%
*$ /N1$AF8

)
•
$

$ /N1 jF83!
É
$d*jHSNK.1 O4$$
îù
96
R AF8

)
•
$

/N1
!
4-LKM1N1$
H<@&
+´µ§ÞñòÛѶ,
x&$$$@:H<4
3v…
è§ÛѶ,
x$$$A:
€Üߓ
$$j
½ïî…

ZInU·G±pP.0¹†Ø

(_%! JM?KMS1 _X.K

TA8
yx“
<;D4*
¢}
!
4-LKM1N1$F-X4*$FL6
…·¸
!
;ô?Ëx…uz
{|
<;D4*
¢}
$
ož¢}K?,
& g$
&
K
=C$
ÿ
×{
#
çq
$*& R
“‚çàᵶ
TA8
ÕÈ
&( R
“
$
÷‘pÏ
<;D4*
¢}
$AF8
þø
*
•
$
ˆo¢}
9¬ù;ò
$
ù;¢}m9¬
$& s$* $$$ g@
šX
/N1
“;…

9¬µ¶‚%¼å¦þڋª
$
‚
<
%$

až¨¬9¬,3LŠÖF„3L3
Á

;
&$
#
U
I‚9¬#ŠÖ
$
f
8E84A3TD
ZS
$
Z¤Ùk
A^E@
6
$j
ý¾Úîù
R
“‚çJ
§
$& s
Þò
(
a
HF8H
’þ“
$
‚çè§
$
R$
k:
HF8H
’þ
$
¢“ˆpݦ
Då¦Öp
Ý
%
ÈI
$AR.K.?R.I #d$
Pםžì+

(_!
¿!ž
!
ˆ
8A88 )d$
P×ô‹™?ä
”f¿!ÀÂ
$
æϧË́ˆ+‘sâ1ž
$
’
’Ë́ˆ
8;G
8I
$Dr$d$
,12G¿!¯n

&!
ì+
&_!TA8
ô
<;D4*
¢}…†‡„ªˆ
!
àáµ
¶…
TA8
ªˆ{z{|¢}Ã
<;D4*
¢}
*&$&($%* R
“
$$d$$d*$$d)$$d& U)C
m
TA8
‘„
<;D4*
¢}…
Ë
$
͝„ªˆdT§
%
µ¶…†‚)à‚±
!
i

®ÎáT§×Çàᵶ
*
ϧ„ø12G¿
!¯n
!Dr$d$$
®ÎᵶÇàáT§×
*
ϧ
„ø12G¿!¯n
!Dr$d$$
8J%¦ÊöT
§›ºÂ

uåævªˆ
<;D4*
¢}
*&$&($%* R
…
:<
$
[,
$d7($$d)7$$d** U)C
m

&_(!TA8
yx
<;D4*
¢}~…ùú
!
œôØÏ
ËÌ
$
:àᵶ…
TA8
ªˆ
&( R
“
$<;D4*
¢}
~øÚp†‚
!
·

ùq
TA8
…†‡„ª
ˆœ‘ÍBÞyx
<;D4*
¢}~8

®ÎáT§×Çàᵶ
*
ϧÎË

Dr$d$(
®ÎᵶÇàá
T§×
*
ϧÎË
*
Dr$d$
i
!
uåævô
<;D4*
¢}…†‡„ªˆ
!

Hv4$6w)
@NUd!DVM-K.VTA8 .1 IS.XNVMSLKN.1 N1RN_NKN.1 .V<;D4* -MX
!

Hv4$6w)
·
!
uåævô
<;D4*
¢}~…ùú
!

Hv4$6w)
HL_XM!DVM-K.1 LI.IK.?N?.V<;D4* -MX?_5TA8 !

Hv4$
6w)
Ï[
¦Ê
=U)C
m
~ø
=j
ôØ
!! m *d$( v$d
uåæv
$d d#7 v$d*7
$d*
$d) v$d#)

$d)
d& v$d%&

$d&
)d% vd(#

!!
)
#
œôØÏÎË

Dr$d$
&_&!B.--R?K4))*(
úIÜÝpq
<;D4*
¢}߅
YDZ[
!B.--R?K4))*(
úIÜÝpqôØÏ¢
}e¨PхÚÝúI
$
¢}ßۀw•
$
®p
TA8
Ïešde,Šµ¶†»
$
~¢}à8àæ

~
¢}8š¢}ÞûY:
$
ÜÝ#à9*
$
¢}ßµ
œG‘
$
ßc´
$
ߊ‘

¢}ßëœ
$
Jk¨š¢
}ßc´

ᵶυ
TA8
EFuz{|
<;D4*
¢}~…ªˆàÚp
$
½
TA8
¸¨
$d& U)C
m
T
$
¨šP˜Ê…¢}ßc´
!
i
*
&_`!
uåævô
<;D4*
¢}»Pì҅ùú
!
ô
ØÏ¢}Þû̘
$
·2GÊ…P2㊅eF

ß6Ü3
$
ß8ÜÝ#¯9*
$
<ÜÝ#ÎÏ
$
2
ÜÝ#̐
$
”¢}ß6¯

߆è$öŠÙ
$
¢
}#8ÁLÞÎÏ
$d& U)C
m
TA8
ïIÏ¢}Þ
ûœ:
$
ۀY™àw•

¢}ß8ÜÝ#Š‘
$
1
ß6å7
$
˜ÜÝ#ì­®:•
$
¢}§œ°
¨ÉGÜÝ#‹•¶¢}#…~:Þ
$

¨¢}~n؅YD
!
i
)
)&))))
v
)(
ªv
7
x
*$)
q
$
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Xd)($:??YM!7
]-K._MS$ *$)
i* !
uåævyx
<;D4*
¢}~…Û€0¹
!:B<$g*$$
@NUd*!9.SIR.X.UN-LX-RL1UM-RLSL-KMSN?KN-.VLI.IK.?N?N1 <;D4
* -MX?N1WY-MW _5TA8!:B<$g*$$
i
)!
uåævyx
<;D4*
¢}»PìÒ0¹
! g( $$$
@NUd)!HSL1?/N??N.1 MXM-KS.1 /N-S.?-.I5.V<;D4* -MX?-YX4
KYSMW _5TA8 ! g( $$$
&_$!>MLX4KN/MA<>
‚%
TA8
ô
<;D4*
!
4-LKM1N1
/>;3
·¸…ùú
!$d$$d*$$d)$$d& U)C
m
…
TA8
yx
<;D4*
¢}
* W
T !
4-LKM1N1
9¬‘
/>4
;3
·¸Cá…Q?[,
! $d7%* v$d $
!$d($ v$d$)7 $ ! $d%$% v$d$ $ ! $d*7( v
$d$
ˆ+‘sâ1žâ¯”f8I
$$d$
$d* U)C
m
TA8
ô !
4-LKM1N1
9¬‘
/>;3
·¸‰
Úpùú
( $d)$ $d& U)C
m
TA8
œap}„
!
4-LKM1N1 />;3
…·¸
$
œôØÏÎËGp}Â1
2
!Dr$d$
þÚ
TA8
‘„
<;D4*
¢}$
!
4-LKM1N1
®¤wðà……·¸

&_a!
šØúI
!
ôØÏ !
4-LKM1N1
9¬®}ß
%
}
©9G·¸
$
:
$d& U)C
m
TA8
ªˆ
&( R
“ !
4-LKM4
1N1
®}ß$·¸ÚpE
$
Í·¸O£ö}ßß}
6¤Ù
H<@&
9¬ÒÓ·¸®}ß
$$d& U)C
m
TA8
ªˆ
&( R
“
$
Í·¸ÊÚpE
!
i
&$
&_%!JM?KMS1 _X.K

TA8
ô
<;D4*
¢} !
4-LKM4
1N1$FL6$F-X4*
9¬·¸…ùú
!
[ˆ
$d$$d*$
!!
i
&!
uåævô
<;D4*
¢}$ !
1-LKM1N1
9¬¯ö·¸
…ùú
!:B<$ g&$$
@NUd&!DVM-K.VTA8 .1 KRMWN?KSN_YKN.1 L1W M6ISM??N.1 .V
!
4
-LKM1N1 .V<;D4* -MX?!:B<$ g&$$
i
!
uåævô
<;D4*
¢}$
H<@&
9¬¯ö·¸…ù
ú
!:B<$ g&$$
@NUd!DVM-K.VTA8 .1 KRMWN?KSN_YKN.1 L1W M6ISM??N.1 .VH<@&
.V<;D4* -MX?!:B<$ g&$$
$d)$$d& U)C
m
TA8
ÀÂ
<;D4*
¢}
&( R
“dµ
¶…†‚ !
4-LKM1N1$F-X4*
9¬·¸Ço
$FL6

·¸…o

:¶nUì+pq
$)
×9¬œp9ô
ØÏÎËGp}12
!Dr$d$!
i
#
`!
‡[
uå͘%E¿í…
,
£H
-
Ó,

Œq8
u¦ešuåævœÚp†±šØõ¿…‘âG
šØ§‚ƒöiU§‚ƒ^Â
.4*/

uåævœa
ù»À¹“ý„…šØ‘
$
®J%j¶…E
‚ƒÀ¹…x–Ä
.&4/

âïIˆ
<¯)ï
#
J
%µ¶…
TA8
ôuz{|¢}Ã
<;D4*
G†‡
„ªˆ
$
â8T§ö¦Ê›FÂ

ïIŽˆÔg¢
})
311M6N1 =^A:
FÜݯ8‚ì+)ï
$TA8
ª
ˆ
<;D4*
¢}
&( R
“
$
e~…¢}?œôØÏ
)))))
v
)(
ªv
7
x
*$)
q
$
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Xd)($:??YM!7
]-K._MS$ *$)
!!
3d
ôØÏ
( FfDd$d f$d& U)C
m
TA8
Ï
(
œôØÏÎË

Dr
$d$
i
#!JM?KMS1 _X.K
‚%
FL6$F-X4*$
!
4-LKM1N1
9¬…·¸
@NUd#!D6ISM??N.1 .VFL6$ F-X4*$
!
4-LKM1N1 WMKM-KMW _5JM?K4
MS1 _X.K
ÎËÚp†‚
B.M-R?K4))*(
ÜݜZ.9pq
:
TA8
ªˆ
&( R
“…
<;D4*
¢}8š¢}~n
؅YD

…mì+)ï
$TA8
œBÞyx~„
<;D4
*
¢}†‡
J1K=
!
4-LKM1N1
BSÍo‹®¢}†‡
¶D…n$
½2
.)/

’“)ï !
4-LKM1N1
(®¥Š|
%
ç|
%
¹
Š|
%
ì6 |öz{|îæ×ïނƒ¢}$»
·¸
$J1K
n
.#/

!
4-LKM1N1
u{o~(Œ­
$
Â›€Ç
$
!
4-LKM1N1
Bޜ569¬
D4-LWRMSN1
…}©OÎm
ÿ)%È{¢}6
$
Êsš… !
4-LKM1N1
œý¢}
©8…9¬³õ¿CÃ
.%/
$
J+®}#ö
!
ö


$¨šÍG‘
$
•<<ùq !
4-LKM1N1
圅nS^†±
.(/

âïI$šØ¢}DïI)ï®
<;D4*
¢
}$
$
!
4-LKM1N1
®}ß$»·¸
$
:
TA8
À“
!
4-LKM1N1
9¬…·¸Cá¯Í·¸O£ö}ßß}
6¤Ù
>MLX4KN/MA<>
ö
JM?KMS1 _X.K
ˆ)ï
TA8
ªˆ
<;D4*
¢}
&( R
“
$
!
4-LKM1N1 />;3
œ9¬·
¸ÊœôØÏÎËÌÚpÇo
$
a…ì+þÚ
TA8
ςo !
4-LKM1N1
‘…¤wö9¬…·¸
H<@&
uß8¤w‘(
$
͒“™Ì,‘…
J1K=
!
4-LKM4
1N1
…Çs(

½
J1K
n$H<@&
…0

J1K
BS…sn<( !
4-LKM1N1 3S/
H€¾
*ªˆÛ€ŽÞ
$
ÊÍö¢}#¤ç¢}ß8
$
)
Q*…
B9T
œœ>(O£…Q‘o‹¾*
Î|ªˆ
$
eXͤwZ^‘
.)$7/

®âïI$
$
šØ¢}Dpq
#H<@&
(®
<;D4*
ÒÓ·¸
{}ß
$TA8
ªˆ“Í·¸ÊCá

‘‡Q‚®
TA8
ô
<;D4*
…ªˆ$
$H<@&
ùúP !
4-LKM1N1
…
ߤȶ͜Qߐ‘쎅^Â

¢}~Í®‘o‹Ç…¢}j¾Â™
$
h¨~Îz9¬…o‹
$F-X4*
ö
FL6
9,~Î
z9¬
F-X4*
Œ­#
.$/

¢}$
F-X4*
œ
FL6
¦
§…Ë°.%P¢}Ípÿhyx~…n<
./

¢}~NO}6™hÞwx…X®BS¶ÁL
Þwx…8®BS
*
K–—

ÁLÞ~–—B<
›º¢}Ýs
…ÑÀ
%Œ
­…^D
%F-X4*
Œ­9¬…åœ

⒓$
<;D4*
:
TA8
À“
$F-X4*
Œ­§~#J
F-X4*
…·
¸h„
$
)¬~#J
FL6
…·¸…o

ùq
TA8
yx
<;D4*
¢}~œ‘ÍBޝ„
J1K=
!
4-LKM1N1=H<@&
n<¤xBS^Â
$
öÁLÞwx
…8®BSEF…

›y€Þ…ƒ„
$
J¢}Ýs
<
…ÑÀ
%
ÁLÞ6ZȅyY¡~y:n…·š
î9U”Jäæ璓

 …‹m
$TA8
‘yx
<;D4*
¢}~
$
̓
„¦Jœ‘͝„
J1K=
!
4-LKM1N1
n<¤xBS
$
E
 !
4-LKM1N1
¤Ù¨}ß88

‘‡
$J1K=
!
4-LKM1N1
BSiœ‘,
TA8
ôz{|¸¹…JK
Q3


}~€
#
. /!
·KÏ
$
{T
$
!˜à
$
î
d
uåævô
G#*
¢}†‡
„¶yxD…ïI’“
.Z/d
vQ·í˜c
$*$$$*%
!##%d
. * /!
!â[
$
{²&
$
ÄÁ
,
uåæv§‚ƒªˆ…’“
.Z/,
u咓
$77!*#**d
. ) /!HL\LRL?RN4PL1LUL@$ 8L?LUYSNHdHRMJ1K=
!
4-LKM1N1 ?NU1LXN1U
ILKR+L5L?LKLSUMKN1 WSYUWN?-.cMS5.Z/dZARLS/L-.X8-N$*$$%$
$&!&#*7)d
. & /!BL1 8 G$ 8.1UZP$ PY1 P8$ MKLXdTN1?L1 N/IS.cMW HR N/4
/Y1MSM?I.1?MN1RN_NKMW _5UL//LSLWNLKN.1 .Z/d3S-R ARLS/
>M?$*$$$*(!)#)&)d
. /!
¹Ý
$
rT
$
›À
$
î
d
uåæv)*òÞXyxu¬¨=¢

G#*
†‡„¶D
.Z/d
$%Ïótj’“œQR

$*$$$&7!&# 7**d
. # /!9N1\MG8$ 8KLN_ A$ AYMKMS3$ MKLXd8/LX/.XM-YXMN1RN_NK.S?
.VJ;H?NU1LXN1UMVM-KNcMX5N1WY-MLI.IK.?N?N1 L-YKM/5MX.NW
XMY\M/NL-MX?.Z/dDYSZBLM/LK.X$*$$7$(*!)##d
. % /!
v¸[
$
ºwÙ
$
›†·
$
î
d
!
4-LKM1N1
‘®¬¨=Ν$
)#))))
v
)(
ªv
7
x
*$)
q
$
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Xd)($:??YM!7
]-K._MS$ *$)
…·¸¶ÍQR¯n
.Z/,
$_¨ò-.
$*$$%$*( !(#
&d
. ( /!8LXWL1RLT$ TRYSL^ $ A.KMSC$ MKLXd;Y-XMLS
!
4-LKM1N1 N1 _L?4
LX-MX-LS-N1./L-.SMXLKM?+NKR N1-SML?MW IS.XNVMSLKN.1.Z/dFSZ
EMS/LK.X$*$$&$!#%d
. 7 /!>M5LH$ ;LKYSM$*$$$&)&!%$)#(&)d
.$/!EXYU.?[AZ$ FNXM1 CA$ 311N?9T$ MKLXdF-X4* -RL1UM?-.14
V.S/LKN.1 K.N1RN_NKFL6.XNU./MSN[LKN.1.Z/dD9F]Z$*$$#$*
!#**(%d
./!]XKMS?W.SVH$ DX/.SM8 J$ 8R.M/L\MS3>$ MKLXd31 N1RN_NK.S.V
F-X4* VL/NX5IS.KMN1?N1WY-M?SMUSM??N.1 .V?.XNW KY/.YS?.Z/,;L4
KYSM$*$$$&)!%$&*##%%d
*LL?JB@LS.AI?AS M@/DI-JJC-E.F?+.AFGJ?F[ABP
!
+J-B?A.AI.SA-/BE-AIFGJB.@A
M-BCY-D @A-M@MB@I.I@LCG,-AA-I@MC-EDAS?-/J-AJ?EJ?/I03*+*
@3;ZNL4/N1U

$ C:Q M`4R.1U
*
$ C:ZN1U
*
$ J3;TPL4IN1U
*
$ P3;TCc45YL1

$ BQ3;TZNL1U40Y

!
! d0(G.&=(6&-/K&-.;36-7.*6@-7-@*1!(2 62 5(9B%8.@(.*$ O3.4&:;-6@I36@ (2397N63E(.43&*$ :;-6@I36@ &$$$#$ :;36(
*d+,-.&-.*-/%&(=:(762 A348(C6@36((.36@$ A(9;36@ 62 $(4(.9; $--=-/!34&-7-@*62 C=,.*-7-@*$
:;-6@I36@ (2397N63E(.43&*$ :;-6@I36@ &$$$#$ :;36
.4KIBE-JB/!6KV?JB.Q?# H.._?MScMKRMMVM-K.VUN1?M1UI.X5?L--RLSNWM!TA8 .1 KRMIS.XNVMSLKN.1 L1W LI.IK.?N?.VRY/L1 1L4
?.IRLS51UMLX-L1-MS-MX?<;D4*$ L1W WN?-Y??KRMI.??N_XM/M-RL1N?/d._?MScMW _5<!$$ $d$ $d*$ $d)$ $d& U)C
m
.VTA8 V.S&( RdHRMVX.+-5K./MKS5+L?Y?MW K.WMKM-KNK?N1WY-KN.1 MVM-K.1 <;D4* -MXLI.IK.?N?d
B.M-R?K4))*( -MX?KLN1N1UL1W MXM-KS.1 /N-S.?-.IM+MSMY?MW K.._?MScMKRM/.SIR.X.UN-LX-RL1UM?.V-MX?dHRM
!
4-LKM1N1 />;3M64
ISM??N.1 +L?WMKM-KMW _5>MLX4KN/MA<>dHRMIS.KMN1 X.-LXN[LKN.1?L1W M6ISM??N.1?.V
!
4-LKM1N1 L1W H<@& +MSMKM?KMW _5KRMN//Y1.4
VXY.SM?-M1-M?KLN1N1UdHRMM6ISM??N.1?.V
!
4-LKM1N1$ F-X4* L1W FL6IS.KMN1?+MSMWMKM-KMW _5JM?KMS1 _X.Kd8?IG/B# <?YXK??R.+MW KRLKTA8 -.YXW SM/LS\L_X5N1RN_NKKRMIS.XNVMSLKN.1 .V<;D4* -MX?$ +NKR W.?M4KN/MWMIM1WM1-Md:<
$
.V-MX?N1WY-MW +NKR
TA8 V.S&( R +L?$d)7 U)C
m
d3VKMS_MN1UIS.-M??MW +NKR TA8 +NKR -.1-M1KSLKN.1?.V$d$ $d*$ $d)$ $d& U)C
m
V.S&( R$ KRM-MX
LI.IK.?N?SLKM?.VRY/L1 1L?.IRLS51UMLX-L1-MS-MX?<;D4* +MSM!d#7 v$d*7j$ !$d) v$d#)j$ !d& v$d%&j L1W
!)d% vd(#j$ SM?IM-KNcMX5d8NU1NVN-L1KWNVMSM1-M+L?._?MScMW -./ILSMW +NKR KRM-.1KS.XUS.YI !*d$( v$d j !Dr$d$d
HRMSM?YXK?.VB.M-R?K4))*( ?KLN1N1U?R.+MW KRM-RLSL-KMSN?KN-?.V-MXLI.IK.?N?dQ1WMSKRMMXM-KS.1 /N-S.?-.IM$ LI.IK.?N?_.WNM?
-.YXW _M._?MScMW L/.1U<;D4* -MX?N1WY-MW +NKR TA8 +NKR KRM-.1-M1KSLKN.1 .V$d& U)C
m
V.S&( RdHRMSM?YXK?.V>MLX4KN/MA<>
?R.+MW L?NU1NVN-L1KSMWY-KN.1 N1
!
4-LKM1N1 />;3M6ISM??N.1dHRMSM?YXK?.VXL?MS-.1V.-LX/N-S.?-.I5SMcMLXMW 1.KL_XMWM-SML?M.V
!
4-LKM1N1 L1W H<@& M6ISM??N.1 N1 1Y-XMY?L1W KSL1?VMSVS./1Y-XMY?K.-MX/M/_SL1M?N1
!
4-LKM1N1 M6ISM??N.1 LSML?LVKMS_MN1UIS.4
-M??MW +NKR TA8 V.S&( RdJM?KMS1 _X.K?R.+MW ?NU1NVN-L1KWM-SML?MN1 KRMM6ISM??N.1?.V
!
4-LKM1N1 L1W L1KN4LI.IK.?N?IS.KMN1 F-X4*$
+NKR L1 N1-SML?N1UM6ISM??N.1 N1 LI.IK.?N?4IS./.KN1UIS.KMN1 FL6!Dr$d$d0@AJ/GI.@A# TA8 -.YXW ?NU1NVN-L1KX5N1RN_NKKRMIS.XNVMS4
LKN.1 .V<;D4* -MX?L1W IS./.KMKRNMSLI.IK.?N?dHRM._?KSY-KN.1 .VJ1K=
!
4-LKM1N1 ?NU1LXN1UILKR+L5/L5_ML1 N/I.SKL1K/M-RL1N?/
V.STA8 K.N1WY-MKRMLI.IK.?N?.VRY/L1 1L?.IRLS51UMLX-L1-MS-MX?<;D4*d
.U?D Y@EFI/!UN1?M1UI.X5?L--RLSNWM!TA8( <;D4* -MX( -MXIS.XNVMSLKN.1( LI.IK.?N?( J1K=
!
4-LKM1N1
F@.#)b`(aPJVJ,,()&#(&

vw-0
!
†‡‡
#
)%))))
v
)(
ªv
7
x
*$)
q
$
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Xd)($:??YM!7
]-K._MS$ *$)